巻号一覧
237 巻 (2015)
- 4 号 p. 249-
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237 巻, 2 号
October
選択された号の論文の10件中1～10を表示しています
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Regular Contribution
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Xingwang Ning, Zijuan Jian, Wei Wang原稿種別: Regular Contribution
2015 年 237 巻 2 号 p. 77-82
発行日: 2015年
公開日: 2015/09/15
ジャーナル フリー HTMLInterleukin 35 (IL-35) is a newly discovered anti-inflammatory cytokine. Recent studies have indicated that it plays a crucial role in the pathogenesis of autoimmune diseases. In humans, IL-35 is predominantly secreted from regulatory T cells. This study aimed to measure serum IL-35 levels in patients with rheumatoid arthritis (RA) and in control individuals, and analyze its association with disease indicators of RA. One hundred patients with RA were recruited, and 50 volunteers were enrolled as healthy controls. Serum IL-35 levels were measured using an enzyme-linked immunosorbent assay kit. RA patients showed significantly lower serum levels of IL-35 compared with healthy controls (p < 0.001). RA patients suffering from erosive arthritis (n = 31) had lower IL-35 levels than those with non-erosive arthritis (n = 69, p = 0.022). In addition, serum IL-35 level was significantly lower in 22 patients with elevated percentage (> 75%) of neutrophils (p < 0.001). Correlation analysis indicated a significantly negative association between IL-35 and age, rheumatoid factor (RF), or percentage of neutrophils. In contrast, the serum IL-35 levels were not significantly different between patients with anti-cyclic citrullinated peptide (CCP) antibodies (n = 78) and those without anti-CCP antibodies (n = 22). However, among patients without anti-CCP antibodies, the serum IL-35 levels were lower in patients with erosive arthritis (n = 8) than those patients without erosion (n = 14) (p < 0.001), although no significant difference was detected in patients with anti-CCP antibodies. In conclusion, IL-35 plays a protective role in the pathogenesis of RA.抄録全体を表示PDF形式でダウンロード (460K) HTML形式で全画面表示 -
Masahiro Tsuchiya, Jun Aida, Yoshihiro Hagiwara, Yumi Sugawara, Yasuta ...原稿種別: Regular Contribution
2015 年 237 巻 2 号 p. 83-90
発行日: 2015年
公開日: 2015/09/17
ジャーナル フリー HTMLIn March 2011, the Great East Japan Earthquake (GEJE), which was followed by a devastating tsunami, destroyed the societal and the public hygiene systems in Japanese coastal areas. Insomnia, the greatest issue among disaster victims, has detrimental effects on both physical and psychological health. Periodontitis causes chronic discomfort and inflammation, and little is known about its impact on insomnia. Three months after the earthquake, a health panel survey was conducted over four surveys, till September 2013, in which information regarding 8,015 adults was collected and used. In addition to the heath-related questionnaire, other variables including subjective symptoms of oral diseases were recorded, and the Athens Insomnia Scale was used to evaluate the severity of insomnia. The association between insomnia and periodontal disease was examined using multilevel logistic models on the panel data, after adjusting for sex, age, economic status, comorbidities, body mass index, post-traumatic stress reactions, habitual smoking and alcohol drinking, and the Kessler Psychological Distress Scale score. In addition to the higher prevalence of insomnia among GEJE victims, significant association was revealed between insomnia and gum problems (OR = 2.16, 95% CI = 1.43-3.26), and difficulty chewing (OR = 2.22, 95% CI = 1.40-3.51), after adjusting for all covariates. The present study revealed significant association between insomnia and periodontal disease among GEJE victims. This indicated that together, integrated oral health care for disaster victims would contribute not only to prevention of oral infectious diseases, but may also help alleviate other problems caused by these harmful events.抄録全体を表示PDF形式でダウンロード (837K) HTML形式で全画面表示
Invited Review
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Koji Minoura, Daisuke Sugawara, Tohru Yamanoi, Tsutomu Yamada原稿種別: Invited Review
2015 年 237 巻 2 号 p. 91-102
発行日: 2015年
公開日: 2015/09/18
ジャーナル フリー HTMLThe 2011 Tohoku-Oki Earthquake is a typical subduction-zone earthquake and is the 4th largest earthquake after the beginning of instrumental observation of earthquakes in the 19th century. In fact, the 2011 Tohoku-Oki Earthquake displaced the northeast Japan island arc horizontally and vertically. The displacement largely changed the tectonic situation of the arc from compressive to tensile. The 9th century in Japan was a period of natural hazards caused by frequent large-scale earthquakes. The aseismic tsunamis that inflicted damage on the Japan Sea coast in the 11th century were related to the occurrence of massive earthquakes that represented the final stage of a period of high seismic activity. Anti-compressive tectonics triggered by the subduction-zone earthquakes induced gravitational instability, which resulted in the generation of tsunamis caused by slope failing at the arc-back-arc boundary. The crustal displacement after the 2011 earthquake infers an increased risk of unexpected local tsunami flooding in the Japan Sea coastal areas.抄録全体を表示PDF形式でダウンロード (9169K) HTML形式で全画面表示
Regular Contribution
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Suzana Bojic, Jelena Kotur-Stevuljevic, Nevena Kalezic, Predrag Stevan ...原稿種別: Regular Contribution
2015 年 237 巻 2 号 p. 103-109
発行日: 2015年
公開日: 2015/09/19
ジャーナル フリー HTMLSepsis-associated acute kidney injury (SA-AKI) severely impacts morbidity and mortality in surgical patients with sepsis. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) have an important role in pathophysiology of sepsis but they have been unexplored in SA-AKI. We aimed to investigate the role of MMP-9 and TIMP-1 in septic surgical patients with SA-AKI and to evaluate them as diagnostic biomarkers of SA-AKI. This prospective observational study compared 53 major abdominal surgery patients with sepsis divided into SA-AKI (n = 37) and non-SA-AKI (n =16) group to 50 controls without sepsis matched by age, gender, comorbidities and type of surgery. Blood and urine samples from septic patients were collected on admission to ICU and 24, 48, 72 and 96 h later and once from the controls. The levels of MMP-9, TIMP-1, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1, urea and creatinine were measured. MMP-9/TIMP-1 ratio and disease severity scores, such as Sequential Organ Failure Assessment (SOFA), were calculated. Septic patients with SA-AKI had higher serum TIMP-1 levels and lower serum MMP-9 levels and lower MMP-9/TIMP ratio, compared to septic patients without SA-AKI and controls. The levels of these biomarkers did not change significantly over time. MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio correlated with urea, creatinine, NGAL, and SOFA scores. Moreover, using the area under ROC curve, we showed that TIMP-1 and MMP-9/TIMP-1 ratio, but not MMP-9, were good diagnostic biomarkers of SA-AKI. We report for the first time the potential diagnostic value of TIMP-1 and MMP-9/TIMP-1 ratio in SA-AKI.抄録全体を表示PDF形式でダウンロード (494K) HTML形式で全画面表示 -
Cagdas Guducu, Serhat Taslica, Raif Cakmur, Murat Ozgoren, Ahmet Omer ...原稿種別: Regular Contribution
2015 年 237 巻 2 号 p. 111-116
発行日: 2015年
公開日: 2015/09/26
ジャーナル フリー HTMLThe relationship between Parkinson’s disease (PD) and olfactory dysfunction has been investigated via psychophysical and electrophysiological assessments. Despite the increasing number of electrophysiological studies focusing on olfactory function, there are still some limitations to observe the chemosensory event-related potentials (CSERP), which are electrophysiological responses of the brain to olfactory and trigeminal stimulations, because of the low sensitivity (low signal-to-noise ratio). Recent studies attempted to establish new techniques to increase the sensitivity for evaluating the CSERP and brain responsiveness. We aimed to inspect CSERP via entropy analysis in assessing chemosensory related brain responses that has been used for the first time. Twelve newly diagnosed and non-medicated PD patients and 12 healthy subjects participated in the study. Psychophysical and electrophysiological evaluation of olfaction were assessed via Sniffin’ Sticks Test (SST) and entropy analysis on CSERP in three time windows. The scores of odor threshold, odor identification and total scores of SST were lower (hyposmic) in PD patients compared to healthy subjects. Electrophysiological assessments revealed a significant change in entropy among time windows for olfactory stimulation with phenyl ethyl alcohol and trigeminal stimulation with carbon dioxide (both p < 0.05) in healthy subjects but not in PD patients. Entropy findings indicate that the brain operates in ordered state among healthy subjects in response to olfactory/trigeminal stimuli, whereas the PD patients displayed a chaotic pattern. This pattern in the PD patients suggests the lack of proper smell function. It should be studied if this pattern can be used as a biomarker for PD.抄録全体を表示PDF形式でダウンロード (1443K) HTML形式で全画面表示 -
Chen Zhou, Zhengde Xie, Liwei Gao, Chunyan Liu, Junhong Ai, Li Zhang, ...原稿種別: Regular Contribution
2015 年 237 巻 2 号 p. 117-126
発行日: 2015年
公開日: 2015/10/01
ジャーナル フリー HTMLEpstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening complication of EBV infection. MicroRNAs (miRNAs) were small non-coding RNA, and EBV could encode miRNAs that are involved in the progression of infection. However, the profiles of EBV-miRNAs in EBV-HLH were unknown. Here, we aimed to profile the expression of EBV-miRNAs in children with EBV-HLH by analyzing 44 known EBV-miRNAs, encoded within the BamHI fragment H rightward open reading frame 1 (BHRF1) and the BamHI-A region rightward transcript (BART), in plasma and cellular targets by real-time quantitative PCR. The study included 15 children with EBV-HLH, 15 children with infectious mononucleosis (IM), and 15 healthy controls. CD8+ T cells were found to be the cellular target of EBV infection in EBV-HLH, while CD19+ B cells were infected with EBV in IM. We also found the greater levels of several miRNAs encoded by BART in EBV-HLH, compared to those in IM and healthy controls, whereas the levels of BHRF1 miRNAs were lower than those in IM. The profile and pattern of EBV-miRNAs in EBV-HLH indicated that EBV could display type II latency in EBV-HLH. Importantly, the level of plasma miR-BART16-1 continued decreasing during the whole chemotherapy, suggesting that plasma miR-BART16-1 could be a potential biomarker for monitoring EBV-HLH progression. The pathogenesis of EBV-HLH might be attributed to the abundance of EBV-miRNAs in EBV-HLH. These findings help elucidate the roles of EBV miRNAs in EBV-HLH, enabling the understanding of the basis of this disease and providing clues for its treatment.抄録全体を表示PDF形式でダウンロード (7016K) HTML形式で全画面表示 -
Turkan Ozturk Topcu, Halil Kavgaci, Feyyaz Ozdemir, Asude Aksoy, Dilek ...原稿種別: Regular Contribution
2015 年 237 巻 2 号 p. 127-132
発行日: 2015年
公開日: 2015/10/03
ジャーナル フリー HTMLBreast cancer (BC) is the most common cancer among women and a major cause of death. Signal Peptide-Cub-Epidermal growth factor domain-containing protein-1 (SCUBE1) is secreted under hypoxia and inflammatory conditions from platelet alpha granules. Its biological function is uncertain, although it may be a procoagulant substance in cancer patients. SCUBE1 is useful for identifying thrombotic diseases, including cancers and acute coronary syndromes. D-dimer reflects the relationship between coagulation activation and fibrinolysis; namely, thrombosis and D-dimer levels are closely linked. This is the first investigation of the potential diagnostic and prognostic value of SCUBE1 levels in patients with BC. Fifty patients and 33 age-matched and body mass index-matched healthy controls were enrolled. Blood samples were collected before chemotherapy regimens commenced. Serum SCUBE1 and D-dimer levels were measured before adjuvant chemotherapy and were compared to the healthy controls. SCUBE1 levels were determined using an enzyme-linked immunosorbent assay (ELISA) method. SCUBE1 and D-dimer levels were significantly higher in patients than in the controls (p = 0.03 and p < 0.001, respectively). A cut-off value of 1.55 ng/mL for SCUBE1 was associated with 62% sensitivity and 72.7% specificity and with positive predictive value of 77.5% and negative predictive value of 55.8%. Two patients with high SCUBE1 and D-dimer levels also developed pulmonary embolism. SCUBE1 may indicate hypercoagulability in patients with BC and thus help identify patients at greater risk of thrombosis and requiring anti-thrombosis treatment. SCUBE1 may also be used as an assistant test for identifying patients at risk of BC.抄録全体を表示PDF形式でダウンロード (464K) HTML形式で全画面表示 -
Yuuki Konno, Ikuko Takahashi, Ayuko Narita, Osamu Takeda, Hiromi Koizu ...原稿種別: Regular Contribution
2015 年 237 巻 2 号 p. 133-140
発行日: 2015年
公開日: 2015/10/07
ジャーナル フリー HTMLKawasaki disease (KD) is an acute systemic vasculitis that affects both small and medium-sized vessels including the coronary arteries in infants and children. Acid sphingomyelinase (ASM) is a lysosomal glycoprotein that hydrolyzes sphingomyelin to ceramide, a lipid, that functions as a second messenger in the regulation of cell functions. ASM activation has been implicated in numerous cellular stress responses and is associated with cellular ASM secretion, either through alternative trafficking of the ASM precursor protein or by means of an unidentified mechanism. Elevation of serum ASM activity has been described in several human diseases, suggesting that patients with diseases involving vascular endothelial cells may exhibit a preferential elevation of serum ASM activity. As acute KD is characterized by systemic vasculitis that could affect vascular endothelial cells, the elevation of serum ASM activity should be considered in these patients. In the present study, serum ASM activity in the sera of 15 patients with acute KD was determined both before and after treatment with infusion of high-dose intravenous immunoglobulin (IVIG), a first-line treatment for acute KD. Serum ASM activity before IVIG was significantly elevated in KD patients when compared to the control group (3.85 ± 1.46 nmol/0.1 ml/6 h vs. 1.15 ± 0.10 nmol/0.1 ml/6 h, p < 0.001), suggesting that ASM activation may be involved in the pathophysiology of this condition. Serum ASM activity before IVIG was significantly correlated with levels of C-reactive protein (p < 0.05). These results suggest the involvement of sphingolipid metabolism in the pathophysiology of KD.抄録全体を表示PDF形式でダウンロード (506K) HTML形式で全画面表示 -
Jiaming Wen, Bohan Wang, Chuanjun Du, Gang Xu, Zhewei Zhang, Yi Li, Na ...原稿種別: Regular Contribution
2015 年 237 巻 2 号 p. 141-148
発行日: 2015年
公開日: 2015/10/07
ジャーナル フリー HTMLDiabetes is an important risk factor for erectile dysfunction (ED). Recent studies have indicated that A2B adenosine receptor (ADORA2B) signaling is essential for penile erection. Thus, we hypothesize that diabetic ED may be attributed to impaired A2B adenosine signaling. To test this hypothesis, we generated diabetic rats by injecting streptozocin as animal model. After 12 weeks, immunohistochemistry staining was used to localize the expression of ADORA2B. Western Blot and quantitative PCR were employed to determine ADORA2B expression level. Intracavernosal pressure (ICP) measurement was used to evaluate erectile function. Diabetic rats received a single intravenous injection of BAY 60-6583, an ADORA2B agonist, or vehicle solution, at 60 min before the ICP measurement. The results showed that ADORA2B expressed in the nerve bundle, smooth muscle, and endothelium in penile tissue of control mice. Western Blot and quantitative PCR results indicated that the expression levels of ADORA2B protein and mRNA were significantly reduced in penile tissues of diabetic rats. Functional studies showed that the erectile response induced by electrical stimulation was remarkably decreased in diabetic rats, compared with age-matched control rats. However, at 60 min after BAY 60-6583 treatment, the erectile function was improved in diabetic rats, suggesting that enhancement of ADORA2B signaling may improve erectile function in diabetic ED. This preclinical study has revealed a previously unrecognized therapeutic possibility of BAY 60-6583 as an effective and mechanism-based drug to treat diabetic ED. In conclusion, we propose that impaired A2B adenosine signaling is one of the pathological mechanisms of diabetic ED.抄録全体を表示PDF形式でダウンロード (1392K) HTML形式で全画面表示 -
Ki Hun Cho, Won-Kyung Song原稿種別: Regular Contribution
2015 年 237 巻 2 号 p. 149-155
発行日: 2015年
公開日: 2015/10/09
ジャーナル フリー HTMLStroke, as a major risk factor for chronic impairment of upper limb function, can severely restrict the activities of daily living. Recently, robotic devices have been used to enhance the functional upper extremity movement of stroke patients. The purpose of the current study was to assess whether a robot-assisted reach training program using a whole arm manipulator (WAM) could improve upper extremity kinematic performance and functional movement for chronic stroke patients. Using a single-group design, this study followed 10 people with chronic stroke (6 men, 61.5 years; Mini-Mental State Examination score: 27.0; onset duration: 8.9 years). WAM with seven degrees of freedom for the shoulder, elbow, and wrist joints was used during robot-assisted reach exercises. Subjects participated in the training program for 40 minutes per day, 2 times a week, for 4 weeks. The main outcome measures were upper extremity kinematic performance (movement velocity) for three directions and functional movement (Action Research Arm Test). Upper extremity kinematic performance and functional movement measures were performed three times: at baseline, during intervention (at 2 weeks), and post intervention. Upper extremity kinematic performance and functional movement showed improvement after two weeks (P < 0.05) and four weeks (P < 0.05) of training compared to baseline. The findings of the current study demonstrated the positive effects of short-term robot-assisted reach training on upper extremity kinematic performance as well as functional movement in individuals with chronic stroke. In addition, the findings of the current study may provide valuable information for subsequent randomized controlled trials.抄録全体を表示PDF形式でダウンロード (1391K) HTML形式で全画面表示
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