The difference of the course and the blood picture of avitaminosis-B between
f-classed (high-classed) and
b-classed (low-classed) detoxieating liver power in rabbits was as follows-
1. Course.
(a) The
f-classed rabbits. In 2 rabbits (Nos. 1 and 8), none of these symptoms-paresis of the legs, diarrhoea dyspnoea and anorexia-occurred. In the No. 6 rabbit paresis of the legs appeared, but recovered readily by a daily injection of vitamin-B. The No. 5 rabbit died in the middle of the 12th week. In this animal, appetite was very _??_ poor from the beginning of B-avitaminotic feeding, but paresis did not occur.
(b) The
b-classed. In 3 rabbits (Nos. 2, 3 and 7), the B-avitaminotic symptoms appeared, namely paresis of the legs, dyspnoea, diarrhoea, anorexia etc. and a daily injection of vitamin-B either with or without yakriton was not successful.
In the No. 4 rabbit, paresis of the legs appeared, but recovered after the administration of vitamin-B.
(c) Difference between
f- and
b-classed rabbits. In the case of
f classed rabbits, it was difficult to make them B-avitaminotic, but once so, it was easy to effect a recovery from the state by the administration of vitamin-B. In
b-classed rabbits, it was the reverse, since it was easy to make them B-avitaminotic, but to restore them to the normal state was very, very difficult.
2. Blood picture.
(a) The
f-classed rabbits. An initial leucocytosis, followed by a leucopenia up to about the 5th or the 7th week. Then as the latter half of the course passed on, a slightly increased or normal leucocyte count. Even when paresis of the legs occurred, there was no change of the total number of white cells. In the No. 5 rabbit a moderate leucocytosis continued after the leucopenia until death occurred. In the first half of the course of avitaminosis-B, a remarkable relative and absolute lymphocytosis, and a relative myelopenia. In the second half of the course, the relation between lymphatic and myeloid cells was almost normal. Even when a B-avitaminotic symptom appeared, this relation was almost normal, or only a slight lymphocytosis was present; but this lymphocytosis however disappeared when vitamin-B was administered. As to the nuclear shift, generally, cells of Types I and II decreased, and cells of Types III, IV and V increased, but the shift was restored to normal by the administration of vitamin-B. No. 5 rabbit was an exception to the rule, since a slight shift to the left (about twice the normal in cells of Type I) occurred, and continued until death. Monocytes and basophiles showed an increase in number, but there was no change of eosinophiles in number during almost the whole course.
(b) The
b-classed rabbits. In general, an initial leucopenia occurred, then, normal white cell count again. With the appearance of paresis, a moderate or a severe leucocytosis occurred suddenly. As to the relation between lymphatic and a myeloid cells, a lymphopenia and amyelocytosis appeared, and the grade of them grew with the appearance of B-avitaminotic symptoms. Concerning the nuclear shift, a slight shift of degenerative nature was seen from the beginning of the B-avitaminotic experiment, and became suddenly very marked, amounting to about three or four times the normal, with the appearance of B-avitaminotic symptoms. A severe initial eosinophilia was seen in No. 3 rabbit, but in the other animals eosinophiles decreased in number gradually. Dlonocytes and basophiles increased slightly in number during the whole course.
(c) Difference between
f- and
b-classed rabbits.
In the case of
f-classed rabbits, an initial leucocytosis was seen, and in the latter half of the course, the leucocytosis became slighter, but in the case of
b-classed animals, leucopenia prevailed almost continuously from the beginning.
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