巻号一覧
30 巻, 2 号
選択された号の論文の11件中1～11を表示しています
- |<
- <
- 1
- >
- >|
-
小笠原 彬, 工藤 昇1936 年 30 巻 2 号 p. 99-102
発行日: 1936/12/30
公開日: 2008/11/28
ジャーナル フリーPDF形式でダウンロード (622K) -
西條 慶四郎1936 年 30 巻 2 号 p. 103-122
発行日: 1936/12/30
公開日: 2008/11/28
ジャーナル フリーIn order to elicite the rôle possibly played by the augmented epinephrine secretion by insulin in altering the blood sugar level, the mean arterial blood pressure, the pulse rate, the body temperature, the clinical symptoms etc., the present writer has attempted to give insulin (Toronto) intravenously into dogs, normal and with the demedullated suprarenals, in uniform dosage of 5 units per kilo of body weight, and in fact:
Insulin alone into normal dogs; few in number, because the experiments by Yen, Aomura and Inaba can be utilized also as the control according to circumstances.
Insulin alone to the dogs with the demedullated suprarenal glands;
Insulin to the dogs, so operated on, with the continuous injection of the physiological saline solution at the velocity of 1 c. c. per minute, with which the saline solution of adrenaline hydrochloride was infused to the dogs with the demedullated suprarenal capsules with or without injection of insulin;
Adrenaline hydrochloride solution to the dogs with the deme-dullated suprarenal capsules with the velocity of 1 c.c. per minute but at the same time with the same velocity, as far as possible, rê adrenaline hydrochloride itself to that with which epinephrine is liberated from the suprarenals when poisoned with 5 units insulin per kilo body weight;
And lastly, adrenaline hydrochloride solution in the above described manner, and insulin intravenously to the dogs with the deme-dullated suprarenal capsu'
The results may be summarized as follows then:
Adrenaline hydrochloride, intravenously introduced in the above described manner and magnitude, is capable of causing the hyperglycaemia of a certain intensity, an accelerated pulse rate, and an increase in the body temperature.
The demedullation of the suprarenal capsules increases the intensity of clinical poisoning symptoms, of hypoglycaemia due to insulin; The pulse rate, on the contrary, shows rather a tendency to decrease, and the body temperature decreases too.
Combined injection of insulin at once and of adrenaline hydroch-loride solution in imitating the augmented epinephrine liberation in the so poisoned normal dogs, brings about in dogs with the deme-dullated suprarenal glands, poisoning symptoms almost similar to those occasionable in normal dogs poisoned with insulin alone, rê the clinical symptoms, the blood sugar content, the heart rate and the body temperature.
Of the blood pressure the same might be the case, but it is difficult to say with definiteness. Hypertonic effect of adrenaline hydrochloride solution in the manner and magnitude, above described, was doubtful, and there were scarcely any material differences rê the blood pressure fall due to insulin between the normal dogs, and those with demedullated capsules, with or without the infusion of adrenaline hydrochloride solution in the above described manner.
Thus it is clearly elucidated that the augmented secretion of epinephrine on poisoning with insulin is acting to lessen the fall of the blood sugar content, and compensates the fall of the pulse rate and of the body temperature. This has been here quantitatively proved, that is the intravenous introduction of adrenaline hydrochloride, if done to replace as accurately as possible, the epinephrine output during the insulin poisoning, can completely compensate the loss of the medulla of the suprarenal glands rê the blood sugar content, the heart rate and the body temperature.抄録全体を表示PDF形式でダウンロード (882K) -
田中 英一1936 年 30 巻 2 号 p. 123-149
発行日: 1936/12/30
公開日: 2008/11/28
ジャーナル フリーOn the base of the experimental evidence of Sato and Ohmi of the whole figure of the oversecretion of the epinephrine output from the suprarenals in the dog by poisoning with morphine, the present writer tried to make clear the share of the oversection of epinephrine in the production of hyperglycaemia occurring simultaneously during the morphine intoxication.
Four sets of experiments were carried out: Morphine into the dogs with the intact suprarenals, morphine into the dogs with the demedullated suprarenals, adrenaline hydrochloride into the dogs so operated on and morphine and adrenaline hydrochloride into the dogs without the suprarenal medulla. Morphine hydrochloride was intravenously injected in the constant dose of 8 mgrms. per kilo of body weight, and adrenaline hydrochloride saline solution was intravenously injected with a constant velocity of 1 c. c. a minute, but its content of the drug was arranged to imitate as faithfully as possible the rate of epinephrine discharge from the suprarenal glands in the dog of Sato and Ohmi, which was injected with that dose. In some dogs all the sets of experiments were carried out, but in others the latter three sets only. The first set of experiments was performed in some other individuals.
The outstanding figures in the outcome are as follows.
(1) The whole figure of the hyperglycaemia, caused by morphine in the normal dogs and of that by morphine plus adrenaline in the dogs with the demedullated suprarenals are almost wholly identical. Morphine alone brought about the hyperglycaemia in the dogs with the demedullated suprarenals, but its figure is different in certain points from those above related to. It is clearly inferior in relation to the magnitude of them, and although the steepness of the as-cending limb is similar to them, it turns relatively early into the slow descending limb without plateau or with a short one. The continuous infusion of adrenaline-saline fluid caused hyperglycaemia definitely inferior in magnitude to those in the normal dogs under morphine, and to those in cases where the suprarenal medulla was already previously deprived of and morphine was injected in addition to the adrenaline infusion, yet it was rather similar in the form to them.
It can be stated therefore that the hyperglycaemia elicitable by morphine has two origins; one due to the oversecretion of epinephrine from the suprarenal glands, and another which has no relation to the suprarenal medulla, and probably the former has some such share therein.
(2) Of the fluctuation in the pulse rate during the morphine poisoning, the oversecretion of epinephrine from the suprarenals or the adrenaline infusion was found, though not so striking, as having some significance, and in fact a paradoxical one; that is they act rather to retard the pulse rate. This is strange enough, but has some analogy in the role of the epinephrine oversecretion in the blood sugar fluctuation during the peptone poisoning, which was elucitated by Kaiwa.
(3) The oversecretion of epinephrine during the morphine poi-soning may be taken as to effecting, though not so decidedly, to lesson the body temperature fall therein.抄録全体を表示PDF形式でダウンロード (1390K) -
三浦 修1936 年 30 巻 2 号 p. 150-169
発行日: 1936/12/30
公開日: 2008/11/28
ジャーナル フリーEin wösseriger Extrakt des Pilzes Clitocybe acromelalga, Ichimura, dessen Genuss bei uns bisweilen mehr oder weniger schwere Vergiftungen hervorruft, verursacht bei Tieren eben falls Vergiftungserscheinungen, die je nach den Tierarten sehr verschieden sind und von denen bei Menschen vor allem darin abweichen, dass bei keinem Tier zu Gangröne führende Rötungen und Schwellungen der Extremitöten eintreten.
Die Vergiftungserscheinungen bestehen beim Frosch hauptsöchlich in einer Löhmung der willkürlichen and der Reflex- und Atembewegungen von zentraler Natur, bei der Maus, Ratte sowie dem Meerschweinchen daneben auch in einer den Atemstillstand herbeifüh-renden Verlangsamungdyspnoe, die nach der Untersuchung an der Ratte auf einer Löhmung des Phrenicus and des Atemzentrums beruht. Das letztgenannte Tier wird auch von anfallsweise auftretenden klonischen und tonischen Krömpfen befallen, die bei den anderen Tieren gönzlich fehlen. Von den untersuchten Tieren ist nur bei der Maus eine betröchtliche Erregbarkeitssteigerung der sensiblen Nervenenden zu beobachten, die ihrer Natur nach vielleicht dem bei der Vergiftung des Menschen eintretenden heftigen Schmerzen gleich zu sein scheint.
Es bewirkt wahrscheinlich infolge einer Erregung der sympathischen Nervenenden eine Vergrösserung des Schlagumfangs des Herzens und eine Verengung der Gefösse und führt dadurch eine Blutdrucksteigeruiig herbei.
Beim Uterus erregt es sowohl die sympathischen als auch die parasympatischen Nervenenden, wöhrend es beim Darm vorzüglich die letzteren in Erregung versetzt. Infolgedessen erfahren die beiden Organe eine Tonussteigerung und Bewegungsförderung.
Die mannigfaltigen Wirkungen des Extraktes beruhen mögli-cherweise darauf, dass in ihm verschiedene wirksame Substanzen ent-halten sind, worüber spöter berichtet werden soll.抄録全体を表示PDF形式でダウンロード (4850K) -
草野 重孝1936 年 30 巻 2 号 p. 170-174
発行日: 1936/12/30
公開日: 2008/11/28
ジャーナル フリーPDF形式でダウンロード (649K) -
草野 重孝1936 年 30 巻 2 号 p. 175-180
発行日: 1936/12/30
公開日: 2008/11/28
ジャーナル フリーPDF形式でダウンロード (274K) -
澁谷 秀雄1936 年 30 巻 2 号 p. 181-185
発行日: 1936/12/30
公開日: 2008/11/28
ジャーナル フリーPDF形式でダウンロード (224K) -
大和田 一男1936 年 30 巻 2 号 p. 186-191
発行日: 1936/12/30
公開日: 2008/11/28
ジャーナル フリーDie Atmung der Gewebszellen der Leber, Milz und Niere sowie der Blutzellen wird durch EinflUsse der ultraakustischen Schallwellen gehemmt.抄録全体を表示PDF形式でダウンロード (264K) -
秋山 新治1936 年 30 巻 2 号 p. 192-195
発行日: 1936/12/30
公開日: 2008/11/28
ジャーナル フリーPDF形式でダウンロード (700K) -
三浦 修1936 年 30 巻 2 号 p. 196-202
発行日: 1936/12/30
公開日: 2008/11/28
ジャーナル フリーClitocybe acromelalga, Ichimura, ein giftiger Pilz, dessen Genuss bei Menschen Vergiftung mit heftigem Schmerz und Nekrose in den Extremitöten verursacht, ruft bei Höhnen eine nekrobiotische Verönderung des Kainmes and der Bartlappen, in denen sick eine hyaline Degeneration mikroskopisch nachweisen lösst, hervor, wöhrend er bei anderen Tierarten, wie Möusen, Ratten, Meerschweinchen und Kaninchen nicht imstande ist, eine solche Verönderung herbeizuführen.
Die nekrobiotische Verönderung von Hahnenkömmen wird wie die Sensibilitötsstörung bei Möusen durch zwei verschiedene wasserlosliche Substanzen hervorgerufen, von denen die eine durch Bleiazetat geföllt und durch Kochen zersetzt wird, wöhrend die andere dagegen mit Bleiazetat keinen Niederschlag bildet und kochbestöndig ist.
Für die technische Hilfe bei der Ausführung dieser Versuche bin ich Herrn Prof. S. Nasu im Pathologischen Institut zu Dank ver-pflichtet.抄録全体を表示PDF形式でダウンロード (718K) -
田中 英一1936 年 30 巻 2 号 p. 203-218
発行日: 1936/12/30
公開日: 2008/11/28
ジャーナル フリーThe blood sugar content of cats was examined in the present investigations in the non-feeding period and on feeding with glucose solution (3 or 2 grms. glucose per kilo body weight by mouth) and in fact while the animals were remaining wholly intact, and after the spleen was removed. The test was carried out several times during a long period after the splenectomy. The latter was carried out under narcosis, so that the control, dummy operation was performed, that is the abdominal cavity was opened simply under ether narcosis with-out combining any other manipulations. Several tests were carried out after the dummy operation.
The loss of the spleen is thus proved in our cats as having no in-fluence upon the blood sugar content in the non-feeding period and the sugar tolerance of the animal as well. A clear demonstration is supplied in the features, ref. Text-figure, originated from a cat in which the alimentary hyperglycaemia was measured several times before the splenectomy in a period over five weeks, many times after the dummy operation in a period over six weeks, and a number of times after the removal of the spleen in a period of four months. The magnitude of the alimentary hyperglycaemia is nott always quite the same, but varies to some extent, though not so excessively, as far as our experiments go, so that it is highly desirable, we think, to carry out the tolerance test several times before removing the spleen, and also several times after it has been done.抄録全体を表示PDF形式でダウンロード (725K)
- |<
- <
- 1
- >
- >|