As stated above, all the 4 rabbits used showed methyl glyoxal like substance in the milk, which showed a certain decrease (up to 2.0 mgrms. %) on a subcutaneous use of vitamin B, until the qualitative tests became negative. When monoiodacetic acid was subcutaneously injected, the methyl glyoxal like substance increased gradually, which was proved both quantitatively and qualitatively. Arakawa's reac-tion became weaker and weaker, as the substance increased. Body weight showed a decrease. These changes due to monoiodacetic acid were recovered by vitamin B
1 alone when they were of a light degree (as in Rabbit 2), but, when they were of a serious degree (as in Rabbits 3 and 4), only a combined use of yakriton and vitamin B
1 was able to improve the condition.
It is to be remarked here, especially because Geiger and Rosenberg
10) reported that an administration of vitamin B caused a temporary increase of methyl glyoxal in urine of B-avitaminotic dogs, that temporary increase of methyl glyoxal like substance soon after the use of vitamin B
1 was seen in the rabbit's milk (Cf. Rabbits 2 and 3) in my own experiment.
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