The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
73 巻, 1 号
選択された号の論文の11件中1~11を表示しています
  • O. Fresen
    1960 年 73 巻 1 号 p. 1-21
    発行日: 1960/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    In Kyoto 1924 Aschoff has suggested, that future researchs would prove, whether it has been justified to unite different but nevertheless cooperating cells to a special system. The conclusions of physiological and pathological examinations just as microscopical and submicroscopical investigations have substantiated, that this retothelial system, at first only functionally established, is characterized by a common morphological substratum.
    This cell system consists, in a closer sense, of the provinces of the reticular cell tissue which forms with its net of argyrophil fibres the stroma of lymphoreticular tissue and bone marrow, and the structural element of the spleen. Reticular coating cells are the endotheloid elements lining the sinusoids of the bone marrow, spleen, liver and lymph nodes; the essential feature distinguishing them from the general vascular endothelium is the absence of a basal border by a collagen basement membrane. The extended portion of the system is formed by mobile histiocytes in the undifferentiated circumvasal and subendothelial zones, where they can also be formed. Submicroscopically the reticular cell tissue, including the lining cells, show cell borders and continuous intercellular clefts which, owing to the spatial connection of the cells, communicats with the sinusiods. Cross striated fibrils are seen in the amorphous ground-substance of the widened clefts; as oriented bundles they correspond to the histological argyrophil reticular fibre. These fibrils occur not only extracellularly but sometimes are connected with the ectoplasm of the reticular cells, which has to be considered for the mode and place of fibrillogenesis. This system, which was first conceived from the agreement in functions of its elements, is seen to have an adequate morphological structure, which is maintained in both reactive and inflammatory manifestations of the system and is formed in the various neoplasias. These findings, when compared with the fine structure of fetal connective tissue, are an indication of the apparently slight differentiation of this cell system. This remainder of the embryonal multipotent mesoderm can be termed the retothelial system, since the ordinary endothelium of the blood-and lymph-parts can be excluded for its form and functions.
    On the examples of granulomatoses and neoplasias it is discussed, that the uniform texture of the reticular histiocytic tissue formations is the essential prerequisite for explaining the pathogenesis and prospective importance also of such retothelial determined diseases, whose origin is not yet known and whose nosological classification is still disputed. Demonstration of the retothelial substrate, including the cells in this stroma, and observation of developmental forms by cytological and histological examination also allowed to determine connections between the origin of regular and morbid hemopoiesis and the retothelial system. A synoptic evaluation of the findings presented confirms the anatomical integrity of the R.S, and its multifarious importance in health and disease.
  • Second Report: Red Cells and Hemoglobin
    山口 厳, 奥口 昭三
    1960 年 73 巻 1 号 p. 22-26
    発行日: 1960/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    Red cell pictures were studied in stomach cancer cases with special reference to their relation with morphological aspects of the tumor, with the results as follows:
    1) Anemia was observed in 47 (66.2%) of 71 stomach cancer cases. The anemia in stomach cancer differed from that in peptic ulcer, not only in the rate of occurrence but also in some other features.
    2) The type of the anemia was various in stomach cancer, suggesting different origins of the anemia.
    3) Of various aspects of the lesion, its extent of the spreads as well as the tumor size was most closely related with the occurrence of the anemia in stomach cancer..
    4) Bleeding from the tumor was found to be a significant but not the only factor resulting in the anemia in stomach cancer.
  • Third Report: Serum Calcium
    山口 厳, 銘木 常正, 元木 良一
    1960 年 73 巻 1 号 p. 27-30
    発行日: 1960/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    Serum calcium figures in stomach cancer were studied with special interest to their relation with the morphological aspects of the lesion, taking ionization of serum calcium into consideration.
    1) The concentration of serum calcium, especially that of the ionized calcium, was generally low in stomach cancer, and significantly lower even when compared with peptic ulcer cases. The abnormal patterns of serum calcium, defined from both the concentration and the extent of dissociation, were found in 89.6 per cent of the stomach cancer cases.
    2) The serum calcium figures in stomach cancer were closely dependent upon the extent of the cancer spreads that was revealed by operations, a little upon the tumor size, but wholly not upon the gross nor microscopic features of the tumor.
  • Fourth Report: Supplement and Conclusions
    山口 厳, 井上 和彦, 西山 安, 鈴木 常正, 吉城 哲夫, 奥口 昭三, 元木 良一, 大沼 弘治
    1960 年 73 巻 1 号 p. 31-36
    発行日: 1960/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    1. Rabbits were injected with (1) a saline extract of the stomach cancer tissue, (2) a saline extract of the normal gastric mucosa and (3) the plain solvent, respectively, successively for 103 days, changes in their blood constituents being studied in relation to the clinical observations in the preceding reports.
    2. A brief discussion was made on the nature of the hematological changes in stomach cancer, particularly on their relation with morphological aspects of the lesion, at the conclusion of the series.
  • 鈴木 雅洲, 村上 裕三, 安部 徹良, 熊谷 一郎
    1960 年 73 巻 1 号 p. 37-45
    発行日: 1960/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    The uterus and such target organs to sex-hormones sometimes fall into dysfunction. The sensitivity of the target organ was analysed by determinations of the weight of the uterus of mice, of ATP in the human endometrium, of acetylcholine in the human endometrium, of 321) uptake of the human endometrium and of the tissue respiration of the human endometrium. In such cases, we must not limit ourselves to hormone administration but also not neglect treatment of the organs with impaired sensitivity to sex hormones. The sensitivity of the target organ was enhanced by treating the endometrium with the co-enzyme DPN.
  • Second Report: Growth Characteristics of Myxoviruses in Tissue Cuture
    石田名 香雄, 大里 外誉郎
    1960 年 73 巻 1 号 p. 46-55
    発行日: 1960/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    The initial stage of virus-cell interaction was studied in a system of PR8 virus and Earle's L cell. Used virus was highly labelled with P32 and not contaminated more than 5% of P32 other than virus.
    In conducting the experiment, these 2 particles, i.e. virus and host cell were combined and agitated for 2 hrs. at 37°C. Then the cells were removed from the mixture by centrifugation and the nature of hemagglutinins and distribution of radioactivity in this supernatant were compared to those in the inoculum.
    Hemagglutinin titer left in the supernatant has been proved to increase after the incubation, particularly when tested with guinea pig red cells. Furthermore, the P32 count detectable after red cell adsorption or after ultracentrifugation which will be enough to sediment elementary bodies, has been increased. Part of them was sedimented with small hemagglutinins and easily extracted with ether, but at 37°C. Moreover, some radioactivity disappeared from the supernate to the L cell debris. Thus the disintegration of virus particles after contact with L cell was suggested.
  • Third Report. Growth Characteristics of Myxoviruses in Tissue Culture
    石田名 香雄, 本間 守男
    1960 年 73 巻 1 号 p. 56-69
    発行日: 1960/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    Growth characteristics of the Sendai virus in Earle's L cell have been studied. As long as 6 hours was necessary to detect soluble antigen in the cell. Positive hemadsorption was found at 7hours. Accumulation of soluble antigen, hemagglutinin and infectious particles were detectable in this time sequence but almost from 6 to 10hours. Non-infectious heniagglutinins were first detectable inside the. cell and the release of these kinds of particles were ahead to the liberation of infectious particles. As a result, obtained harvest had the low I/A ratio, when compared to the virus population obtained after reproduction in chorioallantoic cavities of chick embryos. A kind of host-controlled variation has been observed with the particles liberated from L cells. They were infectious when inoculated into eggs but not infectious when inoculated to L cells again. They also lost the hemolytic activity which had been believed to be a dominant character of this virus, at least when grown in chick embryos.
  • 井手 水月
    1960 年 73 巻 1 号 p. 70-73
    発行日: 1960/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    The noradrenaline and adrenaline contents of the adrenal gland in cats were estimated by the permanganate method of Suzuki and Ozaki. Hypothermia was induced by immersing the animals into cold water.
    After application of cold to the animal body a marked decrease in adrenaline content of the adrenal gland was found, whereas there was no definite alteration in adrenal noradrenaline content.
  • 加藤 正道
    1960 年 73 巻 1 号 p. 74-85
    発行日: 1960/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    An attempt was made to ascertain whether physical exercise might cause increase of the conduction velocity of the nerve fibers in young adults.
    Experiments were carried out on 32 university student athletes and 6 professional athletes with controls of 30 ordinary university students. The ages of these subjects ranged from 20 to 36 years.
    For the purpose of measuring the conduction velocity of the ulnar nerve, square wave stimulation of 0.5 msec. duration was applied to the ulnar nerve at the axilla, elbow and wrist, and evoked myograms were picked up from the hypothenar eminence muscles.
    The spinal reflex time was measured as the latency of the H wave which was recorded from the gastrocnemius muscle by stimulating the posterior tibial nerve at the popliteal fossa.
    Room temperature was carefully kept at 30°C during the experiments.
    (1) The average maximum conduction velocities of ulnar nerve fibers were 67.0±2.5 meters per second in the forearm and 67.6±2.6 meters per second in the upper arm in the control group and 66.5±2.3 meters per second in the forearm and 67.2±2.6 meters per second in the upper arm in the athletes group.
    It was noticeable that any significant differences were recognizable neither between the data of the forearm and upper arm in the two groups nor between those obtained in the athletes group and the control group.
    (2) No significant difference as to the spinal reflex time and the spinal reflex index was seen between the two groups, judging from the patterns of their distribution depicted in the graphs. The spinal reflex index is an index which corresponds to the mean conduction velocity of the impulse over the reflex arc.
    (3) Distinct individual differences in the maximum conduction velocity of ulnar nerve fibers were observed in both groups. However, no factor was found which might be related to the individual differences from the viewpoint of anthropometric measurements and skillfulness in sport.
    From these results, it may be said that no kind of physical exercise increases in the conduction velocity of the nerve fibers in young adults.
  • 細田 峻, 高瀬 貞夫, 吉田 弘一
    1960 年 73 巻 1 号 p. 86-95
    発行日: 1960/12/25
    公開日: 2008/11/28
    ジャーナル フリー
  • 山本 信二郎, 山内 利夫
    1960 年 73 巻 1 号 p. 96-101
    発行日: 1960/12/25
    公開日: 2008/11/28
    ジャーナル フリー
    The evoked potential technique was used to investigate functional organization of the spinal dorsal roots and the cranial nerves in the bullfrog. Afferent stimuli were initiated by brushing or touching on the skin area, and cutaneous tactile fields were mapped. The overlap of innervation was found more marked in the trunk rather than in the extremities. A crossed-over innervation was found in the skin areas surrounding the nostrils and the. anus. The area innervated by the vagus nerve extended from the occiput to the shoulder girdle area, and overlapped extensively the area innervated by the trigeminal nerve and the spinal dorsal roots.
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