All issues
Volume 76 (1962)
- Issue 4 Pages 319-
- Issue 3 Pages 215-
- Issue 2 Pages 107-
- Issue 1 Pages 1-
Volume 76, Issue 3
Displaying 1-9 of 9 articles from this issue
- |<
- <
- 1
- >
- >|
-
Takeo Kuroyanagi1962 Volume 76 Issue 3 Pages 215-223
Published: April 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDownload PDF (490K) -
An Epidemiological HypothesisEiji Takahashi1962 Volume 76 Issue 3 Pages 224-232
Published: April 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe peculiar distribution of the presenile (45-64) death rates from the vascular lesions affecting the central nervous system in the United States is epidemiologically discussed. As an etiological factor of it, the nutritional hypothesis is suggested for the high incidence of the vascular lesions affecting the central nervous system in the Southeastern states, especially of Negroes.
In the Southeast, where there are more people of low income class than in the Northeast, the prevailing diet is one of cereals, lacking in vegetables and fruit as well as meat and milk. Consequently, some vitamin deficiency should result, especially of A, C, and B-complex as well as calcium deficiency. These nutritional deficencies might be considered as an etiological factor of the high incidence of the vascular lesions affecting the central nervous system in the Southeast of the United States as well as in Japan.View full abstractDownload PDF (1610K) -
Koroku Hashimoto, Toshiji Igarashi, Masahiro Saigusa, Iwao Uei, Tsuguo ...1962 Volume 76 Issue 3 Pages 233-240
Published: April 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe process of cardiac anoxia and its recovery was observed on the isolated Langendorff dog's heart preparation when the coronary circulation was occluded for 10 to 20 minutes. Furthermore the effect of cytochrome C was evaluated in the present procedure.
Cytochrome C improved the recovery process from the anoxia produced by coronary occlusion. This drug let the cardiac muscle take up the oxygen more easily. Furthermore it brings a smaller variation of the heart rate, the coronary flow and the oxygen consumption in the recovery process among individual animals. It indicates quite uniform and stable recovery by cytochrome C premedication.
Authors recommend the use of this drug for the expected anoxia in cardiac surgery on their experimental evaluation.View full abstractDownload PDF (1452K) -
Tetsuro Abe1962 Volume 76 Issue 3 Pages 241-250
Published: April 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1) The estradiol-17β dehydrogenase was extracted from human abdominal rectus muscle as a non-target organ, various kinds of human uterus and term placenta as the target organ of sex hormones and its activities were assayed by the Langer and Engel's method.
2) The activity of the estradiol-17β dehydrogenase was neglegible in abdominal rectus muscle, markedly low in senile atrophic uterus, moderately low in normal uterus, moderately high in fibroid or pregnant uterus and markedly high in the term placenta in both estradiol-17β dehydrogenation and estrone hydrogenation reaction. These results suggest that this enzyme is closely related with the uterus-sensitivity to sex hormones.View full abstractDownload PDF (437K) -
Masakuni Suzuki, Katsuyuki Takahashi, Tetsuro Abe, Ichiro Tabuchi, Kic ...1962 Volume 76 Issue 3 Pages 251-266
Published: April 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSNew methods for clinical diagnosis of the functional endocrine disorders of the gonadal system inculding the diencephalon, the hypophysis, the gonads and the uterus were devised and clinical cases of endocrine disturbances were evaluated by these methods.
1) Various kinds of methods of laboratory testing of uterus sensitivity to ovarian hormones, i.e. the 32P-uptake test, the oxygen consumption test, the histological examination test, the cervical-mucus-crystallization test, the withdrawalbleeding test, were devised and clinical cases of lowered sensitivity of the uterus to ovarian hormones, detected by these methods, were reported.
2) A new method of evaluating function of the ovary, i.e. the gonadotrophin administration test, was devised by an intravenous administration of gonadotrophin and an estimation of the change of estrogen contents in urine and blood.
3) New methods of evaluating function of diencephalon, i.e. the basal body temperature test and the copper-salt administration test, were devised and applied clinically.View full abstractDownload PDF (875K) -
Masakuni Suzuki, Motohiko Ichijo, Yoshihiro Okuda, Shuji Shohara, Tets ...1962 Volume 76 Issue 3 Pages 267-277
Published: April 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effect of sex hormones on the target organ, the uterus, was studied electron-microscopically, histochemically and enzyme-chemically. It was found to be accomplished by a varieties of changes in the general metabolism, accompanied by changes in the activity of enzymes and co-enzymes. These effects are considered to result in the known physiological action of sex hormones and to cause morphological changes in tissues. So, when a hormone reaches the target organ, it takes, at first, part in some specific biochemical reaction, which results in inducing a series of many concomitant biochemical processes. The answer to the question of what constitutes this initiative reaction perhaps holds the key to elucidate the mechanism of sex hormone. Whether the kind of initiative reaction upon which the hormones can act is single or multiple is also a question awaiting future study. We must also study the question of the place of sex hormones in the enzymatic system, that is, whether they are substrates, enzymes, coenzymes, stimulator, or inhibitor.View full abstractDownload PDF (601K) -
Yasuo Suda1962 Volume 76 Issue 3 Pages 278-306
Published: April 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1) The anatomical changes of the kidney in acute renal failure were regarded to develop in the stage of partly recovered renal blood flow after temporary renal ischemia.
2) Similar anatomical renal changes were also observed in autopsy cases without serious clinical symptoms of renal impairment and without oliguria.
3) Renal secretion was theoretically treated and possible influences of anatomical changes on urine volume were discussed by means of histometrical investigation. Dilatation of tubular lumen was regarded to be one of the factors which contributed to reduce urine volume.
4) No difference in renal secretory activity was indicated by the histometrical investigation between oliguric and non-oliguric groups.
5) The cause of oliguria was sought in renal changes, which were accidental to renal secretory activity. Quantiative evaluation of injuries of the distal tubule revealed a clear correlation of tubular injuries to urine volume and made possible the separation of oliguric and non-oliguric groups.
6) The majority of the cases of acute renal failure was regarded to fall within the stage, where renal blood flow was more or less restored after temporary renal ischemia, but the kidney was still unable to excrete sufficient amount of urine on account of tubular leakage.View full abstractDownload PDF (5011K) -
Keiya Tada, Yasuhisa Watanabe1962 Volume 76 Issue 3 Pages 307-312
Published: April 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe activity of glucose-6-phosphate dehydrogenase (G6PD), the content of reduced glutathione (GSH) and the GSH stability test were investigated in the umbilical cord blood from premature and full-term infants.
There was no significant difference in the activity of G6PD in erythrocytes between cord blood from full-term infants and venous blood from healthy infants. As to the cord blood from full-term infants and prematures, however, the activity was significantly lower in the latter than in the former.
The content of erythrocyte GSH was higher in cord blood of the newborns than in venous blood of healthy infants. As to the cord blood, there was no significant difference of GSH content. A lower stability of GSH was found in cord blood of the newborns as compared with that in venous blood from healthy infants. There was, however, no remarkable difference in GSH stability of cord blood between full-term and premature infants.View full abstractDownload PDF (313K) -
Tatsuo Stao, Nozomu Ishida, Chuichi Itoh, Yasuo Wada, Kaoru Yoshinaga1962 Volume 76 Issue 3 Pages 313-318
Published: April 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS(1) In three patients with pheochromocytoma, catecholamines and their metabolites in urine and blood before operation were determined and these compounds in removed tumor tissues were also assayed. Procedures of the determination of these compounds in each materials were described briefly.
(2) In all patients, both catecholamines and their metabolites were abnormally increased in urine as well as in blood, while in tumor tissue only the parent amines were contained in large quantities.
(3) No significant difference in the urinary excretion pattern of catecholamines and their metabolites was found between patients with pheochromocytoma and NA infused subjects.
From these data, it is concluded that in these patients relatively pure catecholamines are released from tumor into circulation and then metabolized after developing clinical features and excreted into urine.View full abstractDownload PDF (327K)
- |<
- <
- 1
- >
- >|