巻号一覧
82 巻 (1964)
- 4 号 p. 293-
- 3 号 p. 181-
- 2 号 p. 93-
- 1 号 p. 1-
82 巻, 3 号
選択された号の論文の10件中1～10を表示しています
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斎藤 章1964 年 82 巻 3 号 p. 181-200
発行日: 1964/04/25
公開日: 2008/11/28
ジャーナル フリーAs mentioned in previous reports1-15), infectious diseases are divided into 3 groups according to the field of main defense reaction. Among these 3 groups an orderly and obvious difference can be observed from the standpoint of not only basic science and clinical medicine, but also preventive medicine. In the majority of diseases of the first group the pathogenic microbes appear as balanced parasites, to which the prophylactic vaccination is not highly effective. On the contrary, in the third group the pathogenic microbes are apt to appear as unbalanced parasites, to which the prophylactic vaccination is of great value. Infectious diseases in the second group show intermediate properties of the first and third groups. The course of phylogenesis and ontogenesis in mammalia for 60 million years are the histories of their sturggles against pathogenic microbes. In the process of struggles for existence, the bodies of higher animals such as Homo sapiens are so highly specialized organically and functionally that they adapt so well to the internal environment. For instance, the two phases of neutrophil formation in the bone marrow are an expression of higher adaptation to the internal environment, corresponding to the two fields of their defense reaction (the field of cell-bacterium reaction and that of antibody-antigen reaction) to allow the body to perform the most reasonable and suitable adaptation to preserve life safely.抄録全体を表示PDF形式でダウンロード (1338K) -
山本 敏行1964 年 82 巻 3 号 p. 201-217
発行日: 1964/04/25
公開日: 2008/11/28
ジャーナル フリーInfluences of the section thickness on electron microscopic images of the biological membrane were geometrically analyzed. It has been revealed by this analysis that by means of geometrical effects of the section thickness, a conspicuous error is inevitable in the estimation of the total thickness of the membrane. This sort of error, however, is nearly avoided when the center-to-center distance between the two dense layers of the unit membrane is applied instead of the total thickness. Probability that planar membranes are cut by a section with a cutting angle larger than ψ degree is given by 1-ψ/90+1/6π (8sin2ψ-sin4ψ).抄録全体を表示PDF形式でダウンロード (597K) -
高橋 英次1964 年 82 巻 3 号 p. 218-223
発行日: 1964/04/25
公開日: 2008/11/28
ジャーナル フリーNational average consumption of coffee per person per year is estimated for 5 years (1955-59) on 20 not-producing countries from data in the Yearbook of International Trade Statistics. Age-adjusted death rate from cancer of prostate and of other urogential and digestive organs is adopted from data of Segi and WHO. Correlation between estimated national average consumption of coffee and mortality for prostate cancer is on the significance level, but not between coffee consumption and cancer mortality of other urogential and digestive organs, though sugar consumption has significant correlation not only with prostate cancer but also with cancer of some other organs. The significance of much coffee drinking to prostate cancer is discussed.抄録全体を表示PDF形式でダウンロード (301K) -
畔柳 武雄, 杉山 始1964 年 82 巻 3 号 p. 224-233
発行日: 1964/04/25
公開日: 2008/11/28
ジャーナル フリーThere has been reported an increasing body of evidences suggesting the effectiveness of the immune therapy of leukemia. It is needless to say that anti-leukemic cell antibodies must suppress circulating leukemic cells as well as leukemic cells in the bone marrow and tissues, in order to induce the complete remission. However, until recently little attention has been directed to the in vivo localization of anti-leukemic cell antibodies in the bone marrow and tissues of leukemic animals, because of a lack of the reliable and reproducible method. Therefore, the in vivo bone marrow and liver localization of heterologous anti-leukemic cell antibodies in normal and leukemic mice was studied by means of 1131 labeled antibody.
Anti-bone marrow antibodies agglutinated circulating leukocytes as well as leukemic ascitic tumor cells and anti-leukemic ascitic cell antibodies agglutinated not only leukemic ascitic tumor cells but also circulating normal leukocytes, indicating the presence of common antigens between normal leukocytes and leukemic ascitic tumor cells.
Both I131 labeled anti-bone marrow antibodies and I131 labeled anti-leukemic ascitic cell antibodies were localized specifically in the bone marrow but not in the liver in normal mice. However, they were localized specifically in the bone marrow as well as in the liver in mice with leukemic ascitic tumor. These results suggest that anti-leukemic ascitic cell antibodies not only exert a cytotoxic effect on circulating leukemic cells but also are localized specifically in the bone marrow and tissues and exert a cytotoxic effect on leukemic cells in them. The administration of I131 conjugated anti-leukemic ascitic cell antibodies containing a large amount of 1131 to mice with leukemic ascitic tumor resulted in a marked decrease of the percentage of circulating leukemic cells and in a slight prolongation of the survival period.抄録全体を表示PDF形式でダウンロード (517K) -
熊坂 鉄郎, 西川 泰右, 熊谷 勝男, 石田 名香雄1964 年 82 巻 3 号 p. 234-241
発行日: 1964/04/25
公開日: 2008/11/28
ジャーナル フリーThere are two steps in the process of inactivation of antitumor antibiotics upon in vitro contact with Ehrlich ascites tumor cells or mouse liver homogenate: (1) adsorption of antibotics to the cell or cell homogenate, this occuring rapidly even in the cold, and (2) a temperature-dependent inactivation, which proceeds gradually.
Ayamycin A2, chromomycin A3 and actinomycin D were strongly adsorbed to Ehrlich tumor cells and to the liver homogenate, but mitomycin C and penicillin G were not. The temperature-dependent inactivation was most marked with ayamycin A2, chromoycin A3 and mitomycin C, but only slight or none with actinomycin D, chloramphenicol and penicillin G.
Upon contact with rabbit red blood cells or sera, these inactivations were not marked except for the case of ayamycin A2.抄録全体を表示PDF形式でダウンロード (252K) -
佐久間 貞行1964 年 82 巻 3 号 p. 242-249
発行日: 1964/04/25
公開日: 2008/11/28
ジャーナル フリーSerial enlargement roentgenography was conducted 2 and 5 seconds after injection of 76% Urografin into the carotid artery of rabbits under the exposure condition of 125kVp, 2mA, 0.05 seconds and focus film distance of 100cm. On the enlargement roentgenogram fine structure of the ophthalmic artery of the rabbit was imaged as linear crescent shadow due to contrast filling of the choroidal plexus, linear shadow of the long and short ciliary branches, comb-shaped shadow of irial vessels and sigmoid-shaped shadow of the vorticosal veins. Each of shadow has been difficult to be imaged on the existing normal roentgenogram. The enlargement roentgenography was then applied clinically to eight patients having a foreign body in the orbit and a patient of the retinal tumor. The exposure factor was of 125kVp, 2mA, 0.6-0.9 seconds and focus film distance of 100cm. The quality of the image was similar to that of the rabbits. As crescent shadow of the choroidal plexus was imaged in all the cases, it became possible to us to establish the correct diagnosis of the location of the foreign body, extraocular or retroocular, by changing the direction of roentgen beams. As for retinal tumor the image of the so-called tumor stain was visualized as a fine net-work.抄録全体を表示PDF形式でダウンロード (2672K) -
小泉 昭雄, 吉田 弘一, 高橋 俊雄, 山口 巌, 間島 進1964 年 82 巻 3 号 p. 250-259
発行日: 1964/04/25
公開日: 2008/11/28
ジャーナル フリーTo find an effective chemotherapy for preventing liver metastasis of cancer cells through the circulating blood, Mitomycin C (MMC), Chromomycin A3 (CMA3) and nitrogen mustard N-oxide (NMO) were tested for the effect on the incidence of liver metastasis in C3H or (C3Hxdd) F1 mice intraportally inoculated with the ascites hepatoma MH-134. All these chemotherapeutics, administered via the spleen or into the abdominal cavity, exhibited appreciable inhibitory effects on the formation of metastasis and the life spans of the recipients were considerably prolonged. The effect was most remarkable when MMC was intraperitoneally given three times: immediately after inoculation, 24 hours later and 72 hours later; in this case 37.5 per cent of the animals survived more than 100 days and the incidence of liver metastasis was 50.0 per cent, whereas the tumor killed the untreated mice within 28 days with 100 per cent incidence of liver metastasis. NMO was almost comparable in effect to MMC, but CMA3 appeared to be some-what less effective.抄録全体を表示PDF形式でダウンロード (1142K) -
土田 正義, 渡辺 昌美, 木村 行雄, 大越 高光, 黒坂 真1964 年 82 巻 3 号 p. 260-269
発行日: 1964/04/25
公開日: 2008/11/28
ジャーナル フリーThe variations of serum potassium and of total exchangeable potassium (T. E. potassium) were examined before and after the operations on 75 urological patients: 50 aged patients and, as control subjects, 25 young patients.
In the control group, serum potassium was always within the normal range throughout the course, while slight reduction in T. E. potassium level occurred in 1 to 2 weeks postoperatively.
In the aged group, serum potassium was almost within the normal range before the operation, but it decreased markedly after the operation and the decreased state lasted for a week in many cases, or louger in some cases. T. E. potassium in the aged group was within normal range in many cases, although a fall below the normal range was revealed in some cases. In almost all cases a tendency for the T. E. potassium to lower below normal range was recognized 1 to 2 weeks after the operation. T. E. potassium did not recover the preoperative value 3 to 5 weeks later.
Correlation between serum potassium and T. E. potassium was examined both in the young and aged groups. In the young group, serum potassium and T. E. potassium levels were well correlated in both pre- and postoperative periods. In the aged group, many cases showed a correlation between the two values in preoperative period but no correlation was revealed in the postoperative period, due to reduction of T. E. potassium level. Three to 5 weeks after the operation, serum potassium level lowered to some degree, showing a correlated state below the normal range of both serum and T. E. potassium levels. Eight to 10 weeks later, both potassium levels began to rise and the correlation was reestablished within the normal range.抄録全体を表示PDF形式でダウンロード (505K) -
阿部 圭志, 吉永 馨, 三輪 勣, 相田 光保, 前橋 賢, 渡部 直哉1964 年 82 巻 3 号 p. 270-275
発行日: 1964/04/25
公開日: 2008/11/28
ジャーナル フリーThe excretion of urinary kinin was estimated in many patients under various clinical conditions. The results were in good accordance with those reported by Horton, who used another method of assay. Normal excretions were found ranging 10-30μg per day. Patients with renal failure excreted reduced amounts of the kinin.
No definite change in the kinin output was proved in patients with derma-tological or neurological diseases, in which the kinin has been discussed to be etiologically involved. This and other indirect evidence suggested that the kinin does not originate from the circulating blood, but is secreted by renal tubular cells.抄録全体を表示PDF形式でダウンロード (258K) -
吉田 豊1964 年 82 巻 3 号 p. 276-291
発行日: 1964/04/25
公開日: 2008/11/28
ジャーナル フリーAs a preliminary study for serum transfusion as hemostatic procedure in hemorrhagic disorders, in vitro studies on clot promoting serum factor(s) were carried out by prothrombin time, Thrombo-test and plasma clot time.
Serum was just as effective as control plasma and adsorbed plasma in promoting the clotting time of AHG deficient plasma. Serum was definitely superior to plasma in the clot promotion of PTC deficient plasma and so to commercial hemostatics in the clot promotion of both normal and Warfarin plasmas. In comparative studies of serum with plasma in the clot promoting activity, the former was definitely superior to the latter and it was proved quantitatively further to be more than ten times active in the former.
The serum factor(s) was only partially adsorbed by barium sulfate and maintained the normal activity over 2 days in room temperature. It was completely inactivated after 10 to 15 minutes at 56°C and after 3 minutes at 60°C. The clot promoting activity was found in 25 to 45% (maximum 40 to 45%) ammonium sulfate precipitation of serum and in beta-globulin of serum electrophoresis.
Whether the clot promoting activity of serum was due to a complex of activated known factors or due to a new factor was discussed. A proposal was made to call the serum factor(s) concerned “clot promoting serum factor(s) (CPSF)”.抄録全体を表示PDF形式でダウンロード (853K)
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