The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
85 巻, 3 号
選択された号の論文の10件中1~10を表示しています
  • 矢吹 清一, 陳 世馨, 池内 広重, 安田 真一, 斎藤 隆雄
    1965 年 85 巻 3 号 p. 201-209
    発行日: 1965/04/25
    公開日: 2008/11/28
    ジャーナル フリー
    The authors have been performing pulmonary resection for massive and frequent hemoptysis with the use of Carlens double lumen endobronchial catheter and its specially designed adaptor.
    This operation was performed upon 28 consecutive patients up to date. The diseases were pulmonary tuberculosis (23), bronchiectasis (2), pulmonary abscess (1), moniliasis (1) and aspergillosis (1). The operation consisted of lobectomies (10), pneumoneetomies (17) and a partial resection (1). Of these 28 patients, 25 were well operated to have good results and 3 expired postoperatively. Any accident was not encountered during operation.
    This operation is worthy to be recommended on the basis of the rationality, our experience and results.
  • 松代 隆
    1965 年 85 巻 3 号 p. 210-220
    発行日: 1965/04/25
    公開日: 2008/11/28
    ジャーナル フリー
    As demonstrated in the preceding paper, normal bile has a significant in-hibitory effect on bacterial β-glucuronidase which is known to play an important role in the development of calcium bilirubinate stones. To elucidate the pheno-menon, a number of substances that are generally accepted as bile constituents were independently examined for the effect on the activity of bacterial β-glucuronidase. It was then revealed that fatty acids, lecithin, cholesterol and inorganic ions except Cu++ did not influence the enzyme activity. Bile acids inhibited the activity of a commercial preparation of this enzyme but rather activated bacterial β-glucuronidase of infected bile. Free bilirubin as well as glucuronic acid exhibited a considerable inhibitory power only at a concentration exceeding the actual concentration in normal bile. Cu++ inhibited the enzyme activity at a concentration near the normal Cu content of bile, but there was no significant correlation between the Cu content and the inhibitory power of normal bile specimens. The results thus seem to suggest that bile includes a strong inhibitor of this enzyme which has not yet been identified as a normal constituent of bile.
  • 白井 将文, 今林 健一, 松下 鉛三郎, 加賀 山学, 入沢 俊氏
    1965 年 85 巻 3 号 p. 221-237
    発行日: 1965/04/25
    公開日: 2008/11/28
    ジャーナル フリー
    Histological and biochemical investigations on the testicular tissue of 30 adult dogs were performed one to twenty-one weeks after unilateral section of various spinal nerves innervating it.
    Remarkable changes in the tubules and the interstitial tissue were recognized after section of both the ventral and dorsal roots or the hypogastric nerve. After section of the ventral roots, the germinal cells were decreased remarkablly in number while no significant changes in the interstitial tissue could be found. After section of the dorsal roots or removal of the spinal ganglions, no remarkable change was observed in the tubules while edema and increase of interstitial cells were recognized.
    In general, QO2 and QCO2 of testicular tissue were increased after section of various nerves, especially both the ventral and dorsal roots. No remarkable change of them after removal of the spinal ganglions or section of the hypogastric nerve could be recognized. Succinic and lactic dehydrogenase activities were generally decreased, but the value of SDH/LDH was increased corresponding to the changes in the interstitial tissue.
    It was assumed that these changes corresponding to the kind of the nerve resected would be produced by the direct effect of nerve section on the testicular tissue.
  • 鈴木 範美
    1965 年 85 巻 3 号 p. 238-247
    発行日: 1965/04/25
    公開日: 2008/11/28
    ジャーナル フリー
    Some authors believe that melanin are responsible for occasional black appearance of g _??_ llstones and for brown pigmentation of the liver in the case of Dubin-Johnson syndrome. However, it should be doubtful if melanins are real-ly produced in the hepato-biliary system which is known to be devoid of melanophores in the normal condition. To dissolve the problem, black pigments were isolated from black-appearing gallstones and were chemically and physico-chemically compared with native and synthetic melanins. Although the gallstone pigments resembled melanins in general properties, a definite difference could be pointed out between both kinds of pigments in the infrared absorption spectra, indicating a probable difference in the structure of these substances.
  • 多田 啓也, 林 正
    1965 年 85 巻 3 号 p. 248-251
    発行日: 1965/04/25
    公開日: 2008/11/28
    ジャーナル フリー
    Glucose-6-phosphate dehydrogenase (G6PD) in erythrocyte was determined in two patients with Klinefelter's syndrome. It showed a significantly higher activity, especially in a patient of XXXXY type of the syndrome, than normal range. This result suggests that an excess of genetic material from the X chromosome is responsbile for higher activity of the erythrocyte G6PD in Klinefelter's syndrome.
  • 矢島 聡
    1965 年 85 巻 3 号 p. 252-256
    発行日: 1965/04/25
    公開日: 2008/11/28
    ジャーナル フリー
    In rats, the cerebrum, cerebellum, diencephalon and brain-stem were studied for their nucleic acid content. The values were compared between mature and descrepit rats. It was revealed that as for the decrease in RNA content by decrepitude the diencephalon ranked first, followed by the brain-stem and cereb-rum in order, but the cerebellum showed almost no decrement. In any portion of the brain difference of DNA content due to age was not recognized.
  • 松沢 大樹
    1965 年 85 巻 3 号 p. 257-263
    発行日: 1965/04/25
    公開日: 2008/11/28
    ジャーナル フリー
    The survival time of germfree Swiss-Webster mice to whole-body X-irradia-tion in the range of 500 to 35, 000R was compared to that of conventional Swiss-Webster mice.
    The relationship between the survival time and X-ray dose administered to germfree and conventional mice shows three different straight line segments and cne curved segment, each with distinctive dose response characteristics on a log-log scale. No essential difference can be recognized on the dose-response rela-tions between germfree and conventional mice. However, the mean survival time of germfree mice in the X-ray dose range which causes “hemopoietic death” is 12.5 days as compared to 11.2 days for conventional mice, a difference of 1.3 days. The mean survival time of germfree mice in the so-called “gut death” range is 7.2 days as compared to 3.4 days of conventional mice, more than twice the difference. In general, the survival time of germfree mice in the zone of death caused by damage to the cell renewal system was much longer than that of conventional mice. However, the survival time of germfree mice in the so-called “brain death” X-ray dose range (over 17, 500R) is reversed and is shorter than that of conventional mice.
  • 〓福 哲彦
    1965 年 85 巻 3 号 p. 264-273
    発行日: 1965/04/25
    公開日: 2008/11/28
    ジャーナル フリー
    The present study was designed to determine whether the gastric freezing promotes the healing of peptic ulcer or not. Except for the control group, all the dogs were subjected to the gastric freezing and a standard experimental gastric ulcer was created afterwards at the varying intervals of 1, 3 and 6 months respectively. Control dogs were subjected to the ulcer operation only. Three weeks postoperatively the dogs were sacrificed and the healing of ulcer was studied. Initially, experimentally produced gastric ulcers showed a tendency of healing due to the depression in acid peptic power of the gastric juice. This, however, was followed by the gradual increase of perforation and persistent ulceration when observed up to 6 months following the date of the gastric freeze. These observations lead to conclusion that although the gastric acid pepsin secretion is temporarily depressed by gastric freezing, its return to the control level can be expected with the lapse of time. Problems of gastric freezing technique were also discussed.
  • 夏目 修, 塩 暢夫, 川村 俊三
    1965 年 85 巻 3 号 p. 274-285
    発行日: 1965/04/25
    公開日: 2008/11/28
    ジャーナル フリー
    The authors have observed the change in the blood pressure and histological changes in the kidney of adult dogs in which the renal artery was experimentally constricted. The results obtained show that the sclerotic changes occurred gradually in the glomeruli, Bowman's capsules, intorstitiums, and renal vessels about 3 weeks after the operation. We have also studied the effect of angiotensin on the kidney and some other organs by injecting it to rats. It was found. that the sclerotic changes of the glomeruli, Bowman's capsules, and the renal vessels occurred 10 days after the injection and tended to progress gradually.
  • CEM-thalamotomy
    ト部 美代志, 坪川 孝志
    1965 年 85 巻 3 号 p. 286-298
    発行日: 1965/04/25
    公開日: 2008/11/28
    ジャーナル フリー
    Lesions were made in the nucleus centrum medianum by a stereotaxic technique in 15 cases suffering from intractable pain. The lesson was made unilaterally in 8 and bilaterally in 7. All of the cases were relieved of intract-able pain immediately after the operation without any loss of other sensa-tion. However, unilateral thalamotomy showed a transient effect, while bilateral thalamotomy showed a persistent sufficient effect, for relief of diffuse, poorly localized pain.
    There was no operative death or severe complication in this series. After the operation of bilateral CEM-thalamotomy, no change in the EEG was seen. No alteration of consciousness was observed except in 2 eases whose lesion extended to the nucleus parafascicularis or pretectal region.
    This operative procedure, CEM-thalamotomy, was an appropriate operation for intractable pain caused by malignant tumor.
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