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Volume 87 (1965)
- Issue 3-4 Pages 199-
- Issue 2 Pages 101-
- Issue 1 Pages 1-
Volume 87, Issue 2
Displaying 1-10 of 10 articles from this issue
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Yoshio Hashimoto, Kisaku Kamiya, Koichi Horio1965 Volume 87 Issue 2 Pages 101-104
Published: November 25, 1965
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA single dose of fifty milligrams of ω-heparin (1mg of body weight) newly isolated from the whale lung and intestine was injected intravenously to volunteers. The change of coagulating activity was followed up by the throm-belastogram. Comparing with beef-heparin, ω-heparin was found to have more potent anticoagulant activity and longer duration of the effect at the same dose level. The prolongation of the coagulation time was still observable 6 hours after the use of ω-heparin, while beef-heparin lost its effect within 4 hours.
Neutralization test by protamine sulfate showed that ω-heparin could not be completely neutralized by the same dose of protamine sulfate and a light anticoagulant activity remained after 1:1 neutralization.View full abstractDownload PDF (170K) -
Kazukuni Yamashita1965 Volume 87 Issue 2 Pages 105-109
Published: November 25, 1965
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effect of follicle stimulating hormone (NIH-FSH-Sl), luteinizing hormone (NIH-LH-S1) and human chorionic gonadotrophin (HCG) on testicular 17-ketosteroid secretion in anesthetized dogs was investigated. The intravenous administration of FSH caused a slight rise in 17-ketosteroid secretion from the testis, the response being a transient nature. LH and HCG given intravenously provoked marked increases in the secretion, and the hypersecretion was sustained over at least a 2-4 hour observation period. Furthermore, the administration of FSH, with LH, effected a considerable potentiation of the 17-ketosteroid secretory response to LH.View full abstractDownload PDF (268K) -
Takashi Nakamura, Shozo Nakamura, Tatsuya Aikawa, Teizo Tazawa, Osamu ...1965 Volume 87 Issue 2 Pages 110-122
Published: November 25, 1965
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSPer cent of interstitial tissue was measured in liver biopsy specimens of 62 patients with liver cirrhosis. The frequency curve of the per cent of interstitial tissue showed two peaks in 10-19 per cent and in 40-49 per cent, a dell being observed at 30 per cent. Therefore, liver cirrhosis could be classified into two groups, i. e., the group with less than 30 per cent of interstitial tissue and the group with 30 per cent or more of interstitial tissue.
Edema, liver enlargement, abnormalities in thymol flocculation test, in cephalin cholesterol flocculation test, and in serum γ-globulin concentration, and deformity of the hepatic veins in hepatic venograms were all significantly more frequently observed in the group with 30 per cent or more of interstitial tissue than in the group with less than 30 per cent of interstitial tissue. There was significant correlation between the per cent of interstitial tissue and the per cent of intrahepatic shunt.View full abstractDownload PDF (591K) -
Iwao Yamaguchi, Takeo Sato, Takashi Matsushiro, Hiroshi Sato1965 Volume 87 Issue 2 Pages 123-132
Published: November 25, 1965
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSNormal bile has a considerable effect to inhibit the activity of bacterial β-glucuronidase, and such a property of bile is of practical interest since this enzyme is concerned with formation of calcium bilirubinate gallstones. In relation to this fact, it was demonstrated qualitatively in the preceding paper that bile might contain D-glucaro-l, 4-lactone, a lactone of D-glucaric acid and strong inhibitor of this enzyme. To confirm the fact on a quantitative basis, the method of Ishidate et al. for quantitative estimation of D-glucaric acid in urine was modified so that it was made applicable to bile specimens. The D-glucaric acid content of human gallbladder bile as measured by this method ranged from 38 to 634μg/ml. Furthermore, a significant positive correlation was pointed out between the D-glucaric acid content and the inhibitory power of bile over bacterial β-glucuronidase.View full abstractDownload PDF (508K) -
Keiya Tada, Toshio Morikawa, Toshiyuki Ando, Toshio Yoshida, Akibumi M ...1965 Volume 87 Issue 2 Pages 133-143
Published: November 25, 1965
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDuring a screening program for aminoaciduria, a previously not described disorder of renal tubular transport of amino acids was found in two mentally retarded infants. Urinary analyses of amino acids revealed an excessive excretion of both proline and glycine with a normal range of excretion of the other amino acids. Proline and glycine in sera from the two patients were found to be of normal or subnormal levels. Renal clearance rates of proline and glycine were highly elevated in the patients. It was, therefore, suggested that hyperprolinuria associated with hyperglycinuria observed in the patients was of renal type. Genetic aspects for renal transport of proline and glycine were discussed.View full abstractDownload PDF (1242K) -
Shinji Takahashi, Takashi Kitabatake, Shoichi Yamagata, Tadashi Miyaka ...1965 Volume 87 Issue 2 Pages 144-154
Published: November 25, 1965
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSEpidemiological study of carcinogenesis of thorotrast was made in the following three ways of survey.
1) Prospective study: Of 147 thorotrast patients surveyed, 3 cases of liver cancer (cholangiocareinoma), 2 cases of liver cirrhosis and 1 case of leukemia were found, while, of 1, 678 of non injected cases, 1 case of leukemia, 5 cases of liver cirrhosis and no liver cancer occurred more frequently in the thorotrast group than in controls.
2) Retrospective study: Of 466 liver cancer patients surveyed, 4 or 0.85% had thorotrast shadow in the roentgenogram of the upper abdomen, while, of 1, 938 controls, 1 or 0.07% the thorotrast shadow. Statistically, the thorotrast maintaining rate is higher in liver cancer patients than in contols.
3) Autopsy case study: Of 38 autopsied cases of thorotrast, 21 were primary liver malignancy, which consisted of 4 hepatomas (19%), 14 cholangiocarcinomas (67%) and 3 endotheliomas (14%). As compared with the autopsy cases of Japanese, cholangiocarcinoma and endothelioma are extremely frequent in thorotrast cases with a statistically significant difference.View full abstractDownload PDF (615K) -
Tetsuro Fujiwara, Haruko Hirono, Tsuneo Arakawa1965 Volume 87 Issue 2 Pages 155-167
Published: November 25, 1965
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe influence of dietary cholesterol on the synthesis of cholesterol by the liver was studied in liver biopsy samples from human infants. Dietary cholesterol in amounts of 3 to 4g per day suppressed almost completely the synthesis of cholesterol by the liver. Acetate-C14 was orally administered to the infants fed normal or high-cholesterol diet, and the appearance of labeled lipids in the plasma was studied. The feeding of cholesterol depressed the incorporation of acetate-C14 into the plasma cholesterol fraction. In a patient with idiopathic hypercholesterolemia, the feeding of cholesterol had no inhibitory effect upon the incorporation of acetate-C14 into the plasma cholesterol fraction. The results of these studies indicate that infants do normally possess a feedback control of hepatic cholesterol synthesis and that this mechanism is impaired in an infant with idiopathic hypercholesterolemia.View full abstractDownload PDF (604K) -
John E. Hankiss, Michael Keszthelyi, Peter Demény1965 Volume 87 Issue 2 Pages 168-174
Published: November 25, 1965
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe inactivation of vasopressin by heart as well as skeletal muscle was investigated in in vitro experiments. Heart muscle can inactivate vasopressin while skeletal muscle only binds some vasopressin. The mechanism of vasopres-sin inactivation was studied by heat treatment, by determining pH optimum and by time-dependency studies.
The inactivation of vasopressin by heart muscle proved to be an active process. The possible role of this phenomenon in coronary vasospasm and in coronary diseases is discussed.View full abstractDownload PDF (305K) -
Keishi Abe1965 Volume 87 Issue 2 Pages 175-184
Published: November 25, 1965
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe excretion rate of urinary kinin was estimated in 71 patients under various clinical conditions. The estimated values ranged from 5.3 to 36μg per day in 14 healthy persons. No significant change in the kinin output was recognized in 32 patients with bronchial asthma, dermatological, neurological or pancreatic diseases in which kinin is generally considered to play an etiological role.
The kinin excretion was investigated in man during the intravenous infusion of kallikrein or bradykinin, or in dogs during the bradykinin infusion into renal artery. No correlation was demonstrated between the kinin level in circulating blood and the kinin excretion in urine in six patients. It was concluded from these experiments that circulating kinin is not excreted in urine, and urinary kinin is produced and secreted by the kidney, perhaps by the tubular cells.View full abstractDownload PDF (512K) -
Sadao Ikeda1965 Volume 87 Issue 2 Pages 185-198
Published: November 25, 1965
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe hemodynamics of exsanguination cooling were studied with the use of extracorporeal circulation and a large amount of diluent. 1) The oxygen content of dextran solution after in vitro perfusion through the dog's lung was as much as 3.4 vols% at 5°C. 2) By using the method of exsanguination cooling, a high cooling rate and low gradient of temperature between esophagus and peripheral tissues were obtained. At the end of cooling the hematocrit value fell to 5%. 3) Low total peripheral resistance in exsanguination cooling group during rewarming suggests less vaso-obstruction than in whole blood perfused dogs which showed a significantly higher value. 4) Viscosity of 10% low molecular weight dextran was as high as that of the whole blood at 10°C. This concentration of dextran solution is inadequate for the use in profound hypothermia. 5) The mount of blood necessary for the entire course of an operation in exsanguination cooling was remarkably less than that in whole blood priming group. 6) With this method the high survival rate of 75% was obtained in the experiment of total circulatory arrest of 30 minutes duration at below 10°C esophageal temperature. Further extension of arrest time decreased the survival rate.View full abstractDownload PDF (694K)
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