The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
94 巻, 4 号
選択された号の論文の12件中1~12を表示しています
  • Tsuneo Arakawa, Takashi Mizuno, Fumio Chiba, Kazuo Sakai, Shuichi Wata ...
    1968 年 94 巻 4 号 p. 327-335
    発行日: 1968年
    公開日: 2008/11/28
    ジャーナル フリー
    Frequency analysis of electroencephalograms and estimation of the average latency of photically induced evoked responses were carried out on children aged 8 to 9 years with or without ariboflavinosis associated with low serum folate activity.
    In the ariboflavinotic children, there was a tendency toward prolonged latency of the photically evoked responses and toward an increase in energy percent at the theta band associated with a decrease in energy percent at the alpha band of frequency in the basic wave.
  • Michio Matsumura
    1968 年 94 巻 4 号 p. 337-346
    発行日: 1968年
    公開日: 2008/11/28
    ジャーナル フリー
    An attempt was made to analyze differences in the results obtained by various kinds of finger plethysmography, such as penetration photo-electric plethysmograph (penet.-PTG), reflexion photo-electric PTG (refl.-PTG), mechanoelectric PTG (pneumo-PTG and hydro-PTG) and impedance PTG, by taking simultaneous recordings principally from the same finger tip.
    Comparisons of the time course (onset time and crest time) and the wave form (harmonic analysis and base line deviation) of each pulse wave were made with the standard records of the penet.-PTG depicted simultaneously. Experiments were repeated on 15 healthy adults.
    No significant differences were observed in the time course and wave form among the records obtained by various kinds of plethysmographs, so far as the records obtained from the finger tip were concerned, whereas appreciable differences were recognized in the time course as well as in the wave form, when the proximal phalange of the finger was involved in the plethysmograph, the whole finger cup being employed for mechanoelectric PTG, or one of the electrodes being placed at the proximal phalange for impedance PTG.
  • Togo Horiuchi, Hiroshi Suzuki, Takeshi Ishitoya, Yoshio Taguchi
    1968 年 94 巻 4 号 p. 347-350
    発行日: 1968年
    公開日: 2008/11/28
    ジャーナル フリー
    In order to correct severe metabolic acidosis, peritoneal dialysis was attempted in 2 cases of cyanotic babies. The condition was markedly improved in both of them by peritoneal dialysis with buffer solution, though they died finally of cardiac failure.
    It could be concluded from our experiences that peritoneal dialysis was effective in the correction of severe metabolic acidosis in newborn babies with marked cyanosis.
  • Takao Fukuda
    1968 年 94 巻 4 号 p. 351-360
    発行日: 1968年
    公開日: 2008/11/28
    ジャーナル フリー
    The disease characterized by diffuse irreversible proliferation and leukemic dissemination of lymphatic reticulum cells were previously designated as leukemic reticulosis. The symptoms were similar to those of acute leukemia and the patients ran a rapidly fatal course within 4-6 months.
    An aleukemic variety of leukemic reticulosis in a 40-year-old male is de-scribed. The disease with diffuse irreversible reticulum cell proliferation in the medulla of lymph nodes without destruction of the basic structure and diffuse infiltration of reticulum cells in various organs is termed malignant reticulosis by the author.
  • Hiromu Hayashi
    1968 年 94 巻 4 号 p. 361-375
    発行日: 1968年
    公開日: 2008/11/28
    ジャーナル フリー
    Using the iodine-starch method for visualizing sweat from active sweat gland ducts, the functional activity of the sweat glands in the hairy skin of sheep was studied.
    Intradermal injections of adrenaline elicited a local sweat response at low concentrations such as 10-8 and 10-7. Intravenous infusion of adrenaline at a rate of 0.5 μg/kg•min was definitely effective in producing general sweating. Intradermal noradrenaline was also effective, but it was a little less potent than adrenaline.
    In contrast, intradermal injections of parasympathomimetic agents such as pilocarpine and acetylcholine were without any sudorific effect, even when the concentration was raised up to 10-3. Eserine was also ineffective.
    Thermoregulatory sweating could be produced by heat application. By partial sympathectomy alone or combined with bilateral adrenal medullectomy, it was established that thermoregulatory sweating was produced primarily by excitation of the sympathetic adrenergic sweat nerves when heating was mild, and additionally by catecholamines from the adrenal medulla when their secretion was increased in association with heating.
    By testing with intradermal nicotine and lobeline, it was found that the sweat nerves in the sheep have no receptors responsible for the sweating axon reflex.
  • Tomihisa Funyu, Yasuo Shiraiwa, Mizuo Tamura, Kazuo Nigawara, Yuko Ter ...
    1968 年 94 巻 4 号 p. 377-384
    発行日: 1968年
    公開日: 2008/11/28
    ジャーナル フリー
    The urinary 17-OHCS fractions were estimated using thin layer chromato-graphy upon 48 cases with urologic and renal disorders such as stenosis of the urethra, stones of the tipper urinary tract, renal tuberculosis, glomerulonephritis and hypertension.
    In most cases, the ratio of THE (tetrahydroeortisone) to compound E (cor-tisone) was high. But in this respect there were no obvious differences among the various diseases.
    Excretion of each fraction was less in hypertension.
    Compound F (cortisol) was marked on the upper ordinate, THE (tetra-hydrocortisol) on the lower, compound E (cortisone) on the right abscissa, and THE (tetrahydrocortisone) on the left. When the four spots were connected, a figure of a rhombus stretched upwards was shown in the cases with renal failure in general.
  • Yoichiro Sasai, Hiroshi Akiba
    1968 年 94 巻 4 号 p. 385-391
    発行日: 1968年
    公開日: 2008/11/28
    ジャーナル フリー
    A simple alcian blue method was presented for identifying individual acid mucopolysaccharides in cryostat sections. This method was based on the preci-pitation of acid mucopolysaccharides with alcian blue and the subsequent differentiation of individual acid mucopolysaccharides with MgCl2 solution at a critical salt concentration. In spot test and tissue sections, the present method differentiated successfully between hyaluronic acid, chondroitin sulfate and heparin.
  • Hiromi Tanigawa, Ryozo Higashi, Tatuzi Suzuki
    1968 年 94 巻 4 号 p. 393-396
    発行日: 1968年
    公開日: 2008/11/28
    ジャーナル フリー
    Dogs, anesthetized with sodium pentobarbital, were used. Adrenal venous blood was collected and analyzed for 17-hydroxycorticosteroids (17-OHCS). In intact (non-hypophysectomized) dogs the adrenal 17-OHCS secretion rates increased after injection of eserine (0.2mg/kg) and reached 0.75-1.41μg/kg/min, while they were 0-0.19μg/kg/min before injection. In hypophysectomized dogs an injection of the same dose of eserine did not induce any definite change in adrenal 17-OHCS secretion. Thus, it is concluded that the stimulatory effect of eserine on the adrenal cortical secretion is mediated through pituitary adreno-corticotrophin release.
  • Takashi Matsushiro, Takeshi Nemoto
    1968 年 94 巻 4 号 p. 397-406
    発行日: 1968年
    公開日: 2008/11/28
    ジャーナル フリー
    In order to elucidate the role of mucopolysaccharides in gallstone formation, two kinds of calcium carbonate stones were submitted to examination. Sample I was a simple calcium carbonate stone and Sample II a mixture of calcium carbonate-mantles obtained from three gallstones which had small cholesterol stones in their central parts and were covered by thick calcium carbonate mantles. The crude mucopolysaccharides in both samples resembled each other in then chemical compositions, containing hexose, hexosamine and peptide as the major components, and L-fucose, uronic acid, sialic acid and sulfate as the minor ones. These preparations were fractionated by column chromatography on DEAE-Sephadex A-25, eluting stepwisely with increasing molarity of NaCl solution. The crude mucopolysaccharide from Sp. I was fractionated into 0.1M Fr., 0.7M Fr. and 1.5M Fr., of which 0.1M Fr. was predominant. On the other hand, the crude mucopolysaccharide from Sp. II was fractionated into 0.1M Fr. and 0.7M Fr. as the major fractions, and 0.5M Fr. and 1.25M Fr. as the minor ones.
    The mucopolysaccharide in 0.1M Fr. consisted of hexose (galactose and mannose), hexosamine and L-fucose. In addition to these components, uronic acid and sialic acid were contained in 0.5M Fr., and uronic acid, sialic acid and sulfate in 0.7M Fr. Each acidic fraction was shown to be a mixture of two mucopolysac-charides by electrophoresis on cellulose acetate strips. However, their mobilities and metachromatic figures, together with their analytical data, indicated that 0.1M Fr. contained a neutral mucopolysaccharide; 0.5M Fr., a small amount of neutral mucopolysaccharide and a large amount of hyaluronic acid; 0.7M Fr., a small amount of chondroitin sulfate-like substance and a large amount of another unidentified acid mucopolysaccharide; 1.25M Fr., a large amount of chondroitin sulfate-like substance and a small amount of unidentified acid mucopolysac-charide; and 1.5M Fr., two unidentified acid mucopolysaccharides.
    The acid mucopolysaccharides found in the gallstones were assumed to play a bridging action in the coagulation of calcium carbonate particles.
  • Takashi Kutsuzawa, Satoru Takahashi, Chikahiro Saito, Sohsuke Takahash ...
    1968 年 94 巻 4 号 p. 407-415
    発行日: 1968年
    公開日: 2008/11/28
    ジャーナル フリー
    Cerebral hemodvnamics and nwtaholism in 32 cases of subaraelmoid hemor-rhage were investigated by the nitrous oxide method.
    Cerebral circulation was highly disturbed in the acute stage of the disease, while it remained within the normal range in the remission stage. In patients with angiospasm visualized on the cerebral an giogram. cerebral circulatory disturbances were severer than those without angiospastic patterns. Between the pressure of cerebrospinal fluid at lumbar puncture and cerebral blood flow, there was a negative correlation., whereas a roughly positive correlation was found between cerebral vascular resistance and the pressure. In cases in which surgical clipping of aneurysm was done, remarkable improvement of the cerebral circulatory disturbances was generally noticed immediately after the operation. Cerebral vascular responses to 50, carbon dioxide inhalation and hyperventilation were examined in 9 cases. In the acute stage, poor responsive-ness to the vasodilatative stimulus was observed, while patients in the remission stage showed a normal response. Furthermore, cerebral vasoconstriction by hyperventilation is more remarkable in the acute stage than in the remission stage.
  • Kuniaki Narisawa, Tsunenobu Tamura, Kaneo Tanno, Kazuo Ohara, Tsuneo A ...
    1968 年 94 巻 4 号 p. 417-430
    発行日: 1968年
    公開日: 2008/11/28
    ジャーナル フリー
    Urinary excretion of formiminoglutamic acid (FIGLU) following an oral, intraperitoneal, intramuscular, or intravenous load with L-histidine-monohydro-chloride was markedly reduced in rats when fed on a riboflavin deficient diet for 11-30 days.
    The assay of tetrahydrofolate-dependent enzyme activity of the liver revealed that there were a marked deeraase in the activity of N5, 10 methylenetetrahydro-folate ieductase and a considerable decrease in that of N5 methyltetrahydro-folate transferase of the liver from the riboflavin deficient rats.
    Results of bioassay using L. casei, St. faecalis and Pediococcus cerevisiae of folate compounds of the liver revealed a tendency toward relative increase in folato deriva-tives other than N5 methyltetrahydrofolate in the liver of riboflavin deficient rats.
    From these results it was assumed that a decreased activity in both the N5, 10 methylenetetrahydrofolate reductase and N5 methyltetrahydrofclate trans-ferase was induced by riboflavin deficiency, and then that the decrease in the activity of the both enzymes caused an accumulation of tetrahydrofolate com-pounds other than N5 methyltetrahydrofolate, thus affording a relatively large amount of free tetrahydrofolate available for the formiminotransferase reaction, with a consequence of rapid conversion of FIGLU into glutamic acid.
    Free methionine levels of the liver was not found to be increased but slightly decreased in riboflavin deficient rats as compared with those of control rats.
  • Koroku Hashimoto, Shigetoshi Chiba
    1968 年 94 巻 4 号 p. 431-432
    発行日: 1968年
    公開日: 2008/11/28
    ジャーナル フリー
    The selective administration of any naturally occurring catecholamine (dopamine, norepinephrine and epinephrine) into the sinus node artery induced suddenly deceleration of sinus rhythm in the course of its acceleration response, indicating depression of P wave or shift to A-V nodal rhythm. Atropine blocked the negative chronotropic effect. Phenoxyhenzamine and hemicholinium also blocked this effect, while acetylcholine (ACh) acted ordinarily even after treat-ments with these compounds. These observations suggest catecholamine-ACh interaction in which either phenoxybenzamine or hemicholinium blocks ACh release at the cholinergic nerve terminals.
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