巻号一覧
95 巻 (1968)
- 4 号 p. 317-
- 3 号 p. 203-
- 2 号 p. 107-
- 1 号 p. 1-
95 巻, 1 号
選択された号の論文の7件中1～7を表示しています
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Ken Nagaoka1968 年 95 巻 1 号 p. 1-13
発行日: 1968年
公開日: 2008/11/28
ジャーナル フリーTo clarify the mechanism of delayed gastric emptying after vagotomy and the related problem whether the vagotomized stomach develops pylorospasm under any condition, the author studied the motor function of the canine stomach with the use of electromyography when warm water was instilled before and after vagotomy.
Regardless of whether vagotomy had been performed or not, a marked excita-tion of the pyloric portion of the stomach occurred, resulting in a spasm-like abnormal excitation and anti-peristalsis as the intragastric pressure was elevated by instillation of water. However, the vagotomized stomach required much more water than the non-vagotomized one to develop the same degree of excitation of the pyloric portion. This difference was probably due to hypomotility or hypotonicity of the vagotomized stomach. On the other hand, vagotomy did not cause pylorospasm or abnormal excitation of the pyloric portion, although hypomotility of the stomach was present.
The above results suggested that the vagotomized stomach developed hypo-motility or hypotonicity first, which led to stasis and retention of the gastric content. Furthermore, the elevation of intra-gastric pressure due to this stasis and retention was followed by spasm-like abnormal excitation of the pyloric portion and anti-peristalsis. Therefore, 'pylorospasm' was considered to occur secondarily as a result of gastric stasis and retention, but not primarily by vagotomy.抄録全体を表示PDF形式でダウンロード (622K) -
Norio Fukuhara1968 年 95 巻 1 号 p. 15-33
発行日: 1968年
公開日: 2008/11/28
ジャーナル フリーThough the histological glomerular lesions in diabetes mellitus appear in two distinct types, the diffuse and nodular, the former lacks pathognomonic features, and its differentiation from mild chronic glomerulonephritis has been practically impossible. A histometrical method was introduced into the present study to establish a diagnostic basis of slight diabetic nephropathy. The relative reduc-tion of mesangial nuclei per unit area of mesangial tissue was characteristic of diabetic glomerular lesions and was useful for separating diabetic from mild chronic glomerulonephritic lesions. This was due to hyaline thickening of the mesangial tissue in diabetics without nuclear proliferation.
Diabetic glomerular lesions were further quantitatively evaluated and correlated to a number of clinical symptoms. Positive correlation was confirmed between the grade of glomerular lesions and serum lipid levels. The correlation was regarded as of pathogenetic significance in the diffuse glomerular lesion.
The development of coarse nodular glomerular lesions was ascribed to mesangiolytic changes with subsequent plasmal infiltration into the mesangial tissue and capillary thrombosis. Locally accentuated hyaline deposits in the mesangial tissue occasionally simulated small nodular lesions, but they did not grow to typical large nodules without preceding mesangiolytic changes.抄録全体を表示PDF形式でダウンロード (4022K) -
Shigeru Arai, Atsushi Machida, Toshio Nakamura1968 年 95 巻 1 号 p. 35-54
発行日: 1968年
公開日: 2008/11/28
ジャーナル フリーThe growth of the coronary artery and the myocardial capillarization in hypertrophied hearts were quantitatively evaluated in reference to myocardial volume. In concentric hypertrophy the mean blood flow per unit volume of the heart muscle estimated by the anatomical radii of the three major branches of coro-nary arteries was practically the same as that in the normal heart. A harmonious growth of the coronary artery with increasing myocardial volume was accordingly concluded. The often asserted view that hypertrophied hearts are subject to coronary insufficiency on account of undergrowth of coronary arteries inherent to cardiac hypertrophy was not supported. The total capillary length was found increased in hypertrophied hearts in parallel with the increase of the total surface area of the muscle fibers. However, the capillary length per unit volume of the heart muscle was reduced in hypertrophied hearts.
Histometrical treatments revealed that the configuration of individual heart muscle fibers in concentric hypertrophy was geometrically similar to that in the normal heart. The behavior of the muscle fiber was essentially the same in dilata-tory hypertrophy too, although the growth in length predominated over that in breadth in a small number of cases. A growth in breadth of the muscle fibers not accompanied by one in length did not take place even in concentric hypertrophy. The difference of concentric and dilatatory hypertrophies was sought consequently in different structural arrangement and not in the shape of heart muscle fibers in the myocardial layer.抄録全体を表示PDF形式でダウンロード (1591K) -
Toshio Nakajima1968 年 95 巻 1 号 p. 55-62
発行日: 1968年
公開日: 2008/11/28
ジャーナル フリーDespite various theories on the mechanism of the appearance of DOCA escape, the nature of this phenomenon still remains unknown. In this study the influence of a high or low potassium diet on the sodium retaining effect of DOCA was investigated in dogs.
A low potassium diet facilitated the appearance of DOCA escape, while a high potassium diet delayed its appearance. The rise of blood pH was facilitated by a low potassium diet and inhibited by a high potassium one. Based on these results, the change in blood pH appears to be one of the factors contributing to the development of DOCA escape.抄録全体を表示PDF形式でダウンロード (1122K) -
Hidemi Yamauchi1968 年 95 巻 1 号 p. 63-77
発行日: 1968年
公開日: 2008/11/28
ジャーナル フリーSplenomegaly in Banti's syndrome was found to be accompanied by a growth of the trunk of splenic artery. The blood flow Q of an artery is expressed as a function of the arterial radius r in the form of Q=qrn, q and n being constants. Accordingly, increased blood flow of the Banti spleen was presumed on the anatomical basis. This implies at the same time remarkably decreased resistance to blood flow, because the effective pressure difference between the splenic artery and vein is reduced on account of elevated portal pressure. However, the geometrical configuration of the splenic arterial tree from the trunk to its terminal arterioles was identical in both normal and Banti spleens. The blood pressure level at terminal arterioles in the Banti spleen was regarded as practically the same as in the normal spleen. Consequently, the mechanism of lowered resistance was sought in the structural transformation of the splenic cord. Histological examination demonstrated the presence of direct arteriolosinal shunts, which could be interpreted as one of the anatomical expressions of lowered peripheral resistance in the Banti spleen. No arterial growth was confirmed in splenomegaly not associated with portal hypertension.抄録全体を表示PDF形式でダウンロード (2231K) -
Yoshiyuki Honda1968 年 95 巻 1 号 p. 79-86
発行日: 1968年
公開日: 2008/11/28
ジャーナル フリーColumn chromatography and microbiologic assay of folate derivatives of the liver were made on riboflavin-deficient rats. The results showed that, shortly after an intramuscular injection of pteroylglutamic acid, an impaired conversion of folic acid to N5 methyltetrahydrofolic acid in the liver was observed in rats with riboflavin deficiency.抄録全体を表示PDF形式でダウンロード (338K) -
Tatuo Saito, Takeo Kaneko1968 年 95 巻 1 号 p. 87-106
発行日: 1968年
公開日: 2008/11/28
ジャーナル フリーA study was made of the effect of single and combined administrations of mitomycin C (MMC) and prednisolone (PS) on respiration and glycolysis of Ehrlich ascites tumor cells in vitro, and the following results were obtained.
1) PS had no effect on respiration and glycolysis at concentrations below 0. 15mg/ml, but inhibited respiration and stimulated glycolysis at concentrations above 0. 75 mg/ml.
2) MMC inhibited endogenous respiration, but stimulated oxygen uptake when glucose was added as the substrate at concentrations above 0. 05mg/ml. It was clarified that MMC exerted an inhibitory effect on glycolysis and facilitated the pentose phosphate pathway.
3) The combined effects of MMC and PS were determined by the algebraical sum of both.抄録全体を表示PDF形式でダウンロード (635K)
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