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Volume 97 (1969)
- Issue 4 Pages 289-
- Issue 3 Pages 191-
- Issue 2 Pages 101-
- Issue 1 Pages 1-
Volume 97, Issue 3
Displaying 1-10 of 10 articles from this issue
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Jun Fujii, Hiroshi Kurihara, Hiroshi Yamaguchi, Masao Ikeda1969Volume 97Issue 3 Pages 191-196
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effect of salt-rich feeding on renal hypertension and the role of ischemic kidney in maintaining persistent hypertension were experimentally investigated. Unilateral constriction of the renal artery was produced in rabbits with a silver clip, the opposite kidney being left intact. The mean rise of blood pressure was significantly greater in 20 rabbits which were fed a salt-rich diet than in 11 rabbits which were fed a standard diet. After persistent hypertension was established, the ischemic kidney was removed in 7 rabbits. The operation induced a prompt fall of blood pressure. Plasma renin activity was within normal levels in the chronic stage of renal hypertension. The results indicate that feeding of a salt-rich diet increases the blood pressure in renovascular hypertensive rabbits and some renal mechanism is involved in the chronic stage of renal hypertension even if plasmaa renin activity is not elevated.View full abstractDownload PDF (379K) -
Tsuneo Suzuki1969Volume 97Issue 3 Pages 197-211
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effects of carbon monoxide inhalation on the ultrastructure of the heart muscle of rat were investigated. Rats were exposed to 1% carbon monoxide for 10 minutes and sacrificed immediately, 10 and 30 minutes, and 1, 5 and 24 hours after the cessation of carbon monoxide inhalation, and ultrastructural changes of the hearts were observed.
The cardiac ultrastructural changes consisted of intracellular edema, swelling of mitochondria and sarcoplasmic reticulum, disruption and reduction of cristae, disappearance of mitochondria, appearance of lipofuscin pigment granules and lyso-somes, increase of glycogen granules and fat droplets. The ultrastructural reactions to carbon monoxide were evident in 10 minutes after carbon monoxide inhalation for 10 minutes, and became most prominent in 30 minutes to 1 hour. In 24 hours after the inhalation, the hearts of most rats appeared essentially normal.
These findings suggest that the effects of carbon monoxide on the heart result not only from hypoxemia but also from the direct toxic effects on the specific respiratory enzymes, and the duration of carbon monoxide inhalation is more important than the level of blood CO-Hb concentration in producing these changes.View full abstractDownload PDF (5903K) -
Masataka Kato, Ken-etsu Komata1969Volume 97Issue 3 Pages 213-231
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSympathomimetic agents and their blocking agents were administered drop-wise intravenously alone or in various combinations to 9 normotensive subjects and 16 patients with essential hypertension. Their effects on the cardiovascular reaction (heart rate and blood pressure) were compared in order to estimate the degree of stimulation of α- and β-receptors respectively. When the α- and β-receptor stimulating effects of so-called α- and β-receptor stimulators were completely blocked by corresponding blocking agents respectively, β-effect in the α-stimulator and a-effect in the β-stimulator remained in effect without any modification in the degree of responses. Simultaneous injection of a-stimulator and β-blocker caused no change in the heart rate (β-effect), but produced additive increase in the blood pressure (α-effect) already raised by single treatment of the α-stimulator. A similar additive effect was observed also in the β-effect when β-stimulator and α-blocker were injected simultaneously. Such an increase in the α- or β-effect seemed to be due to conversion of β- or α-effect blocked by β- or α-blocker respectively, but it was not attributable to the α-or β-effect of the blockers themselves. The β-effect induced in this way, that is, the reactivity of α-receptor was greater in hyperensive patients than in nor-motensives, and the β-effect induced in the same way was greater in normotensives than in hypertensive patients.View full abstractDownload PDF (970K) -
Shiro Kosaka1969Volume 97Issue 3 Pages 233-243
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSEffects of SH-compounds such as DL-penicillamine and L-cysteine on the rheumatoid factor in serum of patients with rheumatoid arthritis were examined, and the following results were obtained.
1) In vitro dissociation of the rheumatoid factor was obviously ascertained. This finding was supported by the fall of the serum viscosity, changes in globulin fragment in the serum protein patterns, and depolymerization of macro-globulin in the ultracentrifugal patterns.
2) In vivo SH-compounds exert influence neither on patients with rheumatoid arthritis nor on the rabbit in which RFLS had been produced experimentally in the body. When the drug was administered intra-articularly, temporary dissociation of rheumatoid factor in the synovial fluid took place.View full abstractDownload PDF (1392K) -
Masatoshi Sakka1969Volume 97Issue 3 Pages 245-253
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIt is generally believed that the Cell loss of a growing population does not take place immediately after irradiation but cell death is preceded by cell divi-sions for several generations. In the present study a simple theory is advanced in which the frequency of cell loss after irradiation is expressed by either binominal or Poisson type distribution against time. Sufficiently good fitness was obtained between the theory and experiments in which tumor cells were irradiated in vitro and grown in. vivo.View full abstractDownload PDF (409K) -
Toshihisa Kusano, Isao Yamane, Hiroshi Suzuki1969Volume 97Issue 3 Pages 255-261
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSix cell lines transformed in vitro by adenovirus type 12 were characterized by karyologically heterogenous population, but the mode consisted of diploid cells. This diploid stem seems stable for a long time in vitro culture.View full abstractDownload PDF (269K) -
Kuniaki Narisawa, Tsunenobu Tamura, Yoshinori Honda, Kaneo Tanno, Kazu ...1969Volume 97Issue 3 Pages 263-268
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSWhen rats were fed on either a riboflavin deficient diet or a high methionine diet, tritium labeled folic acid given intramuscularly was liable to be excreted into urine as such. It was assumed that this was partly due to a decreased activity of N5, 10 methylene-tetrahydrofolate reductase of the rat liver induced by either riboflavin deficiency or an excessive dietary methionine.View full abstractDownload PDF (349K) -
Chikashi Ito, Edward E. Mason, Lawrence Den Besten1969Volume 97Issue 3 Pages 269-277
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTwenty-four mongrel dogs were subjected to one of the following operations: sham (biopsy) operation, two-thirds gastric bypass, two-thirds gastric resection and antrectomy with vagotomy. After three weeks all the dogs were given hist-amine in beeswax injections for a month.
Chronic ulcer developed in 50% of dogs with sham operation and 33% of those with antrectomy-vagotomy. None of the dogs with gastric bypass or resection developed chronic ulcer. The frequency of superficial ulcer was least in gastric bypass dogs and largest in antrectomy-vagotomy ones.
Gastric mucosal thickness and parietal cell population were significantly increased in histamine-treated dogs with sham or antrectomy-vagotomy operations but not in the proximal stomach of dogs after gastric resection or gastric bypass. The bypassed retained stomach responded to histamine by increased mucosal thickness and parietal cell count.
Two-thirds distal gastric bypass with Billroth II type gastroenterostomy is as effective in preventing ulcer as is two-thirds gastric resection. Exclusion procedures are effective in preventing histamine-induced ulcer, if the operations are sufficiently extensive.View full abstractDownload PDF (2130K) -
Katsuhisa Sato1969Volume 97Issue 3 Pages 279-282
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSN-acetyl-β-galactosaminidase was first demonstrated by the histochemical method using naphthol AS-BI N-acetyl-β-galactosaminide as a substrate and hexazonium pararosanilin as a diazo reagent. The optimal staining reaction for the human tissues was obtained with 0.5mM of substrate and 3.6mM of hex-azonium pararosanilin at pH 4.4 for 100 minutes at 37°C. The dark red dye was seen mostly as discrete granules at the site of the enzyme activity. Generally, cytological localization of the enzyme in the human tissues was quite similar to that of other lysosomal enzymes.View full abstractDownload PDF (265K) -
Norio Taira, Satoshi Matsumura, Koroku Hashimoto1969Volume 97Issue 3 Pages 283-288
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn dogs anesthetized with pentobarbital, responses of the urinary bladder with the hypogastric nerves intact and the pelvic nerves cut acutely were recorded as changes in intravesical pressure. In order to administer drugs selectively to the bladder, the vesical vascular bed was perfused with arterial blood via the caudal vesical arteries at a constant rate, and drug solutions were injected into the perfusion circuit at a point close to the bladder. Stimulation with a short train of electric pulses of the distal end of the cut pelvic nerve on either side and administration of 1, 1-dimethyl-4-phenylpiperazinium (DMPP) elicited a prompt monophasic contraction of the bladder. The responses to the nerve stimulation and to DMPP were readily abolished by tetrodotoxin. However, contractions in response to 10 and 30μg of acetylcholine were unchanged with that dose of tetrodotoxin which was sufficient to abolish the response to supramaximal stimulation of the pelvic nerve. From these results it was concluded that the contraction elicited by DMPP was mediated predominantly through excitation of the parasympathetic postganglionic neurons in the bladder wall, while that produced by acetylcholine was exclusively due to excitation of the smooth muscle.View full abstractDownload PDF (395K)
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