Rain-induced landslides often occur in clusters on hillslopes that have unique geological characteristics, such as lithology, weathering patterns, and hydrothermal alteration. However, the effects of geological factors on landslides involving rhyolites are not fully understood. A heavy rain event in July 2018 caused numerous debris avalanches and debris flows within areas underlain by the Late Cretaceous Takada Rhyolites, southern Hiroshima Prefecture, Japan. The author performed GIS analyses and field investigations of outcrops and landslide scars in order to understand the geological factors that influence landslides in areas underlain by rhyolites. The study area is rectangular, 9 km long, and 3 km wide, and the long sides, oriented NE-SW, connect Nikyukyo to Akozaka in Kure City. The Norosan Welded Tuff, which forms the rhyolite unit in the study area, has near-vertical joints spaced 0.1-5.0 m, and a large number of high-angle veinlets that record hydrothermal alteration. The average joint spacing is 1.8 m in the SW of the study area (0-3.5 km), decreases from 1.8 to 0.4 m in the center (3.5-5.0 km), and 0.4 m in the NE of the study area (5.0-9.0 km). Tors are developed on the ground surface on hillslopes in the SW of the study area, but the NE of the study area is underlain by clay-rich altered soil without corestones. Most landslides during the 2018 rain event occurred on reddish weathered rhyolite affected by hydrothermal alteration. Precipitation data from High-resolution Precipitation Nowcasts provided by the Japan Meteorological Agency, indicate that the 45 h and 4 h cumulative rainfall distributions prior to the landslide event were similar in the SW and NE parts of the study area. Furthermore, the NE and SW parts of the study area have a comparable proportion of surface area with similar topographic parameters (slope, plan curvature, and catchment area) to those of landslide scars. In spite of these similarities, the landslide density is about ten times higher in the NE of the study area (10-55 km－2), than in the SW. This difference is attributed to differences in joint density, and the intense weathering and alteration on joints within the rhyolite.