Since malaria vaccine development is slow and parasite resistance to anti-malarial drugs is developing rapidly, vector control is still the most practical method for reducing malaria transmission in developing countries. House spraying and treated bed nets have been popular control measures targeting indoor resting mosquitoes; however, chemical insecticides should be treated and managed with great care. In this proposed study, we will evaluate the efficacy of bacterial larvicides combined with environmental management strategies for controlling malaria vectors and transmission in western Kenya. These control methods are less harmful to the environment. The article describes the study design and methods.