A subject with metal hypersensitivity is known to develop contact dermatitis particularly in summer, by wearing an ordinary wrist watch that contains Ni, Co, Cr etc. Clinical provocation test with our Allergen Controlled Wrist Watch of which band and case were made of pure titanium was performed with 13 patients with known history of contact dermatitis to ordinary wrist watchs. Each subject tolerated well a 4-month clinical trial in summer and remained asymptomatic, indicating that titanium must be one of the most hyperallergic metals.
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