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Volume 35, Issue 7
Displaying 1-6 of 6 articles from this issue
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Ryuichi Kikkawa, Yukio Shigeta1992 Volume 35 Issue 7 Pages 533-538
Published: July 30, 1992
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSDownload PDF (1029K) -
Direct Examination by UltrasonographyKiyoshi Oshiro, Keiji Murakami, Goro Mimura1992 Volume 35 Issue 7 Pages 539-545
Published: July 30, 1992
Released on J-STAGE: August 04, 2011
JOURNAL FREE ACCESSIn this study we used ultrasonography combined with the acetaminophen method to evaluate postprandial gastric motility in diabetics with autonomic neuropathy (AN). Six controls (C) and 14 NIDDM patients, half with AN (AN(+)n=7) and half without AN (AN(-)n=7) were included in the study. After overnight fasting all subjects received a test meal containing 1.5 g acetaminophen dissolved in 200 ml of water. Postprandial antral contractions were observed by ultrasound every 10 min. for a total of 60 min. The mean frequencies of contraction in C, AN (-) and AN (+) were 6.4±0.3, 6.0±0.3, 5.9±0.3/2 min, respectively (n.s). However, the mean intensities of contraction in C, AN (-) and AN (+) were 31.3±4.9, 38.9±6.3, 19.9±6.3%, respectively, those in AN (+) being significantly lower than those in AN (-)(p<0.01)or C (p<0.05). There was a positive correlation between the mean intensity of contraction and CVR-R for all subjects (r=0.671, p<0.05). Percent increase of plasma glucose at 15, 45, and 60 min, was significantly lower in AN (+) than in AN (-). Plasma acetaminophen concentrations at the same points in time were significantly lower in AN (+) than in AN (-) and C.
These results suggest that gastric motilty may be disturbed by the progression of diabetic AN, and that a decrease in the intensity of antral contractions may be an early indication of diabetic gastroparesis.View full abstractDownload PDF (1347K) -
Masaki Nagai, Seiryo Takashina, Keiji Kubo, Kazufumi Ishida1992 Volume 35 Issue 7 Pages 547-552
Published: July 30, 1992
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSDuring the fifteen year period from 1975 to 1989 a mass health examination was continuously conducted on the members and their families of all agricultural cooperative associations in Hiroshima prefecture. Using the results from over 12, 000 oral glucose tolerance tests performed on all examinees in the program, the prevalence of diabetes, impaired glucose tolerance (IGT) and borderline diabetes were obtained by sex and age.
The prevalence of diabetes was higher among males than females, and the prevalence increased with age. The prevalence for males was around 5% in the 45-65 year old age group, and was more than 10% in the over 65 year old age group. The prevalence for females was less than 5% in those under 55 years, and went up to between 6 and 9% in those over 60 years olds. The prevalence of IGT and borderline diabetes also increased with age, but the sex differences were not as large as for diabetes. The prevalence of IGT was over 20% in the older generations.View full abstractDownload PDF (1079K) -
Masayoshi Tsukamoto, Hisaya Tada1992 Volume 35 Issue 7 Pages 553-559
Published: July 30, 1992
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThrombospondin (TSP), a multi-functional glycoprotein, has been identified in glomerular mesangial cells (M cell). The purpose of this study was to clarify whether TSP is associated with the pathogenesis of diabetic nephropathy. The TSP content of kidney cortex was higher, and the TSP content of kidney medulla was lower in diabetic rats than in control rats. It was also observed that TSP content and secretion were higher in glomeruli isolated from diabetic rats, and that TSP synthesis was enhanced by a high glucose concentration (33 mM) in cultured rat M cell at both logarithmic and confluent phases. Furthermore, fibronectin-mediated attachment and spreading of M cell were inhibited by additional coating with TSP. From these results, it is concluded that TSP-related metabolic abnormalities exist in the kidney tissue of STZ-diabetic rats. Increased TSP in glomeruli, especially in M cell, may play a role in the pathogenesis of diabetic nephropathy, presumably through its binding to many different macromolecules.View full abstractDownload PDF (3826K) -
Shozo Kobori, Takayuki Sasahara, Masaya Ide, Mchiharu Sakakida, Hideki ...1992 Volume 35 Issue 7 Pages 561-567
Published: July 30, 1992
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe effects of short-term (8 weeks) treatment with three lipid-lowering agents, probucol, pravastatin, and niceritrol on serum lipoprotein (a)[Lp (a)] levels were examined in 82 hypercholesterolemic patients with (43) or without (39) diabetes mellitus (DM) associated with a serum Lp (a) level above 20 mg/dl.
The mean level of serum Lp (a) was significantly higher in the hypercholesterolemic patients with or without DM than in normolipidemic subjects. The mean level in DM without hyperlipidemia also tended to be high. Probucol and pravastatin significantly decreased serum total cholesterol (TC) and apolipoprotein (apo) B levels in both groups at weeks 4 and 8 as compared to week O, whereas niceritrol also slightly but significantly decreased those of levels. Serum high density lipoprotein-cholesterol was decreased by probucol whereas it was increased by pravastatin. Serum Lp (a) was significantly decreased by niceritrol in non-DM (from 38.7±3.9 mg/dl at week 0 to 33.3±4.8mg/dl at week 8, n=15, p<0.01) as well as DM (from 42.6±5.9mg/dl at week 0 to 33.3±4.8mg/dl at week 8, n=12, p<0.01), whereas it was increased by pravastain. There was no significant change in serum Lp (a) level with probucol.
These results suggest that combination therapy of probucol and/or pravastatin plus niceritrol may be useful in protecting against the development of diabetic macroangiopathy in diabetic patients with accompanying hypercholesterolemia and high Lp (a) levels.View full abstractDownload PDF (1058K) -
Y Suzuki, K Matsuoka1992 Volume 35 Issue 7 Pages 569-571
Published: July 30, 1992
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSTo compare the fasting or postprandial blood glucose levels from the fingertip and abdominal wall, 68 patients (male 44, female 24) with diabetes were studied. Blood glucose levels were evaluated using an electrode meter (Glucocard; Kyoto Daiichi). Samples were taken from thefingertip and abdominal wall at various times of the day, that is, in fasting and postprandial states. Results: Blood glucose levels for the fingertip and abdominal wall were, respectively, fasting state group (n=9) 138±43<147±41 (mean±SD;mg/dl) postprandial 1 hour group (n=13) 228±59>216±57; postprandial 2 hours group (n=9) 174±58=173±51; postprandial 3 hours group (n=24) 175±72=180±66; and postprandial 4 hours group (n=13) 173±53<189±51.
These results show that fingertip blood samples tended to have lower glucose levels tha abdominal wall blood samples in the fasting state and 4 hours after meals. This tendency might be explained by the difference in oxygen saturation between fingertip blood and the standard level measured in more central venous blood.View full abstractDownload PDF (446K)
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