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Volume 44, Issue 11
Displaying 1-7 of 7 articles from this issue
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A Hospital-based Study over 15 YearsMichiyo Hase, Hiroki Yokoyama, Tomoko Nakagami, Chieko Takahashi, Yasu ...2001 Volume 44 Issue 11 Pages 873-878
Published: November 30, 2001
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe number of patients with end-stage renal failure (ESRF) who have been newly accepted for dialysis because of diabetic nephropathy (DN) is increasing rapidly in Japan. However it is unknown whether this is due to the increasing prevalence of diabetes or to the increasing incidence of diabetic nephropathy. The aim of the study was to investigate the trends of the prevalence of DN from 1980 to 1995. Consecutive patients who visited the Diabetes Center, TWMU, were randomly recruited in 1980 (n=444), in 1985 (n=552), in 1990 (n=752), and in 1995 (n=645). Among the 4 groups there were no significant differences in % male, age, known duration of diabetes, and % referral. The prevalence of DN increased significantly; 4.3% in 1980, 4.4% in 1985, 7.3% in 1990 and 7.6% in 1995 (χ2 trend=8.2, p<0.01). The trend was significant in patients with a duration of diabetes of more than 5 years (χ2 trend=8.7, p<0.01). In conclusion, our data indicated that not only the increasing incidence of diabetes but also the increasing incidence of DN might contribute to the rapidly increasing number of patients with ESRF in Japan.View full abstractDownload PDF (1187K) -
Kazuo Katsumata, Katsuhiko Furuta, Yutaka Oiso, Motoji Kitagawa, Jiro ...2001 Volume 44 Issue 11 Pages 879-885
Published: November 30, 2001
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSThe Care Network of Diabetes Mellitus in Aichi and Aichi Medical Association (AMS) and Aichi Hospital Association analyzed practical problems related to diabetes mellitus, sending questionnaires to all AMS clinics and all hospitals in Aichi Prefecture. Questionnaires were conducted in November 1999 at clinics and March 2000 at hospitals. Clinic questionnaires were answered without clinic names but those of hospitals used the hospital name. More borderline diabetic patients consulted clinics than hospitals. Diabetic patients consulted many specialized clinics, suggesting that diabetes mellitus was a common disease. All university hospitals, nearly all general hospitals, and many other hospitals with internal medicine departments were consulted by more diabetic patients than clinics, suggesting that hospitals having many therapeutic functions for complications are visited by long-term patients with many complications.
Interestingly, hospitals with special certified doctors or with a specially institute for diabetic training and education certified by the Japan Diabetic Society were consulted by many diabetic patients.
In conclusion, only small numbers of borderline diabetic patients in Aichi Prefecture underwent medical monitoring compared to the numbers of borderline diabetic patients estimated by the Japan Ministry of Health and Welfare in 1998.
We propose that strong measures must be taken for preventing diabetes mellitus focusing on borderline diabetic patients.View full abstractDownload PDF (1313K) -
Clinical Features, Risk Factors, Characterization of Cardiac Function, and Survival PrognosisY. Kida, Y. Murata, M. Tahara, M. Sakaguchi, M. Jyouko, T. Shikano, A. ...2001 Volume 44 Issue 11 Pages 887-894
Published: November 30, 2001
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSAlthough congestive heart failure (CHF) is a common cause of cardiovascular death in diabetics, little data documents the prevalence and clinical characteristics of high-risk groups. We studied the clinical fea tures, risk factors, and survival prognosis of CHF in 1451 patients with type 2 diabetes. CHF prevalence was 6.7%(n=97), 2.5 times more common in women than men (4.1% vs 10.5%). CHF subjects were more likely to be older and have both micro-and macrovascular complications. Ischemic heart disease, renal dys function, and urinary albumin excretion were independently associated with CHF. The echocardiographic correlates of CHF were left atrial dilation, left ventricular hypertrophy, and both systolic and diastolic left ventricle dysfunction. Survival models based on Cox proportional hazards indicates complications of CHF, aging, gender, and ischemic heart disease were independent determinants of survival prognosis in diabetic subjects.View full abstractDownload PDF (1310K) -
Tomom Takeda, Shimpei Fujimoto, Yoshiyuki Tsuura, Kouichi Tanaka, Shir ...2001 Volume 44 Issue 11 Pages 895-899
Published: November 30, 2001
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 50-year-old man whose urine sugar was found to be excessive about ten years earlier in an annual health examination consulted a physician in 1998 and began treatment with an oral hypoglycemic agent as a type 2 diabetes patient, with an Hb A1c of 73% and a C-peptide blood level after eating of 5.6ng/ml. One year later he complained of general fatigue, and became icteric. Because of acute exacerbation due to chronic type B hepatitis, liver transplantation was performed on May 4, 1999, and administration of tacrolimus as an immunosuppressive drug was begun. About one month later, the patient's endogenous in sulin secretion was fomd to be extremely low (C-peptide in blood before eating of O.16ng/ml and urine Cpeptide of 6.0μg/day), and he became insulin-dependent thereafter. Although there is some evidence that tacrolimus can reduce insulin secretion and impair glucose tolerance, there are few reports of such damage resulting in an insulin-dependent state.View full abstractDownload PDF (814K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2001 Volume 44 Issue 11 Pages 901-905
Published: November 30, 2001
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESS -
Kazuki Ohta, Toshihiko Takamoto, Hiroyuki Izumi, Tetsuya Yoshida, Yasu ...2001 Volume 44 Issue 11 Pages 907-912
Published: November 30, 2001
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESSA 61-year-old woman undergoing steroid treatment for mexiletine hypersensitivity syndrome abruptly developed diabetic ketoacidosis (DKA) and became completely insulin-dependent.She has never had diabetes mellitus and fasting plasma glucose was normal (79mg/dl) 4 days before DKA onset.Diabetes-related autoantibodies including anti-GAD-antibody, anti-IA-2 antibody, and antiislet cell antibody were negative. Hypersensitivity syndrome is a severe adverse cutaneous reaction to certain drugs, often damaging several vital organs.This syndrome is considered associated with the reactivation of human herpes virus 6 (HHV 6).Since DKA onset and liver injury developed simultaneously in our case, speculated that reactivated HHV 6 may be partly involved in destroying pancreatic β-cells.Although the pathogenesis of fulminant type 1 diabetes is unclear, HHV 6 reactivation should be considered as a possible candidate.View full abstractDownload PDF (965K) -
[in Japanese], [in Japanese]2001 Volume 44 Issue 11 Pages 913-916
Published: November 30, 2001
Released on J-STAGE: March 02, 2011
JOURNAL FREE ACCESS
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