Journal of the Japan Diabetes Society
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
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Volume 52, Issue 3
Displaying 1-10 of 10 articles from this issue
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Original Article
  • Effectiveness of Step-up Bolus Insulin Addition on Combination Therapy with Sulfonylurea and Once-daily Insulin Glargine in Japanese Type 2 Diabetic Patients (JUN-LAN Study 7)
    Kaede Okayama, Hiromasa Goto, Tomoaki Yoshihara, Fuki Ikeda, Munenori ...
    2009 Volume 52 Issue 3 Pages 197-202
    Published: March 30, 2009
    Released on J-STAGE: March 01, 2010
    DOIhttps://doi.org/10.11213/tonyobyo.52.197
    JOURNAL FREE ACCESS
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    We have evaluated the effectiveness of step-up bolus insulin addition in 16 type 2 diabetic patients with a mean HbA1c of 8.12±0.92% who underwent combination therapy with sulfonylurea and once-daily insulin glargine (bedtime or morning) but whose HbA1c was ≥7.0% over 1 year.
    Patients underwent randomly added bolus insulin before breakfast (n=8) or dinner (n=8). After 12 weeks of treatment, 6 whose HbA1c was ≥7.0% and who agreed to step-up addition of rapid-acting insulin underwent this therapy. After 24 weeks treatment, mean HbA1c in all patients improved from 8.12±0.92% to 7.19±0.54%. Body weight increased slightly but significantly during the study.
    These results suggest that step-up bolus insulin addition during combination therapy with sulfonylurea and once-daily glargine is effective in lowering HbA1c and easily tolerated in patients having difficulty in undergoing intensive insulin therapy.
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  • Investigation of Optimal Waist Circumference Criteria for Metabolic Syndrome Screening Based on Visceral Fat Using CT
    Rumi Fujikawa, Chikako Ito
    2009 Volume 52 Issue 3 Pages 203-208
    Published: March 30, 2009
    Released on J-STAGE: March 01, 2010
    DOIhttps://doi.org/10.11213/tonyobyo.52.203
    JOURNAL FREE ACCESS
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    We clarified waist circumference criteria appropriate for metabolic syndrome (MS) screening based on visceral fat area (VFA) using computed tomography (CT). Subjects numbered 1,617-1,101 men and 516 women-undergoing general health examinations. The accuracy of predicting the presence of two or three categories of MS-hypertension and/or dyslipidemia and/or high fasting glucose-was compared to VFA. The optimal cutoff VFA is 94 cm2 in men and 60 cm2 in women. Sensitivity and specificity were 69% in men and 77% in women. Waist circumferences corresponding to this data were calculated as 86.0 cm in men and 82.4 cm in women. In Japan, we propose that the appropriate MS waist circumference criterion is 85 cm in men and 82 cm in women.
    In men, our result agrees with the present criterion, but not in women, due to the difference between men and women in fat accumulation, i.e. women have a much smaller VFA than men, so the VFA criterion should be reconsidered.
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  • Development of Insulin Delivery System Questionnaire in Japanese (IDSQ-J) and Reproducibility and Adequacy Assessment
    Hitoshi Ishii, Satoru Tsujii, Masami Tanaka, Miyuki Furuya, Tadao Ibur ...
    2009 Volume 52 Issue 3 Pages 209-221
    Published: March 30, 2009
    Released on J-STAGE: March 01, 2010
    DOIhttps://doi.org/10.11213/tonyobyo.52.209
    JOURNAL FREE ACCESS
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    We developed an insulin delivery system questionnaire in Japanese (IDSQ-J) to measure the impact of insulin delivery systems including insulin and its devices, on patient quality of life. The IDSQ-J consists of 4 groups of 18 questions answered by patients. Factor analysis with 16 items excluding 2 questions with low commonality, yielded 4 subscales-satisfaction, ease of use, lifestyle impact, and blood glucose control. Subscale scores proved highly reliable. Validity was confirmed by checking the correlation between IDSQ-J subscale scores and the Diabetes Treatment Satisfaction Questionnaire (DTSQ) or Insulin Therapy Attitude Questionnaire. In conclusion, we found that the IDSQ-J is a reliable and valid rating scale for evaluating insulin delivery systems from the patient's standpoint.
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