The maximum weight prior to the onset of diabetes was studied in 177 patients. The results were as follows: 1) Overweight (10 per cent or more over standard weight) was shown in 74.5 per cent of 177 patients, normal weight in 24.9 per cent and underweight in 0.5 per cent. 2) Remarkable overweight (40 per cent or more over standard weight) was found more frequently in the patients whose onset of diabetes was over 40 years old. 3) Remarkable overweight was more frequently in the male than in the female. 4) Within 2 years after showing the maximum body weight the clinical onset of diabetes was seen in 51 per cent of 177 diabetics, and within 10 years in 73 per cent of the patients. 5) Within 10 years after showing the maximum body weight the onset of diabetes was found in 50 per cent of the patients in 3 decade, 90 per cent in 4 decade, and 100 per cent in 5 decade.The duration between the manifestation of maximum body weight and the onset of diabetes was shorter in the older decade.
Ninty-six diabetic patients who had been treated with insulin at least for 6 months in this clinic were subjected to the studies concerning with insulin lipodystrophy (I-LD). In these 96 patients, insulin lipoatrophy (I-LA) was shown in 26 cases (27%) and lipohypertrophy (I-LH) in 3 cases (3%). The factors which were considered to influence the I-LD were as follows. 1) I-LA was observed in 18 cases of 42 females (48%), and in 8 cases of 54 males (15%).The I-LA was found in 1 case of 10 under 30 years old (10%), in 11 cases of 50 between 30 and 59 years old (22%), and in 14 cases of 36 over 60 years old (39%). The I-LH was found in 1 case under 30 years old and in 2 cases between 30 and 59 years old. 2) Kind and dosage of insulin had no influence on the occurrence of the I-LD. Incidence of the I-LD was much lower in the patients recieved insulin within one year than the patients over one year, whereas in the patients recieved insulin over one year there was no significant relationship between the duration of insulin treatment and I-LD. 3) Condition of diabetes, good or poor, had no relation with the appearance of I-LD, although the incidence of I-LA was significantly high in brittle diabetics. 4) The frequency of I-LA was high in the group of patients who had diabetic microangiopathies found with skin biopsy and ophthalmoscopic examination. 5) The frequency of I-LD was higher in the group of patients who showed high serum phospholipids level than the group showed normal level, although there was not such correlation between other serum lipids, cholesterol and trigricerides, and the I-LD. 6) It was suggested that the insulin-binding antibody influenced the occurrence of I-LD in some cases, however statistically there was no relationship between the level of insulin-binding antibody in the serum and I-LD.