Viva Origino
Online ISSN : 1346-6933
Print ISSN : 0910-4003
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Volume 50, Issue 1
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  • Reconstruction of the ancient beta-barrel with seven amino acid types
    Sota Yagi, Shunsuke Tagami
    2022 Volume 50 Issue 1 Pages 1-
    Published: 2022
    Released on J-STAGE: April 20, 2022
    DOIhttps://doi.org/10.50968/vivaorigino.50_1
    JOURNAL FREE ACCESS
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      Proteins are essential biomolecules that are responsible for nearly all biological processes. Therefore, understanding the origin and evolution of proteins is necessary to solve the mystery of the origin of life. Although many modern proteins have huge and complex structures, they are thought to have originated from shorter and simpler peptides. However, how simple such ancient peptides were is still a mystery. The authors have recently demonstrated that a DPBB structure, one of the ancient protein folds conserved in the active cores of RNA polymerase and other proteins, can be constructed with a peptide consisting of 43 residues of seven amino acid types.

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