巻号一覧
41 巻 (1970)
- 6 号 p. 387-
- 5 号 p. 321-
- 4 号 p. 255-
- 3 号 p. 165-
- 2 号 p. 57-
- 1 号 p. 1-
41 巻, 6 号
選択された号の論文の19件中1～19を表示しています
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美間 博之, 野村 容朗, 今井 祥雄, 高島 弘道原稿種別: 本文
1970 年 41 巻 6 号 p. 387-398
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーBy phosphorylation of 5,6-isopropylidene-L-ascorbic acid, a mixture of some phosphoric acid esters of AsA were obtained, and from this mixture, four esters (AsA-2-phosphate, -3-phosphate, -3-pyrophosphate, bis- AsA-3,3'-phosphate) were isolated. AsA-3-phosphate was most stable among these four esters and the other esters changed to -3-phosphate in aqueous solution. AsA-3-phosphate and its salt were stable in water, especially in neutral or alkaline solution containing boric acid or its salt. AsA-phosphate was hydrolyzed with phosphatase of liver or skin to corresponding AsA and exhibited vitamin C activity. The topical therapy with an ointment containing AsA-phosphate Mg was carried out in the treatment of various pigmented dermatoses for a long time and found to be effective. Accordingly, AsA-phosphate Mg is available for dermatological and cosmetic uses.抄録全体を表示PDF形式でダウンロード (1197K) -
奥田 邦雄, 八島 啓輔, 藤井 輝美, 高良 勲, 北崎 徹郎, 高松 政利原稿種別: 本文
1970 年 41 巻 6 号 p. 403-
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーVarying dosages of ^57Co-labeled methylcobalamin were injected to rats by subcutaneous, intramuscular and intravenous routes and the distribution of radioactivity was measured and compared with those for ^57Co-labeled cyanocobalamin and hydroxocobalamin. The urinary excretion was also determined in comparison with the two common analogues. It was found that methylcobalamin behaved somewhat like hydroxocobalamin with respect to tissue retention and excretion via the kidney. However, if given in large doses, it behaved more like cyanocobalamin in blood. These data seem to suggest a gradual conversion of methylcobalamin to hydroxocobalamin or coenzyme forms in vivo.抄録全体を表示PDF形式でダウンロード (177K) -
宮原 竜郎, 倉田 軍一, 酒井 立夫原稿種別: 本文
1970 年 41 巻 6 号 p. 408-
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーFluorescence of each reaction mixture of BrCN or ferricyanide and benzylimidazolothiamine (I), imidazolothiamine (II), phenyltriazinothiamine (III) or triazinothiamine (IV) in alkaline solution was examined by fluorometer (Hitachi model 203). I showed blue fluorescence on the reaction with BrCN or ferricyanide and III or IV showed purple fluorescence by ferricyanide, but II showed no fluorescence. The fluorescence from I with BrCN was much stronger than that from I, III or IV with ferricyanide. From the reaction mixture of I and BrCN, a crystalline fluorophore was isolated and the calibration curve of its fluorescence on the basis of mole-concentration to I was shown to be nearly identical with that of I solution reacted with BrCN. As the quantitative formation of thiamine on incubation II and 4-methyl-5-(2-hydroxyethyl)-thiazole (MHT) with the cells of Saccharomyces carlsbergensis had been established, estimation of II was enabled through the calibration of the formed thiamine (thiochrome method). The method was also applied successfully for the estimation of III or IV based on the biosynthesis of thiamine from them and MHT.抄録全体を表示PDF形式でダウンロード (170K) -
宮原 竜郎, 倉田 軍一, 酒井 立夫原稿種別: 本文
1970 年 41 巻 6 号 p. 413-
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーThe growth of Lactobacillus fermenti was competitively inhibited by antithiamine compounds ; imidazolothiamine (I), benzylimidazolothiamine (II), butylimidazolothiamine (III) and triazinothiamine (IV) (Vitamins 32,383,1965 ; 33,488,1966 ; 34,289,375,1966). Thiamine uptake of Lactobacilli cells was inhibited by these compounds in the following order of inhibition : pyrithiamine > I ≒ II ≒ III > IV. Correlation between the growth-inhibition indices of the compounds and the uptake of thiamine by the cells in the presence of the compounds was shown in Fig. 1. The stronger inhibition to the growth of L. fermenti in the broth containing thiamine diphosphate than in the broth containing thiamine was shown by all the compounds. The stronger inhibition to cell-uptake of thiamine diphosphate than that of thiamine by the compounds was also demonstrated.抄録全体を表示PDF形式でダウンロード (168K) -
宮原 竜郎, 倉田 軍一, 酒井 立夫原稿種別: 本文
1970 年 41 巻 6 号 p. 414-417
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーIn the presence of 5×10^-11 mole pyridoxine-HCl/4ml, imidazolothiamine compounds (imidazolothiamine, benzyl- or butylimidazolothiamine) showed the inhibition as antithiamine to the growth of Saccharomyces carlsbergensis in the concentrations lower than 10^-8mole thiamine-HCl/4ml. In the concentrations higher than 10^-8 mole thiamine-HCl/4ml, benzylimidazolothiamine showed the growth-inhibition which was recovered by addition of pyridoxine, but not by addition of thiamine. A molar ratio of benzylimidazolothiamine to thiamine or pyridoxine required for 50% growth-inhibition was about 200 or 38,000. Benzylimidazolothiamine inhibited the cell-uptake of thiamine more strongly than the cell-uptake of pyridoxine, when the sufficient amount of thiamine and pyridoxine with benzylimidazolothiamine was added to the broth.抄録全体を表示PDF形式でダウンロード (422K) -
井上 喜久子原稿種別: 本文
1970 年 41 巻 6 号 p. 421-
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーThe conversion of O-benzoylthiamine (OBT) to thiamine in various organs was studied by means of the procedure for the determination of OBT which is deviced by the author. The liver homogenates of albino rat and rabbit have the enzyme, capable of converting OBT to thiamine. Its optimum pH is 7.0-7.5. The enzymatic potency is strogest in liver, followed by kidney, while that in brain is negligible. The enzymatic power of blood varies with the animal species. For example, in rat blood it is negligible, while in human blood it is relatively strong.抄録全体を表示PDF形式でダウンロード (171K) -
野本 直記原稿種別: 本文
1970 年 41 巻 6 号 p. 427-
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーVarious doses of predonisolone of 2,8,and 40mg/kg body weight/day and ACTH of 25 I.U./kg body weight/day for 1,3,10 and 20 days were injected into young albino rats. 1) Hepatic concentration of CoA increased from 3 to 10 days after the injection of 8 or 40mg/kg body weight/day of predonisolone and 3 days after the injection of ACTH. 2) Hepatic concentration of CoA decreased 20 days after the injection of 8 or 40mg/kg body weight/day of predonisolone. 3) Hepatic concentration of total pantothenic acid increased from 1,3 and 10 days after the injection of 8mg/kg body weight/day and 3 days after the injection of 40mg/kg body weight/day of prdonisolone. 4) No remarkable changes in hepatic concentration of CoA precursors and free pantothenic acid in these groups were found.抄録全体を表示PDF形式でダウンロード (180K) -
野本 直記原稿種別: 本文
1970 年 41 巻 6 号 p. 431-
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーHepatic concentration of CoA, its precursors and pantothenic acid in adrenalectomized rats and of those treated with predonisolone 8mg/kg body weight/day for 3 days by intracutaneous injection were studied. 1) Hepatic concentration of CoA and pantothenic acid decreased 4 days after adrenalectomy. 2) Decreased hepatic concentrations of CoA and total pantothenic acid in adrenalectomized rats were recovered by the treatment of predonisolone in the above-mentioned way. 3) Even in shamoperation, however, hepatic concentration of CoA and total pantothenic acid decreased on the level of 66% of the control group. 4) No remarkable changes in hepatic concentration of CoA precursors and free pantothenic acid in each group were shown.抄録全体を表示PDF形式でダウンロード (187K) -
野本 直記原稿種別: 本文
1970 年 41 巻 6 号 p. 436-
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーHepatic concentration of CoA and pantothenic acid in adrenalectomized rat after injection of CoA 0.9 μmoles for 4 days, Ca-pantothenate 0.9 μmoles or 4.5 μmoles for 4 days and predonisolone 8mg/kg body weight/day for 3 days intracutaneously were observed, respectively. 1) The reduction of body weight in the CoA administered group was slighter than in the pantothenate injected group and its activity was better. 2) Hepatic concentration of CoA and total pantothenic acid decreased most remarkably in the pantothenate 0.9 μmoles administered group. 3) Hepatic concentration of CoA and total pantothenic acid increased in the CoA administered group. 4) No differences in hepatic CoA and total pantothenic acid content between CoA and predonisolone administered groups and also between pantothenate 0.9 μmoles and predonisolone 4.5 μmoles administered group were observed.抄録全体を表示PDF形式でダウンロード (163K) -
林 良二, 西宗 高弘原稿種別: 本文
1970 年 41 巻 6 号 p. 437-
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーPDF形式でダウンロード (178K) -
佐橋 佳一, 前川 昭男, 舛重 正一原稿種別: 本文
1970 年 41 巻 6 号 p. 437-438
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーPDF形式でダウンロード (320K) -
緒方 浩一, 谷 吉樹, 中松 亘, 和泉 好計原稿種別: 本文
1970 年 41 巻 6 号 p. 438-439
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーPDF形式でダウンロード (337K) -
勝沼 信彦, 賀治 佐知子原稿種別: 本文
1970 年 41 巻 6 号 p. 439-440
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーPDF形式でダウンロード (339K) -
牧野 堅, 山下 洵子原稿種別: 本文
1970 年 41 巻 6 号 p. 440-
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーPDF形式でダウンロード (197K) -
中村 恒男, 楠 智一, 曽山 浩吉原稿種別: 本文
1970 年 41 巻 6 号 p. 440-441
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーPDF形式でダウンロード (347K) -
福井 三郎, 清水 祥一, 佐藤 一精原稿種別: 本文
1970 年 41 巻 6 号 p. 441-442
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーPDF形式でダウンロード (346K) -
福井 三郎, 佐藤 一精, 石谷 寿, 清水 祥一原稿種別: 本文
1970 年 41 巻 6 号 p. 442-
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーPDF形式でダウンロード (200K) -
中沢 恒幸原稿種別: 本文
1970 年 41 巻 6 号 p. 442-443
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーPDF形式でダウンロード (333K) -
藤原 元典原稿種別: 本文
1970 年 41 巻 6 号 p. 443-
発行日: 1970/06/25
公開日: 2018/02/22
ジャーナル フリーPDF形式でダウンロード (182K)
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