巻号一覧
60 巻, 11 号
選択された号の論文の8件中1～8を表示しています
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福沢 健治原稿種別: 本文
1986 年 60 巻 11 号 p. 521-526
発行日: 1986/11/25
公開日: 2018/03/14
ジャーナル フリーLipid peroxidation is involved in toxic deterioration in aerobic life. Active oxygens, such as singlet oxygen, hydroxyl radicals, superoxide anion radicals and perhydroxyl radicals, take part in induction of lipid peroxidation. Vitamin E (tocopherols), mostly localized in biomembranes, is well known as one of the most effective natural compounds for protection against lipid peroxidation, but the antioxidant mechanism of vitamin E in membranes is obscure. This paper reviews the inhibition mechanism of vitamin E in lipid peroxidation and the scavenging effect on the active oxygens in model membranes such as liposomes and fatty acid micelles.抄録全体を表示PDF形式でダウンロード (579K) -
中島 秀喜原稿種別: 本文
1986 年 60 巻 11 号 p. 527-535
発行日: 1986/11/25
公開日: 2018/03/14
ジャーナル フリーThe inhibitory effect of all-trans-retinoic acid on human immunodeficiency virus (HIV) replication upon infection was studied quantitatively with the novel bioassay system using a HTLV-I-carrying human T-cell line, MT-4. The results were summarized as follow: 1) Appearance of HIV antigen was significantly reduced when the cells were treated with 10μg/ml of the compound after infection. When HIV specific plaque assay was performed to titrate the virus from the supernatant of culture treated with 10μg/ml of all-trans-retinoic acid no plaque was observed. 2) When all-trans-retinoic acid was used directly in the plaque assay, although control showed 102 plaque formation, significant decrease of the number of plaques was discerned showing 66, 47 and 16 at the concentration of 1, 5 and 10μg/ml of all-trans-retinoic acid respectively. 3) Cytopathic effect of MT-4 cells by HIV infection appeared in the all-trans-retinoic acid treated cultures later than in the untreated. 4) Concomitant treatment of the cells with 5μg/ml of all-trans-retinoic acid and various concentra tions of suramin resulted in the more effective inhibition of HIV replication. 5) all-trans-retinoic acid did not inhibit the reverse transcriptase activity of HIV directly. 6) DNA synthesis of MT-4 cells was inhibited when the cells were treated with all-trans-retinoic acid more than 0.1μg/ml with no significant effect on the cell viability. At the concentrations of 0.01μg/ml of all-trans-retinoic acid cellular DNA synthesis was rather enhanced. These data suggest that all-trans-retinoic acid inhibits HIV replication through its DNA inhibitory effect at the higher concentrations whereas it does by inducing antiviral state in the cells at the lower concentrations of all-trans-retinoic acid.抄録全体を表示PDF形式でダウンロード (854K) -
田口 寛, 阪口 宗, 嶋林 幸英原稿種別: 本文
1986 年 60 巻 11 号 p. 537-546
発行日: 1986/11/25
公開日: 2018/03/14
ジャーナル フリーQuinolinic acid, trigonelline, N^1-methylnicotinamide and niacin contents in various common Japanese foods were determined. Quinolinic acid was distributed widely, and the highest content found in "katsuobushi" (dried bonito) was 5.3mg/100g. Very high correlation between quinolinic acid content and niacin content was observed (r=0.936). Trigonelline was localized in some sea foods, pea and coffee bean. Trigonelline content in coffee bean was extremely high, nearly one percent. Generally speaking, N^1-methylnicotinamide was distributed mainly in the foods of animal origin. The highest content was 3.2mg/100g in dried "wakame" seaweed (Undaria pinnatifida). Quinolinic acid, trigonelline and N^1-methylnicotinamide were proved to be converted into nicotinic acid or nicotinamide after being heated at over 180℃. It was suggested that these compounds in foods were converted into vitamin after high temperature cooking. In addition to quinolinic acid, trigonelline and N^1-methylnicotinamide, some unknown compounds which are converted into nicotinic acid or nicotinamide during high temperature cooking may be present in foods.抄録全体を表示PDF形式でダウンロード (761K) -
佐藤 一精原稿種別: 本文
1986 年 60 巻 11 号 p. 547-548
発行日: 1986/11/25
公開日: 2018/03/14
ジャーナル フリーPDF形式でダウンロード (285K) -
小橋 昌裕原稿種別: 本文
1986 年 60 巻 11 号 p. 548-550
発行日: 1986/11/25
公開日: 2018/03/14
ジャーナル フリーPDF形式でダウンロード (405K) -
平原 文子原稿種別: 本文
1986 年 60 巻 11 号 p. 550-551
発行日: 1986/11/25
公開日: 2018/03/14
ジャーナル フリーPDF形式でダウンロード (301K) -
糸川 嘉則原稿種別: 本文
1986 年 60 巻 11 号 p. 551-552
発行日: 1986/11/25
公開日: 2018/03/14
ジャーナル フリーPDF形式でダウンロード (320K) -
紀氏 健雄原稿種別: 本文
1986 年 60 巻 11 号 p. 552-553
発行日: 1986/11/25
公開日: 2018/03/14
ジャーナル フリーPDF形式でダウンロード (240K)
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