VITAMINS

Online ISSN : 2424-080X
Print ISSN : 0006-386X

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Volume 76, Issue 4

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 199-
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_199

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Identification of Nuclear Localization Signal and Antagonist of Vitamin D Receptor

Keiichi Ozono

Article type: Article
2002Volume 76Issue 4 Pages 201-208
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_201

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The localization of vitamin D receptor (VDR) in the absence of its ligand 1α,25-dihydroxyvitamin D_3 [1α,25(OH)_2D_3] was investigated using chimera proteins fused to green fluorescent protein (GFP) The obtained results indicate that VDR is located predominantly in nuclei with a significant presence in cytoplasm in the absence of the ligand and that a NLS consisting of 20 amino acids in the hinge region facilitates the transfer of VDR to the nucleus. Next, we showed that 10^-7 M TEI-9647, the novel 1α,25(OH)_2D_3 analogue, inhibited the transactivation effect of 10^-8 1α, 25(OH)_2D_3, while TEI-9647 alone did not activate the reporter activity driven by SV40 promoter containing two vitamin D response elements in Saos-2 cells. The results demonstrate that TEI-9647 is the first synthetic ligand for the VDR which efficiently antagonizes the action of 1α,25(OH)_2D_3, although the extent of its antagonism depends on cell-type.

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 209-211
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_209

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 213-221
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_213

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 223-224
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_223

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 224-226
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_224

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 226-228
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_226

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 228-231
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_228

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 233-235
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_233

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[title in Japanese]

Article type: Bibliography
2002Volume 76Issue 4 Pages 237-
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_237_1

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[title in Japanese]

Article type: Bibliography
2002Volume 76Issue 4 Pages 237-
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_237_2

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[title in Japanese]

Article type: Bibliography
2002Volume 76Issue 4 Pages 238-
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_238_1

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[title in Japanese]

Article type: Bibliography
2002Volume 76Issue 4 Pages 238-
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_238_2

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[title in Japanese]

Article type: Bibliography
2002Volume 76Issue 4 Pages 238-
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_238_3

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[title in Japanese]

Article type: Bibliography
2002Volume 76Issue 4 Pages 239-
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_239_1

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[title in Japanese]

Article type: Bibliography
2002Volume 76Issue 4 Pages 239-
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_239_2

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 241-
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_241_1

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 241-242
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_241_2

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 242-243
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_242

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

Article type: Article
2002Volume 76Issue 4 Pages 244-245
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_244

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 245-246
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_245

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 246-248
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_246

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 248-
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_248

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 249-
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_249_1

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 249-251
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_249_2

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 251-252
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_251

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 252-253
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_252

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 253-
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_253_1

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 253-254
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_253_2

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 254-255
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_254

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 257-258
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_257

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 258-259
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_258

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 259-260
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_259

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 260-262
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_260

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 262-
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_262

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 263-
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_263_1

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 263-264
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_263_2

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[title in Japanese]

[in Japanese]

Article type: Article
2002Volume 76Issue 4 Pages 265-
Published: April 25, 2002
Released on J-STAGE: December 26, 2017

DOIhttps://doi.org/10.20632/vso.76.4_265

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