VITAMINS

Online ISSN : 2424-080X
Print ISSN : 0006-386X

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Volume 89, Issue 3

Displaying 1-30 of 30 articles from this issue

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Studies on phospholipid mediators : physiological roles as a biofactor and food factor

Akira Tokumura

Article type: Article
2015 Volume 89 Issue 3 Pages 97-107
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_97

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This paper overviews our early studies on the roles of lysophosphatidic acid (LPA) in soybean lecithin, platelet-activating factor (PAF) in bovine brain lipid extract, and PAF-like phosphatidylcholines having an sn-2 oxidatively shortened fatty acyl group (PAF-like lipids) as a biofactor. Our subsequent important finding is the identification of autotaxin (ATX) as plasma lysophospholipase D which produces LPA in animal biological fluids. Recently, we have obtained evidence that LPA produced by blood cell-associated autotaxin is involved in the induction of pruritus in a mouse model of atopic dermatitis. It has been shown preliminarily that LPA is produced by human oral mucosa cell-bound lysophospholipase D in the oral cavity. We detected LPA in various foods and showed that stress-induced gastric ulcer in rats and aspirin-induced gastric ulcer in mice were protected by administration of LPA into their stomachs. These findings suggest that LPA exerts physiological roles not only as a biofactor but also as a food factor.

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Effect of vitamin E deficiency on anxiety-like behavior

Yuki Okura, Yuki Terada, Rieko Hashimoto, Seiji Nomura, Hiroya Ohashi, ...

Article type: Article
2015 Volume 89 Issue 3 Pages 108-115
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_108

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Oxidative stress plays a causative role in the pathogenesis of neurodegenerative disorders. Vitamin E is a well-known antioxidant; however, little is known about the effect of vitamin E on neurological health. In this study, we investigated the effect of dietary vitamin E deficiency on anxiety-like behavior in rats. Initially, we found that dietary vitamin E deprivation increased anxiety-like behavior in rats subjected to the elevated plus maze test. The anxiety level increased after 2 weeks of vitamin E deprivation and this time point was much earlier than that at which the symptoms of vitamin E deficiency such as ataxia manifested. Because anxiety was not observed in adrenalectomized rats, we believe that glucocorticoid secretion from the adrenal glands plays an important role in the anxiogenic effect of vitamin E deficiency. Furthermore, negative feedback regulation of glucocorticoid secretion was found to be reduced in vitamin E-deficient rats. This finding allowed us to think that increased blood glucocorticoid level and enhanced stress-induced response including anxiety-like behavior in vitamin E-deficient rats were due to the reduction of the negative feedback regulation. These results demonstrate that reduced vitamin E intake may increase the risk of anxiety disorders, especially under stress conditions.

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Ascorbic acid deficiency affects genes for oxidation-reduction and lipid metabolism in livers from SMP30/GNL knockout mice

Keita Takahashi, Yuki Kishimoto, Tomokazu Konishi, Yasunori Fujita, Ma ...

Article type: Article
2015 Volume 89 Issue 3 Pages 116-118
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_116

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Secondary biotin deficiency caused by special formulas in Japan

Fumihito Nozaki, Masahiro Yuasa, Wanti Shen, Toshiaki Watanabe

Article type: Article
2015 Volume 89 Issue 3 Pages 119-124
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_119

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Change in microRNA-122 (miR-122) in liver diseases and its regulation by biofactors

Shosuke Kojo

Article type: Article
2015 Volume 89 Issue 3 Pages 125-132
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_125

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How is vitamin B_<12> requirement decided in Dietary Reference Intakes (DRIs)?

Akiko Kuwabara, Misora Ao, Kiyoshi Tanaka

Article type: Article
2015 Volume 89 Issue 3 Pages 133-135
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_133

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Novel glycoside, leptosperin, which is exclusively found in manuka honey

Yoji Kato, Akari Ishisaka

Article type: Article
2015 Volume 89 Issue 3 Pages 136-140
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_136

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 141-
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_141_1

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 141-143
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_141_2

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 144-145
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_144

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 145-146
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_145

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 146-147
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_146

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

Article type: Article
2015 Volume 89 Issue 3 Pages 148-149
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_148

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 149-150
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_149

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 150-151
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_150

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 151-152
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_151

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 152-
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_152_1

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 152-153
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_152_2

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 153-154
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_153

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

Article type: Article
2015 Volume 89 Issue 3 Pages 154-
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_154

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 155-
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_155_1

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 155-156
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_155_2

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 156-157
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_156

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 157-158
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_157

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 158-159
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_158

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 159-160
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_159

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 160-161
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_160

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 161-162
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_161

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 162-163
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_162

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[title in Japanese]

[in Japanese]

Article type: Article
2015 Volume 89 Issue 3 Pages 163-
Published: March 25, 2015
Released on J-STAGE: August 10, 2017

DOIhttps://doi.org/10.20632/vso.89.3_163

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