The relationships between adherence of zymosan and phagocytosis by macrophages with the release of 6-keto-prostaglandin F
1α (6KF
1α) and thromboxane B
2 (TXB
2), the stable endometabolites PGI
2 and TXA
2 respectively, from macrophages were investigated with mouse peritoneal macrophages. Zymosan-induced release of 6KF
1α and TXB
2 was inhibited by indomethacin, an inhibitor of cyclo-oxygenase, and by hydrocortisone, an inducer of the inhibitor of phospholipase A
2. Although release of 6KF
1α and TXB
2 was significantly enhanced by the interaction of attachment of zymosan particles to cell membranes, the interaction was inhibited by hydrocortisone, not by indomethacin. From these results it is suggested that phospholipase A
2 participates in the interaction of zymosan particles with cell membranes for the release of 6KF
1α and TXB
2.
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