All issues
Predecessor
Volume 109, Issue 4
Displaying 1-8 of 8 articles from this issue
- |<
- <
- 1
- >
- >|
-
Yuichi SUGIYAMA1989 Volume 109 Issue 4 Pages 199-231
Published: April 25, 1989
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSI initially reviewed successful attempts of us and others to reconstruct in vivo drug dispositions from in vitro biochemical parameters (representing the plasma binding and hepatic metabolism). Despite these successes, however, recent evidence suggests that several factors, which have been overlooked so far, should be also taken into consideration to facilitate more reliable predictions. Those include ; (i) possible existence of diffusional barrier (membrane limited tissue distribution), (ii) uneven distribution of metabolizing enzymes along the blood flow path in the liver, and (iii) the so called proteinmediated transport mechanism. The details of each factor have been discussed mainly based on our recent observations. The studies have been also extended to the analysis of pharmacokinetics of polypeptide hormones. The kinetic analysis of receptor-mediated endocytosis (RME) of polypeptides has been focused on, on the basis of the observations of the kinetics of epidermal growth factor (EGF) in the liver. The experimental systems include the in vitro isolated hepatocytes, perfused rat liver, and in vivo system, and the kinetic parameters representing the interaction of EGF with the cell surface receptors have been compared among the experimental systems.View full abstractDownload PDF (2757K) -
Makio KITAZAWA, Masuo AKAHANE, Yasushi NAKANO, Kazuhide HAYAKAWA, Kazu ...1989 Volume 109 Issue 4 Pages 232-240
Published: April 25, 1989
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSThe derivatives of 3-[3-oxospiro [benzofuran-2 (3H), 1'-cyclopropan]-5-yl] acrylic acid (8) were synthesized and tested for antiulcer activities. As a result, 1-[3-[3-oxospiro-[benzofuran-2 (3H), 1'-cyclopropan]-5-yl] acryloyl] piperidine (3t) and 4-[3-[3-oxospiro [benzofuran-2 (3H), 1'-cyclopropan]-5-yl] acryloyl] morpholine (3u) exhibited potent antiulcer activities.View full abstractDownload PDF (823K) -
Makio KITAZAWA, Masuo AKAHANE, Yasushi NAKANO, Kazuhide HAYAKAWA, Kazu ...1989 Volume 109 Issue 4 Pages 241-249
Published: April 25, 1989
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSIn the preceding paper, we reported that 1-[3-[3-oxospiro [benzofuran-2 (3H), 1'-cyclopropan]-5-yl] acryloyl] piperidine (1a) and 4-[3-[3-oxospiro [benzofuran-2 (3H), 1'-cyclopropan]-5-yl] acryloyl] morpholine (1b) have potent antiulcer activities. In this paper, propionic acid derivatives (2, 3) and oxyacetic acid derivatives (4, 5, 10) were prepared by converting the acryloyl moiety into propionyl and oxyacetyl groups, and tested for antiulcer activities. As a result, [3-oxospiro [benzofuran-2 (3H), 1'-cyclopropan]-5-yloxy]-acetamide (4j) exhibited significant antiulcer activities.View full abstractDownload PDF (691K) -
Junichi KITAJIMA, Yasuko TANAKA1989 Volume 109 Issue 4 Pages 250-255
Published: April 25, 1989
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSFrom the fresh roots of Trichosanthes kirilowii MAXIM. var. japonicum KITAM., the following substances were identified : methyl palmitate, palmitic acid, suberic acid, α-spinasterol, stigmast-7-en-3β-ol, α-spinasterol 3-O-β-D-glucopyranoside, stigmast-7-en-3β-ol 3-O-β-D-glucopyranoside, bryonolic acid, cucurbitacin B, cucurbitacin D, vomifoliol, ethyl α-L-arabinofranoside and D-glucose. The bitter taste of Trichosanthes Root was considered to be due to cucurbitacin B and D.View full abstractDownload PDF (646K) -
Junichi KITAJIMA, Yasuko TANAKA1989 Volume 109 Issue 4 Pages 256-264
Published: April 25, 1989
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSFrom the fresh roots of Trichosanthes cucumeroides MAIXM., three new triterpenoid glycosides with a bitter taste were obtained together with methyl palmitate, palmitic acid, α-spinasterol, stigmast-7-en-3β-ol, α-spinasterol 3-O-β-D-glucopyranoside, stigmast-7-en-3β-ol 3-O-β-D-glucopyranoside and vanillic acid. On the basis of the results of spectral and chemical investigations, these glycosides were characterized as 25-O-β-D-glucopyranosyl-11-oxocucurbit-5-ene-3β, 24 (R), 25-triol 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside, 25-O-β-D-(6-O-acetyl)-glucopyranosyl-11-oxocucurbit-5-ene-3β, 24 (R), 25-triol 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside and 11-oxocucurbit-5-ene-3β, 24 (R), 25-triol 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside.View full abstractDownload PDF (826K) -
Junichi KITAJIMA, Akiko MUKAI, Yasuko MASUDA, Yasuko TANAKA1989 Volume 109 Issue 4 Pages 265-270
Published: April 25, 1989
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSFrom the fresh roots of Trichosanthes bracteata VOIGT., the following substances were identified : methyl palmitate, palmitic acid, suberic acid, α-spinasterol, stigmast-7-en-3β-ol, α-spinasterol 3-O-β-D-glucopyranoside, stigmast-7-en-3β-ol 3-O-β-D-glucopyranoside, glyceryl 1-palmitate, glyceryl 1-stearate, bryonolic acid, cucurbitacin B, isocucurbitacin B, 3-epi-isocucurbitacin B, 23, 24-dihydrocucurbitacin B, 23, 24-dihydroisocucurbitacin B, 23, 24-dihydro-3-epi-isocucurbitacin B, cucurbitacin D, isocucurbitacin D and D-glucose. This root contains more than 6 times cucurbitacin of the root of T. kirilowii MAXIM. var. japonicum KITAM.View full abstractDownload PDF (625K) -
Mizuo MIZUNO, Munekazu IINUMA, Toshiyuki TANAKA, Sakura IWASHIMA, Nori ...1989 Volume 109 Issue 4 Pages 271-273
Published: April 25, 1989
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSThe seasonal fluctuation of flavonol glycosides in the leaves of Epimedium grandiflorum var. thunbergianum, E. cremeum and E. sempervirens (Berberidaceae) was investigated. The total content of glycosides was shown in the highest quantity at the flowering time, and as the leaves mature it has become stable amount with a little decrease. The suitable period for the harvest of Epimedium leaves was concluded to be two or three months after the flowering time.View full abstractDownload PDF (386K) -
XiXiong KANG, Kitaro OKA1989 Volume 109 Issue 4 Pages 274-279
Published: April 25, 1989
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSColumn extraction technique was applied to acid-base fractionation of urinary lipophilic components. The acidified urine was retained on an extraction column packed with diatomaceous earth granules. Extraction solvent passed through the column was introduced directly into alkaline columns to fractionate strong and weak acidic components, the former being trapped on sodium hydrogen carbonate and the latter on sodium hydroxide column. Neutral components were eluted out without any chemical interaction with the support reagents. Acidic components retained in the columns were recovered after acidified with acetic acid. Each fraction thus obtained was analyzed by silica gel high performance liquid chromatography equipped with a multi-channel ultraviolet detector using a solvent system consisted of 0.2% distilled water, 0.2% acetic acid, 15% ethanol and appropriate volume of n-hexane. Thus the comparative chromatographic studies of these three fractions became very easy. In our experiment, urinary components were extracted and chromatographed in the order of their partition coefficients. The method was applied to xanthine derivatives after the administration of caffeine tablets to a healthy volunteer.View full abstractDownload PDF (682K)
- |<
- <
- 1
- >
- >|