YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
119 巻, 3 号
選択された号の論文の5件中1~5を表示しています
  • 飛永 精照
    1999 年 119 巻 3 号 p. 185-198
    発行日: 1999/03/01
    公開日: 2008/05/30
    ジャーナル フリー
    This paper describes the selected topics from my ethnopharmacochemical studies particularly emphasizing the following ethnological viewpoints; (i) a pharmacochemical investigation of the roots of Petasites japonicum MAXIM. derived from the fork usage of a newborn baby for purgation in Japan; (ii) studies on the hypnotic active constituents of Hemerocallis fulva depending on the designation (forget one's sorrow) of the plant in Japan and China;(iii) traditional ritual and medical usages of Peucedanum japonicum THUNB. in Japan and its pharmacologically active constituents; (iv) a pharmacological investigation of the constituents of Centella asiatica URBAN corrresponding to the usage in Ayuruvedic medicine as the drug of Brahma; (v) a total synthesis of plumbazeylanone, a constituent of Plumbago zeylanica L., started from an interest in the description of the Bower manuscript; and (vi) ethnopharmacomedical interests in the republic of Fuji and other South Pacific Countries from the viewpoint of drugs in human life.
  • 小泉 京子
    1999 年 119 巻 3 号 p. 199-214
    発行日: 1999/03/01
    公開日: 2008/05/30
    ジャーナル フリー
    Characteristics of three kinds of columns used for the separation and analyses of saccharides by HPLC, and of a pulsed amperometric detector (PAD) as a high sensitive detector for the microanalysis of saccharides were described. The following several examples of studies on the separation and analyses of saccharides were illustrated : (1) separation of maltosaccharides on an amino column, (2) isolation of each maltooligomer of DP6-17 on an CDS column, (3) retention behavior of α-cyclodextrin (αCD) and branched αCDs on an ODS column, (4) separation of three positional isomers of dimaltosyl-βCD on an ODS column and a graphitized carbon (GC) column, (5) separation of diastereoisomers of glucosyl-inositol on a GC column, (6) chromatographic behavior of nine glucobioses on a GC column, (7) estimation of the distributions of chain length of amylopectins with the pulsed amperometric detection, (8) microanalysis of βCD and glucosyl-βCD in biological matrices by HPLC with PAD. In addition, methods for the structural analyses of branched CDs by FAB-MS, 13C-NMR and enzymatic degradation were expressed.
  • 秋野 治郎, 島森 美光, 武市 由美子, 宮田 崇博, 早瀬 幸俊
    1999 年 119 巻 3 号 p. 215-220
    発行日: 1999/03/01
    公開日: 2008/05/30
    ジャーナル フリー
    The number of patients prescribed medicine for allergies increased in May and September. Therefore, we suspected that the cause for the increase was pollen. Many kinds of pollen occur in Otaru, such as alder in April, Japanese black pine, white birch, acacia, larch in May, oak in June, and mugwort in September. The total number of pollen count of white birch was about 9 times that of mugwort, but the total number of patients prescribed Celestamine in the season of white birch pollen was about 0.8 times that of mugwort pollen. These results seen in Otaru differed from those in neighboring Sapporo. The coefficient of the correlation of the number of mugwort and white birch pollen and those of patients prescribed Celestamine were γ=0.304 and γ=0.766, respectively. We believe that making available information on pollen is very useful to improve the quality of life of patients.
  • 岩尾 一生, 齊藤 浩司, 武田 清孝, 安海 義曜, 高田 昌彦
    1999 年 119 巻 3 号 p. 221-228
    発行日: 1999/03/01
    公開日: 2008/05/30
    ジャーナル フリー
    Plasma levels of omeprazole (OPZ) in Japanese male subjects were compared after a single oral administration of 20 mg of OPZ enteric-coated tablets with and without coadministration of Maalox[○!R] (MLX suspension) or Maalox[○!R] dry suspension granules (MLX granules). After coadministration of MLX granules, plasma levels of OPZ markedly decreased, and aera under the blood concentration-time curve (AUC) decreased to 26% of that of OPZ alone. In contrast, Only a slight decrease in AUC was observed after coadministration of OPZ and MLX suspension. Both MLX suspension and MLX granules exhibited similar degrees of the inhibitory effect on the renal excretion of levofloxacin. It was suggested that a specific and unexpected drug interaction occurred between OPZ enteric-coated tablets and MLX granules via a distinct mechanism from that reported for fluoroquinolones and MLX suspension.
  • 伊藤 瑞紀, 青山 隆夫, 山村 喜一, 中島 克佳, 中村 幸一, 小瀧 一, 松山 智洋, 斎藤 俊樹, 上 昌広, 千葉 滋, 平井 ...
    1999 年 119 巻 3 号 p. 229-235
    発行日: 1999/03/01
    公開日: 2008/05/30
    ジャーナル フリー
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