YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
121 巻 , 10 号
選択された号の論文の6件中1~6を表示しています
総説
  • 森 逸男
    2001 年 121 巻 10 号 p. 707-731
    発行日: 2001/10/01
    公開日: 2002/09/27
    ジャーナル フリー
    Firstly, the syntheses of various organic reagents {R} containing such xanthene derivatives as O-hydroxyhydro-quinonephthalein (QnPh), and 3,4,5,6-tetrahydroxyfluoran (gallein, Gall) were studied. Secondarily, the coexisting effects of surfactant (cationic-, anionic-, amphoteric- and nonionic-surfactants alone or combination) on the coloring or fluorescence reactions between various {R} such as xanthene derivatives, aromatic amines and various metal ions {M} such as bismuth (III), tin (IV), iron (III), molybdenum (VI), uranium (VI), cobalt (II), aluminum (III), etc. were systematically investigated. Thirdly, numerous simple and sensitive photometric analyses (spectrophotometry and fluorophotometry) for various {M} and organic compounds {Org} such as biological samples, and pharmaceutical preparations by formation reactions of {R-M} binary or {(R-M)-Org} ternary complexes were established in the coexistence of surfactant alone or combination.
  • 大野 浩章
    2001 年 121 巻 10 号 p. 733-741
    発行日: 2001/10/01
    公開日: 2002/09/27
    ジャーナル フリー
    Palladium-catalyzed synthesis of alkenylaziridines and azetidines from α- and β-amino allenes are presented. Whereas palladium-catalyzed reaction of N-arylsulfonyl-α-amino allenes with an aryl iodide in the presence of potassium carbonate in DMF at around 70 °C affords the corresponding 3-pyrroline derivatives, the reaction in refluxing 1,4-dioxane under similar conditions yields exclusively or most predominantly the corresponding 2-alkenylaziridines bearing an aryl group on the double bond. Similarly, N-arylsulfonyl-β-amino allenes can be also cyclized into the corresponding alkenylazetidines bearing 2,4-cis-sunstituents under palladium-catalyzed cyclization conditions in DMF.
  • 加藤 伸一
    2001 年 121 巻 10 号 p. 743-751
    発行日: 2001/10/01
    公開日: 2002/09/27
    ジャーナル フリー
    Gastroenteropathy is the most common among patients who use non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of inflammatory disorders. It is known that rheumatoid arthritic (RA) patients are more susceptible to NSAID-induced gastropathy than other NSAID users. This article reviewed our recent studies concerning the influence of arthritis on gastric mucosal integrity in adjuvant-induced arthritic rats. The gastric mucosal lesions induced by indomethacin, one of conventional NSAIDs, were markedly aggravated in arthritic rats. Likewise, the healing of chronic gastric ulcers induced by thermal cauterization was significantly delayed in arthritic rats. The underlying mechanisms of these phenomena observed in arthritic rats may be attributable to the enhancement of iNOS/NO pathway in the former and the less expression of various growth factors in the ulcerated mucosa, such as basic fibroblast growth factors (bFGF) or insulin-like growth factors (IGF-1) in the latter. In addition, we recently found that cyclooxygenase-2 (COX-2) selective inhibitors, such as rofecoxib or celecoxib, induced apparent gastric lesions in arthritic rats, suggesting that a caution should be paid on the use of COX-2 selective inhibitors in RA patients.
一般論文
  • 林 千嘉子, 片岡 裕美, 扇間 昌規, 伊藤 誉志男
    2001 年 121 巻 10 号 p. 753-759
    発行日: 2001/10/01
    公開日: 2002/09/27
    ジャーナル フリー
    The purpose of the present study was to investigate the effects of stress on allergic reaction. We studied changes in the contact hypersensitivity reaction (CHR) of mice exposed to foot shock (FS) stress or psychological (PSY) stress induced by the communication box. CHR was elicited by applying antigen (2,4-dinitrofluorobenzene, DNFB) to the ear of the mice at 4 days after DNFB sensitization. In acute stress experiments, DNFB-sensitized mice were exposed for 2 h to FS or PSY stress after contact challenge with DNFB. Acute FS stress significantly inhibited CHR immediately after the end of the stress period (3 h after DNFB-challenge), and a significant enhancement of the CHR was observed at 5 h after DNFB-challenge. The concentration of the serum corticosterone level of the mice exposed to acute FS stress significantly increased compared to the control mice, immediately after stress loading. Both CHR and serum corticosterone levels after acute PSY stress loading were almost the same as those of the control groups. The temporary decrease of the inflammatory reaction at CHR caused by acute FS stress loading may have been correlated with serum corticosterone produced by the stress, and the increase of corticosterone may act as a trigger of enhancement of the CHR (delayed-type hypersensitivity). Chronic stress experiments were designed to expose mice to FS or PSY stress 2 h daily after sensitization with DNFB. These chronic stresses caused a significant reduction in the body weight of mice. The temporary decrease effect on the CHR of chronic FS stress-loaded mice was similar to the acute FS stress-loaded mice. In contrast, no significant enhancement of the CHR (late phase) at 24 h and 48 h after challenge was observed. Although the changes in body weight suggested that mice were influenced by chronic PSY stress, no significant difference from the control group for the CHR of mice exposed to chronic PSY stress was found, as in the case of acute PSY stress loading. The correlation between chronic PSY stress and CHR remains to be ascertained.
  • Hiroshi MARUMO, Kumi SATOH, Atsuko YAMAMOTO, Shigeru KANETA, Kazuo ICH ...
    原稿種別: Review
    2001 年 121 巻 10 号 p. 761-764
    発行日: 2001/10/01
    公開日: 2002/09/27
    ジャーナル フリー
    Effects of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, simvastatin and atorvastatin, on diltiazem-induced hypotension were examined in anaesthetized rats and compared to that of pravastatin. Vehicle, 2 mg/kg/day simvastatin, 2 mg/kg/day atorvastatin, or 4 mg/kg/day pravastatin was administered orally for 4 days. Diltiazem at 3 mg/kg was given orally 2 hours after the final administration of the inhibitors. Arterial blood pressure was measured via a cannula introduced into the left carotid artery, and heart rate was counted from the pulse pressure. In all groups, diltiazem significantly decreased the mean arterial blood pressure without any changes in heart rate. Pretreatment with simvastatin and atorvastatin significantly enhanced the hypotensive effect of diltiazem, while that with pravastatin did not. Heart rate was not modified by pretreatment with the inhibitors. The results indicate that concomitant use of diltiazem with simvastatin or atorvastatin enhances diltiazem-induced hypotension, probably by competitive inhibition of diltiazem metabolism with simvastatin and atorvastatin metabolisms.
資料
  • 守安 貴子, 重岡 捨身, 岸本 清子, 石川 ふさ子, 中嶋 順一, 上村 尚, 安田 一郎
    2001 年 121 巻 10 号 p. 765-769
    発行日: 2001/10/01
    公開日: 2002/09/27
    ジャーナル フリー
    A substantially available identification system for Sildenafil in health foods was established using 3 different analytical methods; i.e. TLC, preparative TLC/MS and HPLC/photo-diode array. Sildenafil in health foods was extracted with ethyl acetate under alkaline conditions as sample solutions for TLC and preparative TLC, and also extracted with 50% methanol and then diluted with solution of HPLC mobile phase for HPLC. The sample solution for TLC was applied to Silica gel 60 F254 plates with chloroform/methanol/28% ammonia (90:1:5, under layer) as mobile phase. Spots were located under UV radiation at 254 nm and 366 nm, and spraying dragendorff reagent. The conditions for preparative TLC were the same as these of TLC method, and samples abtained from preparative TLC were determined by MS with APCI interface, under both positive and negative modes. The HPLC analysis was carried out on a column of Cosmosil 5C18-AR (4.6 mm × 150 mm, 5 μm) with 0.05 mol/l phosphate buffer pH 3.0/acetonitrile (73:27) as mobile phase and the eluate was monitored by a photo-diode array detector. The quantitative analysis was available, when the peak of this sample on HPLC was detected at 290 nm. When this system was applied to commercial health foods, Sildenafil was identified and their contents were 25 mg-45 mg/tablet or bottle. These contents nearly correspond to that in Viagra, 25 mg, 50 mg/tablet. Therefore, there is a fear of side effects for Sildenafil, when it is taken as health foods.
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