All issues
Volume 68 (1948)
- Issue 10-12 Pages 258･･･
- Issue 7-9 Pages 201-
- Issue 5-6 Pages 143-
- Issue 3-4 Pages 81-
- Issue 1-2 Pages 1-
Predecessor
Volume 68, Issue 10-12
Displaying 1-19 of 19 articles from this issue
- |<
- <
- 1
- >
- >|
-
Seizo Kanao, Kiyoshi Shinozuka1948 Volume 68 Issue 10-12 Pages 258-261
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSThe ketone compound obtained by the reaction of methylamine and bromo-p-methoxypropiophenone was catalytically reduced with PtO2⋅H2 and a normal base of p-methoxyephedrine was quantitatively obtained. By the use of amalgamated Na and 2N-HCl, normal and iso compounds were obtained in a ratio of 3:1. N-Benzoyl derivative of p-methoxy-ephedrine gives ester of benzoic acid by treatment with mineral acid and subsequent alkaline saponification yields p-methoxy-iso-ephedrine. Emde's degradation of the iodide of methylated quarternary base of p-methoxy-iso-ephedrine results in obtaining (β) p-methoxyphenyl-propyleneglycol, m.p. 116°, (β) being in iso compound.View full abstractDownload PDF (702K) -
Seizo Kanao, Kiyoshi Shinozuka1948 Volume 68 Issue 10-12 Pages 261-265
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSNormal base of β-amino-β-anisyl-isopropyl alcohol was obtained by the reaction of NH3 and anethol-bromo-hydrine or anetholoxide with α-imino-bis-[p-methoxyphenyl-β-hydroxypropane] as a by-product. Hydrolysis of anethol-ψ-urea by NaOH gives an iso-form whereas the base obtained from anethol-acetyl-ψ-urea is a normal compound. Normal base of β-methylamino-β-anisyl-isopropyl alcohol was obtained by the reaction of α-bromo-p-methoxybenzyl methyl ketone and methylamine and subsequent catalytic reduction. A small amount of iso-base is obtained by the reduction with 5% amalgamated sodium and 2N-HCl. Normal base was also obtained by the reaction of methylamine and anethol-bromohydrine, and an iso compound from anethol-methyl-ψ-urea. The ammonium base expected was not obtained by shaking the primary and secondary normal bases with Mel and KOH solutions and tetramethylammonium iodide was here obtained. The original material scems to have transited from unsaturated carbinol to p-methoxybenzyl methyl ketone. On the contrary, the iso compound is remarkably stable.View full abstractDownload PDF (871K) -
Seizo Kanao, Kiyoshi Shinozuka1948 Volume 68 Issue 10-12 Pages 265-269
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSIso-base of m, p-methylenedioxy-nor-ephedrine was obtained by the condensation of piperonal, nitromethane and KHCO3 and subsequent reduction with Zn+H2SO4. The normal base does not separate out here and the compound obtained by Bruckner from nitrosite is also an iso-base. Reaction of alcoholic or aqueous NH3 and isosafrol-bromohydrine or isosafrol oxide yielded normal-base of β-amino-β piperonyl-isopropyl alcohol with a by-product of α-imino bis-[m, p-methylenedioxyphenyl-β-hydroxypropane] (hydrochloride, m.p. 227°). It is assumed that the hydrochloride of m.p. 154°, obtaind by Read and Reid, is a mixture of normal and iso compounds and the base obtained by Krassuski is a normal compound. Normal base of β-methylamino-β-piperonyl-isopropyl alcohol was obtained by the reaction of alcoholic or aqueous methylamine and isosafrol-bromohydrine or isosafrol oxide. By the alkaline saponification of isosafrol-methyl-Ψ-urea, only the iso-base was obtained. The base obtained by Mannich must be a normal compound.View full abstractDownload PDF (813K) -
Tatsuo Kariyone, Tomijiro Fukui, Tasaburo Kiguchi, Motaro Ishimasa, Ka ...1948 Volume 68 Issue 10-12 Pages 269-271
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESS“Mibuyomogi”, Artemisia monogyna Waldst. et Kit. yielded, besides santonin, 2 new lactones, monoginin, C15H18O3, m.p. 138°, and mibulactone, C15H22O4, m.p. 228-9°, and a kind of acidic substance, artemisic acid, C18H36O5, m.p. 108°.View full abstractDownload PDF (458K) -
Constitution of Artemisic Acid. 1Tatsuo Kariyone, Tomijiro Fukui, Motaro Ishimasa1948 Volume 68 Issue 10-12 Pages 271-272
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSArtemisic acid, C18H36O5, gives a triacetate. Its methyl ester has an m.p. 64.5°, anilide, m.p. 115°. Reduction with red phosphorus and hydriodic acid gives stearic acid. It is assumed, therefore, that artemisic acid is a kind of trihydroxy-stearic acid.View full abstractDownload PDF (367K) -
Tatsuo Kariyone, Tomijiro Fukui, Motaro Ishimasa1948 Volume 68 Issue 10-12 Pages 272-275
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSBy the oxidation of artemisic acid with Na2Cr2O7+H2SO4, azelaic, glutaric, succinic, n-valeric and n-butyric acids were obtained. Oxidation by lead tetra acetate gave azelaic aldehyde acid and 5-hydroxypel-argonaldehyde, m.p. 68°. Azelaic acid was obtained by the oxidation of the former and, glutaric and succinic acids from the latter. The authors, therefore, suggest 9, 10, 14-trihydroxystearic acid as the constitution of artemisic acid.View full abstractDownload PDF (759K) -
Tatsuo Kariyone, Tomijiro Fukui1948 Volume 68 Issue 10-12 Pages 275-276
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSFriedel-Crafts reaction of decaline and acetyl chloride does not give acetyldecaline but is accompanied by dehydrogenation to give 5, 6, 7, 8-tetrahydronaphthyl-(2) methyl ketone (I). A substance that is easily nitrated is obtained by decaline and aluminum chloride so that, it can be assumed that decaline is dehydrogenated by aluminum chloride and then undergoes condensation to give (I).View full abstractDownload PDF (410K) -
Tatsuo Kariyone, Tomijiro Fukui, Hiroshi Nagata1948 Volume 68 Issue 10-12 Pages 276-278
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSβ-(p-Nitnophenyl)-β-hydroxymethylacrylic lactone, decompn. 245°, is obtained by the nitration of β-phehyl-β-hydroxymethyl-acrylic lactone. Reduction of the former to an amino compound, decompn. 203-6°, and a subsequent diazotation give β-(p-hydroxy-phenyl)-β-hydroxymethylacrylic lactone, m.p. 253-4°.View full abstractDownload PDF (528K) -
Masuo Murakami, Shigeru Oae1948 Volume 68 Issue 10-12 Pages 278-282
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSBoilig p-rhodaniline with glacial AcOH and then reacting halogen result in the formation of p-acetamino-benzene sulfohalide (I). It was found that this formation was due to concurrent hydrolysis at the time of acetylation of p-rhodaniline, to which a halogen atom would react to give (I). p-Rhodanacetanilide, which has not been hydrolysed would give 2-halogeno-4-rhodanacetanilide by the substitution of halogen atom in the nucleus.View full abstractDownload PDF (890K) -
Syntheses of Antibacterial ThiocarbocyaninesYoshihisa Mizuno, Takashi Uyemura, Kazuo Shibata, Eiji Hase, Masujiro ...1948 Volume 68 Issue 10-12 Pages 282-285
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSIt has been found in Tamiya Laboratory, Botanical Inst., University of Tokyo, that benzothiocarbocyanines greatly inhibit the growth of staphylococci in comparatively minute quantities. In order to test bacteriostatic effects of its allied compounds having substituents at 8-position, syntheses of those compounds were planned. After observation of known synthetic methods, a novel simple method was found. By this means, 7 new kinds of benzothiocarbocyanine were synthesized in order to test their bactericidal action.View full abstractDownload PDF (563K) -
Taizo Matsukawa, Takeo Iwatsu, Shojiro Yurugi1948 Volume 68 Issue 10-12 Pages 285-287
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSγ-Aceto-γ-acetylmercaptopropyl acetate (I), γ-aceto-γ-carbethoxy-mercaptopropyl acetate (II) and γ-aceto-γ-methylmercaptopropyl acetate (III) were synthesized. Heating (I), (II) and (III) respectively with 2-methyl-4-amino-5-formaminomethylpyrimidine hydrochloride in formic acid gives vitamin B1 in cases of (I) and (II) but the condensation does not occur in the case of (III).View full abstractDownload PDF (468K) -
Takeo Tsukamoto, Takeo Ohtaki1948 Volume 68 Issue 10-12 Pages 287-289
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSBarks of mulberry used for drugs is believed to be derived from Morus acidosa Griff. Alcoholic extract of the bark was concentrated and the precipitate that separated out on cooling was saponified with alcoholic potash and α- and β-amyrin and stearic acid were obtained. Isolation of β-amyrin from mulberry bark is worthy of notice.View full abstractDownload PDF (507K) -
Takeo Tsukamoto, Takeo Ohtaki1948 Volume 68 Issue 10-12 Pages 289-291
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSThe alcoholic extract of mulberry bark, from which the precipitate has been removed, was concentrated under vacuum and put to water distillation and obtained volatile oil (ca 0.07% of the material).
The non-volatile portion was dissolved in ether and shaken with 5% Na2CO3 and then with 2% KOH solutions. KOH solution contained a substance believed to be resinotannol. From the portion existing between ether and alkaline layers, sitosterol-d-glucoside was obtained. Ether soluble portion was saponified with alcoholic potash and α-amyrin, sitosterol and pale yellow powder (probably resen of Tschirch's) were obtained from the neutral portion. Acid portion yielded palmitic and stearic acids.View full abstractDownload PDF (564K) -
Phospholipids. (2). Structure of Corynin of Chargaff'sHideo Takahashi1948 Volume 68 Issue 10-12 Pages 292-296
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSCorynolic acid the so-called corynin, of Chargaff's, and dehydroxy-corynin were oxidized and their decomposition products were compared with compounds synthesized. As a result, following formula has been given to corynin.
CH3-CH-(CH2)7-CH-(CH2)17-CH-(CH2)14-CH3View full abstractDownload PDF (760K) -
Syntheses of Sulfaminopyrimidines. (1)Taizo Matsukawa, Ken-ichi Seki1948 Volume 68 Issue 10-12 Pages 296-297
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSSeveral derivatives of sulfaminopyrimidine were synthesized by reacting various aromatic sulfonamides and 2-methyl (or ethyl)-mercapto-4-methyl-6-hydroxypyrimidine.View full abstractDownload PDF (261K) -
Shoji Shibata, Yoshiaki Miura, Tyunosin Ukita, Tomie Tamura1948 Volume 68 Issue 10-12 Pages 298-300
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSAntibacterial effects in vitro of usnic acid, a component of lichens of Usnea specie, and its derivatives were tested. Usnic acid and its derivatives have growth inhibitory actions against Gram-positive bacteria. Usnic acid inhibits the growth of avian type tubercular bacilli after 10 days' incubation at 160, 000 dilution and that of Staphylococcs aureus after 24 hours at 160, 000-320, 000 dilution. Antibacterial activities against avian tubercular bacilli of usnic diacetate and dihydro-usnic acid are 1/2 to 1/4 that of usnic acid, this decreasing to 1/16 in that of dihydro-usnic acid diacetate (Table I.). These experiments prove that the antibacterial activity of usnic acid is controlled by the presence of 2 hydroxyl radicals and α, β-unsaturated ketone.View full abstractDownload PDF (379K) -
Comparative Studies on Antibacterial Effects of Various Types of Lichen SubstancesShoji Shibata, Yoshiaki Miura, Hisako Sugimura, Yuri Toyoizumi1948 Volume 68 Issue 10-12 Pages 300-303
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSRepresentative components of various lichen substances, according to the classification forwarded by Prof. Asahina, were chosen to test their growth inhibitory actions in vitro against bacteria. Antibacterial effect against Gram-positive bacteria were found with compounds of lichesterinic acid series and depsides of orcinol series where there were a large number of carbon atoms in their alkyl radical. No such properties were found with fatty acids of caperatic acid type, zeorin series compounds, depsides of β-orcinol series and depsidones. None showed any antibacterial action against Gram-negative bacteria.View full abstractDownload PDF (454K) -
Antibacterial Effects of Didymic Acid and Related CompoundsShoji Shibata, Yoshiaki Miura, Hisako Sugimura, Yuri Toyoizumi1948 Volume 68 Issue 10-12 Pages 303-305
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSRemarkable antibacterial action against Gram-positive bacteria were shown by didymic and decarbo-nordidymic acids belonging to the dibenzofuran derivatives of lichen substances. Comparison with other dibenzofuran derivatives showed that their antibacterial activity was controlled by their dibenzofuran nucleus, hydroxyl groups and the number of C-atoms of alkyl groups attached to it.View full abstractDownload PDF (478K) -
2-Aminovinylbenzothiazole EthiodideTorizo Takahashi, Hiroshi Yanagihara1948 Volume 68 Issue 10-12 Pages 305-307
Published: June 10, 1949
Released on J-STAGE: February 19, 2010
JOURNAL FREE ACCESSThe following 2-aminovinyl-benzothiazole ethiodide were prepared to use them as chemotherapeutic remedies. When condensed 2, 2′-dimethoxy-diphenyl-formamidine upon 2-methyl-benzothiazole ethiodide (I). 2-{ω-[o-methoxy-anilido]-vinyl}-benzothiazole ethiodide of m.p. 232° (decomp.) is readily obtained The ethiodide (I) also combines with 4, 4′-diethoxy-diphenyl-formamidine at about 90° to form 2-{ω-[p-diethoxy-anilido]-vinyl}-benzothiazole ethiodide of m.p. 194-196° (decomp.) and 3, 3′-diethyl-2, 2′-trimethine-benzothiazolocyanine (3) iodide (II) of m.p. 268° (decomp), while at about 110° chiefly the latter dyestuff (II). Again, on heating the ethiodide (I) respectively with 5, 5′-dichloro-2, 2′-dipyridylformamidine, 5, 5′-dibromo-2, 2′-dipyridyl-formamidine and 5, 5′-diiodo-2, 2′-dipyridyl-formamidine, 2-{ω-[5′-chloropyridyl-(2′)-amino]-vinyl}-benzothiazole ethiodide of m.p. 236° (decomp.), 2-{ω-[5′-bromopyridyl-(2′)-amino]-vinyl}-benzothiazole ethiodide of m.p. 239° and 2-{ω-[5′-iodopyridyl-(2′)-amino]-vinyl}-benzothiazole ethiodide of m.p. 236-9°, are produced.View full abstractDownload PDF (444K)
- |<
- <
- 1
- >
- >|