YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
70 巻, 6 号
選択された号の論文の21件中1~21を表示しています
  • 溝口 歌子
    1950 年 70 巻 6 号 p. 291-296
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
  • 厚生省藥務局監視課
    1950 年 70 巻 6 号 p. 297-304
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
  • 大田 正樹, 須藤 六郎
    1950 年 70 巻 6 号 p. 305-307
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Behavior of p-nitrophenoxyacetone against bromination was clarified from the structure of thiazole compounds formed by the condensation of the product of the former reaction with thiourea. Bromination in benzene gives an oily substance of α-bromo compound with concurrent formation of γ-bromo compound of m.p. 102°. Their respective condensation with thiourea give 2-amino-4-methyl-5-p-nitrophenoxythiazole and 2-amino-4-p-nitrophenoxymethylthiazole, respectively. The structures of these thiazole compounds were determined by the formation of their derivatives or their syntheses by other methods.
  • 石館 守三, 坂口 武一
    1950 年 70 巻 6 号 p. 308-310
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Reaction mechanism of sodium nitroprusside and pentacyanoamminferroate was examined. On the other hand, a novel qualitative reactions for hydroxylamine and aldehyde were discovered.
  • ペプトン中のチフス菌発育素に就いて
    荒井 岩夫
    1950 年 70 巻 6 号 p. 311-319
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    The conclusion was drawn that the chief growth factor in peptone against Shikata strain of typhoid bacillus was tryptophane, from following reason:
    1) The fraction obtained by the solvent extraction of peptone and its treatment by esterification, etc., possessed the most growth promoting effect in the one giving positive reaction to tryptophane coloration.
    2) The fractionation of peptone by the adsorptive affinity to active charcoal showed that those having adsorptive affinity possessed growth promoting effect, the affinity being in direct proportion to the content of tryptophane.
    3) The rise and fall of tryptophane in the pancreatin digested product of casein is approximately in direct proportion to the growth promoting effect and the rise and fall of amino form nitrogen has little, if any, effect.
    4) Pancreatin digest product of gelatine, a protein not containing any tryptophane, does not have any effect of growth promotion.
    5) The growth promoting effect of the pepsin digested product of casein is also in approximate proportion to the tryptophane content. Moreover, strepogenin has no relationn to the growth of typhoid bacillus.
  • トリプトファンの発育素としての作用機序 (其の1)
    荒井 岩夫
    1950 年 70 巻 6 号 p. 319-325
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    As a result of the observations of the action mechanism of tryptophane against growth of the Shikata strain of typhoid bacillus from the following 2 points, the importance of indole nucleus was determined.
    1) In order to determine whether the physical metabolic products of tryptophane manifested a secondary growth promoting action during the growth of bacilli, experiments were conducted with kynurenine and kynurenic, anthranilic, hydroxyanthranilic and nicotinic acids but all were found to be ineffective.
    2) Since the above-mentioned compounds are those in which the indole nucleus of tryptophane had been destroyed or secondarily cyclized, assumption was made that the reaction centre of tryptophane lay in the indole nucleus. Upon this assumption, experiments were made with 10 derivatives of indole and it was found that those derivatives in which the α-position was vacant and a specific substituent was present in the β-positon, or those in which both positions were vacant, alone possessed growth promoting effect. Experiments conducted with 17 derivatives of indolizine and pyrrol, chemical properties of which are similar to those of indole, showed that 3 derivatives of pyrrol possessed weak effect. Indole was found to be approximately equally effective as tryptophane, being 10-7 to 10-8mol./l, and those strains which were susceptible to tryptophane, regardless of their antigenic properties, possessed about an equal amount of susceptibility to indole.
  • インドールの発育素としての作用機序
    荒井 岩夫
    1950 年 70 巻 6 号 p. 326-331
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    1) From the fact that indole possesses about an equal amount of growth promoting action as tryptophane against a certain group of typhoid bacilli that is susceptible to tryptophane, an observation was made regarding interrelationship between the two compounds inside the bacterial body. It was determined that a substance giving positive tryptophane-like coloration reaction was formed inside the body of bacteria cultivated in a medium containing indole.
    2) Since the presence of cystine is necessary for the appearance of growth promoting effect in indole, experiments were conducted with various compounds possessing -SH and all were found effective. Sodium thiosulfate and sodium sulfide were found to possess especial cooperative effect against growth promoting action of indole, they being able to substitute for cystine. By the use of these salts, composition of the medium for typhoid bacillus growth can be simplified and it became possible to obtain facilities for the analyses of metabolic mechanism of this bacillus.
  • Thiazolium化合体の新合成法について (其の2)
    松川 泰三, 万木 庄次郎
    1950 年 70 巻 6 号 p. 331-334
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    2-Alkyl-4-amino-5-formaminomethylpyrimidine hydrochloride, α-halogen ketones and H2S were condensed at 110-120° in anhydrous formic acid as a solvent, and following were synthesized: 4-Methyl-5-β-hydroxyethyl-N-(2′-ethyl-4′-aminopyrimidyl-5′)-, 4-methyl-5-β-hydroxyethyl-N-(2′-benzyl-4′-aminopyrimidyl-5′)-, 4-methyl-5-ethyl-N-(2′-methyl-4′-aminopyrimidyl-5′)-, 4-methyl-5-phenyl-N-(2′-methyl-4′-aminopyrimidyl-5′)-, 4-methyl-5-carboxy-N-(2′-methyl-4′-aminopyrimidyl-5′)-, and 4-methyl-5-carbethoxymethyl-N-(2′-methyl-4′-aminopyrimidyl-5′)-methylthiazolium chloride hydrochloride. However, the yields of compounds other than the first two were very poor. This fact is interesting in connection with physical synthesis of vitamin B1 inside the body.
  • ac. β-Tetralol-α-acetic Acid Lactone及び同族体の合成
    春川 忠二, 石川 尚
    1950 年 70 巻 6 号 p. 335-338
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    By the malonic ester synthesis of ac. β-tetralol-α-acetic lactone and its homologs from ac. β-bromo-α-tetralol, a simplified method of synthesis was found. A reaction mechanism whereby ac. α, β-tetralolin oxide is an intermediate compound was advanced and later proved.
  • 数種のCyclohexadienone類の合成
    春川 忠二, 石川 尚
    1950 年 70 巻 6 号 p. 338-341
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    The Tiemann-Reimer reaction was utilized in the syntheses of cyclohexadienone homologs of tetraline, with 5-bromo-, 5-methyl- and 7-methyl-6-tetralol as the original material to obtain 5-bromo-, 5-methyl- and 7-methyl-6-keto-9-dichloromethyl-Δ7, 8⋅5, 10, -hexahydronaphthalene, and 5-bromo-7-aldehyde-6-tetralol was obtained as the only aldehyde. As cyclohexadienone homolog of biphenyl, 4-phenyl-4-dichloromethyl-Δ2, 3⋅5, 6, -cyclohexadienone was obtained together with 4-hydroxybiphenyl-3-aldehyde from 4-hydroxybiphenyl. From 4-hydroxybiphenylmethane and 4-hydroxy-4′-chlorobiphenylmethane, cyclohexadienone homologs of biphenylmethane were not obtained and only the corresponding aldehydes were found.
  • ペナルド酸アセタールの合成
    於勢 眞輔, 中村 清, 川合 一夫, 松本 伊三郎, 碓井 常夫, 出口 陽二
    1950 年 70 巻 6 号 p. 342-344
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    In order to synthesize penaldic acid having various acyl radicals, potassium α-chloro-β, β-diethoxypropionate was aminated to dl-α-amino-β, β-diethoxypropionic acid, decompn. 193°. This was acylated with phenylacetic chloride to penaldic acid-G acetal, decompn. 108-110°, and with benzoyl chloride to dl-α-benzoylamino-β, β-diethoxypropionic acid, decompn. 94-95°. Saponification of penaldic acid-G acetal gave free penaldic acid which was so unstable that it immediately underwent decaroboxylation to penilloaldehyde-G, m.p. 111-113°.
    An attempt was made to obtain α-formylglycine by the saponification of dl-α-amino-β, β-diethoxypropionic acid but the product did not crystallize.
  • ペニロアルデハイドの合成
    於勢 眞輔, 中村 清, 森口 昭司
    1950 年 70 巻 6 号 p. 344-346
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    As a part of penicillin synthesis, penilloaldehyde-G and carbethoxypenilloaldehyde-X were synthesized.
    Needle crystals of penilloaldehyde-G acetal, m.p. 40-41°, were obtained from phenylacetic chloride and aminoacetal. The former was saponified with 10% sulfuric acid to penilloaldehyde-G, m.p. 111-114°, which gave yellow needles of 2, 4-dinitrophenylhydrazone, decompn. 198°.
    Needle crystals of acid chloride, m.p. 43°, was obtained from p-hydroxyphenylacetic acid through p-carbethoxyhydroxyphenylacetic acid, prisms, m.p. 87-88°. Condensation of the former with aminoacetal gave white needles of the acetal of carbethoxypenilloaldehyde-X, m.p. 83-84°. Saponification of this acetal with 10% sulfuric acid gave carbethoxypenilloaldehyde-X, white needles containing 1/2mol. water of crystallization, m.p. 86-88°. In this reaction, the carbethoxy radical in the p-position could not be liberated so that the objective penilloaldehyde-X could not be obtained. 2, 4-Dinitrophenylhydrazone of carbethoxypenilloaldehyde-X is yellow needles of decompn. 192°.
  • 岡崎 寛藏, 加藤 宏, 河口 達二
    1950 年 70 巻 6 号 p. 347-349
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Antibacterial actions against Staph. aureus (Terashima strain) of 54 kinds of wild plants collected at the foot of Mount Asama and in the suburbs of Mayebashi City were examined. Antibacterial actions were found in the following plants: Roripa Nasturtium-aquaticum, Sophora angustifolia, Perilla frutescens var. crispa, Fagopyrum esculentum, Eclipta alba, Ligularia tussilaginea, Allium fistulosum, Siphonostegia chinensis, Calystegia japonica, Paederia chinensis, Artemissia vulgaris var. indica.
  • 岡崎 寛藏, 加藤 宏, 若田部 武男
    1950 年 70 巻 6 号 p. 349-350
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Antibacterial actions against Staphylococcus aureus Terashima were examined of 64 kinds of wild plants collected in the suburbs of Mayebashi City, at the foot of Mt. Asama and the Akagi mountains, and the following 16 were found effective: Solidago Virga-aurea, Gnaphalium hypoleucum, Acanthopanax Sieboldianum, Rhus verniciflua, Hypericum erectum, Chrysanthemum morifolium var. sinense, Clerodendron trichotomum, Orixa japonica, Biota orientalis, Macleya cordata, Coriaria japonica, Sambucus Sieboldiana, Mentha arvensis var. piperascens, Petasites japonicum, Lespedeza sericea, Carpesium abrotanoides.
  • 岡崎 寛藏, 加藤 宏, 若田部 武男
    1950 年 70 巻 6 号 p. 350-351
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Antibacterial action against Staphylococci was examined of 66 kinds of wild plants found on the campus of college of Gumma and the following were found effective: Ginkgo biloba, Deutzia crenata, Hydrangea macrophylla, Rubus trifidus, Spiraea japonica, Campsis chinensis, Weigela hortensis formas pontanea, Cornus officinalis, Buddleja insignis, Tradescantia reflexa, and Torreya nucifera.
  • 岡崎 寛藏, 加藤 宏, 若田部 武男
    1950 年 70 巻 6 号 p. 351-352
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Antibacterial actions against Staphylococcus aureus Terashima were examined with 102 kinds of seeds from wild plants, vegetables and medicinal plants, using hot digested aqueous solutions, and seeds of the following were found effective: coreopsis (Coreopsis Drummondii), forget-me-not (Myosotis scorpioides.), Chrysanthemum cinerariae-folium, and Conium maculatum.
  • 生薬類の抗菌性 (1)
    岡崎 寛藏, 加藤 宏, 若田部 武男
    1950 年 70 巻 6 号 p. 353-355
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Antibacterial actions against Staphylococcus aureus Terashima were examined with aqueous and acetone digested solutions of 50 kinds of crude drugs. Aqueous solutions of the following were found effective: Cortex Quillaiae, Rhizoma Coptidis, Rhizoma Rhei, Folium Menthae, Folium Uvae Ursii, Fol. Vitis-Idaeae, Flos Arnicae, Flos Cinae and Flos Koso. Acetone solutions of the following were also found effective: Cortex Rhamni Purshianae, Lignum Guajaci, Rhizoma Coptidis, Rhiz. Filicis, Rhiz. Galangae, Rhiz. Rhei, Radix Liquiritiae, Folium Eucalypti, Fol. Jaborandii, Fol. Uvae Ursii, Flos Caryophylli, Flos Koso, Flos Pyrethri, Fructus Alpiniae, Fruct. Anisi.
  • 中山 巖
    1950 年 70 巻 6 号 p. 355-356
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    By the Reissert reaction of 4-substituted quinoline-N-oxides, 4-substituted quinaldic nitriles are obtained easily and in a good yield. The latter were utilized in the syntheses of quinaldic diethylaminoethylamides having methoxyl, ethoxyl, n-propoxy, and n-butoxy radicals in the 4-position. Comparative tests of the local anesthetic actions of these compounds with percaine were the objective.
  • 早津 了一
    1950 年 70 巻 6 号 p. 357-358
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
  • Hiroshi Mitsuhashi
    1950 年 70 巻 6 号 p. 358-359
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
  • 1950 年 70 巻 6 号 p. 360-361
    発行日: 1950/06/25
    公開日: 2010/02/19
    ジャーナル フリー
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