YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
72 巻 , 11 号
選択された号の論文の47件中1~47を表示しています
  • モルヒネ定量に於ける測定条件の考察
    松本 和夫
    1952 年 72 巻 11 号 p. 1393-1396
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Morphine was nitrosated to 2-nitrosomorphine, and the morphine-2, 3-quinone-2-monopotassium oxime formed upon the addition of alakli to it was determined by polarograph under following conditions. By this means, it was found that the relationship id=CK is established within a range of 2×10-3 to 1×10-4 mole concentration. E1/2=1.13 volt vs (S.C.E.), kp=(I-1=C⋅kD-1⋅id-1)=1.113. The procedure follows: An aqueous solution of morphine was prepared in a range of 2×10-3 to 1×10-4 mole concentration. To 1cc. of this solution, 1.5cc. of N hydrochloric acid, and then 1.5cc. of 1 mole potassium nitrite were added, and allowed to stand at a room temperature for 1 minute to effect nitrosation. To this was added 1.5cc. of 20% potassium hydroxide solution, and its id, E1/2, and kp were determined by automatic recording between -0.4 to -1.3 V, at 25°±1°.
  • モルヒネ製剤中モルヒネの定量法
    松本 和夫
    1952 年 72 巻 11 号 p. 1396-1398
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    In order to establish quantitative determination of morphine preparations under the conditions investigated in the previous report, effect of the presence of impurities and coexisting substances were examined. As a result, a method for such determination has been proposed. This method was found to be effective when alkaloids such as various esters of morphine, dihydroxymorphine, atropine sulfate, and scopolamine hydrobromide, were present with morphine, but was not applicable with injections of morphine containing 0.3-0.5% phenol, and powders and tablets using sdsorption agents, such as aluminum silicate, as bulking agents. E1/2 of the quinone potassium oxime formed by the addition of alkali to the nitrosated phenol was found, to be -0.81 volts (S. C. E.).
  • 阿片製剤中モルヒネの定量法
    松本 和夫
    1952 年 72 巻 11 号 p. 1398-1399
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    A method for the determination of opium preparations was proposed as in the foregoing report. This followed in general the Stucki method modified by Ichikawa and Itoh. Morphine was extracted by a mixture of isopropyl alcohol and chloroform, and the extract was polarographically measured under conditions stipulated in the 1st Report. This method was found to be ineffective in determining marketed injections of opium preparations containing higher alcohols, such as glycerol or glycol.
  • 抗ヒスタミン剤の抗黴性
    岡崎 寛蔵, 河口 達二
    1952 年 72 巻 11 号 p. 1400-1402
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Fungistatic and sporostatic effects of marketed antihistamines were tested against pathogenical fungi such as Trichophyton, Achorion, and Epidermophyton, by which Restamin and Anergen were found to be effective. With references to the works of others, it was seen that the antihistaminic compounds that are effective against fungi contain benzhydrol, phenothiazine, and benzylaniline group in their molecules. It was then found that these groups themselves exhibited far stronger fungistatic and spo-rostatic effects, sometimes surpassing 10 times the effect of the antihistamines. In other words, the efficacy of the antihistamines against fungi is not due to its antihist aminic activity but to the fungicidal action of their nuclear groups.
  • ビス並びにトリフェノールの抗黴性
    岡崎 寛蔵, 河口 達二, 松井 弘次
    1952 年 72 巻 11 号 p. 1403-1404
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Fungistatic activities were tested with 24 kinds of bis- and triphenols against pathogenic fungi such as Trichophyton interdigitale and Achorion Schoenleini. In spite of their high antibacterial activities, only a few of the compounds were found to be effective in 1:8, 000 dilution, the others being ineffective at below 1:4, 000 dilution. The results show that there is no parallel relationship between bacteriostatic and fungistatic actions.
  • 鈴木 友二, 村岡 三郎
    1952 年 72 巻 11 号 p. 1405-1407
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Using Lactobacillus fermenti, Lact. arabinosus and Streptococcus faecalis, tests were made of octopine, arcaine, and agmatine, the metabolic products of arginine, as to their arginine activity in arginine-free medium and inhibitory action in medium containing arginine. It was found that these three compounds do not act as arginine substitute or inhibitory in arginine determination. These results, together with the reports of Snell, seem to indicate that it would be possible to determine the content of arginine in the presence of ornithine, citrulline, agmatine, arcaine, and octopine, using Strept. faecalis.
  • 長谷川 淳
    1952 年 72 巻 11 号 p. 1407-1410
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Filter-type colorimeter, with a stable error of within 0.5%, was constructed using multiplier phototube MS-6S and RCA 931-A. The high voltage circuit is shown in Fig. 2, and their stability is shown in Figs. 4 and 5.
  • 延長可動炉を用いた炭水素用自働燒却装置に就いて
    穗積 啓一郎, 今枝 一男, 田中 原子
    1952 年 72 巻 11 号 p. 1410-1413
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    An automatic combustion apparatus for elemental analyses using a low frequency oscillation with Thyratron was used to test a few ideas on the speed of the movable furnace. From the results obtained, it was found that a constant speed of 1cm/min. for the driving area, and a few modifications in the fixed furnace and the combustion tube would result in a practical unit. These modifications would allow simplification of the driving unit and a shortening of the burning time.
  • 炭水素分析に於ける過酸化鉛用加熱モルタルに就いて
    穗積 啓一郎, 今枝 一男, 田中 原子
    1952 年 72 巻 11 号 p. 1414-1415
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Automatic temperature control method for heated mortar used for lead peroxide is described for laboratory use. The apparatus is an aluminum cylinder in whose wall several holes are punched and through which bimetal, combustion tube and nichrome wire are inserted. The movement of the contact point of bimetal is conducted by Thyratron, through which the main circuit is controlled. The aluminum cylinder is surface-treated with alumite so as to enable insertion of a live nichrome wire. The temperature variation inside the combustion tube, when this thermostatic furnace is used, was hardly detected by a thermometer.
  • 炭水素分析に於る水分吸収剤の改良
    穗積 啓一郎, 今枝 一男, 田中 原子
    1952 年 72 巻 11 号 p. 1416-1420
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    The capacity of Anhydrone as a water absorbent in the analyses of carbon and hydrogen had been clearly demonstrated but it had the fault of being deliquescent and capable of contraction. In order to eliminate these shortcomings, the absorption tube was packed with Desichlora in the first half portion, and with Dehydrite in the latter portion, by which good results were obtained. This absorption tube, when the water absorptive power has reached a certain value, could be dehydrated at 140°, and repeatedly used.
  • 炭水素分析に於ける水分吸収管中窒素酸化物通過の影響に就て
    穗積 啓一郎, 今枝 一男, 田中 原子
    1952 年 72 巻 11 号 p. 1421-1425
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    By the elimination of lead peroxide and placing an absorbents of nitrogen oxides, there does not seem to occur any increase in the weight of water absorption tube due to the passage of nitrogen oxides. By the use of an absorbent tube filled with Desichlora and Dehydrite with glass-wool, no great obstruction was found in carrying out routine analyses. The use of cotton wool instead of glass-wool was found to give statistically a slight increase when there were a large formation of nitrogen oxides.
  • 4-エチルピリヂンの接触酸化によるイソニコチン酸の製造
    石黒 武雄, 北村 英一, 松村 正毅
    1952 年 72 巻 11 号 p. 1425-1426
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Formation of isonicotinic acid was examined by passing a mixed gas of 4-ethylpyridine and air, heated at 300-400°, over a catalyst, which included tin vanadate, vanadium pentoxide, and vanadium oxide containing a small amount of chromium oxide and tungsten oxide, with pumice stone as the carrier. The best result was obtained by the use of vanadium oxide containing a small amount of chromium oxide and tungsten oxide. The most suitable temperature was approximately 350° when the yield of isonicotinic acid was approximately 30% of the theoretical amount. No reaction products other than isonicotinic acid was detected.
  • ピリジン-N-オキシドとα-ブロムピリジン及びα-ブロムキノリンとの反応
    武田 健一, 浜元 要, 刀彌 晴雄
    1952 年 72 巻 11 号 p. 1427-1430
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    By heating pyridine N-oxide and α-bromopyridine on a water bath, N-(α′-pyridyl)-α-pyridone was obtained. The same substance was also obtained by heating the sodium salt of α-pyridone and α-bromopyridine with copper dust at 200°. Similarly, N-(α′-pyridyl)-carbostyril was prepared from pyridine N-oxide and α-brolnoquinoline. This compound was also obtained by heating the sodium salt of carbostyril and α-bromopyridine with copper dust at 200°.
  • 3-〔2´-Methyl-4´-amino pyrimidyl-(5´)〕-methyl-4-methyl-5-β-hydroxyethyl-thiothiazolone-(2)の合成 その3
    吉田 茂, 鵜木 諄
    1952 年 72 巻 11 号 p. 1431-1434
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    By the condensation of γ-aceto-γ-chloropropyl chloride (III), obtained by treating α-aceto-α-chlorobutyrolactone (II) with conc. hydrochloric acid in the presence of glacial acetic acid, with 2-methyl-4-amino-5-aminomethylpyrimidine (VI), ammonia, and carbon disulfide, 2′-methyl-2′-chlorotetrahydrofuryl-(3′) [2-methyl-4-aminopyrimidyl-(5)]-methyldithiocarbamate (VII) is obtained. Hydrogen chloride is easily liberated from (VII), and it transits easily to 2′-methyl-4′, 5′-dihydrof aryl-(3′) [2-methyl-4-aminopyrimidyl-(5)]-methyldithiocarbamate (VIII) by heating at 100°, or by treatment with alkali. (VIII) undergoes isomerization by treatment with diluted acids to 3-[2′-methyl-4′-aminopyrimidyl-(5′)]-methyl-4-methyl-5-β-hydroxyethylthiothiazolone-(2) (SB1) (I).
  • ペトロセリン酸のエライヂン反応に就いて
    黒野 吾市, 酒井 健, 石田 知子
    1952 年 72 巻 11 号 p. 1434-1436
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    It was described in the previous paper that petroselidic acid was detected in the fruit oil of Anthriscus sylvestyis Hoffm., but that it was unknown whether the acid was contained, per se, in the fruit oil or whether it had been formed from petroselic acid during the extraction process. As a result of subsequent studies on the elaidination of petroselic acid, it was found that this acid underwent elaidination much more easily than oleic acid and, consequently, petroselic acid in the plant gradually underwent elaidination by the irradiation of ultraviolet light. However, elaidination was found not to occur by heating, saponification with alkalis, or by the action of diluted acids. Since the irradiation of ultraviolet light for an extended period failed to yield 100% petroselidic acid, it would be assumed that the fact that some crystals, m. p. 53°, of petroselidic acid had been obtained from the fruit oil of Anthriscus sylvestyis, shows that petroselidic acid is contained, per se, in the fruit oil, even in small quantities.
  • みやませんきう果実油の脂肪酸の研究
    黒野 吾市, 酒井 健
    1952 年 72 巻 11 号 p. 1436-1439
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    From 490g. of the fruit of Conioselinum univittatum Turcz., 55g. of crude fatty acids was obtained, and fractional distillation of their methyl ester (Cf. Table) gave four fractions. Fraction (A) and (B) yielded solid acids, that from the former being m. p. 61-62°, identical with palmitic acid, from and the latter, m. p. 55-58°, was identified by the paper chromatography of its hydroxamic acid as a mixture of palmitic acid and petroselic acid. Fraction (C) and (D) yielded solid acids of m. p. 31-32° and 32-33°, respectively, and the paper chromatography of their hydroxamic acids identified the former to be petroselic acid containing a minute amount of petroselidic acid, and the latter as petroselic acid. The liquid acids obtained from Fractions (C) and (D) were oxidized by the Hazula method and both yielded 6, 7-dihydroxystearic acid and 9, 10, 12, -13-tetrahydroxystearic acid. From these results, it was clarified that the fatty acids constituting the fruit oil was composed of palmitic, petroselic, petroselidic and linolic acids.
  • 龍涎香の無機成分
    石黒 武雄, 古賀 直文, 松尾 喜正
    1952 年 72 巻 11 号 p. 1439-1443
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Studies were made on the inorganic constituent of ambergris obtained from the intestines of the sperm whale. The ether-insoluble matter (11.8%) of the ambergris is a dark brown powder, and contained some fragments of snout-like bone formations found in cuttle fish. Incineration of this powder yielded 16.3% of grayish white ash whose spectral analysis by the quartz spectrograph indicated the presence of the following. Group I - Ga, Fe*, K*, Mg, Na, (P), Si, Sr*, Zn; Group II - Al, Nb*, Cr*, Cu, La*, Mn, Ni*, Ti*, W* (where* denotes presence in minute amounts). The elements of the Group I were detected directly from the spectral lines, and those of the Group II were determined by comparing with spectrographs taken under the same conditions of the known compounds, such as aluminum oxide, columbite, chromium oxide, titanium oxide, and tungsten oxide, with that of ambergris ash. Phosphorus was confrmed as ammonium phosphomolybdate. It was assumed that a very minute amount of Ag, Co, Gd, and Hg were also present, although they were not determined. The quantitative analysis of the ash gave the following results. CaO 6.21%, MgO 9.88%, P2O5 4.65%, SiO2 6.02%.
  • N,N-Dimethyl-N´-benzyl-N´-(2-pyrimidyl)-ethylenediamine類の合成
    西条 茂彌
    1952 年 72 巻 11 号 p. 1444-1447
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    2-Benzylaminopyrimidine was prepared by the application of propargyl aldehyde to benzylguanidine, and condensation with dimethylaminoethyl chloride gave N, N-dimethyl-N′-benzyl-N′-(2-pyrimidyl)-ethylenediamine. By a similar method, compounds containing methoxyl, bromine, chlorine, and fluorine in the para-position of the benzyl group were prepared. Application of cyanamide to N, N-dimethyl-N′-benzylethylenediamine gave 1-dimethylaminoethyl-1-benzylguanidine, reaction of propargyl aldehyde to which yielded N, N-dimethyl-N′-benzyl-N′-(2-pyrimidyl)-ethylenediamine. Pharmacological tests revealed that the compound possessing fluorine in the para-position of the benzyl group had the most strongest antihistamine acitivity.
  • Thiazolylpropylamine誘導体の合成
    西条 茂彌
    1952 年 72 巻 11 号 p. 1447-1451
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    By the condensation of 2-benzylthiazoles (III), obtained by the application of dichloroether to phenylthioacetamides (II), and dimethyl aminoethyl chloride or N-piperidylethyl chloride, thiazolylpropylamine derivatives (IV and V) were prepared. These were also obtained by the application of dichloroether to thiobutyroamide derivatives (VIII and IX), obtained by the reaction of hydrogen sulfide to α-phenyl-γ-dimethylaminobutyronitrile (VI) or α-phenyl-γ-(N-piperidyl)-butyronitrile (VII). Of these compounds, N, N-dimethyl-3-phenyl-3-(2-thiazolyl)-propylamine derivatives possessing a halogen atom in the para-position in the phenyl ring have excellent antihistamine properties. It was also found that the efficacy increased in the order of fluorine, chlorine, and bromine.
  • α-〔2-Hydroxy-3-ketocyclohexyl〕-propionic Acid Lactoneの合成研究
    阿部 泰夫, 春川 忠二, 石川 尚, 三木 卓一
    1952 年 72 巻 11 号 p. 1451-1455
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Attempts to obtain the lactone of α-(2-hydroxy-3-ketocyclohexyl)-propionic acid (II) by the hydration of the double bond of diethyl (3-ketocyclohexen-(1)-yl)-methylmalonate (I) were unsuccessful and, therefore, the double bond in (I) was hydroxylated in aqueous solution of potassium permanganate, saponif ied, and heated in acetic anhydride, by which the following three unsaturated lactones, closely analogous to (II), were obtained: Lactones of α-(2-hydroxy-3-acetoxycyclohexen-(2)-ylidene)-propionic acid (XII), of α-(2-hydroxy-3-acetoxycyclohexadien-(1, 3)-yl)-propionic acid (XIII), and of α-(2-hydroxycyclohexen-(1)-yl)-propionic acid (XIV). Other allied compounds are also described.
  • 松尾 恒雄, 武蔵 彬彦, 内藤 善彦
    1952 年 72 巻 11 号 p. 1456-1459
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    As a reagent for testing the properties of oxine derivatives in inducing diabetes, oxine homologs and their azo derivatives were synthesized, and the following facts were found:
    1) Compounds which have better inducing properties than oxine: 8-Hydroxyquinaldine, 2, 4-dimethyl-8-hydroxyquinoline, and 5-(phenyl)-azo, 5-(p-tolyl)-azo, and 5-(p-hydroxyphenyl)-azo derivatives of oxine and 8-hydroxyquinaldine.
    2) Compounds which do not induce diabetes: 5-(p-Sulfophenyl)- and 5-(m-carboxy-phenyl)-azo-8-hydroxyquinoline, 2, 4-dihydroxyquinaldine, xanthurenic acid, 8-methoxy-quinoline, and 8-methoxyquinaldine.
    3) Compounds which induce diabetes and which selectively dyes the Langerhans' island cells: 5-(p-Hydroxyphenyl)-azo-8-hydroxyquinoline and 5-(p-hydroxypherlyl)-azo-8-hydroxyquinaldine.
    The syntheses of xanthurenic acid and 2, 4-dihydroxyquinaldine gave slightly different melting points of the intermediate of the former and that of the latter from those described by Mebane and Wiederkehr.
  • 犬伏 康夫, 天野 為之
    1952 年 72 巻 11 号 p. 1459-1461
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    3, 2′, 6′-Trimethoxydiphenyl ether-5, 4′-dicarboxylic acid and 2, 3, 2′, 6′-tetramethoxy-diphenyl ether-5, 4′-dicarboxylic acid were synthesized. Their data are given in Table I.
  • 馬耳下腺からパロチンの分離並びに牛-パロチンとの比較
    伊藤 四十二, 水谷 彰
    1952 年 72 巻 11 号 p. 1462-1464
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Equine parotic gland is fairly different from bovine parotic gland, both in outward appearance and in properties. The pH 5.4-precipitate obtained from equine gland is larger in yield than that from bovine gland, but its effect is far weaker. The 12% (NH4)2SO4-fraction, obtained by the purification of the equine pH 5.4-precipitate by fractional precipitation with ammonium sulfate, could not be induced to crystallize, remaining granular. The effect of this fraction is much weaker than the 12.1% (NH4)2SO4-fraction from the bovine gland, and was found to be still rather impure from the results of electrophoretic analysis. The mobility of the active fraction obtained from the equine parotic gland is much larger than that of the active fraction from the bovine gland. The presence of a substance in the equine parotic gland which lowers the calcium level of rabbit serum is similar to the case in bovine gland, but its properties other than such physiological action, are slightly different from those of the bovine gland.
  • パロチン及びその他血清カルシウム量低下作用を有する諸臟器成分の血清燐量に及ぼす影響について
    伊藤 四十二, 青沼 繁, 東 恭子
    1952 年 72 巻 11 号 p. 1465-1468
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Parotin not only lowers the calcium level of rabbit serum but it also remarkably increases the phosphorus level, especially that of inorganic phosphorus. The fractions corresponding to parotin, obtained from bovine thymus glands, spleen, and heart, and the bovine serum albumin and globulin, also increase the serum phosphorus level but the rate of increase is extremely small. Their action on phosphorus, as is the case on calcium, is of different type from that of parotin.
  • 牛耳下腺有効部分 (パロチン) と他の血清カルシウム量低下性臟器成分との異同
    伊藤 四十二, 水谷 彰
    1952 年 72 巻 11 号 p. 1468-1471
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    A fraction (precipitating at the isoelectric point), corresponding to crude parotin, obtained from the aqueous extracts of bovine liver, thymus, and spleen, and the albumin and globulin from bovine serum, also showed activity of decreasing the calcium level of rabbit serum, but its mode of action differs from that of parotin (Ogata, Ito, Nozaki, and Okabe: This Journal, 64, 114 (1944): Ogata, Ito: This Journal.. 64, 332 (1944)). By a similar procedure, pH 5.7-precipitate and pH 5.4-precipitate were obtained from the aqueous extract of bovine heart muscles. The pH 5.7-precipitate also possesses an action like parotin of lowering serum calcium level, but in higher dosage (30mg./2kg. wt.), it acts reversely to increase the calcium level. Solubilities of these various principles in water of various pH, and the manner of denaturation when boiled with water of various pH values, were examined. Quantitative determination of total nitrogen, amino nitrogen, phosphorus, and sulfur contents of these products showed that their properties differed from those of parotin except the pH 5.7-precipitate from bovine heart which was very similar in its properties to parotin.
  • Aminoalkyl Thiobenzhydryl Etherの合成
    福田 弘一
    1952 年 72 巻 11 号 p. 1472-1473
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    β-Dimethylaminoethyl thiobenzhydryl ether hydrochloride has been found to be effective as an antihistamine from clinical tests. Following compounds, belonging to the same series of compounds, were prepared, of which, the first one had been synthesized by Rieveshl: β-Dimethylaminoethyl p-methylthiobenzhydryl, p-chlorothiobenzhydryl, and p, p′-dichlorothiobenzhydryl ether hydrochloride.
  • 清水 正夫, 内藤 武男, 太田 元吉, 吉川 徹, 堂森 廉三
    1952 年 72 巻 11 号 p. 1474-1477
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    In order to examine the effect of chemical structure on antibacterial activity, some pyridine carboxylic acid derivatives shown in the Table were prepared. The results of in vitro tests against the so-called “Mycobacterium tuberculosis A. T. C. C. No. 607” are also given in the Table. Of the three isomers of acid hydrazide, the one of γ-substituent, i.e. isonicotinic acid hydrazide (INAH), alone showed excellent antibacterial action, which decreased when the compound was derived to its N-oxide. During the preparation of above samples, ethyl picolinate was found to undergo saponification by treatment with hydrogen peroxide and glacial acetic acid, forming picolinic acid N-oxide. With the others, esters were derived to their N-oxides by treatment with hydrogen peroxide and glacial acetic acid, then led to acid amides and acid hydrazides with aqueous ammonia and hydrazine hydrate, respectively.
  • 川谷 豊彦, 大野 忠郎
    1952 年 72 巻 11 号 p. 1478-1482
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    It has been maintained that the essential oil (Chenopodium Oil) obtained from Chenopodium ambrosioides L. var. anthelminticum A. Gray cultivated in the cooler districts of Japan is not quite as good a quality as that from the plants cultivated in the warmer climates, but no experimental evidence for it has ever been offered. The plant was experimentally cultivated in the highlands of the Nagano Prefecture, the Tohoku Districts, and in the Hokkaido, which are in a cooler region, and distillation tests and determination of ascaridol were carried out on the crop. The results obtained were as follows:
    1) Table I shows the growth, yields of crop and fruits, content of the essential oil, and the content of ascaridol. Tables II and III respectively show the atmospheric temperature and the rainfall in these districts.
    2) The growth, especially in the first stage, is retarded in cooler regions, but the yields of crop and of fruits were not necessarily less than those from the warm region.
    3) The yield of the oil and the content of ascaridol were also not particularly less in the crop from the cooler region compared to those from the warm region.
  • 3-オキシイミノ-4-オキソホモカンファーに就いて
    武田 健一, 永田 亘, 橘川 郁男
    1952 年 72 巻 11 号 p. 1482-1486
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Particulars obtained for 3-oximino-4-oxohomocamphor, m. p. 112°, described in the previous report, are as follows:
    1) Besides forming colored complex salts with potassium and ferrous ions, it also forms colored salts with other metallic ions.
    2) It gives camphoric acid and camphoric anhydride in a good yield with reagents that induces the Beckmann rearrangement. It was also confirmed that, in the case of conc. sulfuric acid, carbon monoxide is generated at the same time, so that its reaction mechanism must belong to the second type Beckmann rearrangement, and the formation of camphoric acid monocyanide (VIII) as an unstable intermediate, was assumed.
    3) Of the two possible structures of (Va) and (Vb), (Va) was assumed to be more appropriate for 3-oximino-4-oxohomocamphor.
  • Benzaldazineのニトロ化
    宮武 一夫
    1952 年 72 巻 11 号 p. 1486-1488
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Nitration of benzaldazine with sulfuric and nitric acids gave o, o′-dinitrobenzaldazine and p, p′-dinitrobenzaldazine, but their yields were very poor, the majority undergoing decomposition. However, this has definitely shown that nitro substitutions occurred in both the ortho and the para positions. Nitration of benzaldazine with acetic anhydride and nitric acid yielded benzaldehyde and 4-benzalamino-3, 5-diphenyhl-1, 2, 4-triazole, m. p. 205.5-206.5° (picrate, 169-170°), but no nitro derivatives. Benzaldazine refused to be nitrated with nitric acid in glacial acetic acid, the starting material being recovered. It was assumed that the activation of ortho and para positions during the nitration of benzaldazine with sulfuric and nitric acids was due probably to the electron displacement by the liberation of a proton, which took up an unstable coordination against a weak base by the effect of sulfuric acid.
  • Benzaldazineの酸化について その1
    宮武 一夫
    1952 年 72 巻 11 号 p. 1489-1490
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Oxidation of benzaldazine in ether solution with perphthalic acid gives monobenzyl-phthalate, while oxidation with hydrogen peroxide in glacial acetic acid gives benzyl-acetate, Benzaldazine hardly undergoes oxidation in neutral medium The mechanism of the formation of benzylesters by the oxidation of benzaldazine was assumed to be due to the formation of phenyl diazomethane as an intermediate during the reaction.
  • ピリド-2,3:5´,4´-チアゾール類の合成
    高橋 酉蔵, 山本 讓
    1952 年 72 巻 11 号 p. 1491-1492
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    In the preparation of 2-thiocyano-3-nitropyridine by the condensation of 2-chloro-3-nitropyridine and potassium thiocyanate, the addition of activated copper dust results in an increased yield. Respective application of benzoyl chloride and p-nitrobenzoyl chloride to 2-mercapto-3-amino-6-chloropyridine gave pyrido-2, 3:5′, 4′-thiazole derivatives. Application of p-nitrosodimethylaniline and p-nitrosodiethylaniline to 2′-methyl-6-chloropyrido-2, 3:5′, 4′-thiazole gave the corresponding azomethine compounds.
  • ベンゾチアゾール誘導体について その4
    高橋 酉蔵, 岡田 寿太郎
    1952 年 72 巻 11 号 p. 1492-1495
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    2-Dimethylamino-6-methoxybenzothiazole was changed to its 6-hydroxy derivative by boiling with hydriodic acid (d=1.7), and the respective condensation of isopropyl iodide, butyl bromide, and isoamyl bromide to the hydroxy derivative gave the corresponding 6-alcoxy derivatives. By the condensation of aromatic aldehydes to 2-allyl-mercapto (chloro)-6-aminobenzothiazole, 16 kinds of Schiff's bases were prepared. Some of these bases showed strong tuberculostatic activity, in vitro.
  • 内藤 多喜夫, 高橋 礼子
    1952 年 72 巻 11 号 p. 1495-1498
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    1) Reaction between 1-phenylthiosemicarbazide and various metallic ions was examined and it was found that the compound gave sharp coloration with copper, silver, gold, zinc, cadmium, mercury, bismuth, iron, cobalt, nickel, and platinum ions.
    2) It was found that the color reaction with cupric ion was especially sharp and that the isoamyl alcohol solution of this reagent was able to detect 2×10-8g./cc. of cupric ion.
    3) Reagent test papers were prepared and the limit of the detection of copper ion and the limit ratio, in the presence of other metallic ions, were examined with these papers.
    4) The use of this reagent as the color developer in the paper chromatography enabled the concurrent separatory detection of various metallic ions.
  • パロチンの物理・化学的性質ならびに安定性について
    伊藤 四十二, 水谷 彰
    1952 年 72 巻 11 号 p. 1499-1502
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Physical and chemical constants of parotin (Fig. 4), which is eletrophoretically almost homogeneous, were determined (Tables I and II). The stability of the aqueous solution of parotin was also examined (Table II).
  • パロチンの化学的研究 その1 化学試薬のパロチンの生理作用に及ぼす影響
    水谷 彰
    1952 年 72 巻 11 号 p. 1503-1507
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Various chemical reagents were applied on parotin in order to examine the essential groups responsible for the appearance of its effect as the lowering of serum calcium level. This effect was found to either decrease or disappear when the free amino radical in parotin was fixed or shielded by the ketene, nitrous acid, or formaldehyde, or when the thyrosine-phenyl ring was substituted by iodine. Treatment of parotin with 40 volumes of cysteine hydrochloride, in order to reduce the -S-S- bond in its molecule, gave no effect on the calcium lowering activity, but the treatment with 20 volumes of thioglycollic acid was found to decrease the effect (at level of significance 7.3%). From these experiments, it is assumed that the free amino radical, thyrosinephenyl ring, and the -S-S- bond are responsible for the appearance of the specific effect in parotin.
  • パロチンの化学的研究 その2 変性剤のパロチンに及ぼす影響に就いて
    水谷 彰
    1952 年 72 巻 11 号 p. 1507-1510
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    It was found that, taking the parotin test of the lowering of calcium level in rabbit serum as the criterion, treatment of parotin with 3.0 and 6.66 moles urea solution (pH 7.0) resulted in reversible denaturation (Table I), while the treatment with 6.0 moles guanidine hydrochloride solution (pH 7.0) resulted in irreversible denaturation (Table II). The mean lowering rate of serum calcium level, when 4cc. per 2kg. wt. of physiological saline solution is intravenously injected, into rabbits (5 rabbits were used), is 5.61%, while it is 2.13% when 1cc. per 2kg. wt. is injected (Table IV). It was assumed that if the amount of sample intravenously injected into rabbits is around 1cc. per 2kg. of weight, such injection has practically no effect on the lowering rate of serum calcium level.
  • パロチンの化学的研究 その3 パロチン中の糖について (1)
    水谷 彰
    1952 年 72 巻 11 号 p. 1511-1513
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    The parotin preparation of 93% purity (electrophoretically analyzed. Fig. 1) gives negative pentose reaction (by phloroglucinol-hydrochloric acid and orcinol-hydrochloric acid), but gives positive carbazole-sulfuric acid reaction. The absorption curve of the parotin preparation by the latter reaction greatly differs from those of mannose, galactose and glucose (Fig. 2), but the curve for parotin hydrolyzate is very similar to those of the sugars (Fig. 3). In the absorption curves shown in Fig. 3, the E520/E420 for parotin hydrolyzate is 0.73, while those of galactose is 0.99 and mannose, 0.76 (Gurin: galactose 1.10, mannose 0.68), showing its value approximating that of mannose. However, from the color tone, absorption curve, and the E520/E420 value, parotin hydrolyzate does not seem to contain glucose.
  • 唾液腺ホルモンの研究 第22報
    水谷 彰
    1952 年 72 巻 11 号 p. 1514-1517
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Based on the assumption that the sugar in parotin is mannose, the amount of sugar contained in parotin of approximately 93% purity was 0.73%. Less pure parotin, recovered from the precipitation mother liquor, obtained during the purification of parotin, contained 1.78% of sugar. From these results, it is assumed that the sugar content of parotin itself is in a range of 0.79 to 0.48%. It is also assumed that hexos amine is either nonexistent or is contained in a minute amount, and that a very minute amount of pyrrole dye is contained in parotin preparation.
  • 顎下腺抽出物の血清燐及びカルシウム量に及ぼす影響について
    伊藤 四十二, 青沼 繁
    1952 年 72 巻 11 号 p. 1517-1520
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Bovine submaxillary gland contains a substance which remarkably lowers the serum phosphorus level. This substance is present in a water-soluble fraction, and precipitates at pH 4.5. It is unstable to heat, and seems to be affected by alcohol. Its solubility to water of various pH and coagulation reactions are similar to those of parotin, a substanc eobtained from the bovine parotic gland and possessing the action of decreasing serum calcium level.
  • ジオキシ及びトリオキシ安息香酸類の合成
    堀井 善一, 小宮山 康之, 大槻 一夫, 山村 雄一
    1952 年 72 巻 11 号 p. 1520-1522
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Some isomers of di- and tri-hydroxybenzoic acids were prepared to test their activities on tubercle bacilli. Of the compounds prepared, 2, 3, 6-trihydroxybenzoic acid is unknown in literature, whose preparation from 2, 6-dihydroxybenzoic acid by means of alkaline persulfate oxidation was found to yield no crystalline product. The methylation of the crude product with dimethyl sulfate finally yielded 2, 3, 6-trimethoxybenzoic acid.
  • Thea-saponin及びThea-prosapogenolに就いて
    石館 守三, 上田 陽
    1952 年 72 巻 11 号 p. 1523-1524
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    An acidic saponin was isolated in a pure crystalline state from the seed of Thea sinensis L., cultivated in Shizuoka Prefecture, and was designated thea-saponin. It melted at 224-225° (decomp.) (corr.), [α]D19=+37.6° (dil. EtOH); hemolytic index, ca. 100, 000 (with rabbit blood). From the results of analytical data and the sugar components, the formula of C57H90O26 was given for this triterpenoid saponin. Alkaline hydrolysis of thea-saponin converted it into thea-prosapogenol A, C52H84O25, m. p. 227°, [α]D19=+43.6° (dil. EtOH)., with liberation of one mole of angelic acid.
  • Thea-saponinの構成物質に就いて
    上田 陽
    1952 年 72 巻 11 号 p. 1525-1528
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    Thea-saponin was finally hydrolyzed to a monoacidic sapogenin, thea-sapogenol, m.p. 301-302.5°, [α]D19=+77.3° (EtOH), four sugar components, and one mole of angelic acid. The four sugars were identified, both by paper chromatography and as osazone derivatives. These results can be summarized as follows:
    Thea-saponin C57H90O26+5H2O=Thea-sapogenol C30H50O6+glucuronic C6H10O7 acid+galactose C6H12O6+arabinose C5H10O5+xylose C5H10O5+angelic C5H8O2 acid
  • N,N-Dimethyl-3-(2-pyridyl)-propylamine誘導体
    西条 茂彌
    1952 年 72 巻 11 号 p. 1529-1530
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
  • 三橋 靖, 辰已 雅子
    1952 年 72 巻 11 号 p. 1530-1531
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
    A method of determining chlorine ion in drinking water by titration with mercury was examined and it was found to give better results than the existing method using silver.
  • Yohei Hashimoto, Itsuhiko Mori
    1952 年 72 巻 11 号 p. 1532
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
  • 1952 年 72 巻 11 号 p. A1-A8
    発行日: 1952/11/25
    公開日: 2010/02/19
    ジャーナル フリー
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