YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
72 巻 , 12 号
選択された号の論文の114件中1~50を表示しています
  • 大田 正樹, 神山 弘章
    1952 年 72 巻 12 号 p. 1533-1535
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    It has been found that the report by Janniah and Guha should be denied regarding the existence of two isomers of hydrazodithiodicarbamide (I) as thiol type, m.p. 223°, and dithiol type, m.p. 203°. These two show identical absorption curves and should, therefore, be polymorphs. The two authors' report that there is an endo-form, m.p. 245°, to 2-amino-5-mercaptothiodiazole, m.p. 234°, obtained by the hydrochloric acid cyclization of (I), should also be denied, since no compound with m.p. 245° was obtained in the present experiments in this authors' laboratory. Further denial has been obtained on the report by Janniah and Guha that the substance of m.p. 177° obtained by the conc. hydrochloric acid cyclization of hydrazomonothiodicarbamide is 2-amino-5-hydroxythiodiazole (II), and that of m.p. 235° obtained by acetic anhydride cyclization of (II) is the endo-form. The latter compound is 2-amino-5-hydroxythiodiazole. No definite confirmation has yet been obtained as to the structure of the substance with m.p. 177°.
  • 大田 正樹
    1952 年 72 巻 12 号 p. 1536-1537
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    By the condensation of malonic or succinic ester chlorides respectively with thiosemi-carbazide, in the presence of phosphorus trichloride, ethyl 2-amino-1, 3, 4-thiodiazole-5-acetate and methyl 2-amino-1, 3, 4-thiodiazole-5-propionate were obtained. Their hydrolyses afforded the corresponding acids. Their respective acid amides and acid hydrazides were also prepared.
  • 亀谷 哲治
    1952 年 72 巻 12 号 p. 1537-1539
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    As described in the previous report, 1-substituted 3-methyl-6, 7-methylenedioxy-3, 4-dihydroisoquinoline is formed by reacting safrol and acid amide in a suitable solvent in the presence of phosphoryl chloride. Application of this reaction to methyleugenol successfully yielded 1-substituted 3-methyl-6, 7-dimethoxy-3, 4-dihydroisoquinoline. For example, the use of acetamide, benzamide, 3, 4-dimethoxybenzamide, 3, 4-methylenedioxy-benzamide, and phenylacetamide as acid amide in the reaction of methyleugenol and phosphoryl chloride respectively yielded 1-methyl-, 1-phenyl-, 1-(3′, 4′-dimethoxyphenyl)-, 1-(3′, 4′-methylenedioxyphenyl)-, and 1-benzyl-3-methyl-6, 7-dimethoxy-3, 4-dihydroiso-quinolines.
  • 亀谷 哲治, 二宮 吉次郎
    1952 年 72 巻 12 号 p. 1539-1541
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    In order to increase the yield of dihydroisoquinoline derivatives obtained by the condensation of safrol or methyleugenol with various acid amides, several kinds of condensation agents were tried but phosphoryl chloride seemed to be the most effective. In the preparation of 3, 4-dihydroneupaverine, i.e. 1-(3′, 4′-methylenedioxyphenyl)-3-methyl-6, 7-methylenedioxy-3, 4-dihydroisoquinoline, 3, 4-methylenedioxybenzonitrile is formed as a by-product, and therefore, p-nitrobenzonitrile or p-nitrobenzamide was applied to safrol by which the objective isoquinoline derivative was obtained in either case but it required a long period of time in the case of the former with a very poor yield. It is assumed, from this result, that nitrile itself does not directly react with safrol in this reaction but the amide adds to the double bond in safrol and then undergoes isoquinoline cyclization by the action of phosphoryl benzamide. It can also be assumed that the initially formed nitrile by the dehydration of acid amide also takes part in the reaction.
  • 栗原 藤三郎, 丹羽 弘司, 田中 文彦
    1952 年 72 巻 12 号 p. 1541-1545
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    In order to find the effect of thioalkyl group introduced into a benzene nucleus on local anesthetic properties, 15 kinds of alkylaminoacetanilide substituted in the ortho and para positions with thioalkyl group were prepared and their local anesthetic properties were compared. In general, the anesthetic action increased with the increase of the number of carbon atoms in the thioalkyl group, with attendant increase in toxicity. The maximum efficacy was found in p-thioamyldiethylaminoacetanilide which possessed 2.3 times the surface anesthetic power of cocaine. These substances possess a certain amount of local irritating action, similar to the corresponding alcoxyl compounds, but it was observed that their anesthetic properties are slightly better than those of oxygen compounds. Reduction of alcoxyl compounds, to decrease irritating action, to hydroxyl derivatives resulted in the loss of local anesthetic action together with the decrease of irritating properties.
  • 刈米 達夫, 山田 肇, 高橋 三雄, 大味谷 輝男, 岡本 喜八郎, 柏原 良男
    1952 年 72 巻 12 号 p. 1545-1547
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    For the purpose of preparing antispasmodics with strong effect and small toxicity, glycerol ethers of nitrogen-free bicyclic compounds were prepared and pharmacological tests were carried out. Of the new compounds prepared, 3-(1, 2, 3, 4-tetrahydro-7-naphthyloxy)-1, 2-propanediol was found to be better than Myanesin in slackening and paralysing the muscles, toxicity, action time, safety rate, and inhibition of convulsions induced by spasmodic poisons. 3-(1, 2, 3, 4-Tetrahydro-8-naphthyloxy)-1, 2-propanediol was found to be the next, with properties slightly lower than those of Myanesin. Such actions were found to be weak in compounds of this series such as 3-methylphenoxy-, 3-m-propylphenoxy-, and 3-m-butylphenoxy-1, 2-propanediols.
  • 田中 邦喜, 須川 利男
    1952 年 72 巻 12 号 p. 1548-1551
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Relationship between substitution reaction and steric rearrangement in N-methylephedrine was examined and the result was compared with that in the case of ephedrine. Application of phosphorus pentachloride to d-N-methylephedrine (I) and to l-φ-N-methylephedrine (II) respectively yielded (-)-φ-1-phenyl-1-chloro-2-dimethylaminopropane hydrochloride (III) from (I), and (III) and (+)-1-phenyl-1-chloro-2-dimethylaminopropane hydrochloride (IV) from (II). Application of aqueous solution of silver nitrate to (III) yielded a mixture of (I) and (II), while heating (III) with aqueous solution of sodium hydroxide gave (II) alone. Application of sodium hydroxide to (IV) gave (I). It was assumed that ethylene-immonium ion is formed as an intermediate in the reaction of (III) to (II), and two Walden inversions occurred consecutively during its cyclization and cleavage. Exactly the same relationships were found to exist in l-N- and d-φ-N-methylephedrines.
    In the previous paper, the ethylene-imine derivative, formed during the formation of φ-1-phenyl-1-chloro-2-acylmethylaminopropane (VII) through N-methyl-1-phenyl-2-methylethylene-imine (VI) from φ-1-phenyl-1-chloro-2-methylaminopropane, derived from ephedrine or φ-ephedrine, was assumed to belong to the pseudo series, but later experimental results seem to point that the compound belongs to the normal (cis-form) series and that Walden inversions occured during its cyclization and cleavage.
  • 田中 邦喜, 須川 利男
    1952 年 72 巻 12 号 p. 1551-1554
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Relationship between substitution reaction and steric rearrangement between erythro and threo compounds of 1, 2-diphenyl-2-methylaminoethanol-(1) was examined and it was found that the situation identical with ephedrine also existed. Treatment of the N-acetyl derivative (VI) of erythro-1, 2-diphenyl-2-methylaminoethanol-(1) (I) with alcoholic hydrochloric acid results in its rearrangement to the O-acetyl derivative (VIII) of the threo series while the threo-1, 2-diphenyl-2-aminoethanol-(1) (II) obtained by the hydrolysis of (VIII) undergoes rearrangement to the N-acetyl (VI) or O-acetyl (VIII) derivative of the erythro-series via threo-chloro (III), erythro-ethylene-imine (IV), and threo-N-acetylchloro (V) derivatives. Hydrolysis of (VI) or (VIII) was found to yield (I).
  • 秋谷 七郎, 奧井 誠一, 鈴木 茂生
    1952 年 72 巻 12 号 p. 1554-1558
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    The hexasaccharides of Schardinger and Akiya-Watanabe were oxidized with periodic acid to aldehydes and derived to p-nitrophenylhydrazones. The hydrazone obtained from Schardinger's hexasaccharide contained four p-nitrophenylhydrazine groups bonded on both sides of glyoxal and erythrose. The hydrazone obtained from Akiya-Watanabe's hexasaccharide contained six p-nitrophenylhydrazine goups in a molecule, bonded to the glyoxal sides alone. Acid decomposition of the two hydrazones were also carried out.
  • 秋谷 七郎, 奧井 誠一
    1952 年 72 巻 12 号 p. 1558-1560
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Oxidation of the p-nitrophenylhydrazone of D-glucose with periodic acid gave glyoxal p-nitrophenylhydrazone. This compound was stable in a neutral medium but easily changed to glyoxal p-nitrophenylosazone and free glyoxal in an acid medium.
  • 今井 統雄, 古谷 潔
    1952 年 72 巻 12 号 p. 1560-1564
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Attempt was made to find a simple and rapid determination method for rutin in Kaika, a crude drug composed of the flower buds of Sophora japonica L. The reaction conditions of rutin-Al complex, and the correlation between rutin concentration and absorption were statistically examined. The flower buds were extracted with 99% methanol, using a new type extractor, treated with ether to remove quercetin, and diluted with a suitable amount of methanol to prepare a sample solution. To 2cc. of this sample solution, 3cc. of 0.1 mole aqueous solution of aluminum chloride and 5cc. of 1 mole aqueous solution of potassium acetate were added, allowed to stand at a room temperature for two hours, and the absorption (y) of rutin-Al complex was measured by a photoelectric colorimeter, using S-47 filter. The percentage of rutin (x) at 95% confidence limit was calculated from the following equation: x=(0.0612y-0.00072)±0.00049.
  • 小田 武
    1952 年 72 巻 12 号 p. 1564-1566
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Penitrinic acid, C15H17O5N, was isolated from the culture medium of Penicillium notatum P176. α- and β-Penitrin were obtained by the respective cleavage of peni-trinic acid by sulfuric acid and alkali. A new, nitrogen-free phenol, penitrinol, C13H18O3, was obtained by the hydrogenolysis of penitrinic acid.
  • 永田 亘, 武田 健一
    1952 年 72 巻 12 号 p. 1566-1570
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Following considerations were made regarding the so-called second-type Beckmann rearrangement by which nitrile is formed from ketoxime.
    1) Such rearrangement easily occurs with compounds in which C-C bond (C-H bond in aldoxime) in the transposition of the oxime group is easily cleaved.
    2) Such rearrangement was confirmed to occur primarily by cleavage without passing through an intermediate of acid aride or imide, by detailed studies on camphor oxime and anti-α-isonitrosocamphor.
    3) It was pointed out that the rearrangement agent does not directly attack the β-carbon, the carbon atom next to the carbon bonding with nitrogen.
  • 砂川 玄俊, 久島 諦史朗, 市井 武
    1952 年 72 巻 12 号 p. 1570-1574
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    1) The benzylamine derivatives possessing a substituent with comparatively strong -E effect in the para-position, such as the methoxyl, and an aromatic residue bonded to its nitrogen, easily undergo decomposition by acids.
    2) Respective decomposition by hydrochloric acid of 2-p-methoxybenzylaminopyrimidine and p-methoxybenzylaniline yielded α-aminopyridine, 2-anzinopyrimidine, and aniline, as the bases, with p, p′-dimethoxydiphenylmethane and formaldehyde.
  • 秋谷 七郎, 手島 節三
    1952 年 72 巻 12 号 p. 1574-1576
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    By the methylation of phenylglucosazone, phenyl(1)-methylphenyl(2)-glucosazone was isolated. Condensation of acetone to the latter resulted in the bonding of acetone at C5 and C6, to form 5, 6-monoacetone-phenyl(1)-methylphenyl(2)-glucosazone, whose further methylation gave 3, 4-dimethyl-5, 6-monoacetone-phenyl(1)-methylphenyl(2)-glucosazone. Phenyl(1)-methylphenyl(2)-glucosazone required 3 moles of periodic acid to form 2 moles of formic acid and precipitated yellow needles of mesoxaldehyde-phenyl(1)-methylphenyl-(2)-osazone, whose color changed to blood red on irradiation of sunlight. However, the melting point of the red crystals was no different from that of the yellow one, the color being recovered on recrystallization. This change was reversible and could be repeated number of times.
  • 秋谷 七郎, 手島 節三
    1952 年 72 巻 12 号 p. 1577-1579
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Phenyl(1)-alkylphenyl(2)-glucosazones in which the alkyl was ethyl, allyl, and butyl, were prepared. These compounds required 3 moles of periodic acid to form 2 moles of formic acid and precipitated corresponding mesoxaldehyde-phenyl(1)-alkylphenyl(2)-osazones. The color of these crystals also changed by sunlight, that of ethyl derivative from yellow to orange yellow, that of allyl and butyl from yellow to red, without any change in their melting points. These changes were also found to be reversible, the original yellow crystals being obtained on recrystallization, and vice versa.
  • 秋谷 七郎, 手島 節三
    1952 年 72 巻 12 号 p. 1580-1582
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Ofner reported (Ber. 37, 4400 (1904)) that the application of methylphenylhydrazine to D-glucose in 50% acetic acid solution yielded D -glucose methylphenylhydrazone. Reëxamination of this experiment failed to furnish the hydrazone but glucosone methylphenylhydrazone-(2) as pale yellow needles, m.p. 170°, was obtained.
  • 伊藤 〓, 浜中 渉
    1952 年 72 巻 12 号 p. 1583-1584
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Electrochemical studies were made on the acyl rearrangement from oxygen to nitrogen in compounds of chloramphenicol series. As a means of dynamic study of this rearrangement, potential titration was found to be suitable, through which it was learned that the acetyl group easily underwent rearrangement in the presence of sodium hydroxide, but that the dichloroacetyl group refused to undergo such arrangement and finally decomposed as dichloroacetic acid.
  • 松川 泰三, 万木 庄次郎
    1952 年 72 巻 12 号 p. 1585-1588
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    2-β-Hydroxyethyl-4-amino-5-cyanopyrimidine (III) was prepared from β-hydroxypropionitrile by deriving it first to β-hydroxypropioimidoether by the application of the alcohol and hydrogen chloride, then to β-hydroxypropioamidine by the application of ammonia to the ether, and by the condensation of ethoxymethylenemalonitrile. (III) forms 2-β-chloroethyl derivative (IV) by the action of phosphoryl chloride, and 2-β-acetoxyethyl derivative (V) by acetylation with acetic anhydride in pyridine. Heating of (III) with acetic anhydride alone results in the formation of 2-vinyl derivative (VI) with (V). Electrolytic reduction of (III) in hydrochloric acid, with palladium-black as the cathode, yields 2-β-hydroxyethyl-4-amino-5-aminomethylpyrimidine (VII) hydrochloride. Application of carbon disulfide and γ-aceto-γ-chloropropyl acetate to (VII), in the presence of ammonia, results in the formation of α-aceto-γ-acetoxypropyl N-[2-β-hydroxyethyl-4-aminopyrimidyl(5)]-methyldithiocarbamate (VIII), whose heating with diluted hydrochloric acid yields 3-[2′-β-hydroxyethyl-4′-aminopyrimidyl(5′)]-methyl-4-methyl-5-β-hydroxyethylthiazol-2-thione (IX) The treatment of (VIII) with alkali yields 2-thio-7-β-hydroxyethyl-1, 2, 3, 4-tetrahydropyrimido-(4, 5-d)-pyrimidine (X). Application of ethyl iodide to (IX) yields 2, 9-di(β-hydroxyethyl)-3-methylthiochromine (XI), and application of hydrogen peroxide to the dil. hydrochloric acid solution of (IX) results in the formation of 3-[2′-β-hydroxyethyl-4′-aminopyrimidyl(5′)]-methyl-4-methyl-5-β-hydroxyethylthiazolium compound (II). The hydrochloride of (II) was found to possess one-third to one-quarter the effect of thiamine, tested with rice birds. (IX) was found to be totally ineffective.
  • 鍛冶 健司, 長島 弘
    1952 年 72 巻 12 号 p. 1589-1591
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    As ethylenediamine compounds of indole series assumed to possess antihistaminic properties, two kinds of N-(β-diethylaminoethyl)-α-methylindoles and four kinds of N-(β-diethylaminoethyl)-α-arylindoles were prepared by heating sodium salts of α-substituted indoles and β-diethylaminoethyl chloride in anhydrous toluene or xylene in the presence of sodium amide.
  • 高木 敬次郎, 粕谷 豊, 服部 和夫
    1952 年 72 巻 12 号 p. 1592-1594
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Five kinds of diphenylbutanolamines and two kinds of diphenylpropanolamines were prepared to examine their antispasmodic actions. The butanolamines are all new compounds and were prepared by the Grignard reaction of β-aminobutyric esters. The anticholinergic activity of these compounds was found to be the strongest in 1, 1-diphenyl-3-piperidylbutanol, being one-third to one-half of the action of atropine sulfate when tested with excised small intestines of guinea pigs.
  • 藤田 路一, 西本 和光
    1952 年 72 巻 12 号 p. 1595-1598
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    The morphology of Japanese senega, said to originate from Polygala Senega L. var. latifolia Torr. et Gray, was studied. The Japanese senega was found to be similar to the Northern senega, generally used as drugs, in that it possessed many branched lateral roots and fine rootlets, especially with strong tendency of lateral roots to bend, and showing keel and abnormal growth of internal structure. These facts probably indicate that the botanical origin of the two drugs are quite closely related. It was also found that the characteristics of Japanese senega were almost identical with those of Southern senega.
  • 松川 泰三, 万木 庄次郎
    1952 年 72 巻 12 号 p. 1599-1601
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    The change of vitamin B1 when it was heated in an aqueous solution of pH 8 at 60° for 2.5 hours was examined by paper partition chromatography, and it was found that thiochrome (IV), SB1 (VII), B1 disulfide (V), and B1 thiazolone (VI) had been formed. However, a large amount of vitamin B1 was found to be still intact. The same procedure carried out in alcohol, instead of water, showed that almost none of vitamin B1 remained, and that the formation of SB1 (VII) was larger than in the case of aqueous solutions, SB1 being obtained as crystals. Other compounds formed were (IV), (V), and (VI), as in the case of aqueous solutions
  • 松川 泰三, 万木 庄次郎
    1952 年 72 巻 12 号 p. 1602-1604
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Allithiamine, a compound formed by the reaction of vitamin B1 and the component of garlic (Allium sativum L. var. japonicum Kitamura), was isolated in crystals of m.p. 132-133° (decomp.) as recrystallized from benzene, or of m.p. 141-142° (decomp.) as recrystallized from water. Molecular weight determination by the Barger method and analytical values suggest the empirical formula of C15H22O2N4S2. It was assumed from absorption spectra and other properties that it possessed a structure similar to “Aneurindisulfid.”
  • 落合 英二, 岡本 敏彦, 菅沢 勉, 谷 英郎
    1952 年 72 巻 12 号 p. 1605-1607
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Aconitum tasiromontanum Nakai roots (Tashiroyamabushi) were collected in the forests around Nasu-Sandogoya, in central Japan, and their alkaloid content was examined. Crude base was obtained in approximately 0.1% yield as against fresh root. Of the crude base, 64% precipitate out from the hydrochloric acid solution upon the addition of ammonia water, and 9.8% are obtained by extraction of its mother liquor with chloroform. Purification of the former by chromatography yielded hypaconitine, mesaconitine, aconitine, and ignavine, as crystalline bases. The characteristics of this plant are that its alkaloid contains a very large amount of mesaconitine, a small amount of hypaconitine and aconitine, and that it contains, although in a small amount, the newly found ignavine.
  • 駒井 知好, 入江 さわ子, 宇都木 允之, 水野 伝一
    1952 年 72 巻 12 号 p. 1608-1610
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    1) Dried B. C. G. Vaccine and Dried Normal Human Serum are marked as lyophilized product sealed in hermetic ampuls. In such a country as Japan where atmospheric moisture is very high, the moisture content of air in the room where ampuls are opened for examination of moisture content gives a great deal of effect on the determined values. For this reason, the relationship between the moisture content of air and the time spent in weighing was examined. Both preparations were found to absorb approximately 1-5% of moisture during 3 minutes of weighing in the air containing 50% or more moisture. When the relative moisture was below 30%, there were almost no increase in the weight of a sample by weighing during 3 minutes.
    2) The moisture content of Dried B. C. G. Vaccine and Dried Serum is carried out by the weight method. Comparison of this method with that using the Karl Fischer reagent (time of contact with the reagent: 45 minutes) showed that both preparations gave a larger value by the Karl Fischer method, but with penicillin and streptomycin, there were no difference between the values by the two methods.
  • 伊勢田 駿
    1952 年 72 巻 12 号 p. 1611-1613
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    White bird-lime was purified with ether from which 48% of purified bird-lime was obtained. Its hydrolysis yielded 42.8% of fatty acids, 41.4% of crystalline unsaponifiable matter, and 4.3% of non-crystalline unsaponifiable matter. Acetylation of the crystalline unsaponifiable matter, followed by recrystallization from ethyl acetate yielded a new triterpene alcohol in 1.61% yield, designated as ilexol, of m.p. 205-206°, [α]D28: -16.81°(CHCl3), which gives an acetate of m.p. 282-283°, [α]D28: +22.29°(CHCl3), and a benzoate of m.p. 242-243°. α-Amyrin and lupeol were detected in the residue, with a larger amount of α-amyrin. No evidence was obtained for the presence of β-amyrin.
  • 百瀬 勉, 友枝 宗光
    1952 年 72 巻 12 号 p. 1614-1616
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Biological changes of p-(α-aminoethyl)-phenylsulfonamide (I), p-(α-aminoethyl)-phenyl methyl sulfone (II), p-(β-aminoethyl)-phenylsulfonamide (III), and p-(β-aminoethyl)-phenyl methyl sulfone (IV) in rabbit were observed by the direct injection of the aqueous solution of the hydrochlorides of these compounds into rabbit stomach by Nela-ton's catheter. The urine was collected about 40 hours after injection, and extracted with ether or ethyl acetate at an optimum pH. Unchanged, free bases of (I) and (II) were obtained in 57% and 26% yield, respectively, and a very small amount of the acetylated compound of (I). (III) and (IV) yielded oxidation products, p-(carboxymethyl)-phenylsulfonamide and p-(carboxymethyl)-phenyl methyl sulfone in 58% and 55% yield, respectively. The free bases of these compounds were not recovered These results led to the conclusion that the oxidation of aminomethyl group was interfered by the introduction of a methyl group into the α-position of the amino radical.
  • 松川 泰三, 万木 庄次郎
    1952 年 72 巻 12 号 p. 1616-1619
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Hydrolysis of allithiamine with hydrochloric acid was found to yield formic acid, 2-methyl-4-amino-5-aminomethylpyrimidine (I), and α-aceto-γ-hydroxypropyl allyl disulfide (II). Reduction of (II) in acetic acid solution with zinc dust yielded allylmercaptan (IV) and γ-aceto-γ-mercaptopropyl alcohol (III). Reduction of allithiamine in alcoholic hydrochloric acid with zinc dust resulted in the formation of allyimercaptan (IV) and vitamin B1 (VI). From these results, the structure of 2-[2′-methyl-4′-amino-pyrimidyl(5′)]-methylformamino-5-hydroxy-Δ2-pentenyl(3) allyl disulfide (VII) can be given to allithiamine. Further examinations were made to find which of the component of garlic bulbs reacted with vitamin B1 to form allithiamine and it was found that the latter was formed by the reaction of allicin (IX) and vitamin B1.
  • 上農 義雄
    1952 年 72 巻 12 号 p. 1620-1622
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    The reaction of cholesteryl acetate with N, N-dichlorobenzenesulfonamide (Dichloramine-B) under the conditions used by Fieser in his oxidative reaction with N-bromosuccinimide (NBS) produced two hypochlorous acid adducts, (A) C29H49O3Cl, m.p. 195-196° (yield, 48%), and (B) C29H49O3Cl, m.p. 186-187° (yield, 7%). The melting point of (A) coincides with that of 5α-chlorocholestane -3β, 6β-diol 3-acetate. When (A) is heated with alcoholic NaOH, it undergoes saponiicatron and at the same time an oxide ring is formed to give the known cholesterol β-oxide, m.p. 131-132.5°. The acetylation of (A) results in the formation of 5α-cholestane-3β, 6β-diol 3, 6-diacetate. (B) is in complete agreement with 6β-chlorocholestane -3β, 5α-diol 3-acetate.
    The reaction of cholesterol with Dichloramine-B under the same conditions as in the case of cholesteryl acetate produced only one hypochlorous acid adduct, C27H47O2Cl, m.p. 165-166° (decomp.), in 23% yield, which corresponded with the compound representable by 5α-chlorocholestane-3β, 6β-diol. In this case the isomer having C5-OH and C6-Cl could not be isolated, probably due to the formation of this compound in a small quantity and the coexistence of several other compounds. In accordance with the inference by Urushibara, Mori, Fürst, and the others, these compounds are believed to have the above-mentioned structural arrangements.
  • 上農 義雄
    1952 年 72 巻 12 号 p. 1622-1625
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Reaction of cholesteryl acetate with N, N-dibromobenzenesulfonamide (Dibrornamine-B) in dilute acetone containing some acetic acid gave two compounds, (A) and (B). (A), C29H49O3Br, m.p. 175° (decomp.), [α]D20=-33.8° (yield, 37%), was established as 5α-bromocholestane-3β, 6β-diol 3-acetate from its acetyl derivative, oxidation product, debrominated product of the oxidation product, and the formation of a β-oxide compound by treating with alcoholic KOH. (B), C29H49O3Br, m.p. 188° (decomp.), [α]D32=-34.7° (yield, 6%), was found to be 6β-bromocholestane-3β, 5α-diol 3-acetate from the properties of the α-oxide compound obtained by treating with alcoholic KOH. Cholesteryl acetate was reacted with NBS according to the Fieser's report. In this case two compounds, (C) and (D), corresponding to the above (A) and (B) were obtained, but the 6-one compound reported by Fieser could not be isolated.
  • 上農 義雄
    1952 年 72 巻 12 号 p. 1626-1628
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Reaction of cholesterol with Dibromamine-B produced two compounds, (A) and (B). (A), C27H48O3, m.p. 236-238° (yield, 61%), was identical with cholestane-3β, 5α, 6β-triol, and (B), C27H48O2Br, m.p. 154-155° (decomp.), [α]D32=+21.1°, seemed to be the HOBr adduct of cholesterol, but this product could not be thoroughly investigated owing to its poor yield. Reaction of the triol compound (A) with Dibromamine-B or with Dichloramine-B in dioxane containing some water yielded cholestane-3β, 5α-diol-6-one, C27H46O3, m.p. 232-234°, in a good yield.
  • 禪野 久直
    1952 年 72 巻 12 号 p. 1628-1630
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Carbocyanine dyes were prepared from orthoformate and quinaldine methiodide or ethiodide or 2-methylbenzothiazole ethiodide, using 2-aminothiazole hydrochloride, formamide, p-nitrotoluene, 2-am ino-4-methylthiazole, acetamide, acetanilide, propionitrile, ammonium chloride, ethylene glycol, pyrocatechol, or dimethylaniline as an addition agent.
  • 禪野 久直
    1952 年 72 巻 12 号 p. 1630-1633
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Merocarbocyanine dyes, similar to the dyes obtained from dye intermediates and ethoxymethylene cyanoacetate, cyanoacetamide or acetoacetate, were prepared by the reaction of orthoformate and quinaldine methiodide or 2-methylbenzothiazole ethiodide, using a large amount of cyanoacetate, cyanoacetamide, cyanoacetanilide, acetoacetate, or benzoylacetonitrile as an addition agent.
  • 禪野 久直
    1952 年 72 巻 12 号 p. 1633-1636
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Merocarbocyanine dyes were prepared by reacting quinaldine methiodide or ethiodide, 2-methylbenzothiazole ethiodide, or 2-methyloxazole ethiodide, with several kinds of formyl compounds, formylcyanoacetate, formylacetate, or 2-formyl-3(2H)-thionaphthe-none, or several kinds of sodium salts of formyl compounds, formylacetone, formylacetophenone, or the sodium salt of 4-formyl-1, 3-indandione. Pentamethine cyanine dyes possessing phenyl or methyl substituents in the β-position were prepared by reacting one-half molar equivalent of the sodium salt of formylacetophenone or formylacetone to quinaldine methiodide.
  • 大田 正樹
    1952 年 72 巻 12 号 p. 1636-1639
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    By heating the hydrochloric acid solution of the hydrazides of acetic, hippuric, benzoic, phenylacetic, salicylic, p-hydroxybenzoic, and o- and p-nitrobenzoic acids with potassium thiocyanate, corresponding acylthiosemicarbazides are obtained. Treatment of these acylthiosemicarbazides with conc. sulfuric acid at a room temperature resulted in the formation of the following 5-substituted 2-amino-1, 3, 4-thiadiazoles: 5-Phenyl compound, m.p. 225°; 5-benzyl compound, m.p. 203°; 5-(o-hydroxyphenyl) compound, m.p. 223°; 5-(p-hydroxyphenyl) compound, m.p. 216°; 5-(o-nitrophenyl) compound, m.p. 232-234°; 5-(p-nitrophenyl) compound, m.p. 260°; and 5-benzoylarninomethyl compound, m.p. 218°. Hydrolysis of the 5-benzoylaminomethyl derivative yielded 2-amino-5-aminomethylthiadiazole hydrochloride. 5-Aminomethyl- and 5-aminoethyl derivatives were prepared from phthaliminoacetyl- and β-phthaliminopropionylthiosemicarbazides, respectively.
  • 清水 正夫, 内藤 武男, 太田 元吉, 鈴木 喜久次, 笠原 昭, 村井 賢三, 浅野 和夫
    1952 年 72 巻 12 号 p. 1639-1642
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Number of acid hydrazide derivatives, as given in the accompanying Table, were prepared and their antibacterial activity, in vitro, was examined in Lockemann-Bloch medium, using the so-called “Mycobacterium tuberculosis A. T. C. C. No. 607, ” with isonicotinic acid hydrazide (INAH) as the control. The compounds which possessed activities equal to or almost equal to INAH were those in which carbonyl compounds such as acetone (No. 7 in Table) or glucose (No. 8) were bonded to the amino group in INAH, or the one (No. 9) in which sodium hdyroxymethane sulfonate was bonded. The compounds marked with asterisks in the Table are new compounds prepared for the first time.
  • 清水 正夫, 堂森 廉三
    1952 年 72 巻 12 号 p. 1643-1644
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Pyridine N-oxide and its homologs undergo deoxidation when heated to 200-210° with selenium and sulfuric acid. Increase of this temperature to 290-300° results in the oxidation of the alkyl group.
  • 藤田 路一, 西本 和光
    1952 年 72 巻 12 号 p. 1645-1646
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Existing literature on the hemolytic methods for potency determination of saponinbearing drugs was examined. In the activity determination of Japanese senega, hemolytic index was obtained by using rabbit blood in a phosphate buffer solution of pH 7.4, Merck's pure Saponin as the standard. As a result, it was found that the domestic product possessed a potency equal to the drug of S. B. Penick & Co., which is assumed to be the Northern senega (cf. Table I)
  • 柿本 七郎, 関川 勳, 由本 健一
    1952 年 72 巻 12 号 p. 1646-1648
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    Several kinds of acid hydrazides were prepared and their antibacterial action in vitro was examined. As shown in Table III, p-aminosalicylic acid hydrazide was found to be far more effective than isonicotinic acid hydrazide against Mycobacterium tuberculosis. It was also pointed out that, in order for acid hydrazide to show any effective antitubercular action, the presence of a double bond in the α-position of the carbonyl would be one of the requisites.
  • 島野 武, 野村 新太郎
    1952 年 72 巻 12 号 p. 1648-1649
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
    The essential oil obtained from Thymus Serpyllum L. var. Przewalskii Komarow by steam distillation was fractionally distilled under a reduced pressure by which the chief component was found to be thymol, comprising about 35%. Other components found were linalool, p-cymene, α-pinene, and a trace of d-borneol. The oil did not contain carvacrol but it could be used in place of thymus oil.
  • 犬伏 康夫
    1952 年 72 巻 12 号 p. 1650
    発行日: 1952/12/25
    公開日: 2010/02/19
    ジャーナル フリー
  • 1952 年 72 巻 12 号 p. e6af
    発行日: 1952年
    公開日: 2010/02/19
    ジャーナル フリー
  • 1952 年 72 巻 12 号 p. e6ag
    発行日: 1952年
    公開日: 2010/02/19
    ジャーナル フリー
  • 1952 年 72 巻 12 号 p. e6b-e7
    発行日: 1952年
    公開日: 2010/02/19
    ジャーナル フリー
  • 1952 年 72 巻 12 号 p. e7aa
    発行日: 1952年
    公開日: 2010/02/19
    ジャーナル フリー
  • 1952 年 72 巻 12 号 p. e7ab
    発行日: 1952年
    公開日: 2010/02/19
    ジャーナル フリー
  • 1952 年 72 巻 12 号 p. e7ac
    発行日: 1952年
    公開日: 2010/02/19
    ジャーナル フリー
  • 1952 年 72 巻 12 号 p. e7ad
    発行日: 1952年
    公開日: 2010/02/19
    ジャーナル フリー
  • 1952 年 72 巻 12 号 p. e7ae
    発行日: 1952年
    公開日: 2010/02/19
    ジャーナル フリー
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