YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
74 巻 , 6 号
選択された号の論文の71件中1~50を表示しています
  • INAH投与による尿中成分の変化
    岩本 多喜男
    1954 年 74 巻 6 号 p. 561-565
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Oral administration of 2.0-6.5mg./kg. of INAH resulted in the increase of the amount in urine of acid and alkaline reductive substances, conjugated glucuronide, and N1-methylated INAH derivative. On the other hand, there was a decrease of ethereal sulfate. From these facts, the formation of isonicotinic acid glucuronide and N1-methylated derivative as the biologically changed products of INAH was assumed.
  • 炭水素分析に於けるPregl型吸収管の構造に関する理論的考察
    穗積 啓一郎, 今枝 一男
    1954 年 74 巻 6 号 p. 565-569
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    The Pregl type absorption tube, shown in Fig. 1, contains two peculiar parts at each end of the filling chamber; the first is the “double capillary tube” which contains a small air chamber B in the inside and the second is the “antechamber” C, separated from the filling chamber by a thin diaphragm provided with a small center hole. Diffusion rate of water vapor into the double capillary tube (shown in Fig. 2) was considered from which equation (2), was derived where the diffusion rate dw/dt consists of the permanent term and transient term (see Fig. 3). From equation (12), which means the total diffusate, it was concluded that the internal air chamber B is not indispensable because the double capillary tube would cause slightly excess amount of diffusate than that of a single-type capillary tube eliminates the internal small air chamber. The antechamber C is also dispensable by the same reason.
  • 炭水素分析用吸収管の毛細管寸法に関する理論的考察
    穗積 啓一郎, 今枝 一男
    1954 年 74 巻 6 号 p. 570-574
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    The capillary parts of absorption tube have two important duties in assuring fine operation of analyses; one is to prevent the diffusion of water vapor (or oxygen), and the other is to facilitate the flow of combustion gas. The relationship between diffusion rate, pressure drop, and the dimension of capillary tube was discussed and it was concluded that the pressure drop would decrease in proportion to the length of capillary tube when the diffusion rate is maintained at the same value. On the other hand, the internal diameter should consequently increase its previous dimension. Thus, varied dimensions of capillary tube (see Table I) which possess quite favorable characters; high diffusion-resistance and low flow-resistance were proposed, and the combination of (j) H2O, (k) CO2 for normal process, and (1) H2O, (m) CO2 for Mitsui's double combustion process, were recommended.
  • 炭水素分析に於ける低通気抵抗吸収管の設計に就いて
    穗積 啓一郎, 今枝 一男
    1954 年 74 巻 6 号 p. 574-576
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    As was concluded theoretically in the preceding papers, the absorption tube should preferably be of simplest form consisting of the filling chamber and single-type capillary tubes connected directly to each end. Moreover, some favorable dimensions were proposed for low flow-resistance capillary tube by increasing its length and internal diameter. A simplified absorption tube based on such views (shown in Fig.1) was designed to be substituted for the original Pregl type. The amount of filling agents are 1.2g. of Anhydrone and 1.1g of sodium-asbestos or sodium hydroxide granules by which the absorption capacity is sufficient for 40 analyses. The observed values of diffusion rate of water vapor on the proposed-type absorption tubes are shown in Fig. 3, compared with the types already reported.
  • 感光色素について その11
    高橋 酉藏, 佐竹 健三, 安井 茂夫
    1954 年 74 巻 6 号 p. 577-580
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    1) Application of 2, 6-lutidine ethiodide to 5, 5′-dibromodipyridyl-(2, 2′)-formamidine (I) gave, besides 2-ω-[5′-bromopyridyl-(2′)-amino]-vinyl-6-methylpyridine ethiodide (II), 2, 6-bis {ω-[5′-bromopyridyl-(2′)-amino]-vinyl}-pyridine ethiodide (III) as a by-product. (III) is also obtained by the application of (II) to (I). A bis-compound of (III)-type is obtained by the application of (II) to 5, 5′-dichloro (or diiodo)-dipyridyl-(2, 2′)-formamidine.
    2) Fusion of 2, 6-lutidine ethiodide with 2, 2′-diethoxydipyridyl-(5, 5′)-formamidine gave 2-ω-[2′-ethoxypyridyl-(5′)-amino]-vinyl-6-methylpyridine.
    3) Using the quaternary salts of 4-ethylpyridine and 5, 5′-dichloro (dibromo, diiodo)-dipyridyl-(2, 2′)-formamidine, 15 kinds of new aminovinyl compounds were prepared.
  • 感光色素について その12
    高橋 酉藏, 佐竹 健三, 安井 茂夫
    1954 年 74 巻 6 号 p. 580-583
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Twenty-five kinds of new aminovinyl compounds were prepared by the application of 3, 3′, 5, 5′-tetrachloro (or tetrabromo) dipyridyl-(2, 2′) or 5, 5′-dinitrodipyridyl-(2, 2′)-formamidine, or 2, 2′-dichloro (or diethoxy) dipyridyl-(5, 5′)-formamidine to the 4-ethyl-pyridinium salts.
  • Trichosanthes属種子の研究
    宗定 哲二, 村上 誠愨
    1954 年 74 巻 6 号 p. 584-587
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Pharmacognostical studies were made on the seeds of Trichosanthes spp., and their differentiation was made possible from their morphological and anatomical characteristics.
    I) Seed is composed of 3 chambers and contains calcium oxalate crystals.
    A) Side-chamber is empty and grooved holes are present on both ends.
    Trichosanthes cucumeroides Max.
    B) Side-chamber is filled and no grooved holes on both ends.
    T. rostrata Kitamura.
    II) Seed is flat with one chamber and no calcium oxalate crystals present.
    A) Epidermal cells are not palisaded. T. Kirilowii Max. var. japonica Kitamura.
    B) Epidermal cells are palisaded.
    1) Borders are not distinct. T. bracteata Voigt.
    2) Borders are pronounced and forms an edge. T. multiloba Miq.
  • シオール型Vitamin B1誘導体について その3
    川崎 弌
    1954 年 74 巻 6 号 p. 588-590
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Eleven kinds of 2-methyl-4-amino-5-[N-(3′-acylthio-5′-acyloxy-Δ2′-pentenyl-2′)]-formaminopyrimidine (O, S-diacyl-B1) were prepared by the application of acid anhydride or chlorde to the sodium salt of the thiol-type vitamin B1 homologs (B1, homo-B1, O-benzoyl-B1). These synthetic compounds were found to possess approximately the same effect as vitamin B1 in preventing B1-deficiency in Urolonca domestica.
  • 7-Methyl-3-alkylcoumarinの合成及びその駆虫作用
    中林 利平, 山崎 幸二
    1954 年 74 巻 6 号 p. 590-593
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Since 7-methyl- and 3-methylcoumarin showed marked anthelmintic activity, the effect of the methyl group in 7-position of 3-alkylcoumarin was examined with 7-methyl-3-alkylcoumarins synthesized. The compounds were prepared into a saturated Locke's solution and in vitro tests were carried out as in the previous papers. The compounds tested were 3, 7-dimethyl-†:, 7-methyl-3-ethyl-, 7-methyl-3-isopropyl-†:, 7-methyl-3-butyl-†:, 7-methyl-3-hexyl-†:, and 7-methyl-3-octyl-coumarin†: (those marked with†: are new compounds). Results obtained were as follows:
    1) Effect is decreased by the introduction of methyl in 7-position of 3-alkylcoumarins.
    2) In the case of 3-alkylcoumarins, spasmodic struggle of hog ascaris starts 1-2 hours after putting them in the test solution, but the same starts immediately after putting them in the solution of 7-methyl-3-alkylcoumarins.
    3) The appearance of the intermittent motionless state in hog ascaris is slightly retarded in 7-methyl derivatives, compared to 3-alkylcoumarins but such a state continues longer.
    4) The anthelmintic effect tends to decrease with the increase of the number of carbon atoms in the alkyl group of 7-methyl-3-alkylcoumarins. With the exception of 7-methylcoumarin, solubility of the lower homologs than butyl derivative became lower with the increase in the number of carbon atoms in the alkyl group, but the decrease of the anthelmintic effect was only slight.
  • 内藤 武男, 堂森 廉三, 長瀬 脩
    1954 年 74 巻 6 号 p. 593-595
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    It was found that when N-acetoactyl-p- or -o-nitrobenzenesulfonamide in aqueous solution of sodium hydroxide, carbonate, or bicarbonate, magnesium, calcium, or barium hydroxide, ammonia, or sodium cyanide, is allowed to stand at a room temperature or heated at 80-90°, a conversion reaction unknown to date in literature occurs, with liberation of sulfurous acid. It was confirmed that p- or o-nitrophenylacetamide is obtained in 73-92% yield. This reaction did not occur with compounds with substituents other than the nitro radical.
  • 内藤 武男, 堂森 廉三, 佐野 光司
    1954 年 74 巻 6 号 p. 596-599
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    The conversion accompanied by the liberation of sulfurous acid was attempted on the compounds of NO2-C6H4-SO2-NH-CO-R (p-and o-NO2) type with sodium hydroxide or carbonate. Such conversion was found to occur in the compound with R=CN to form α-(nitrophenyl)-α-cyanoacetamide; p-nitro compound, m.p. 135°, and o-nitro compound, m.p. 171-171.5° (decomp): in the case of R=COOC2H5, p-nitrophenylacetamide; and in the case of R=C6H5, p-nitrodiphenylacetamide, m.p. 142-144°, and 3-phenyl-indazole, m.p. 107-109°.
  • Ninhydrin反応中間成績体の構造
    山岸 正治
    1954 年 74 巻 6 号 p. 599-601
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    The yellow crystals obtained by the reaction of 2-methyl-4-amino-5-aminomethyl-pyrimidine and ninhydrin were heated with N hydrochloric acid on a boiling water bath for 1 hour. The decomposition products thereby obtained were 2-methyl-4-amino-pyrimidyl-(5)-aldehyde, NH4Cl, 1, 3-dioxohydrindole, hydrindantine, and bis (1, 3-indanedione). Of these, the chief products are the aldehyde, NH4Cl, and 1, 3-dioxohydrindole from which it was confirmed that the yellow crystals were those of 2-methyl-4-aminopyrimidyl-(5)-methylidene-dioxohydrindamine.
  • ケトカルボン酸エステルのdithiocarbamateについて
    吉田 茂, 石塚 亘
    1954 年 74 巻 6 号 p. 602-605
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Reaction of benzylamine or 2-methyl-4-amino-5-aminomethylpyrimidine, carbon disulfide, and α- or β-haloketocarboxylic ester respectively yielded N-substituted 4-hydroxythiazolidine-2-thione (IV), (XVII), and (XXIII). The objective compound could not be obtained in the case of α-alkyl-α-haloketocarboxylic ester. The reaction of dimethylamine, α-haloketocarboxylic ester, and carbon disulfide gave N-substituted dithiocarbamate (VII). (IV) does not give any coloration with ferric chloride but (VII) gives a blue violet coloration, from which the structure of (IV) was confirmed.
  • 吉田 茂, 岩重 忠博
    1954 年 74 巻 6 号 p. 605-607
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Ammonium salts of several kinds of carboxylic alkamine esters were prepared, as compounds possessing anticonvulsant action, by the rearrangement of ammonium carboxylate compounds and examinations were made on their reaction mechanisms.
  • キサンテン-9-カルボン酸の合成について
    赤木 三郎, 岩重 忠博
    1954 年 74 巻 6 号 p. 608-610
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Xanthylmalonic acid was prepared from xanthydrol and malonic acid in a mixed solvent of glacial acetic acid, alcohol, and water. Methyl xanthylacetate prepared therefrom was submitted to the Grignard reaction to derive it to the corresponding tertiary alcohol and its oxidative decomposition was carried out in an attempt to obtain xanthene-9-carboxylic acid but resulted in the formation of xanthone. Oxidation of the acid similarly forms xanthone easily. Xanthene-9-carboxylic acid was finally prepared from 1 mole of xanthene and 1 mole of sodium phenoxide, mixed in benzene, and ether added at 0° to -20°, and by bubbling carbon dioxide through this mixture.
  • キサンテンジカルボン酸及びキサンテン-9-アリル-9-カルボン酸について
    赤木 三郎, 岩重 忠博
    1954 年 74 巻 6 号 p. 610-614
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    When over two moles of sodium phenoxide are applied to xanthene, not only 9- but also 4- and 9-positions undergo sodium metalation or two in 9-position. These were confirmed by their respective derivation to xanthene-9-carboxylic acid, xanthene-4, 9- and -9, 9-dicarboxylic acids. In order to test the analgesic action of 9-arylxanthene-9-carboxylic alkamine esters, xanthene-9-(o-tolyl)-9-carboxylic acid was prepared. Iodine substituted in the nucleus of a diphenylmethane-type was found to undergo halogen-metal interconversion without undergoing metallation with the methylene group.
  • キサンテン核を有するカルボン酸アルカミンエステルアンモニウム塩の合成並びに鎭痙作用について
    岩重 忠博, 高木 弘
    1954 年 74 巻 6 号 p. 614-618
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    1) Preparation of the ammonium salts of carboxylic alkamine esters possessing structures similar to β-diethylaminoethylxanthene-9-carboxylate methobromide was carried out and comparative examination of their pharmacological action was made.
    2) The compounds substituted with phenyl (IX) and o-tolyl (X) in 9-position of the xanthene ring possessed very weak antiacetylcholinergic and antihistamine actions, possessed a high toxicity, and only a slightly stronger antibarium chloride activity.
    3) A substance in which -CH2- (XI) or -CH (CH3)- (XII) was substituted between 9-position of the xanthene ring and the carboxyl group possessed weak antiacetylcholinergic, antibarium chloride, and antihistamine actions while there was no change in toxicity. However, antiacetylcholinergic action was stronger than those of (IX), (X), and (XII).
    4) The variation by each chemical and by the difference in experimental animals and intestinal specimens against experimental error was found to be significant in the difference between the chemical and animal.
  • 菅澤 重彦, 太刀川 隆治
    1954 年 74 巻 6 号 p. 619-620
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    In order to test the influence of the position occupied by 3, 4-dimethoxybenzyl group of papaverine upon its physiological poperties, 6, 7-dimethoxy-3-(3′, 4′-dimethoxybenzyl)-isoquinoline, an isomer of papaverine, was synthesized. The known 6, 7-dimethoxy-3-(3′, 4′-dimethoxybenzyl)-3, 4-dihydroisoquinoline was dehydrogenated by boiling its p-cymene solution in the presence of palladium-carbon and cinnamic acid in carbon dioxide atmosphere.
  • パパベリン類似化合物の合成研究その6
    亀谷 哲治, 大槻 一夫
    1954 年 74 巻 6 号 p. 621-625
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Papaverine, neupaverine, and eupaverine are important antispasmodics of the isoquinoline compounds. In order to examine the pharmacological action of the substance formed by the exchange of substituents in 1-and 3-positions, 1-methyl-3-(3′, 4′-methylenedioxyphenyl)-6, 7-methylenedioxyisoquinoline was prepared. Attempt to cyclize N-acyl-α, β-bis (3, 4-methylenedioxyphenyl)-ethylamine by the Bischler-Napieralski reaction to 3, 4-dihydroisoquinoline derivative ended in failure. Ethylamine with hydroxyl in β-position, i.e. N-acyl-β-hydroxy (or methoxy)-α, β-bis (3, 4-methylenedioxyphenyl)-ethylamine was prepared by various methods and submitted to the Bischler-Napieralski reaction from which the objective 1-methyl (or phenyl)-3-(3′, 4′-methylenedioxyphenyl)-6, 7-methylenedioxyisoquinoline was obtained. 1-Methyl compound came as colorless needles of m.p. 136-137.5°.
  • 菅澤 重彦, 吉田 二郎
    1954 年 74 巻 6 号 p. 625-632
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Nine new 1-tert-alkyl-6, 7-methylenedioxy-3-methylisoquinolines were synthesized by treating α-3, 4-methylenedioxyphenyl-α-methoxyisopropylamide of tri-substituted acetic acid with phosphoryl chloride by the Rosenmund-Mannich reaction. Xylene was found to be the solvent of choice. The ring-closure was more difficult than in the usual cases and under milder conditions-benzene or toluene as a solvent and shorter heating time- oxazolines were obtained exclusively or chiefly together with some isoquinolines. These oxazolines were converted into the corresponding isoquinolines by heating with POCl3- xylene, so the former can be regarded as the intermediate of the latter. The yield of isoquinoline decreases with the increase of the molecular weight of the tertiary alkyl group and thus 1-triisoamylisoquinoline could not be synthesized by the present method. Pharmacological properties of these isoquinolines are now being examined.
  • 吉田 二郎
    1954 年 74 巻 6 号 p. 633-640
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    In the synthesis of isoquinolines through cyclization of acyl β-(3, 4-methylenedioxyphenyl)-β-methoxyphenethylamides by means of phosphoryl chloride according to the Rosenmund Mannich, it was found that oxazolines are formed in preference to isoquinolines under milder cyclizing conditions. The former are to be regarded as the intermediate of the latter, since they, regardless of cis- or trans-form, can be converted into the corresponding isoqninolines in good yields under a more vigorous conditions.
  • サポゲノールの誘導体
    石館 守三, 高村 圭一
    1954 年 74 巻 6 号 p. 641-644
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Isopropylidene condensation of Camellia-sapogenol was carried out by conc. sulfuric acid and dehydrated acetone and colorless plates, m.p. 225-226° (corr.), [α]D: +63.25° (c=1.00, 94% EtOH) were obtained. Isopropylidenesapogenol was acetylated by the usual method to diacetylisopropylidenesapogenol as needles, m.p. 193-195° (decomp.) (corr.), [α]D: +23.0° (c=1.00, 94% EtOH) whose hydrolysis with 70% alcohol containing 1-0.5% hydrochloric acid yielded monoacetylsapogenol as prisms, m.p. 247-249° (decomp.) (corr.), [α]D: -6° (c=1.00, 94% EtOH). The oxygen atoms in camellia-sapogenol C30H50O4, are those in four hydroxyls, of which, two hydroxyls in the isopropylidene linkage were assumed to take 1:3-configuration rather than α-glycol form, while the other two hydroxyls seem to be of different nature, according to their respective behavior to hydrolysis by alcohol containing hydrochloric acid.
  • サポゲノール並びに誘導体の酸化
    高村 圭一
    1954 年 74 巻 6 号 p. 645-649
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Chromic acid oxidation of camellia-sapogenol in glacial acetic acid solution gave crystals of m.p. 254-258° (decomp.) (corr.), [α]D18: 0° (c=0.405, CHCl3), whose analytical values agreed with those of a tetrone compound, C30H42O4. Similar chromic acid oxidation of isopropylidene-sapogenol gave crystals of m.p. 240-245° (decomp.) (corr.), [α]D18: +113.2° (c=0.265, CHCl3), whose elemental analysis indicated it to be the dione compound, C33H50O4. Since the chromic acid oxidation product of sapogenol does not possess acid, aldehyde, hydroxyl, or lactone grouping, all four hydroxyls in sapogenol are assumed to be secondary hydroxyls. Oxidation of diacetylisopropylidene sapogenol in glacial acetic acid solution with selenium dioxide gave crystals of m.p. 234-234.5° (corr.), [α]D18: 0° (c=0.135, CHCl3), λmax 251mμ, corresponding to the diene compound, C37H56O6. Similar oxidation of triterpenes of α- and β-amyrin series with selenium dioxide resulted in complete recovery of the α-amyrin series but facile dehydrogenation occured in those of β-amyrin series to the diene compound with maximum absorption at 251mμ, from which it was assumed that camellia-sapogenol belonged to the triterpene of β-amyrin series, rather than that of α-amyrin series.
  • β-(2´-Amino-4´-methyl-5´-thiazolyl)-ethylisothiouronium塩に就いて その1
    谷田 博, 田村 郁子, 澤 芳郎
    1954 年 74 巻 6 号 p. 649-652
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Acetylation of γ-aceto-γ-chloropropyl alcohol by heating with glacial acetic acid yielded yellow fraction containing halogen, besides γ-aceto-γ-chloropropyl acetate. Reaction of the yellow fraction with thiourea gave a substance assumed to be β-(2′-amino-4′-methyl-5′-thiazolyl)-ethylisothiouronium dihydrochloride. This salt, when dissolved in sodium hydroxide solution and oxidized with hydrogen peroxide, gave bis (2-amino-4-methyl-5-thiazolyl ethyl) disulfide, m.p. 174.5-175.5°.
  • β-(2´-Amino-4´-methyl-5´-thiazolyl)-ethylisothiouronium塩に就いてその2
    谷田 博, 田村 郁子, 澤 芳郎
    1954 年 74 巻 6 号 p. 652-654
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    The new substance of m.p. 241-242°, described in the previous paper, was found to be β-(2′-amino-4′-methyl-5′-thiazolyl)-ethylisothiouronium hydrochloride by its agreement with the substance synthesized by the following two different methods:
    1) Reaction between γ-aceto-γ-chloropropyl chloride and thiourea.
    2) Alkali treatment of 2-acetylamino-4-methyl-5-acetoxyethylthiazole, obtained from 2-amino-4-methyl-5-hydroxy (or acetoxy)-ethylthiazole, to 2-acetylamino-4-methyl-5-hydroxyethylthiazole, its chlorination to the 5-chloroethyl compound, with subsequent reaction with thiourea and saponification with hydrochloric acid.
  • 抗結核菌性について
    宮木 高明, 池田 仁三郎
    1954 年 74 巻 6 号 p. 655-657
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Antibacterial activity of 30 kinds of 1, 4-naphthoquinones substituted in 2- and 2, 3-positions was tested with human type Kawakami strain, H37RV, and Frankfurt strain of tubercle bacilli, with streptomycin and INAH as controls. The results are shown in Tables I and II from which it has been shown that 2-amino-3-chloro-1, 4-naphthoquinone (No. 20) and 2-bromo-3-methylthio-1, 4-naphthoquinone (No. 25) possessed antibacterial activity close to that of dihydrostreptomycin.
  • Imidazo化合体の合成その4 Imidazo [2, 1-b] thiadiazole 誘導体 (2)
    伴 彰一
    1954 年 74 巻 6 号 p. 658-661
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    1) By reacting 2-amino-5-R-1, 3, 4-thiadiazoles (R=H, CH3, C2H5, or C6H5) with bromoacetone in alcohol, 2-imino-3-acetonyl-5-R-2, 3-dihydro-1, 3, 4-thiadiazoles were obtained which on boiling with water, yielded 2-R-6-methylimidazo [2, 1-b] thiadiazole.
    2) Heating of 2-amino-5-R′-1, 3, 4-thiadiazoles (R′=H, CH3, C2H5) and ethyl α-chloro (or bromo)-acetoacetate in hydrated alcohol gave 2-R′-6-methyl-5-carbethoxyimidazo [2, 1-b] thiadiazoles which were derived to the 5-carbohydrazino compounds.
    3) Saponification of 6-methyl-5-carbethoxyimidazo [2, 1-b] thiadiazole was attempted but corresponding carboxylic acid could not be isolated.
    4) Reaction of 2-amino-1, 3, 4-thiadiazole with bromophenylacetone or α-bromo-cyclohexanone resulted in resinification. Reaction of 2-amino-1, 3, 4-thiadiazole with α, β-dibromoethyl acetate in pure alcohol gave 2-acetamino-1, 3, 4-thiadiazole in almost quantitative yield.
  • 山岸 正治, 森本 浩, 吉田 慰子, 松岡 敏郎
    1954 年 74 巻 6 号 p. 662-665
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    The coloration of digenic acid, the effective principle of Digenea simplex, with ninhydrin differs in acid and alkaline reaction. In acid solution, the dye produced transits to the organic solvent layer, and that in the isobutyl alcohol solution shows absorption maximum at 410mμ, the color fading by light. In the case of alkaline solution, the production of the dye increases by the addition of a reductive agent, such as ascorbic acid, besides ninhydrin. The colored solution exhibits the absorption maximum at 425mμ. Both reactions can be utilized for the colorimetric determination of digenic acid. After warming at 70° the solution of digenic acid with ninhydrin at pH 4, the dye is transited to the isobutyl alcohol layer, or the acid is heated in aqueous pyridine solution or in a buffer of pH 8.5, with the addition of a small amount of ascorbic acid, for 15 minutes at 100°, the red color of reduced ninhydrin is discolored by air oxidation, and the resultant solution is submitted to colorimetry. The optimal determination range is 10-50 γ in acid reaction, and 30-150γ in alkaline reaction. With Digenea extract, digenic acid is isolated by paper partition chromatography and colorimetrically determined. The content of digenic acid in Digenea simplex Ag. is usually around 450-500mg. per kg.
  • 山岸 正治, 吉田 慰子
    1954 年 74 巻 6 号 p. 665-666
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Digenic acid, the effective principle of Digenea simplex Ag., can be colorimetrically determined by the Troll method with sodium 1, 2-naphthoquinone-4-sulfonate as the reagent, similar to proline and hydroxyproline.
  • 3,5-Dinitro-4-cyanopyridinの合成
    落合 英二, 鈴木 郁生, 二木 清
    1954 年 74 巻 6 号 p. 666-668
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    3, 5-Dinitro-4-cyanopyridine was prepared from 3, 5-dinitro-4-chloropyridine by heating it with cuprous cyanide, directly or in nitrobenzene, as platelet crystals of m.p. 140°, with a maximum yield of 45%. Treatment of 4-hydroxy-3, 5-dinitro-α-picoline 1-oxide with phosphorus trichloride in ethyl acetate gave 3, 5-dinitro-4-hydroxy-α-picoline in 87% yield, as pale yellow plates, m.p. 269° (decomp.). Further heating of the latter with phosphoryl chloride gave 3, 5-dinitro-4-chloro-α-picoline in 73% yield as colorless prisms, m.p. 108°. The latter was easily sublimable and its heating with cuprous cyanide failed to yield 4-cyano derivative, resulting in the recovery of 70-90% of the starting material.
  • 和田 正三
    1954 年 74 巻 6 号 p. 668-671
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    It was found that the raw cotton used for the cotton plugging of test tubes contained numerous growth factors for bacteria and such action was tested by a bioassay. It was thereby found that such factors were contained in approximately 3.5γ/g. as pantothenic acid, approx. 7γ/g. as biotin, approx. 4γ/g. as nicotinamide, approx. 0.15γ/g. as riboflavine, and approx. 0.8-5mγ/g. as vitamin B12. Same tests were carried out on absorbent cotton and glass wool but such activities were not found in them. It is therefore concluded that a strict caution is necessary in using cotton plugging for test tubes in microbiological assay.
  • 1-Amino-2-thiohydantoinに就いて
    卯尾田 秀隆, 高井 明, 中村 善之助
    1954 年 74 巻 6 号 p. 672-674
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Ethyl hydrazinoacetate hydrochloride (II) and potassium thiocyanate (III) were fused together to form ethyl N1-thiocarbamylhydrazinoacetate (IV), m.p. 130°, which was cyclized by treatment with dilute mineral acid. Rendering this solution slightly acid by the addition of alkali yielded 1-amino-2-thiohydantoin (VI), which was also formed by the heating of (II) and (III) at a high temperature for a long period, as pale yellow needle crystals, m.p. 188° (decomp.). Hydrochloride of (VI), colorless rhombic crystals, m.p. 168° (decomp.). These compounds were derived through the benzylidene compounds to the known compounds by desulfurization and their structures confirmed.
  • 4-アミノウラシルのメチル化に就いて その1
    鵜飼 貞二, 山本 讓, 金友 昭一
    1954 年 74 巻 6 号 p. 674-677
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Methylation of 4-aminouracil (I) was examined and it was found that the 3-methylated compound (II) was chiefly formed, and a substance (III) of m.p. 320-321° (decomp.), that was formed by the addition of H2O to (I), was also produced. Coloration of allied substances to conc. nitric acid was examined for comparison.
  • 4-アミノウラシルのメチル化に就いて その2
    鵜飼 貞二, 山本 讓, 金友 昭一
    1954 年 74 巻 6 号 p. 678-681
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    In the formation of 3-methyl-4-aminouracil (II) from 4-aminouracil (I), the relationship between the methylation agent, pH, amount of sodium hydroxide, and the reaction temperature was examined and the maximum yield of 65% was obtained. The structure of 4-aminouracil was examined from its chemical reactions and the spectrum and equilibrium formulae by the change of pH were forwarded. The perchlorate of allied substances were prepared for comparative identification and detection.
  • 卵巣油を構成する高級アルコール その1
    梅澤 文輔
    1954 年 74 巻 6 号 p. 682-686
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    The higher alcohols from the oily non-saponifiable matter of globefish ovaries were isolated and purified by derivation to urea complex and fractionation of the acetate. Docosanol and cetyl alcohol were confirmed as the saturated alcohols, and cis-Δ11-eicosenol and oleyl alcohol as unsaturated alcohols. Determination of the latter was made by hydrogenation, oxidative decomposition, and synthesis.
  • 増田 亨, 那波 速男, 淺井 滿子
    1954 年 74 巻 6 号 p. 687-690
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    Separatory determination of digenic acid was carried out by filter paper electrophoresis and the effect of various buffer solutions was examined. It was found that the Theorell buffer of pH 8.5 was the best while 100 γ to 2mg. of the sample spotted on the filter paper gave satisfactory results. Colorimetric determination was made with ninhydrin and the range of error was ±2%.
  • 4,4´-Diaminodiphenyl Sulfoneによるグルクロン酸の比色定量
    石館 守三, 栗山 勳, 瀧谷 昭司
    1954 年 74 巻 6 号 p. 690-692
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    In order to study the determination method for glucuronic acid, coloration of 20 kinds of aromatic amines and glucuronic acid was examined. It was thereby found that coloration with 4, 4′-diaminodiphenyl sulfone was comparatively good. Various conditions for its use in the determination were examined and the following procedure was found to be satisfactory. To 1 cc. of the sample, 5 cc. of 1% solution of 4, 4′-di-aminodiphenyl sulfone in 3.5% hydrochloric acid and 3cc. of conc. hydrochloric acid are added, and the whole volume is brought to 10cc. with water. After warming this on a boiling water bath for 30 minutes, it is cooled, allowed to stand for 35 minutes, and filtered. The absorbence at 500mμ is determined with the Beckman photoelectric spectrophotometer and the concentration of glucuronic acid is obtained from the detection curve preliminarily calculated. The accuracy is within 10%. This method is not so satisfactory for the determination of glucuronic acid but is advantageous in that it is not hinderd by the presence of other neutral sugars.
  • 高田 善之, 松田 敏雄
    1954 年 74 巻 6 号 p. 693-694
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    A solution of the diazonium compound obtained from 3, 4-methylenedioxyaniline was decomposed by adding it dropwise into the hot aqueous solution of urea, copper sulfate, and sulfuric acid, the mixture was distilled by the passage of steam, and the distillate was extracted with ether from which sesamol (3, 4-methylenedioxyphenol) was obtained in 12% yield.
  • 2-Amino-1,3,4-thiadiazole及び2-Amino-5-methyl-1,3,4-thiadiazoleの製造法について
    伴 彰一
    1954 年 74 巻 6 号 p. 694-697
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    1) 2-Amino-1, 3, 4-thiadiazole was prepared from thiosemicarbazide by application of 80% formic acid to 1-formylthiosemicarbazide which was derived to 2-formamino-1, 3, 4-thiadiazole.
    2) 1-Acetylthiosemicarbazide was heated with acetic anhydride to form 2-acetamino-5-methyl-1, 3, 4-thiadiazole which was derived to 2-amino-5-methyl-1, 3, 4-thiadiazole.
    3) Heating of 1-acetylthiosemicarbazide with 80% formic acid resulted in transacylation with cyclization to form 2-formamino-1, 3, 4-thiadiazole.
    4) 5-Substituted 2-acetamino-1, 3, 4-thiadiazole was not generally obtained pure when 1-acylthiosemicarbazide was heated with acetic anhydride.
  • 1-Aminohydantoinに就いて
    卯尾田 秀隆, 高井 明, 谷崎 太吉, 横井 敏子
    1954 年 74 巻 6 号 p. 697-698
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
    1-Aminohydantoin hydrochloride was neutralized with alkali carbonate, evaporated to dryness, and the residue treated with hot alcohol by which 1-aminohydantoin was isolated in a free state as colorless needle crystals, m. p. 193°. Ethyl N1-carbamido-N2-benzylidenehydrazinoacetate, m. p. 154-155°, obtained by the application of benzaldehyde to ethyl N1-carbamidohydrazinoacetate was found to undergo cyclization with acid or alkali to form N1-benzylidene-1-aminohydantoin.
  • 徳山 幹治, 武田 健一, F. Sorm, V. Herout
    1954 年 74 巻 6 号 p. 699-700
    発行日: 1954/06/25
    公開日: 2010/02/19
    ジャーナル フリー
  • 1954 年 74 巻 6 号 p. e1a
    発行日: 1954年
    公開日: 2010/02/19
    ジャーナル フリー
  • 1954 年 74 巻 6 号 p. e1b
    発行日: 1954年
    公開日: 2010/02/19
    ジャーナル フリー
  • 1954 年 74 巻 6 号 p. e1c
    発行日: 1954年
    公開日: 2010/02/19
    ジャーナル フリー
  • 1954 年 74 巻 6 号 p. e1d
    発行日: 1954年
    公開日: 2010/02/19
    ジャーナル フリー
  • 1954 年 74 巻 6 号 p. e1e
    発行日: 1954年
    公開日: 2010/02/19
    ジャーナル フリー
  • 1954 年 74 巻 6 号 p. e2aa
    発行日: 1954年
    公開日: 2010/02/19
    ジャーナル フリー
  • 1954 年 74 巻 6 号 p. e2ab
    発行日: 1954年
    公開日: 2010/02/19
    ジャーナル フリー
  • 1954 年 74 巻 6 号 p. e2ac
    発行日: 1954年
    公開日: 2010/02/19
    ジャーナル フリー
  • 1954 年 74 巻 6 号 p. e2ad
    発行日: 1954年
    公開日: 2010/02/19
    ジャーナル フリー
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