The biotin
d-sulfoxide-like factor, contained in a large amount in royal jelly, was examined as to what form it is present in the larva of queen bee. It was thereby learned, from the activity ratio against
L. arabinosus and
L. casei, that the majority is present as biotin and the factor corresponding to biotin
d-sulfoxide is present only in about 1/3 the amount of biotin. The bacterial body of
L. arabinosus, grown by the biotin
d-sulfoxide-like factor in royal jelly, also contains biotin similar to that grown with biotin.
From the experimental results obtained to date, the mutual relationship of the biotin-like factors in honey, royal jelly, and allied substances may be summarized as follows: (1) Biotin in bee bread comes from the pollens. (2) Biotin and biotin
d-sulfoxide in mature working bees were probably produced by the biological oxidation of biotin in pollens and bee-bread to biotin
d-sulfoxide. (3) Biotin in the honey must have been dissolved out from the pollens mixed in honey and biotin
d-sulfoxide must have been secreted by working bees. (4) Biotin
d-sulfoxide in royal jelly was secreted by working bees. (5) Biotin in the larva of queen bee must have been formed by the reduction of biotin
d-sulfoxide in royal jelly.
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