巻号一覧
82 巻, 9 号
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郡 定之, 河野 通文1962 年 82 巻 9 号 p. 1211-1213
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーThere are several methods for the determination of Ipecacuanha roots, such as the determination of total alkaloids as emetine, or separation into phenolic and nonphenolic bases and determination of each base as cephaeline or emetine, but neither of these can be termed a perfect one for separation of the componental alkaloids. Systematic separation of various alkaloids in the Ipecacuanha root was attempted through partition chromatography. Two chromatographic columns were connected end to end, using Celite as the retaining agent for the stationary phase of N sodium hydroxide and a buffer of pH 6.4 for each of the columns. The total alkaloids were charged on the upper column and the columns were developed with ether as the moving phase to fix the phenolic bases in the first alkaline column and separated from the non-phenolic bases. The columns were then eluted consecutively with chloroform and chloroform-ethanol mixture (5:1) to elute out cephaeline and psychotrine. The non-phenolic bases that transited to the second column were eluted consecutively with ether, chloroform, and chloroform-ethanol mixture (5:1) to separate emetine from other non-phenolic bases such as emetamine and O-methyl-psychotrine. The separated emetine, cephaeline, and psychotrine were determined by non-aqueous titration with a good result.抄録全体を表示PDF形式でダウンロード (399K) -
中国産延胡索成分のアルカロイド新塩基CorydalmineおよびDehydrocorydalmineについて今関 和泉, 田口 平八郎1962 年 82 巻 9 号 p. 1214-1219
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーThe isolation of 10 sorts of alkaloid, shown in Table I, extracted from Engosan, Chinese plant are described. Two new phenolic bases isolated in protoberberine series alkaloid among them have been named Corydalmine (V) (m.p. 238-239°(vac), [α]D30+337.4 (CHCl3), C20H23O4N, colorless needles) and dehydrocorydalmine (VII) (Iodide, m.p. 228-230° (docomp) C20H20O4NI⋅2.5H2O, yellowish orange needles), respectively. It has been confirmed that O-CH3 derivative of (VII) corresponded palmatine and that the tetrahydro derivative to (V). The compound (V) provides one hydroxyl group and 3 methoxy groups which may attach at 2, 3, 9 and 10 position.
From the nature of negative reaction to the Gibbs reagents, no hydroxyl group at 3 or 9 position of the tetrahydroberberine nuclei has been found to exist. Furthermore, an admixture of the samples and a comparison with IR spectrum showed that they were not coincidend with tetrahydrojatrorrhizine (II), tetrahydrocolumbamine (III) or palmatrubine (IV). This fact suggested the presence of hydroxy group at 10 and the OCH3 at 2, 3 and 9. (VII) is the dehydroform of (V).抄録全体を表示PDF形式でダウンロード (881K) -
アルキルサルフェイトの製剤への応用 その4 包接化合物の形成内海 勇, 原田 清, 河野 啓一1962 年 82 巻 9 号 p. 1219-1225
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーIt has been found that higher alkyl sulfate (C 10-18) of several basic chemicals such as thiamine form complexes comparatively easily with cyclodextrin, especially α-dextrin in water or hydrated ethanol solution.
The complexes contain about 10% of alkyl sulfate which was extracted by 90% ethanol at room temperature. A comparison of X-ray diffraction patterns by the powder method showed that these complexes have a resembling crystalline structure with the cyclodetrin complexes already known and it was concluded to be inclusion compounds having constant molar ratio.
It was also observed that the thiamin dilauryl sulfate among α- and β-cyclodextrin complexes provided pretty higher stabilities against alkali under high temperature and high humidity.
Water soluble chemicals which are usually difficultly included, will form inclusion compound when it will be transfered to alkyl sulfate.抄録全体を表示PDF形式でダウンロード (863K) -
森口 昭司, 於勢 真輔, 高松 秀二1962 年 82 巻 9 号 p. 1226-1229
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリー1-Phenyl-1, 2-bisbenzamido-1-propene (III) was obtained by treating 4(5)-methyl-5(4)-phenylimidazole (II) with benzoyl chloride, prepared by the reaction between 1-hydroxy-1-phenyl-2-propanone (I) and formamide. By the reduction of (III), followed by the hydrolysis, it gave erythro-1-phenyl-1, 2-propanediamine (V), which was also derived from the imidazol compound (VI), prepared by the reaction between (I) and urea. When methylbromide was reacted to N, N, N′, N′-tetramethyl compound of (V), N-methylephedrine methobromide were produced by the partial decomposition. The hydrolysis of (III) gave N-(α-acetylbenzyl) benzamide, from which were prepared erythro-1-amino-1-phenyl-2-propanols and threo-isomers, shown in Chart 2.抄録全体を表示PDF形式でダウンロード (688K) -
森口 昭司, 於勢 真輔, 高松 秀二1962 年 82 巻 9 号 p. 1230-1233
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーThe preparations of N-substituted 3-hydroxy-3-phenyl-4-amino-2-butanone (II) from 1-hydroxy-1-phenyl-2-propanone (I) by the Mannich reaction are described. The reduction of the above compound obtained gave 1-amino-2-phenyl-2, 3-butanediol derivative (III) and its diastereoisomer, and the Grignard reaction gave 1-amino-2-phenyl-3-alkyl (or aryl)-2, 3-butanediol derivative (V). The Mannich base of 1-phenyl-2-propanone was reduced to N-substituted 3-phenyl-4-amino-2-butanol.抄録全体を表示PDF形式でダウンロード (537K) -
森口 昭司, 於勢 真輔, 高松 秀二1962 年 82 巻 9 号 p. 1233-1236
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリー1-Dimethylamino-3-phenyl-2-butanone and 1-dimethylamino-2-phenyl-3-butanone were synthesized by the pinacol rearrangement of 1-dimethylamino-2-phenyl-2, 3-butanediol. When 1-dimethylamino-3-phenyl-2-butanol which was reduced previously from the former 2-butanone derivative was treated by thionyl chloride, it gave chloro compound, but, phosphorous pentachloride reacted to N, N-dimethyl-2-phenyl-3-chlorobutylamine by the Wagner-Meerwein rearrangement.
Similar results were also obtained with 1-piperidino-2-phenyl-2, 3-butanediol.抄録全体を表示PDF形式でダウンロード (593K) -
ホモジナイザー処理による転相現象について島本 次雄1962 年 82 巻 9 号 p. 1237-1240
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーIt is well known that the homogenizer is a very effective equipment for O/W emulsification. However, when the preliminary emulsion containing a large amount of oil as the internal phase was processed with the Hydropulse homogenizer at high pressure, it happened to decrease the emulsion viscosity and increase the specific resistance. The phenomenon was found to be a phase inversion with partial separation of oil phase and this occurred at a lower processing pressure when the oil phase volume was larger and the preliminary emulsion temperature was higher. Tolerable maximum processing pressure at which phase inversion did not occur was called “critical processing pressure.”
The data of this study were subjected to statistical evaluation and indicated that the first- and second-order term of oil phase volume and the first-order term of preliminary emulsion temperature significantly affected “critical processing pressure.” Moreover, the observation equation was introduced by the method of least squares, as follows: P=6.53V2-1100V-17T+47350 where P is the critical processing pressure (psi), V is the oil phase volume (in %), and T is the preliminary emulsion temperature (°C). The possibility that the hydrodynamic cavitation might be a significant factor in phase inversion was discussed.抄録全体を表示PDF形式でダウンロード (521K) -
O/W型乳剤の安定性試験島本 次雄1962 年 82 巻 9 号 p. 1241-1245
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーEmulsion is broken in two passages, by drainage and coalescence. In order to estimate the coalescence of emulsion, the constant amount of oil-in-water sample emulsion on a flat glass plate was dried by maintaining at relative humidity of 11%, and the coalescence of oil particles was accelerated. The increase in size of oil particles with time was measured by the turbidimetric method.
As shown in Figs. 1, 2, and 3, where extinction was plotted in logarithmic scale against drying time, it was observed that the most plots were linear and consisted of two fairly well-defined regions, one in which the change of extinction was very little with time, and the other in which the decrease of extinction was much more rapid. There was a marked correspondence between the sustaining time to coalescence determined by this method and the shelf stability found at room temperature for long period, except for a viscous sample.抄録全体を表示PDF形式でダウンロード (588K) -
3-Substituted 2-Hydrazinoquinoxalineとカルボニル化合物との反応 (2)西海枝 東雄, 田上 昇一郎1962 年 82 巻 9 号 p. 1246-1251
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリー2-Chloro-3-R-quinoxaline (R=OCH3, OC2H5, OCH(CH3)2, OC4H9, OCH2CH(CH3)2, OCH(CH3)(C2H5)) is prepared by addition of sodium alkoxide to 2, 3-dichloroquinoxaline. Addition of hydrazine hydrate to it easily gives 2-hydrazino-3-R-quinoxaline. This hydrazino compound undergoes cyclization to 1-substituted 4-R-s-triazolo[4, 3-a]quinoxaline by reaction with ortho-ester and acetic anhydride. Although it undergoes cyclization to the triazole compound by reaction with formic acid, R is hydrolyzed when it is OCH(CH3)2 and OCH(CH3)(C2H5), and forms s-triazolo[4, 3-a]quinoxalin-4-ol. Heating of 1-methyl-4-methoxy-s-triazolo[4, 3-a]quinoxaline to above its melting point results in rearrangement of the methyl group in methoxyl to the nitrogen in 5-position to form 1, 5-dimethyl-s-triazolo[4, 3-a]quinoxalin-4(5H)-one.抄録全体を表示PDF形式でダウンロード (658K) -
フェノール性および中性成分 その2 新フェノール性ダイテルペンCryptojaponolについて近藤 民雄, 須田 元茂, 手島 睦子1962 年 82 巻 9 号 p. 1252-1255
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーFrom cryptomeria resin, a phenolic diterpene, C21H30O3, m.p. 204-205°, [α]D25 25.3° has been newly obtained. It was named cryptojaponol, which provided one each of methoxyl, carbonyl and phenolic hydroxyl group.
An investigation on the location of the reciprocal functional groups suggested a presentation of (V) as a presumptive structure.抄録全体を表示PDF形式でダウンロード (538K) -
4,4´-Diphenyl-6,6´-dimethyl-2,2´-biquinolineによる銅の比色定量について中野 三郎1962 年 82 巻 9 号 p. 1256-1261
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーThe calibration curves of the main compounds among 2, 2′-biquinoline derivatives (unsubstituted, 4, 4′-dimethyl, 4, 4′, 6, 6′- and 4, 4′, 7, 7′-tetramethyl, 4, 4′-diphenyl, 4, 4′-diphenyl-6, 6′- and -7, 7′-dimethyl, 4, 4′-dimethyl-6, 6′-dimethoxy, 1, 1′-dimethyl-3, 3′-bibenzo[f]quinoline), in isopentyl alcohol and dimethylformamide, were established.
The extraction method with isopentyl alcohol was found to be very suitable for the micro quantitative determination of copper (ca. less than 1γ/cc.) and, 4, 4′-diphenyl-6, 6′-dimethyl-2, 2′-biquinoline (PMB), the most sensitive reagent among them, has been employed for the determination. UV spectrum of PMB, as well as UV and visible region spectra of cuprous chelate were measured and the colorimetric determination of trace of copper has been established by measuring at 554mμ. The molar ratio of copper to PMB was found to be 1:2 in isopentyl alcohol and it may be capable to determine quantitatively within 0.02γ to 0.8γ/cc., following the Beer's law. Various conditions of pH, temperature, as well as the copresent ions in this determination was examined and the quantitative determination of copper in animal organs was attempted.抄録全体を表示PDF形式でダウンロード (732K) -
Ethyl α,γ-Alkylated-5-nitro-2-thiophene-2,4-pentadienoate類およびEthyl-2,3-disubstituted Acrilate類の合成西海枝 東雄, 谷口 陽一, 小川 晴1962 年 82 巻 9 号 p. 1262-1267
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーSix kinds of ethyl 2, 3-disubstituted acrilates and ethyl α, γ-alkylated 5-nitro-2-thiophene-2, 4-pentadienate were synthesized from 5-nitro-2-thiophene carboxaldehyd, as a starting material, by the stepwise and alternative condensation with the Wittig reagent, (1-ethoxycarbonylalkylidene) triphenylphosphorane, and their ultraviolet absorption spectra were studied.抄録全体を表示PDF形式でダウンロード (689K) -
1-メトキシ-4-アルコキシピリジニウム塩とシアン化カリウムの反応西本 喜重, 中島 辰巳1962 年 82 巻 9 号 p. 1267-1273
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーBy the reaction of 1, 4-dimethoxypyridine iodide with KCN in methanol, 4-methoxypyridine (I), methyl 4-cyanopicolinimidate (II), methyl 4-methoxypicolinimidate (III), dimethyl 2, 4-pyridinecarboximidate (IV), 4-methoxypicolinamide (VI), 2, 4, 6-tris(4-methoxy-2-pyridyl)-1, 3, 5-triazine (VII), 4-cyanopicolinamide (VIII) and 2, 4-pyridinecarboxamide (IX) were produced but a very little of the expected 4-methoxypicolinonitrile (V) was obtained.
When dioxane, instead of methanol, was used, (V) was obtained in 30% yield, besides a small amount of (I) and 2, 4-pyridinedicarbonitrile (XIV).
On the other hand, 1-methoxy-4-ethoxypyridinium iodide was reacted with KCN in methanol into 4-ethoxypyridine (XV), 4-ethoxypicolinamide (XVI), (VIII) and (IX). In dioxane, 4-ethoxypicolinonitrile (XVII) was obtained in 32% yield, together with (XIV) and (XV).抄録全体を表示PDF形式でダウンロード (1036K) -
グアニジン誘導体のカエル骨格筋に対する作用小澤 光, 福田 英臣, 後藤 正義1962 年 82 巻 9 号 p. 1274-1277
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーAn effect of various drugs of skeletal muscle function on Rana nigromaculata has been examined by the methods of employing N. rectus abdominis, N. ischiadicus-M. gastrocnemius preparation and N. ischiadicus-M. sartorius preparation. Among them, indirect electric stimulation of N. isochiadicus-M. sartorius preparation was found to be the best method with high sensitivity. The compounds tested were 1, 1′-(octamethylene) diguanidine⋅2HCl (I), 1, 1′-(decamethylene) diguanidine⋅2HCl (II), 4, 4′-diamidinostilbene⋅2HCl (III), bis(p-guanidinophenyl)-sulfide⋅HCl (IV), -sulfoxide⋅2HCl (V), -sulfone⋅H2SO4 (VI) and streptidine (VII), which provided only muscle relaxation action, without having muscle stimulation action. According to the method of employing N. ischiadicus-M. sartorius preparation, (II) showed the strongest action, which was followed by (I) and (IV). (III), (V) and (VI) were pretty weak and (VII) very weak.抄録全体を表示PDF形式でダウンロード (445K) -
アリタソウの構造研究 その3中島 正1962 年 82 巻 9 号 p. 1278-1281
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーThe dehydrogenation of aritasone and its hydrolyzed compound gave the substance, C20H26O2, m.p. 140°, [α]D ±0°. This compound has been confirmed to be 1, 2-bis[-(2-hydroxy-4-isopropyl) phenyl] ethane (III) synthetically. Therefore, the structure of the aritasone was confirmed to be authentic with (Ib) chemically.抄録全体を表示PDF形式でダウンロード (523K) -
フェニルヒドラジン類とクロラミンTとによるフェノール類の呈色反応桜井 寛, 梅田 益雄1962 年 82 巻 9 号 p. 1282-1286
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーThe reaction of phenols and phenylhydrazines in the presence of an oxidation agent and basification of the reaction mixture resulted in coloration of phenols to red to blue. In general, phenols possessing positive groups color easily but those having a negative group do not undergo coloration. Phenols with positive group in the para-position hardly undergo coloration.
Phenol was reacted with 2, 4-dinitrophenylhydrazine, in the presence of Chloramine T, and separation of its reaction product was attempted. Extraction of the reaction mixture with chloroform and purification of its product by alumina chromatography afforded reddish brown needles, m.p. 186.0°, whose analytical values and absorption spectra in the ultraviolet, visible and infrared regions agreed with those of p-benzoquinone 2, 4-dinitrophenylhydrazone. The prodnct was identified with p-benzoquinone 2, 4-dinitrophenylhydrazone, synthesized from p-benzoquinone, by mixed fusion.抄録全体を表示PDF形式でダウンロード (602K) -
テトラリン誘導体の紫外線吸収スペクトルおよび日光に対する安定性百瀬 勉, 上田 陽, 増田 義人1962 年 82 巻 9 号 p. 1286-1297
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリー48 varieties of 2-acyl(or aroyl)-5, 6, 7, 8-tetrahydro-1(or 3)-naphthol, aryl 1-(or 3-)hydroxy-5, 6, 7, 8-tetrahydro-2-naphthoate and 1-(or 3-)methoxy-2-aroyl-5, 6, 7, 8-tetrahydronaphthalen were synthesized. They provided two absorption maxima in the U V region. Except two cases, the maxima of 1-hydroxy-2-carbonyl compounds in shorter wave length region shifted 3-9mμ to longer wave length region from that of 3-hydroxy-2-carbonyl compounds. The absorption maxima of the former in longer wave length region shifted 4-9mμ to shorter wave length region from that of the latter.
The shift in the shorter wave length region is explained by the stronger intermolecular chelate formation of 1-hydroxy-2-carbonyl compounds and the shift in the longer wave length region is supposed to be easier formation of para-quinoid form of 3-hydroxy-2-carbonyl compounds.
Though 1-hydroxyketone compounds are very stable against sun light, o-hydroxy-carboxylic acid esters are generally unstable and o-methoxy ketones are also unstable.抄録全体を表示PDF形式でダウンロード (1335K) -
1-(3´,4´-Dihydroxyphenacyl)-4-(2-hydroxypropyl) piperazine Dihydrochlorideの鎮咳効果の作用点の追究加瀬 佳年, 由井 薗倫一, 益田 光雄, 六藤 美江子, 宮本 純男, 田川 洋吉1962 年 82 巻 9 号 p. 1298-1302
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーIt has been found that 1-(3′, 4′-dihydroxyphenazyl)-4-(2-hydroxypropyl) piperazine dihydrochloride (TN-1261) is an effective antitussives of having 12% (with dogs) and 10% (with cats) of codein action. The action towards centripetal path (the action for stretch receptor impulse), the comparison of medication dosage in the different administration process, the influence of decerebration by midcollicular transaction, the action towards medullary cough center and the action towards centrifugal path of respiration have determined that the action site was central nervous, being different from the narcotic antitussive effect of morphine group.抄録全体を表示PDF形式でダウンロード (810K) -
多塩基性酸エステル類とアミン類との縮合反応 その1 Diethyl 2-Ethoxycarbonyl-3-methylglutarateとHomoveratrylamineとの溶融縮合成績体について亀谷 哲治, 柳瀬 良文1962 年 82 巻 9 号 p. 1303-1306
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーThe fusion reaction between homoveratrylamine and diethyl 2-ethoxycarbonyl-3-methyl glutarate was investigated and two kinds of monoamide diester, two kinds of diamide and a triamide were obtained. One of the monoamides was hydrolyzed, decarboxylated and later cyclized to N-homoveratryl-3-methylglutarimide, which was identified by the admixture with the sample synthesized by the other route. Similary, the cyclization of diamide afforded imide derivative, partially cyclized to isoquinoline. The structure of the cyclized products from triamide is still examining.抄録全体を表示PDF形式でダウンロード (565K) -
Ullmann反応によるDiphenyl Etherの合成ならびにOxepine環の生成反応について複素環式化合物の合成研究 第75報亀谷 哲治, 福本 圭一郎, 中野 卓雄1962 年 82 巻 9 号 p. 1307-1311
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリー2, 3, 6-Trimethoxydibenzo [b, f] oxepin-10(11H)-one, considered to be the starting material for cularine synthesis, was prepared by intramolecular cyclization of [2-(2-methoxyphenoxy)-4, 5-dimethoxyphenyl] acetic acid or its methyl ester with polyphosphoric acid. The starting carboxylic acid and its ester was prepared by the Ullmann reaction of methyl (2-bromo-4, 5-dimethoxyphenyl) acetate or 6-bromovera-traldehyde and guaiacol, and through azlactone.抄録全体を表示PDF形式でダウンロード (628K) -
p-Dithiin化合物の合成西海枝 東雄, 田上 昇一郎1962 年 82 巻 9 号 p. 1312-1313
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーp-Dithiino [2, 3-b] quinoxaline-2, 3-dinitrile was synthesized by the reaction of 2, 3-dichloroquinoxaline and sodium salt of cis-1, 2-dimercapto-1, 2-dicyanoethane in a mixture of acetone and water. 1) Heating p-dithiino [2, 3-b] quinoxaline-2, 3-dinitrile in conc. H2SO4 at 50-80° for a short period of time gave 1, 3-dihydro-2H-pyrrolo-[3′, 4′:5, 6]-dithiino [2, 3-b] quinoxaline-1, 3-dione. 2) Reacting p-dithiino [2, 3-b] quinoxaline-2, 3-dinitrile in either conc. H2SO4 or 10% NaOH at 100° for a long period of time afforded the compound which was supposed to be p-dithiino [2, 3-b] quinoxaline-2, 3-dicarboxylic acid, though its structure has not been determined, because of the difficulty to obtain in a purified state.抄録全体を表示PDF形式でダウンロード (317K) -
小澤 光, 福田 英臣, 大槻 勲夫, 千葉 祐広1962 年 82 巻 9 号 p. 1314-1317
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーAntitussive activities, antispasmodic activities, as well as acute toxicities of oxeladin have been investigated. The antitussive activities of oxeladin citrate on guinea pig by the mechanical stimulation method was a little weaker than that of codeine phosphate, when injected intraperitoneally, and the activities of less soluble oxelaldin tannate, when administered per os, was as same as codeine, being converted to the free base, with longer duration. As to the antispasmodic activities by employing isolated tracheal chain preparation, it showed strong papaverine-like action and very weak atropine-like action, without having any antihistaminic activities. LD 50 by subcutaneous injectione of oxeladin citrate to mice was 244mg./kg. and that of oxelaldin tannate to mice per os was not less than 1500mg./kg.抄録全体を表示PDF形式でダウンロード (561K) -
塚本 赳夫, 木下 洋夫, 安東 朝子1962 年 82 巻 9 号 p. 1317-1319
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーFollowing the Panouse and Lyle method, 12 sorts of arecoline and its homologs, as well as its analogs were synthesized, from 1-methyl-3 (and 4)-alkoxycarbonylpyridinum iodides, as a starting material. Though 4-alkoxycarbonyl derivatives were obtained in 60-80% yield, 3-alkoxycarbonyl derivatives were prepared in 30-40% yield, together with the yellowish dihydro compound, seemed to be a by-product.抄録全体を表示PDF形式でダウンロード (402K) -
Desglucocheirotoxinの分離木村 道也, 藤間 貞彦, 菊池 登代子1962 年 82 巻 9 号 p. 1320-1323
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーA paper chromatographic separation of the cardiac glycosides, contained in the dried flowers of Convallaria Keisukei MIQ. from Hokkaido has been attempted and more than 10 sorts of spots which are positive to the Kedde reaction have been identified by the water saturated MeCOEt as a developing solvent. By the investigation of the isolation method through alumina chromatography, developed by 6% MeOH-CHCl3, C29H42O10, colorless needles, m.p. 188-191° (MeOH-Et2O), [α]D13 -7.8° (MeOH), Rf: 0.80 (MeCOEt-H2O), Rf: 0.53 (To-Bu-H2O), Rf: 0.52 (H2O-PeOH), acetate, C35H48O13⋅H2O, m.p. 160-162° (MeOH-H2O) was obtained.
The Aglycone has been identified to be Strophanthidin by the hydrolysis of the Mannich-Siewert method, UV and IR spectra, and the sugar portion to be D-gulomethylose by the hydrolysis with Kiliani's mixture The glucoside identified with the desglucocheirotoxin which was obtained from the enzymatic hydrolysis of cheirotoxin, extracted from Cheiranthus Cheiri L. by Reichstein et al. by the admixture, PPC and IR has been also identified to be desglucocheirotoxin.抄録全体を表示PDF形式でダウンロード (620K) -
中島 正1962 年 82 巻 9 号 p. 1323-1326
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーThe component of essential oil from Artemisia annua L. was investigated and both hexanal and l-α-pinene were isolated as a low boiling point component. Benzylalcohol acetate, d-2-methyl butyrate, cuminal, caryophyllene oxide, and pentacosane were isolated as a high boiling point component. Besides that, aldehyde compound (semicarbazone, m.p. 200°, 2, 4-dinitrophenylhydrazone, m.p. 157-159°) of C10H16O, and ketonic derivative (2, 4-dinitrophenylhydrazone, m.p. 181-183°) of C15H24O have been isolated and also a presence of monoterpene alcohol derivative bp5 90-95°, as well as the sesquiterpene alcohol derivative of bp5 134-140°, have been suggested, though their identification have not yet been made.抄録全体を表示PDF形式でダウンロード (640K) -
今関 和泉, 北畠 芳子1962 年 82 巻 9 号 p. 1326-1328
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーThe relationship between the actions toward small intestine and the chemical structures of the various kinds of compounds, providing hydrocarbon, or alcoholic or phenolic hydroxyl group, which are the main component of plant essential oils, applicable to the therapeutic chemicals, has been studied.
In this connection the action to small intestine has been examined by the Magnus method using extracted small intestine from mouse with the plant essential oils themselves in which the effective component are considered to exist.
The monoterpenoids, namely α-pinene, limonene and dipentene, which belong to hydrocarbon group showed stronger contracted action and the substances of having alcoholic hydroxyl group such as linalool, citronellol, geraniol and menthol showed musclotropic antispasmodic action. This action was also found to be strengthened considerably with thymol, carvacrol and eugenol which have phenolic hydroxyl group. The contracted action was also observed with the orange oil, mandarine oil, turpentine oil and fennel oil but peppermint oil and clove oil showed musclotropic antispasmodic action. These actions are supposed to be represented by the main component of the oil, but the contracted action was also observed with mosla oil, Oyamajiso oil, and eucalyptus oil and it showed different reaction from that of the main component.抄録全体を表示PDF形式でダウンロード (432K) -
有富 正和1962 年 82 巻 9 号 p. 1329-1331
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーThe yellow plates crystals, m.p. 260-261°(decomp.), isolated from leaves of Acer palmatum THUNBERG has been cofirmed to be vitexin.抄録全体を表示PDF形式でダウンロード (483K) -
有富 正和1962 年 82 巻 9 号 p. 1331-1332
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーCosmosiin and vitexin, besides luteolin 7-D-glucoside which was already reported, have been isolated and identified from Humulus japonicus SIEBOLD et ZUCCARINI.抄録全体を表示PDF形式でダウンロード (317K) -
Dibenzo-p-dioxin誘導体に対するFriedel-Crafts反応について その4上田 伸一, 寺岡 章雄1962 年 82 巻 9 号 p. 1333-1336
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーThe Friedel-Crafts reaction of 1, 6-dimethoxydibenzo-p-dioxin (II) with acetylchloride in carbon disulfide, in the presence of AlCl3 gave diacetyl derivative (III) in a better yield. Oxidation of (III) with potassium permanganate in a mixture of 2.5% KOH and pyridine afforded corresponding dicarboxylic acid (IV) in a better yield, which was esterified quantitatively to methyl 1, 6-dimethoxydibenzo-p-dioxin-4, 9-dicarboxylate (V) by diazomethane.
In the Friedel-Crafts reaction, a small amount of colorless needle crystals, m.p. 228-230° was produced as a by-product, which might be either 1-acetoxy-4-acetyl-6-methoxydibenzo-p-dioxin or 1-acetoxy-2-acetyl-6-methoxydibenzo-p-dioxin (VII), suggested from various investigations. Therefore, it was found that the substitution at the nucleus in this reaction took place dominantly at para position of methoxyl group of (II).抄録全体を表示PDF形式でダウンロード (553K) -
赤木 満洲雄, 手島 節三, 中村 博, 犬伏 康夫, 津田 喜典, 石井 永, 細川 満里子, 佐野 武弘1962 年 82 巻 9 号 p. 1337-1339
発行日: 1962/09/25
公開日: 2010/02/19
ジャーナル フリーPDF形式でダウンロード (291K)
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