巻号一覧
83 巻, 1 号
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オロチン酸の溶解補助剤について中谷 弘実1963 年 83 巻 1 号 p. 1-5
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーFor the purpose of solubilization of orotic acid in water, such solubilizing agents as chained lower aliphatic primary amine, N, N-dimethylnicotinamide, N, N-dipropylnicotinamide, N-methylglucamine and alkanolamine derivatives have been used. As to about 40 kinds of medical compounds which have been often used for watersolubilization of difficultly soluble medicines, the author has been examined the solubility reinforcement action for orotic acid and it was found that formamide, nicotinamide, nicotinic acid and some sort of amines showed the action. Except a few cases, monoamine was found to possess the reinforcement action in the ratio of 1:1 with orotic acid, suggesting the complex formation.抄録全体を表示PDF形式でダウンロード (467K) -
オロチン酸-アミン反応体の単離と反応体の水に対する溶解性中谷 弘実1963 年 83 巻 1 号 p. 6-9
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーWater soluble products were isolated as crystals, when orotic acid and equimolar monoamine were reacted in the concentrated water solution. All of 16 sorts of the product obtained were colorless prisms and the analytical values were coincided with the theoretical ones calculated as the binding ratio of orotic acid to amine to be 1:1. When either nicotinamide or ammonia was reacted with orotic acid by the same method, a similar product was obtained in the ratio of 1:1. The products were very soluble in water and the solubilities were varied with the kind of amine and the structure. There is an interrelative correlation between the solubility and the melting point, that is, the product having lower melting point possesses a larger solubility.抄録全体を表示PDF形式でダウンロード (597K) -
α-Halogeno-5-nitro-2-furanacrylic Acidの合成西海枝 東雄, 田中 昭1963 年 83 巻 1 号 p. 9-15
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーα-Chloro-5-nitro-2-furanacrylic acid was synthesized by the condensation (Perkin reaction) of 5-nitrofurfural and potassium monochloroacetate. α-Bromo-5-nitro-2-furanacrylic acid was obtained by hydrolysis of ethyl α-bromo-5-nitro-2-furanacry-late obtained by dehydrobromination of ethyl α, β-dibromo-5-nitro-2-furanpropionate. On the other hand, dehydrobromination of α, β-dibromo-5-nitro-2-furanpropionic acid gave β-bromo-5-nitro-2-furanacrylic acid. Heat treatment of α-bromo and β-bromo compounds was found to result in geometrical isomerization from the α-from (low m.p.) to β-form (high m.p.) and these facts were confirmed by suitable chemical reactions.抄録全体を表示PDF形式でダウンロード (1177K) -
オオバタブMachilus Kusanoi HAYATAのアルカロイド その1 L-(-)-N-Norarmepavineの単離富田 真雄, 楊 藏雄, 蘆 盛徳1963 年 83 巻 1 号 p. 15-18
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーTwo kinds of phenolic bases, Base-I, m. p. 157-158°, and Base-II, m. p. 219-220°, were isolated from the wood of Formosan Machilus kusanoi HAYATA (Family Lauraceae. Japanese name “Ohba-tabu”). The Base-I formed colorless microprisms, m. p. 157-158°, [α]D26-30.46°(CHCl3), and is a new base with the composition of C18-H21O3N=C16H13(OCH3)2(OH)(NH). Permanganate oxidation of its N, O-diethyl ethiodide gave p-ethoxybenzoic acid. The physical properties of the methine base obtained by the first-step Hofmann degradation of its N, O-dimethyl methiodide, and the methine methiodide were in good agreement with those of N, O, O-trimethylcoclaurine methine and its methine methiodide. N-Methylated compound of Base-I, obtained by treatment with formic acid and formaldehyde, agreed with L-(+)-armepavine (II), m. p. 145-146°, whose steric structure had already been proved, identified through mixed fusion and infrared spectral comparison (Nujol). Consequently, Base-I was clarified as L-(-)-N-norarmepavine (I). The structure of Base-II is now being examined.抄録全体を表示PDF形式でダウンロード (689K) -
オオバタブMachilus Kusanoi HAYATAのアルカロイド その2 dl-Coclaurilleの単離蘆 盛徳1963 年 83 巻 1 号 p. 19-21
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーDetailed examination made on Base-II showed it to be dl-coclaurine (II). Base-II, m. p. 219-220°, C17H19O3N, was isolated from Machilus kusanoi HAYATA, together with Base-I, which was identified as L-(-)-N-norarmepavine (I). Coclaurine had been isolated only from Cocculus laurifolius DC. (Menispermaceae. Japanese name “Koshu-uyaku”) and it had been viewed with interest as the proto-base of biscoclaurine-type bases, from the point of biogenesis. It is interesting that this alkaloid had been found in the Machilus sp. of the Lauraceae family.抄録全体を表示PDF形式でダウンロード (532K) -
カチラチライノキMagnolia Kachirachirai DANDYのアルカロイド その2 D-(+)-N-Norarmepavineの単離楊 藏雄, 蘆 盛徳1963 年 83 巻 1 号 p. 22-25
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーIn an earlier work, examinations were made on the alkaloids contained in Magnolia kachirachirai DANDY (=Michelia kachirachirai DANDY) (Japanese name “Kachirachirainoki”). Glaucine and two kinds of bases showing m. p. 130-131° in minute quantity were isolated as the tertiary non-phenolic bases and magnoflorine as the watersol-uble quaternary base. In the present series of work, the phenolic bases were purified by alumina chromatography and separated into crystalline Base-I, m. p. 157-158°, and Base-II, m. p. 191-192°.
Base-I, formed colorless needles, m. p. 157-158°, [α]D+31.49° (CHCl3), is a new base with the composition of C18H21O3N⋅C16H13(OH)(OCH3) (NH). The N-methylated compounds, N-methyl methiodide, and N, O-dimethyl methiodide of this base were compared with the corresponding derivatives of L-(-)-N-norarmepavine, obtained from Machilus kusanoi HAYATA and, as shown in Table I, all the data were in complete agreement, except for the reversed direction of the optical rotation, suggesting that the two are antipodes. Mixed fusion and comparison of the infrared spectrum (in Nujol) of the N-methylated compound of Base-I with D-(-)-armepavine, whose structure had already been established, showed that the two are identical substances. This has proved that Base-I is D-(+)-N-norarmepavine (I). No detailed examination has yet been made on Base-II due to the minute amount available.抄録全体を表示PDF形式でダウンロード (664K) -
小延 鑑一, 鈴木 友二1963 年 83 巻 1 号 p. 25-29
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーCanavanine does not show inhibitive action on the growth of microörganisms which require arginine, although there are some arginine-requiring organisms whose growth is inhibited by canavanine. Action of canavanine was examined with three arginine-requiring mutant strains of Neurospora crassa and inhibition of their growth was observed. This antagonism is non-competitive in the strain having ability to biosynthesize arginine and competitive in the strain requiring arginine itself. These experimental facts suggest that canavanine interferes in the biosynthesis of arginine in the strain having ability to synthesize arginine and inhibits of arginine uptake into the cells by arginine-requiring strain.抄録全体を表示PDF形式でダウンロード (759K) -
小延 鑑一, 鈴木 友二1963 年 83 巻 1 号 p. 29-33
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーSeven strains of Lactobacillus of the Streptococcus genus, isolated from infants' stool, were examined for their effect on the growth inhibition by canavanine. Strains able to synthesize arginine were all effected by canavanine and the antagonism between arginine and canavanine, was non-competitive. Lactobacillus SK-9 strain, requiring arginine itself, was also affected by canavanine and, in this strain, canavanine and arginine showed competitive antagonism. Desimination of canavanine and formation of homoserine by reductive decomposition of canavanine in Lactobacillus was found to be independent of the toxicity of canavanine. The SR 3-3 strain isolated in this experiment was found to be a new type of Lactobacillus which utilized arginine or citrulline but not ornithine.抄録全体を表示PDF形式でダウンロード (790K) -
小延 鑑一1963 年 83 巻 1 号 p. 33-36
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーEscherichia coli No. 1 was cultured in the media in the presence and absence of amino acid and formic hydrogenlyase was adaptively formed in the resting cells. It was found that arginine took part in this enzyme formation and that canavanine inhibited enzyme formation, either by inhibiting the uptake of arginine into the cells or by liberating arginine from the cells. It was also clarified that canavanine shows antagonism against arginine, not only in the proliferating stage but also in the resting stage of microörganisms.抄録全体を表示PDF形式でダウンロード (466K) -
小延 鑑一1963 年 83 巻 1 号 p. 37-39
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーUptake of arginine in the medium by cells was examined by the use of arginine-requiring mutant strain S36703 a of Neurospora crassa and canavanine was found to inhibit this uptake of arginine into the cells. In this case, canavanine is also taken into the cells and the total amount of arginine and canavanine taken into a cell was found to show an approximately constant value. Consequently, one of the actions of canavanine as the antimetabolite of arginine is its entrance into the microörganism cells due to similarity in structure to arginine and thereby inhibit further uptake of arginine.抄録全体を表示PDF形式でダウンロード (373K) -
岡田 寿太郎, 安部 孝子1963 年 83 巻 1 号 p. 39-44
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーInternal friction coefficient and adhesive force of various powdered drugs were measured by the apparatus (Fig. 1) made according to the method of Derjagin. Samples used were those meeting Japanese Pharmacopoeia standards and passed through a standard sieve or those below a certain mesh size. This particle size distribution was confirmed to agree with the exponential rule of Rosin-Rammler.
Correlation of moisture rate (w) to internal friction coefficient (b) and adhesive force (c) four kinds of starch was found to be represented as follows: b=b0enw, c=c0-mw, w: 0-20%.抄録全体を表示PDF形式でダウンロード (838K) -
高級脂肪酸のヒドロキサム酸のFe(III)錯塩の結晶および溶液中における構造ならびに組成について酒井 健1963 年 83 巻 1 号 p. 44-50
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーThe crystal of ferric complex with hydroxamic acid of higher fatty acids was prepared (Table I). The analytical data showed two kinds of complex crystal of having a molar ratio of 2:1 (pH 6.0, λmax 470mμ in dehyd. ethanol) and 3:1 (pH 7.0, λmax 425mμ in dehyd. ethanol) (Table III). The infrared spectrum of the complex crystal showed the presence of the amido II and III absorption band at 1520cm-1 and 1300cm-1 and the trans configuration of >NH to >C=O (Fig. 1-3). This fact suggested the bonding type of the complex to be .
The composition of the complex in the solution was varied by pH. The measurement of the complex in solution, by the application of absorption spectrum of ultraviolet and visible region, pH and the molar ratio method indicated a formation of the 1:1 complex (pH 2.0, λmax 525mμ in dehyd. ethanol), besides 2:1 in solution (Table II, Fig. 4-7).抄録全体を表示PDF形式でダウンロード (1025K) -
虫体の酸化還元酵素に及ぼす作用 その2田村 三郎1963 年 83 巻 1 号 p. 51-55
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーKainic acid has an unsaturated bond in the side chain at 3-position of its pyrrolidine ring and examination was made to see if it undergoes non-enzymatic reaction with reduced diphosphopyridine nucleotide (DPNH) to oxidize it since DPNH is said to be contained in comparatively large amount in hog ascaris. Decrease in the absorbance at E340 was very small and therefore, the homogenate of hog ascaris was submitted to centrifugation and the effect of kainic acid on the oxidation of DNPH in its supernatant was examined. Kainic acid was found to inhibit the oxidation of DPNH and it was assumed that kainic acid not only oxidized DPNH non-enzymatically to a small extent but also inhibited electron transfer of DPNH, which might be one of the factors of its anthelmintic action. The presence of FAD was found in hog ascaris but D-amino acid oxidase was not detected. Kainic acid does inhibit electron transfer of DPNH by FAD but does not inhibit oxidation of DL-alanine by D-amino acid oxidase of hog kidney, so that the acid is not considered to give direct effect on FAD.抄録全体を表示PDF形式でダウンロード (704K) -
ニトロメトリーによるジアゾアミノ窒素の微量分析について国峯 登, 宇賀神 久和, 中丸 三次1963 年 83 巻 1 号 p. 56-58
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーThe micro quantitative determination of diazoamino nitrogen was described. Applying the usual apparatus of micro Dumas analysis, equipped with empty combustion tube, the sample and cupprous oxide powder was taken in platinum boat and was placed on it a small ampoule which contained conc. hydrochloric acid. Decomposition was carried out at 200° under carbondioxide stream and the nitrogen gas produced was determined by the usual micro Dumas method. Two azotometers were employed in this analysis and the continuons analysis was found to be available. Total period of time for one analysis takes 25 min. Any nitrogen gas production could not be observed in the general nitrogen compound without the diazoamino group. The standard deviation of this experiment was 0.21% and less, resulted from 3 sorts of arene diazonium compounds.抄録全体を表示PDF形式でダウンロード (377K) -
有機セレン化合物中のセレン微量定量について国峯 登, 宇賀神 久和, 中丸 三次1963 年 83 巻 1 号 p. 59-61
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーThe micro quantitative method of selenium in organo selenium compounds was described. The sample was ignited in oxygen stream and the selenium dioxide produced was collected by absorption funnel. The spectrophotometric determination was carried out in 3, 3′-diaminobenzidine solution at 372mμ.
The calibration curve prepared by the combustion method of selenium dioxide was coincided well with that of the curve prepared by nitric acid oxidation of pure metal selenium.
An application of this method to several sorts of organo selenium compounds was found to be very favorable, without any influence by sulphur and halogenes.抄録全体を表示PDF形式でダウンロード (462K) -
AminoalkylanilineのAcyl誘導体の薬理作用林 五朗, 重松 暹, 甲和 良夫1963 年 83 巻 1 号 p. 62-73
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーAnalgesic action of aminoalkylaniline derivatives was examined and pharmacological action of some of the compounds with comparatively strong activity was compared with that of morphine. Compounds having methylphenethylamino group in the tertiary amino possessed the strongest analgesic effect, followed by those having a piperidyl group. Analgesic effect of these compounds is antagonized by Levallorphane and continued administration in mice produced greater tolerance. These compounds acted synergetical with barbital hypnotics, the fortifying action being stronger in compounds with stronger analgesic action. The compounds indicated, similar to morphine, mydriasis of pupils in mice, elevated body temperature of rats, and depressed the body temperature of mice. The compounds also suppressed intestinal transport in mice and rabbit respiration, and all these pharmacological actions tended to parallel their analgesic action.
Antipyretic action was found in 3′-hydroxypropionanilide derivatives. The compound having methylphenethylamino group in the tertiary amino had stronger local anesthetic and hypotensive effects than the others, and stronger action of depressing isolated heart of a toad and isolated intestine of a rabbit. All these compounds had antihistamine and antiacetylcholine actions.抄録全体を表示PDF形式でダウンロード (1865K) -
非牽引性球形粒子の場合中垣 正幸, 砂田 久一1963 年 83 巻 1 号 p. 73-78
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーVolume fraction of a non-attracting spherical particles was calculated. In such particles attraction is very weak and does not work between separated particles. The volume fraction was theoretically calculated as a function of p, the probability with which the particle stay in the place by adhesive force when in contact with other particles and from (1-p), the probability with which the particle would slide over the sphere and not staying in that place. The calculation was made by the modified method of Vold, as reported in the preceding paper, and considerations were made on the effect of particles present outside this range. It was thereby found that a ternary relationship, ρ⋅Vs=3.9p2(3-2p)+1.7, existed between the sedimentation volume, Vs, and p. Number of contacts in each case was also examined.
Various experimental data reported in the past literature for numerous particles were used to obtain p by the present equation, and relationship among p, temperature, T, and dielectric constant, D, was found to give a straight line corresponding to lnp=B/DT+lnp0 and lnp=B′/D+lnp0 (where T is constant).抄録全体を表示PDF形式でダウンロード (868K) -
川骨アルカロイドの合成研究 その2 (±)-Desoxynupharamineの合成荒田 義雄, 大橋 力, 奥村 次郎, 和田 豊, 石川 道子1963 年 83 巻 1 号 p. 79-83
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーKetonic acid (VII) was synthesized from acetoacetic ester, as shown in Chart 2. After the methylesterification (IX) of oxime (VIII) of VII, IX was reduced to amino acid ester (X), which has a possibility of forming two kinds of racemic compound due to two asymmetric carbon atom.
Therefore, a repeated recrystallization of amino acid (XI), derived from X, separated into (XIa) and (XIb.) Ethyl ester of XIa was led to N-furoyl derivative (XIV) and further enamine (XV) by dry distillation with soda lime. The IR absorption (Fig. 4) of (XVIa) obtained by NaBH4 reduction of XV was completely identical with that of (-)-desoxynupharamine (III) (Fig. 3), derived from (-)-nuphramine (I). Thus, the structure of III postulated by the authors has been certified to be correct by the fact. (XVIb, ) derived from XIb by the similar method to XIa, differed from III in its finger-print region of IR spectrum and considered to be steric isomer of III.抄録全体を表示PDF形式でダウンロード (803K) -
4,5,6-トリメチルレゾルシンのヨード化深間内 久雄, 出野 竜子, 柳田 みつ子, 松原 チヨ1963 年 83 巻 1 号 p. 84-86
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーFollowing previously reported iodination of resorcinol, orcinol, cresorcinol, resorcinol monomethylether, β-resorcylic acid, methyl-β-resorcylate, cresorcinol carboxylic acid, and p-orcellinic acid, iodination of 4, 5, 6-trimethylresorcinol was carried out. For the iodination of 4, 5, 6-trimethylresorcinol, iodine-potassium iodide solution was added at 4° to the phosphoric acid disodium phosphate solution (pH 1.77) of the substance and the mixture was allowed to stand for two hours at 4°. 2-Iodo-4, 5, 6-trimethylresorcinol was obtained in good yield as white needles, m. p. 121-122° (decomp.). Its diacetate formed white crystals, m. p. 139-140°(decomp.). Both these substances are new compounds. The iodination described, viz. iodination in the acetate buffer solution or in the phosphate buffer solution, gave negative results in the case of 4, 6-dimethylresorcinol, α-resorcylic acid, and γ-resorcylic acid by the previous report, and 4, 5-dimethylresorcinol by this report.抄録全体を表示PDF形式でダウンロード (431K) -
dl-N-Methyldihydromenisarineの合成富田 真雄, 上田 伸一, 寺岡 章雄1963 年 83 巻 1 号 p. 87-92
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーIn order to confirm the structure of menisarine (Ia or Ib), the alkaloid of Formosan Menispermaceous plant, Cocculus sarmentosus DIELS (Japanese name “Hohzan-tsuzura-fuji”, Chinese name “Te-niu-zu-su”) by synthesis, condensation of 2, 7-bis(2-amino-ethyl)-4, 9-dimethoxydibenzo-p-dioxin (II) and 2-methoxy-5-chlorocarbonylmethyl-phenyl p-chlorocarbonylmethylphenyl ether (VII) was carried out. The bis-acetamide (VIII) thereby formed was submitted to the Bischler-Napieralski reaction to effect isoquinoline cyclization and reduction of its product gave 1, 2, 3, 4-tetrahydroisoquinolinetype base (X). This base X was N-methylated with formic acid and formaldehyde to 2-methyl-1, 2, 3, 4-tetrahydroisoquinoline derivative (XII), m.p. 180-183°, whose infrared spectrum (in CHCl3) agreed with that of N-methyldihydromenisarine, obtained by N-methylation of dihydromenisarine (XIa or XIb) derived from the natural product (Fig. 1).
dl-N-Methyldihydromenisarine (XII) thereby synthesized was submitted to the first Hofmann degradation and the infrared spectrum (in CHCl3) and ultraviolet spectrum (in EtOH) of the methine base so obtained were identical with those of the optically inactive N-methyldihydromenisarine methylmethine (XIII) derived from natural menisarine. These experimental evidences have confirmed that menisarine would be represented by the structural formula of Ia or Ib.抄録全体を表示PDF形式でダウンロード (1038K) -
N-置換グリシンアミド誘導体の合成里田 勲, 福井 富次郎, 森 一雄, 山本 泰男, 立脇 信清1963 年 83 巻 1 号 p. 93-98
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーCondensation of aminoquinoline derivatives (III, IV, XII, XX) with N, N-dimethyl-2-chloroacetamide affords glycinamide-type quinoline derivatives (V, VI, XIII, XXI) and addition of a small quantity of potassium iodide in this reaction markedly increases the yield. Acetylation of V, VI, XIII, and XXI so formed with acetic anhydride afforded the acetylated compounds (VII, VIII, XIV, XXII) which were far more soluble in water than the starting materials. The use of N, N-dimethyl-2-bromopropionamide in place of N, N-dimethyl-2-chloroacetamide failed to give the condensation product in majority of cases except for XII which formed the objective condensate XV. 2-Phenylcinchoninic acid (XXIII) was derived to its acid chloride (XXIV) or ester (XXV) and condensed with glycine derivatives to obtain the amino acid amide derivatives (XXVI, XXVII, XXIX) of XXIII.抄録全体を表示PDF形式でダウンロード (727K) -
アミノピリンの定量入谷 信彦, 鈴木 信子1963 年 83 巻 1 号 p. 98-100
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーThe application method of cadmium iodide and cadmium thiocyanate as a precipitation reagent has been compared, when aminopyrine was determined quantitatively as cadmium complex by chelatometric titration. Though iodine complex was difficultly precipitated quantitatively, thiocyanate complex was precipitated quantitatively at a pH of 6.5-8.2 and the composition of the precipitate was constant. Therefore, the Cd(CNS)2 method will be recommended, rather than the CdI2 method, as a quantitative method of aminopyrine.抄録全体を表示PDF形式でダウンロード (410K) -
解膠剤の血中濃度持続について山本 孫兵衛1963 年 83 巻 1 号 p. 100-103
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーComparative examinations were made on the colloidal properties of a suspension of aluminum distearate-Nujol gel, in which its peptizer, p-aminobenzoic acid or ethyl p-aminobenzoate, was dispersed, and the periodial variation in the blood level of these substances after intramuscular injection of these suspensions in a dog. Maintenance of blood level was found in p-aminobenzoic acid, which has a more marked peptizing action against aluminum distearate gel, and the blood level was found to be not affected by the particle diameter or viscosity of the suspension.抄録全体を表示PDF形式でダウンロード (515K) -
5-Hydroxy-7-nitro-3-coumarincarboxylic Acidの合成 その3市川 正孝, 一番ケ瀬 尚1963 年 83 巻 1 号 p. 103-106
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーThe Reimer-Tiemann reaction of 5-nitroresorcinol monomethyl ether (I) and addition of aniline to the ether-soluble product gave N-(2-hydroxy-4-nitro-6-methoxy-benzylidene) aniline (II), m.p. 143-144°, whose hydrolysis afforded 4-nitro-6-methoxy-salicylaldehyde (III), m.p. 97-98.5°. III formed a 2, 4-dinitrophenylhydrazone (IV) of m.p. 242-243°, whose reaction with piperidine and diethyl malonate in ethanol afforded ethyl 5-methoxy-7-nitro-3-coumarincarboxylate (V), m.p. 163.5-165°. Catalytic reduction of V over palladium-carbon gave ethyl 5-methoxy-7-amino-3-coumarincarboxylate (VI), m.p. 214-215.5°, whose diazotization followed by hydrolysis produced 5-methoxy-7-hydroxy-3-coumarincarboxylic acid (VII), m.p. 264°. 5-Methoxy-7-nitro-3-coumarincarboxylic acid (VIII), m.p. 172°, was obtained by heating V with dil. hydrochloric acid while heating of V with hydrobromic acid (d=1.48) gave 5-hydroxy-7-nitro-3-coumarincarboxylic acid (IX), m.p. 250-252°.抄録全体を表示PDF形式でダウンロード (599K) -
“Bebeerine Hydrochlorate” (E. Merck) について富田 真雄, 富士谷 憲徳, 岸本 禎二1963 年 83 巻 1 号 p. 106-107
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーExamination of “Bebeerine Hydrochlorate” (E. Merck) revealed that it contained an amorphous base besides the bases melting at above 280° and at 203-210°. The base with higher melting point was identified with d-isochondodendrine.抄録全体を表示PDF形式でダウンロード (347K) -
乙益 寛隆, 渡部 恵美子, 仲嶋 正一1963 年 83 巻 1 号 p. 107-108
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーThe metabolic products from the mycelium of Aspergillus itaconicus were examined. Ergosteryl palmitate, palmitic acid, mannitol and an unknown steroid of high melting point were obtained.抄録全体を表示PDF形式でダウンロード (378K) -
久恒 和仁1963 年 83 巻 1 号 p. 109-113
発行日: 1963/01/25
公開日: 2010/02/19
ジャーナル フリーPDF形式でダウンロード (715K)
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