巻号一覧
83 巻, 7 号
選択された号の論文の20件中1～20を表示しています
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エステル型高分子誘導体伊田 忠夫, 高橋 省二, 野田 和夫, 内海 勇1963 年 83 巻 7 号 p. 663-671
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーVarious O-acyithiamines were prepared by the oxidation of O-acrylate, O-methacrylate, O-crotonate, and O-undecylenate of thiothiamine and high-molecular derivatives of thiamine were obtained by their polymerization. Copolymer of these with vinyl compounds was also prepared.
Oral administration of these high-molecular derivatives in man and measurement of the amount of thiamine excreted in the urine showed that the total amount excreted during 24 hours was 1/2 to 1/4 of that after administration of thiamine hydrochloride. The peak of excretion appeared much later, 7-12 hours later than that of thiamine, and indicated the lasting effect of high-molecular derivatives. Of these derivatives, those with smaller molecular weight were excreted in larger amount, and copolymers were excreted in larger amount than homopolymers. Greater urinary excretion was found in basic comonomers than acid comonomers among these copolymers.
These experimental results showed the same tendency as that shown by hydrolysis of high molecular derivatives with alkali or diastase. O-Methacryloyl derivative was not hydrolyzed by alkali or diastase but was hydrolyzed in vivo to be excreted into urine in a similar manner as the other derivatives.抄録全体を表示PDF形式でダウンロード (1234K) -
アセビの花のトリテルペノイド その1近藤 嘉和, 竹本 常松1963 年 83 巻 7 号 p. 671-673
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーTriterpenoid components were examined in the flowers of Pieris japonica (THUNBERG) D. DON, and β-amyrin, oleanolic acid, ursolic acid, and β-sitosterol were isolated and identified. In addition, a hitherto unknown neutral triterpenoid (C32H52O2, m. p. 188-189°) was isolated. Its infrared spectrum suggested the presence of endo-methylene group and the spectrum was similar to that of lupeol acetate except for the region of 1000-1100cm-1. It was therefore assumed that this new triterpenoid is its epimer with respect to its 3-hydroxyl group but no evidence has yet been obtained.抄録全体を表示PDF形式でダウンロード (429K) -
ホツツジの成分 その1近藤 嘉和, 永谷 富子, 武内 康義, 竹本 常松1963 年 83 巻 7 号 p. 674-676
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーThe present series of work was carried out in order to extract and isolate poisonous component from the leaves of Tripetaleia paniculata SIEB. et ZUCC. Presence of grayanotoxin series substance was assumed from the toxic symptoms of the leaves to mice and such a fraction was obtained but did not crystallize. At the same time, hexa-consane (?), 1-triacontanol, 1-octacosanoi, ursolic acid, and quercetin were separated and identified. Presence of kaempferol was observed in paper chromatography. A new triterpenoid of m. p. 210-211°, C30H50O (acetate, m. p. 210.5-211°), was also isolated.抄録全体を表示PDF形式でダウンロード (510K) -
TrilobineおよびIsotrilobineの構造 その15 EpistephanineよりIsotrilobine Antipodeの合成富田 真雄, 古川 宏1963 年 83 巻 7 号 p. 676-679
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーY. Inubushi and K. Nomura reported a ring cleavage reaction of natural isotrilobine with sodium in liquid ammonia and represented its structure by II. In the present paper authors showed that the demethylation and dehydration of N-methyldihydroepistephanine (V) with hydrobromic acid followed by O-methylation gave O-methylanhydrodemethyl-N-methyldihydroepistephanine (VIII) (picrate, m. p. 188-189° (decomp.), [α]D -226.7° (acetone)), which is the antipode of natural isotrilobine (cf. Table I).抄録全体を表示PDF形式でダウンロード (583K) -
2,3,4,4a,5,6-Hexahydro-1H-pyrazino[1,2-a]quinolineの新合成法永田 正典, 山崎 高応1963 年 83 巻 7 号 p. 679-682
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリー2-Aminomethylquinoline was converted to the corresponding haloacetyl compound (V, VI), followed by cyclization to the corresponding quinolinium salt (VII) by warming in a sealed tube at 90° for 2hr. The salt (VII) was then reduced with lithium aluminum hydride to 2, 3, 4, 4a, 5, 6-hexahydro-1H-pyrazino [1, 2-a] quinoline (IV), identified with the authentic specimen. The compound (IV) was also prepared by the reduction of I with lithium aluminium hydride.抄録全体を表示PDF形式でダウンロード (597K) -
2,3,4,4a,5,6-Hexahydro-1H-pyrimido[1,2-a]quinoline類の合成永田 正典, 山崎 高応1963 年 83 巻 7 号 p. 682-689
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーReaction of 2-chloroquinoline with 3-amino propanol gave 2-(3-hydroxypropylamino)-quinoline (I). I was treated with phosphoryl chloride to give the corresponding 4-aza-benzo[c]quinolizine derivative (III). III was reduced to 2, 3, 4, 4a, 5, 6-hexahydro-1H-pyrimido[1, 2-a]quinoline (IVa) over platinium oxide catalyst.
The hydrochloride of IVa absorbed one mole of hydrogen over platinium oxide catalyst to give 1-(3-aminopropyl)-1, 2, 3, 4-tetrahydroquinoline (IVb), whose structure was elucidated by another method of its synthesis. The compound IVa was prepared also by another method, according to the following process. 2-Aminoquinoline was reacted with ethyl 3-chloropropionate to give 1, 2-dihydro-3H-pyrimido[1, 2-a]quinolin-3-one (VII), followed by its catalytic reduction over platinium oxide catalyst to give 1, 2, 4, 4a, 5, 6-hexahydro-3H-pyrimido[1, 2-a]quinolin-3-one (XIII), which was reduced with lithium aluminum hydride to IVa.抄録全体を表示PDF形式でダウンロード (1215K) -
N-(Dimethylaminoalkyl) aniline系化合物の合成気賀沢 和雄, 菅原 宏, 柊木 峯治1963 年 83 巻 7 号 p. 689-695
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーBy the reaction of N, N-dimethyl-2-chloropropylamine (or N, N-1-trimethyl-2-chloro-ethylamine), Y-C6H4NRH (Y=H, OC2H5; R=H, CH3, CH2C6H5) represented by the general formula produced a mixture of two kinds of Y-C6H4NRCH(CH3)CH2N(CH3)2 (III) and Y-C6H4NRCH2CH(CH3)N(CH3)2 (IV). A series of such compounds (III) and (IV) was synthesized aiming the analgesics shown in Table I and II. A mixture of two kinds was separated by recrystallization as maleates and picrates and the structure was determined by the method shown in Chart 2.
In order to obtain the III-type compound, N-(1-methyl-2-dimethylaminoethyl)-p-phenetidine was prepared by the reductive reaction of p-phenetidine and CH3COCH2-N(CH3)2 in the presence of PtO2 catalyst.抄録全体を表示PDF形式でダウンロード (1057K) -
N-(Dimethylaminoalkyl) aniline系化合物の合成と薬理作用気賀沢 和雄, 菅原 宏, 柊木 峯治, 府川 和永1963 年 83 巻 7 号 p. 696-700
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーIn continuation to the previous report, aminobenzene derivatives, represented by the general formula, Y-C6H4NR-CH2CH2CH2N(CH3)2, Y-C6H4NRCH2CH2N(CH3)2 (Y=H, OC2H5; R=H, CH3, CH2C6H5, COCH3, COC6H5) being also ethylenediamine derivatives, were synthesized as is shown in Table I and II. All of the analgesic activities were examined and some of the superior derivatives to aminopyrine were shown in Table III and IV.抄録全体を表示PDF形式でダウンロード (738K) -
チオクト酸誘導体とビタミンB1との結合化合物の合成 その1出口 義雄, 中西 和夫1963 年 83 巻 7 号 p. 701-704
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーBoth thioetic acid and thiamine play important rôle in the metabolic process of pyruvic acid and preparation of their conjugate would be significant for biological studies. The present series of synthetic work was undertaken in order to obtain such compounds.
Attempt was first made to synthesize a compound in which the sulfur atoms in 6- and 8-positions of thioctlc acid was bonded in disulfide-form to thiamine. Application of sodium thiosulfate to methyl 6, 8-dichloroöctanoate (VI) to obtain the Bunte salt (VII) showed that chlorine in 6-position is less reactive and, by the use of the methyl ester (VIII) and amide (XIV) of 6-bromo-8-chloroöctanoic acid, the objective 6, 8-bis{2-{N-[(4-amino-2-methyl-5 -pyrimidinyl) methyl] formamido}-1-(2-hydroxyethyl) propenyldithio}-octanoic acid was obtained as its methyl ester (II) and amide (IV). Although II retained its thioctic acid activity in approximately 90% of the original acid, transition of thiamine into blood cells was hardly observed.抄録全体を表示PDF形式でダウンロード (588K) -
チオクト酸誘導体とビタミンB1との結合化合物の合成 その2出口 義雄, 中西 和夫1963 年 83 巻 7 号 p. 704-707
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーFollowing the previous work*1 on the disulfide conjugate (I) of thioctic acid and thiamine, whose thiamine did not transit into blood cells, attempt was made to obtain compounds (IIa and IIb), in which the sulfur atom at 6- or 8-position of thioctic acid was bonded in disulfide form to thiamine and the other sulfur was in a dimer form. Methyl 8-chloro-6-hydroxyoctanoate (III), which was easily available, was converted into methyl 8-mercapto-6-bromo-octanoate (VIa) and from it, methyl 8, 8′-dithiobis[6-{2-{N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamido}-1-(2-hydroxyethyl)propenyl-dithio}öctanoate] (IIa) was obtained. Although transition of thiamine into blood cells was observed in II, its thioctic acid activity was abnormally low.抄録全体を表示PDF形式でダウンロード (610K) -
チオクト酸誘導体とビタミンB1との結合化合物の合成 その3出口 義雄, 三浦 一子1963 年 83 巻 7 号 p. 708-713
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーIn continuation of previous works, attempt was made to synthesize a compound in which the sulfur atom at 6-position of thioctic acid was bonded in disulfide form to thiamine and the sulfur atom in 8-position was acetylated, i.e. methyl 8-acetylthio-6-{2-{N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamido}-1-(2-hydroxyethyl)propenyldithio}octanoate (IIIa). This compound, IIIa showed satisfactory result in thioctic acid activity and transition of its thiamine into blood cells. Among the various methods of synthesis tried, even that showing the highest yield gave the objective substance in a total yield of ca. 6% from methyl 8-chloro-6-hydroxyoctanoate (IV). It was found that the one of the reasons for this poor yield was the extremely slow reaction of the halogen atom in 6-position of methyl 8-acetylthio-6-halogenoöctanoate (VII) to form the Bunte salt (VIII) by the action of sodium thiosulfate and the fact that VIII is easily decomposed by heat.抄録全体を表示PDF形式でダウンロード (992K) -
6-アシルチオ-8-クロロオクタン酸エステルの新合成法出口 義雄, 三浦 一子, 伊藤 真純1963 年 83 巻 7 号 p. 713-717
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーIt had been found that derivatives of haloöctanoic acid in 6- and 8-positions differed in their behavior towards sodium thiosulfate and that the use of 8-substituted derivative would be more desirable. In the present series of work, methyl 8-chloro-6-hydroxy-octanoate was derived to methyl 8-chloro-6-tosyloxyoctanoate (VII) by the action of tosyl chloride and methyl 6-acetylthio-8-chioroöctanoate (Va) was finally synthesized in a high yield of 73% by the application of thioacetic acid and calcium hydroxide in acetone.抄録全体を表示PDF形式でダウンロード (744K) -
チオクト酸誘導体とビタミンB1との結合化合物の合成 その4出口 義雄, 三浦 一子1963 年 83 巻 7 号 p. 717-721
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーStarting with methyl 6-acetylthio-8-chloroöctanoate (Ia) obtained in a previous work, the objective methyl 6-acetylthio-8-{2-{N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-formamido}-1-(2-hydroxyethyl)propenyldithio}octanoate (IIIa) hydrochloride was obtained in 42% yield from methyl 8-chloro-6-hydroxyoctanoate.
The values of thioctic acid activity of the conjugates of thioctic acid deriyatives and thiamine obtained in this series of work and transition of thiamine into blood cells, using washed blood cell suspension from a rabbit, are presented.抄録全体を表示PDF形式でダウンロード (807K) -
保存剤のガスクロマトグラフィー井口 定男, 山本 孫兵衛, 青山 敏信1963 年 83 巻 7 号 p. 721-723
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーSeparatory detection of preservatives by gas chromatography was examined. A mixture of sorbic acid, benzoic acid, salicylic acid, dehydroacetic acid, menadione, and methyl, ethyl, butyl, and propyl p-hydroxybenzoate was separated completely into the componental compounds without any pretreatment, under the conditions of 30% DC 550 silicone on Celite 545, at 190°, with carrier gas of hydrogen. Salicylic acid tended to undergo thermal decomposition and phenol peak sometimes appeared in the product but no such decomposition occurred in other compounds.抄録全体を表示PDF形式でダウンロード (386K) -
百瀬 勉, 稲葉 顕1963 年 83 巻 7 号 p. 724-725
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリー3, 6-Dinitrophthalic acid underwent degradation with aqueous sodium hydroxide at a room temperature in about 60 days to 3-hydroxy-6-nitrophthalic acid, which gave a yellow color in alkaline medium. The degradation also occurred gradually in aqueous sodium carbonate, but the acid was very stable when it was stored in tablets mixed with anhydrous alkali carbonate.抄録全体を表示PDF形式でダウンロード (334K) -
ピリダゾン誘導体よりピラゾロン誘導体への縮環反応牧 敬文, 木津 弘子, 小畑 和永1963 年 83 巻 7 号 p. 725-728
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリー1-Phenyl-3, 5-dichloro-6(1H)-pyridazinone (IV) was converted into 1-phenyl-3-hydroxy-pyrazolecarboxylic acid (VI) by treatment with alkali hydroxide solution. The structure of VI was established mainly from infrared spectra of VI and its derivatives. The mechanism of this ring-contraction reaction was assumed.抄録全体を表示PDF形式でダウンロード (684K) -
4-Thienyl-3-buten-2-one誘導体の合成ならびに抗菌作用について藤川 福二郎, 平井 邦夫, 沢田 乙吉, 後藤 淳子, 内藤 益一, 津久間 俊次1963 年 83 巻 7 号 p. 728-731
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーNineteen kinds of 4-thienyl-3-buten-2-one derivatives were synthesized and their antibacterial activity was examined with a sensitive strain of human-type tubercle bacilli H37Rv and a strain resistant to INH, PAS, and streptomycin. Thiosemicarbazone, 4-methyl-, 4-ethyl, and 4-allyl-thiosemicarbazones of 4-thienyl-3-buten-2-one showed antibacterial activity against both sensitive and resistant strains at 6.25γ/ml. and salicyloylhydrazone at 12.5γ/ml., while 4-propyyl-, 4-butyl-, 4-(p-tolyl)-, 4-(o-methoxyphenyl)-, 4-(p-methoxyphenyl)-thiosemicarbazones, p-hydroxybenzoylhydrazone, p-aminobenzoylhydrazone, phenylhydrazone, and p-nitrophenylhydrazone at 25γ/ml.抄録全体を表示PDF形式でダウンロード (601K) -
ハナヒリノキのトリテルペノイド近藤 嘉和, 杉山 淑美, 土出 百合子, 竹本 常松1963 年 83 巻 7 号 p. 731-733
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーUrsolic acid and oleanolic acid were isolated and identified newly from Leucothoe Grayana MAXIM. (Japanese name, “Hanahirinoki”), besides a paraffin, considered to be nonacosane or triacontane.抄録全体を表示PDF形式でダウンロード (470K) -
チオクトイルアミノ酸の合成出口 義雄, 三浦 一子1963 年 83 巻 7 号 p. 733-737
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーIn the previous report, the synthesis of thioctamide which shows normal ultraviolet absorption spectra was reported. In this report, a comparison between the synthetic method of N-thioctoylamino acid and the other method which have been known so far, has been made. Especially, N-thioctoylamino acid (methionine, glycine, valine and glutamic acid) which indicates normal ultraviolet absorption spectra was obtained from the reaction of thioctoyl chloride and amino acid ester easily in a better yield.抄録全体を表示PDF形式でダウンロード (723K) -
Flavonoid Constituents in the Leaves of Acer palmatum THUNBEAG有富 正和1963 年 83 巻 7 号 p. 737-740
発行日: 1963/07/25
公開日: 2010/02/19
ジャーナル フリーBesides vitexin, saponaretin, orientin, and homo-orientin have now been isolated in pure state from the leaves of Acer palmatum THUNBERG and identified as such.抄録全体を表示PDF形式でダウンロード (647K)
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