巻号一覧
84 巻, 9 号
選択された号の論文の24件中1～24を表示しています
- |<
- <
- 1
- >
- >|
-
水野 伝一1964 年 84 巻 9 号 p. 787-792
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーPDF形式でダウンロード (834K) -
3-(5-Nitro-3-furyl) acryl-Heterocyclic体の合成と抗微生物性入倉 勉, 白井 一誠, 佐藤 志摩夫1964 年 84 巻 9 号 p. 793-796
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーIn a search for new antibacterial agents, combination of nitrofuran ring and heterocycle was attempted and over 10 kinds of new derivatives were prepared. An antifungal compound, S-(1-oxido-2-pyridyl)-5-nitro-2-furanthioacrylate, was found by antifungal tests using Trichophyton.抄録全体を表示PDF形式でダウンロード (467K) -
1-Phenyl-2 (or 3)-aminoalkanethiol類の合成西村 温樹, 高松 秀二1964 年 84 巻 9 号 p. 797-805
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーVarious derivatives (II) of 1-phenyl-2-aminoethanol were obtained by the application of an amine to 2-bromoacetophenone followed by reduction, or by amination of 1-phenyl-2-bromoethanol, and chlorination of II afforded the corresponding 2-chloro-2-phenylethylamine derivatives (III). Application of sodium hydrosulfide, sodium thiosulfate, or thiourea to III gave the corresponding thiosulfonic acid (IV) or isothiuronium salt (V), and treatment of IV with hydrochloric acid or of V with alkali produced 1-phenyl-2-aminoethanethiol derivatives (VI), which were oxidized to the corresponding disulfides (VII). VI was also obtained by the amination of α, β-epithiostyrene (VIII), while desulfurization of IV with Raney nickel gave 2-phenylethylamine derivatives. These experiments proved that the reaction of III to IV and V was not accompanied by rearrangement-substitution. 1-Phenyl-3-alkylaminopropanethiol and its disulfide were synthesized from 1-phenyl-3-alkylaminopropanol in a similar manner.抄録全体を表示PDF形式でダウンロード (1271K) -
1-Phenyl-2-alkylaminopropanethiolの立体配位 その1西村 温樹1964 年 84 巻 9 号 p. 806-811
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーFrom the strength of the hydrogen bonding between N and SH in the infrared absorption spectra of (+)- and (-)-1-phenyl-2-dimethylaminopropanethiol (III and III′), obtained by the application of sodium thiosulfate to L-(+)-threo- and L-(-)-erythro-N, N-dimethyl-1-chloro-1-phenyl-2-propylamine hydrochlorides (I and I′), followed by hydrolysis, it was assumed that III is the threo series and III′, the erythro series. III is also obtained by the application of potassium thioacetate or sodium hydrosulfide to I or by application of thiourea followed by alkali treatment of the isothiuronium salt (V) thereby formed.
Similarly, two kinds of 1-phenyl-2-methylaminopropanethiol (VIII and VIII′) and 2-imino-3, 4-dimethyl-5-phenylthiazolidine (X and X′), derived from L-(+)-threo- and L-(-)-erythro-N-methyl-1-chloro-1-phenyl-2-propylamine hydrochloride (VI and VI′) by the application of foregoing reagents, were also determined of their steric configuration in relation to III and III′. These experiments proved that application of nucleophilic reagents to I, I′, VI, and VI′ afforded derivatives without change in their steric configuration.抄録全体を表示PDF形式でダウンロード (1029K) -
1-Phenyl-2-alkylaminopropanethiolの立体配位 その2 1-Phenyl-2-dimethylaminopropanethiol四級塩のホフマン分解西村 温樹1964 年 84 巻 9 号 p. 811-817
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーApplication of sodium thiosulfate to L-(+)-threo-N, N-dimethyl-1-chloro-1-phenyl-2-propylamine hydrochloride, followed by hydrolysis gave (+)-1-phenyl-2-dimethylaminopropanethiol (II) which was derived to the quaternary salt (IV or V) and treated with sodium hydroxide to form (+)-1, 2-epithiopropylbenzene (VI′). Treatment of D-(+)-erythro-1, 2-epoxypropylbenzene (VIII′) with potassium thiocyanate gave L-(-)-erythro-1, 2-epithiopropylbenzene (IX′), which was found to be the antipode of VI′. It is therefore assumed that VI′ is the D-(+)-erythro series and II, the L-(+)-threo series.
(-)-Aminothiol (II′), similarly derived from L-(-)-erythro-N, N-dimethyl-1-chloro-1-phenyl-2-propylamine hydrochloride (I′) was found to be the L-(-)-erythro series and that D-(+)-threo-epithio compound (VI) is derived from it. Steric configuration of VI and VI′ was also determined from their nuclear magnetic resonance spectra. Hofmann degradation of the quaternary salt of 1-phenyl-2-dimethylaminoethanethiol also gave the same result. Epithio compounds (VI and VI′) underwent desulfurization by heating and produced trans-β-methylstyrene.抄録全体を表示PDF形式でダウンロード (1118K) -
N-Alkyl-1-phenyl-2-chloropropylamineの立体配位ならびにその求核試薬による転位置換反応西村 温樹1964 年 84 巻 9 号 p. 817-824
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーTreatment of DL-erythro-1-methylamino-1-phenyl-2-propanol (V) hydrochloride with phosphorus pentachloride or with thionyl chloride results in the formation of two kinds of N-methyl-1-phenyl-2-chloropropylamine hydrochloride (VI and VI′). Application of sodium thiosulfate to VI and VI′ gave the thiosulfonic acid derivatives (VII and VII′). VII′ obtained from VI′ was found to be DL-threo-1-phenyl-2-methylaminopropylthiosulfonic acid, and VII obtained from VI was found to be the erythro compound formed by rearrangement. This result indicates that this reaction proceeds with two Walden inversions via the intermediate aziridinium compound. Actually, treatment of VI and VI′ with sodium hydroxide respectively afforded DL-threo- and DL-erythro-1, 2-dimethyl-3-phenylaziridine (XVIII′ and XVIII). This fact shows that VI is the erythro series and VI′, the threo series. Application of hydrosulfide or thioacetate to VI and VI′ gave the expected rearrangement products.
The only product, N, N-dimethyl-1-phenyl-2-chloropropylamine hydrochloride (XX), obtained by chlorination of DL-1-dimethylamino-1-phenyl-2-propanol, also afforded the rearranged erythro compound by application of similar nucleophilic reagents and XX was found to be the erythro series compound.抄録全体を表示PDF形式でダウンロード (1233K) -
1-Phenyl-2-chloroethylamine類の求核試薬による転位置換反応西村 温樹1964 年 84 巻 9 号 p. 824-830
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーApplication of nucleophilic reagents, such as alkoxides, sodium hydroxide, sodium thiosulfate, and sodium hydrosulfide, to DL- and D-N, N-dimethyl-1-phenyl-2-chloroethylamine (VI and XIV) gave DL- and L-N, N-dimethyl-1-phenyl-1-(substituted)ethylamines. This reaction showed that there is apparently a steric correlation between the starting. compounds and the products. The same reaction of 1-phenyl-2-chloroethylamine by the application of sodium thiosulfate or sodium hydrosulfide gave the rearrangement products, 1-phenyl-2-aminoethylthiosulfonic acid and 1-phenyl-2-aminoethanethiol. VI and XIV were found to undergo facile rearrangement by heating to DL- and L-N, N-dimethyl-2-chloro-2-phenylethylamines. Based on these results, steric configuration of the optically active N, N-dimethyl-2-chloro(mercapto-, substituted mercapto-, or alkoxy)-2-phenylethylamines was determined.抄録全体を表示PDF形式でダウンロード (1128K) -
豊島 昭二, 田中 悟, 小牧 竜夫1964 年 84 巻 9 号 p. 830-836
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリー1-Arylsulfonyl-2, 3-dialkyl-2-thiopseudoureas (VI) were synthesized via 1, 2-dialkyl-2-thiopseudoureas (V) according to the method of Winthrop, and the properties of these V and VI are given in Tables I and II. VI, similar to sulfonylthioureas, undergo desulfurization by silver salt, iron salt, and chromium trioxide to form the corresponding 1-arylsulfonyl-3-alkylureas (VII). Desulfurization of 1-(p-acetylbenzenesulfonyl)-2-benzyl-3-cyclohexyl-2-thiopseudourea (VI-32), symthesized via p-acetylbenzenesulfonyl chloride (XII) which obtained by oxidation of p-ethylbenzenesulfonyl chloride (XI) with chromium trioxide, affords 1-(p-acetylbenzenesulfonyl)-3-cyclohexylurea (VII-3) but chromium trioxide oxidation of 1-(p-ethylbenzenesulfonyl)-2-benzyl-3-cyclohexyl-2-thiopseudourea (VI-37) gives VII-3 in one step. Under a mild oxidation condition, 1-(p-ethylbenzenesulfonyl)-3-cyclohexylurea (VII-4) is formed.抄録全体を表示PDF形式でダウンロード (920K) -
1-ニトロソ-2-ナフトールによるフェノール類の呈色反応について梅田 益雄1964 年 84 巻 9 号 p. 836-838
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーColoration of phenols with 1-nitroso-2-naphthol in nitric acid solution was examined. About fifty phenolic compounds were examined and the specificity of para-substituted phenols to this coloration reported to date does not seem to be necessarily true. This coloration reaction occurs with all phenols having a positive substituent and those with negative substituent hardly undergo this coloration. Specificity of 1-nitroso-2-naphthol to para-substituted phenols is observed only when the concentration of this reagent is low. This is probably due to the fact that para-substituted phenols easily undergo nitration with nitric acid and form nitrophenols which do not react with 1-nitroso-2-naphthol. The same coloration occurs with 2-nitroso-1-naphthol and disodium 3-hydroxy-4-nitroso-2, 7-naphthalenedisulfonate, but less readily than with 1-nitroso-2-naphthol. The same coloration reaction was also found to occur with the use of ammonium cerium sulfate in place of nitric acid.抄録全体を表示PDF形式でダウンロード (453K) -
1-ニトロソ-2-ナフトール・硝酸によるp-置換フェノールの呈色反応の機構について梅田 益雄1964 年 84 巻 9 号 p. 839-845
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーExaminations were made on the mechanism of coloration reaction of para-substituted phenols with 1-nitroso-2-naphthol·nitric acid. The structure of the reaction product was clarified and the mechanism was elucidated. p-Cresol, 2-naphthol, and 4′-hydroxy-acetanilide were used as the para-substituted phenol, they were colored by 1-nitroso-2-naphthol in nitric acidity, and extract of the colored solution with ethyl acetate was chromatographed over alumina column. The product thereby obtained were 10-methyl-5H-benzo [a] phenoxazin-5-one (I) from p-cresol, 5H-dibenzo [a, j]-phenoxazin-5-one (II) from 2-naphthol, and 10-acetamido-5H-benzo [a] phenoxazin-5-one (III) from 4′-hydroxy-acetanilide. Besides III, 10-acetamidobenzo [a] phenoxazonium nitrate (IV) was also obtained, which is responsible for coloration and easily converted to III in an aqueous solution. It is assumed from these evidences that, in this coloration reaction, condensation of para-substituted phenols with 1-nitroso-2-naphthol in nitric acidity takes place first to form labile benzo [a] phenoxazonium nitrate with coloration, and this compound further undergoes oxidation to form the 5H-benzo [a] phenoxazin-5-one derivatives.抄録全体を表示PDF形式でダウンロード (1023K) -
1-ニトロソ-2-ナフトール・硝酸によるレゾルシンの比色定量法およびその反応機構について梅田 益雄1964 年 84 巻 9 号 p. 846-851
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーColorimetric determination of resorcinol with 1-nitroso-2-naphthol in nitric acid solution was established and its reaction mechanism was clarified. Reaction of resorcinol and 1-nitroso-2-naphthol in the presence of nitric acid and a minute quantity of sodium nitrite produces reddish violet color which has absorption maximum at 550mμ. This colored solution was diluted with a large volume of water, extracted with chloroform, and the product was purified by silica column chromatography. The product was found to be 9H-benzo [a] phenoxazin-9-one, agreeing with the compound synthesized by another route. It was assumed that this product, formed via an indophenol compound, colors reddish violet on being dissolved in nitric acid. For the colorimetric determination of resorcinol, the following method is recommended.
One ml. of the sample solution (containing 10-120γ/ml. of resorcinol) is accurately measured into a 10ml. flask, 1ml. of 0.1% 1-nitroso-2-naphthol solution, 1ml. of 0.05% sodium nitrite solution, and 1ml. of 2.5N nitric acid are added. The mixture is shaken well and allowed to stand at 50° for 15 minutes. The flask is immersed in an ice bath and the cooled content is brought exactly to 10ml. with ethanol. Absorbancy of the solution is measured at 550mμ. A blank test is carried ont with the same amount of the same reagent, using 1ml. of water in place of the sample solution. Accuracy of this method is σ=1.36% (n=6).抄録全体を表示PDF形式でダウンロード (886K) -
成形錠剤の見かけの誘電率と含水量について堀越 勇, 佐野 肇1964 年 84 巻 9 号 p. 851-856
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーSolid pharmaceutics were made into tablets by high-pressure, tabletting and apparent dielectric constant and dielectric loss of the tablets were measured. This made it possible to know the difference in the binding of the substrate and water. When water is contained as the water of crystallization, apparent dielectric constant is in the range of 2 to 5, and when present as adsorbed water, as is the case in high molecules, the value was found to become large.抄録全体を表示PDF形式でダウンロード (918K) -
温度変化に対する水和物の誘電特性および重量変化について堀越 勇, 氷室 育三, 佐野 肇1964 年 84 巻 9 号 p. 856-861
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーApparent dielectric constant and dielectric loss of hydrates in accordance with temperature changes were measured and by comparison of these values with weight changes as measured by thermobalance, nature of water in hydrates was examined in detail. This method was found to make simple discrimination of water of crystallization, sorbed water, and free water. The method also enables measurement of melting and decomposition points.抄録全体を表示PDF形式でダウンロード (898K) -
結晶化における陰イオンの影響中垣 正幸, 藤江 忠雄1964 年 84 巻 9 号 p. 861-869
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーEffect of anions on the synthesis of crystalline aluminosilicates was studied in connection with the hitherto reported fact that aluminum chloride can be used instead of sodium aluminate as the aluminum source.
Anions such as C1-, NO3-, CO32-, SO42-, PO43-, SCN-, and I- were used and their effect was examined by using solutions instead of suspensions, since hydrothermal reaction was effected by the use of sodium aluminate solution as the aluminum source, and silica solution as the silicon source.
When silica/alumina ratio n is large and alkali is present in excess of above 300%, species P instead of species R was likely to be produced in the presence of anions, especially of PO43-, in the solution. When n<1, species Q was formed.抄録全体を表示PDF形式でダウンロード (1088K) -
ピコリンおよびそのN-オキシドとヨウ化メチルおよび塩化ベンジルとの反応加藤 鉄三, 後藤 良宜, 引地 学, 川又 健1964 年 84 巻 9 号 p. 869-873
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーα-Picoline 1-oxide undergoes reaction with benzyl chloride in liquid ammonia, in the presence of potassium amide, to form 2-dibenzylmethylpyridine 1-oxide in far larger amounts than phenethylpyridine 1-oxide. This fact indicates that the methyl group had been activated by the presence of N-oxide, compared to the reaction of α-picoline reported by Bergstrom and others.
Reaction of three kinds of picoline and their N-oxides with methyl iodide indicated that the methyl group is activated by the N-oxide group, that β-methyl group has less reactivity, and that the ease of alkylation decreases in the order of γ, α, β in the case of picolines and in the decreasing order of α, γ, β in picoline 1-oxides.抄録全体を表示PDF形式でダウンロード (619K) -
Wollenberg型化合物の合成およびIRスペクトルによる構造研究加藤 鉄三, 北川 常廣1964 年 84 巻 9 号 p. 874-879
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーIsoquinoline, lepidine, and methyl isonicotinate react with diketene to form Wollenberg-type compounds (III, IV, and V). These compounds form dehydro derivatives by dehydrogenation. Hydrolysis of the dehydro compound of III affords compounds with the γ-pyrone ring opened. The ultraviolet absorption spectra of these compounds endorsed these reactions. Examination of their infrared absorption spectra indicated that the Wollenberg-type compounds previously reported, including pyridine-diketene adduct (I) and quinoline-diketene adduct (II), take the a-type structure.抄録全体を表示PDF形式でダウンロード (807K) -
アルキルピリジン誘導体の分析根岸 文平, 西 桂四郎1964 年 84 巻 9 号 p. 879-883
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーAnalysis of alkylpyridines in dry distillate of non-fat soybean was examined. Analysis by infrared spectra of the fractional distillate was almost identical with the result of direct analysis of the component by gas chromatography. Twelve alkylpyridines were thus identified.抄録全体を表示PDF形式でダウンロード (681K) -
川野 タツ, 朝川 雅子1964 年 84 巻 9 号 p. 884-886
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーDecarboxylase activity of 12 kinds of microorganisms on 21 kinds of amino acid was examined by paper electrophoresis. It was thereby found that Escherichia coli No.1 effected decarboxylation of arginine, glutamic acid, lysine, ornithine, histidine, aspartic acid, and canavanine, E. coli K12 that of arginine, glutamic acid, lysine, ornithine, histidine, tyrosine, aspartic acid, and canavanine, Streptococcus faecalis ATCC-8043 that of tyrosine, Proteus vulgaris HX 19 and Lactobacillus arabinosus 17-5 that of glutamic acid, Lact. fermenti 36 that of glutamic acid and histidine, Aerobacter aerogenes No.3059 and Proteus morganii No.3168 that of glutamic acid and ornithine, and Clostridium welchii SR 12 that of glutamic and aspartic acids.
Carbon dioxide formed by decarboxylation of glutamic acid by Lact. arabinosus 17-5 was approximately 90% of the calculated amount in 1 hour so that this cannot be used for the determination of glutamic acid.
Microbiological determination of the decarboxylatlon product of aspartic acid by E. coli No.1 showed that the amount of α-alanine formed is only about 1% of the calculated and the main decarboxylation product is assumed to be β-alanine.抄録全体を表示PDF形式でダウンロード (451K) -
アオギリ樹皮成分について田辺 良久, 小倉 紀代, 酒井 重礼, 高橋 幸太郎1964 年 84 巻 9 号 p. 887-889
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーLupenone, octacosanol, and sucrose were isolated from the bark of Firmiana platanifolia SCHOTT et ENDL.抄録全体を表示PDF形式でダウンロード (460K) -
5-Nitrofurfural N-Substituted Aminoacylhydrazone誘導体および関連類似化合物の合成藤田 昭夫, 南 新作, 高松 秀二1964 年 84 巻 9 号 p. 890-893
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーIn order to test their antibacterial activity N-substituted aminoacylhydrazone, N-(substituted phenylsulfonyl)aminoacylhydrazone, and N-(substituted phenyl)carbamoylacetyl-hydrazone derivatives of 5-nitrofurfural (I) and 5-nitro-2-furanacrolein (II) were synthesized.抄録全体を表示PDF形式でダウンロード (510K) -
有富 正和, 宮崎 州子, 真崎 辰次1964 年 84 巻 9 号 p. 894-895
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーPresence of quercitrin was proved in the leaves of Rhus javanicus L. (Anacardiaceae), and of rutin and kaempherol 3-L-rhamno-D-glucoside in the leaves of Melia Azedarach var. subtripinnata MIQUEL (Meliaceae).抄録全体を表示PDF形式でダウンロード (342K) -
有富 正和, 下城 道子, 真崎 辰次1964 年 84 巻 9 号 p. 895-896
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーA flavonoid glycoside, C21H20O11⋅3H2O, m.p. 168-178°, was isolated in a pure state from the flowers of Gnaphalium affine D. DON (Compositae), and identified as luteolin 4′-β-D-glucoside.抄録全体を表示PDF形式でダウンロード (295K) -
1-置換3-ジメチルアミノ-1,2,3,4-テトラハイドロキノリン誘導体の合成里田 勲, 楠田 冬樹, 松尾 義治, 立脇 信清1964 年 84 巻 9 号 p. 897-899
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーAs part of attempts to find new antipyretic-analgesic agents, following the previous work on the syntheses of quinoline and cinchophen derivatives, derivatives of 1-acyl-3-dimethylamino-1, 2, 3, 4-tetrahydroquinoline and its related compounds were synthesized. Some examinations were made on their synthetic methods and some of its observations are reported.抄録全体を表示PDF形式でダウンロード (404K) -
遠田 稔, 桑名 徳明, 河部 靖1964 年 84 巻 9 号 p. 900-904
発行日: 1964/09/25
公開日: 2010/02/19
ジャーナル フリーMorpholinoacetohydrazide (I) and 4-hydrazinoformylmethyl-4-methylmorpholinium halide (II) were found to have the capacity to separate effectively the two components from a mixture of 4-en-3-one and 1, 4-dien-3-one steroids in a pure state. I and II had the property of selectively binding with 4-en-3-one steroid and their selectivity was equal to that of the Girard reagent. The hydrazone formed with II is water-soluble and separation of the unreacted 1, 4-dien-3-one steroid becomes easy. Actual application of these compounds effected recovery of each component in a high yield from a mixture of these steroids. II is less hygroscopic than the Girard reagent.抄録全体を表示PDF形式でダウンロード (580K)
- |<
- <
- 1
- >
- >|