巻号一覧
88 巻, 11 号
選択された号の論文の26件中1～26を表示しています
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濱田 喜樹, 富田 扶美子1968 年 88 巻 11 号 p. 1361-1366
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリー1) 2-Chloro (or bromo)-4-(p-thiocyanatophenylazo) phenol (I or II), 2-chloro-4-(3-chloro-4-thiocyanatophenylazo) phenol (III), 2, 6-dichloro-4-(p-thiocyanatophenylazo)-phenol (IV), and 4-chloro-4'-iodo-(V) and 4-bromo-4'-chloro-2-amino-5-thiocyanatodiphenyl ether (VI) were derived to their corresponding acetyl compounds (VII to XII) by the application of acetic anhydride. The nitro compound (XIII), obtained by the application of 2-chloro-5-fluoronitrobenzene to the potassium salt of p-fluorophenol, and 2, 2'-dinitro-4, 4'-dichlorodiphenylether were reduced with stannous chloride and hydrochloric acid to the respective amino compounds (XV and XVI), and further thiocyanated with ammonium thiocyanate and bromine to thiocyanato compounds (XVII and XVIII). 2) 1-Aminonaphthalene, 5-aminoisoquinoline, and 3-aminoquinoline were derived to their thiocyanato compounds (XIX to XXI) by diazotization followed by the Sandmeyer reaction. 4-Chloroquinoline 1-oxide, 4-chloroquinazoline, and 2-chloroquinoxaline were derived to their thiocyanato compounds (XXII to XXV) by the application of potassium thiocyanate in acetic acid. 3) Antibacterial activity of all the foregoing thiocyanato compounds was tested.抄録全体を表示PDF形式でダウンロード (579K) -
木村 正康, 長田 永三朗, 野上 裕治1968 年 88 巻 11 号 p. 1367-1370
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーInhibitory effect of Rokusingan and crude drugs contained in it was examined with dd-strain albino mice on the capillary permeability stimulated with acetic acid. The potency of Rokusingan was comparable to that of rutin and each of Bezoar, Moschus, and Bufonis had higher activity than rutin. Combination of these three crude drugs showed synergistic effect and this combined action was antagonized by other crude drugs, such as Realgar, Pearl, and Borneo-camphora. All the components contained in Bezoar, sodium cholate, deoxycholate, and the smooth muscle contracting substances showed higher activity than bezoar. It was concluded from these results that the synergistic effect of Rokusingan is recognized in capillary permeability.抄録全体を表示PDF形式でダウンロード (531K) -
杉井 篤, 椛澤 洋三, 赤松 俊明1968 年 88 巻 11 号 p. 1371-1374
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーAC and DC polarographic behavior of anethole-trithione [5-(p-methoxyphenyl)-1, 2-dithia-4-cyclopentene-3-thione], widely employed as a cholegogic, was examined, using hydrochloric acid-pyridine as the supporting electrolyte. Controlled potential electrolysis was carried out and an electrode reaction mechanism was proposed. Anethole-trithione shows a two-step reduction wave in both AC and DC polarography, and the first wave shows a linear increase in proportion to the concentration. Variation of these peak potentials or half-wave potentials by concentration is such that it can be neglected. The AC peak current varies according to the amount of dioxan and hydrochloric acid-pyridine in the electrolytic solution and with the period of standing. Then DC polarogram of the electrolytic solution submitted to controlled potential electrolysis at -0.60 V exhibits the oxidation-reduction wave as the first wave, and that electrolyzed at -0.85 V shows the presence of a mercaptide and mercury sulfide, suggesting that the first wave is that of a reversible reaction from 1, 2-dithiol bond to thiol, and the second wave is that of a reduction of the 1, 2-dithiol-3-thione bond, resulting in the formation of a thiol and a sulfur ion.抄録全体を表示PDF形式でダウンロード (556K) -
中垣 正幸, 砂田 久一, 谷口 光夫, 中村 康彦1968 年 88 巻 11 号 p. 1375-1382
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーDispersion action of soduim carboxymethyl cellulose (CMC) against alumina was examined by the measurement of sedimentation volume, sedimentation velocity, and filtration rate. Two fractions of different particle radius obtained by levigation of alumina were used as the samples. It was thereby found that maximum flocculation occurs at around 0.03% concentration of sodium-CMC, and that this phenomenon transited to the dispersed state with increase in the concentration. It was also found that the concentration showing maximum flocculation was higher with smaller particle radius. Radius (R) and internal porosity (ε) of secondary particles, and porosity (ε') between secondary particles in the sedimentation bed were calculated, and a method for knowing the flocculation state of primary and secondary particles was explained. Then the values of R, ε, and ε' were calculated from the result of present measurements and it was found that the flocculation power of the primary particles was larger than that of secondary particles, and that the dispersion and flocculation action of sodium-CMC is not to change this flocculation power of alumina particles but changes the radius of secondary particles.抄録全体を表示PDF形式でダウンロード (796K) -
山口 良二, 町田 孝夫1968 年 88 巻 11 号 p. 1383-1387
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーA new good method for the determination of ammonia by the use of o-phenylphenol was proposed. The analytical procedure is as follows : A sample solution (0.5 ml) is pipeted into a glass-stoppered test tube, to which 0.25 ml of 1% sodium nitroprusside, 1.0 ml of 5% dimethylformamide solution of o-phenylphenol, and 1.0 ml of 1% sodium hypochlorite are added successively. The solution is mixed thoroughly, warmed at 37° for 30 min, cooled under running water, and diluted with 3.0 ml of dimethylformamide. This mixture is shaken strongly until the whole solution becomes entirely clear, and the absorbance is estimated at 690 mμ against the reference of reagent blank. Standard deviation and apparent molar extinction coefficient of this method were 2.4% and 6.72×104, respectively. Therefore, the present method is more advantageous than other up-to-date methods for determination of ammonia in the light of three criteria, sensitivity, reproducibility, and color stability.抄録全体を表示PDF形式でダウンロード (571K) -
亀谷 哲治, 照井 恒一, 福本 圭一郎1968 年 88 巻 11 号 p. 1388-1392
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーIn order to examine an analgesic action of 1-chlorophenethylisoquinoline derivatives, 1-(m-chlorophenethyl) (XV) and 1-(m-chlorophenylethenyl)-1, 2, 3, 4-tetrahydro-6, 7-dimethoxyisoquinoline (XXI) were synthesized. Benzyne reaction of the former isoquinoline derivative (XV) with sodium amide in liquid ammonia afforded a cyclized compound (XXII), whose structure was determined by its NMR spectrum.抄録全体を表示PDF形式でダウンロード (611K) -
柴崎 利雄1968 年 88 巻 11 号 p. 1393-1397
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーFluorescence determination of salicylic acid esters was examined. Salicylic acid esters react with acetic anhydride solution of boric acid in acetic anhydride and form fluorescent complex of salicylic acid ester-boron of 1 : 1 ratio. Relationship between the substituents in salicylic acid esters and fluorescence intensity increases in the order of nonfluorescent p-nitrophenyl group, p-methylphenyl group, phenyl group, benzyl group, and alkyl group. Maximum excitation wave length of the fluorescence tended to be in a longer wave length region in the order of alkyl, benzyl, p-methylphenyl, and phenyl group. The same tendency was seen in the case of maximum wave length of the fluorescence. The fluorescence was quite stable. The present method was used in the determination of methyl salicylate in the commercial mixed preparations (ointments) and the values therefrom agreed fairly well with the values obtained by colorimetric determination.抄録全体を表示PDF形式でダウンロード (598K) -
柴崎 利雄1968 年 88 巻 11 号 p. 1398-1403
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーIn order to determine the trace of dehydroacetic acid added to various kinds of foodstuff, the fluorescence determination of dehydroacetic acid reported earlier3) was modified. Dehydroacetic acid reacts with boric acid in 88-77% (v/v) sulfuric acid to form a fluorescent complex salt. The maximum excitation wave length (fluorescence wave length set at 370 mμ) of this complex salt solution is at 325 mμ (corr.) and the maximum wave length of the fluorescence is at 368 mμ (corr.). For this determination, the sample is submitted to steam distillation, 1.0 ml of the distillate (containing 0.03-3 μg/ml of dehydroacetic acid) is placed in a 30 ml glass-stoppered test tube, 8.0 ml of sulfuric acid is added dropwise while cooling the test tube in an ice-water bath, and 1.0 ml of sulfuric acid solution of boric acid is added. The mixture is allowed to stand at 30-35° for 20 minutes, and intensity of fluorescence of this solution is measured. Calibration curve of this solution showed a good lineality in a concentration range of 0.0004-0.7 μg/ml of dehydroacetic acid at the time of fluorescence measurement, and the fluorescence was stable. It was found that sodium dehydroacetate contained in foodstuff (such as fruit juice, Miso, bean paste, fermented milk, and butter) can be determined satisfactorily by this fluorescence method by using the partially modified steam distillation.抄録全体を表示PDF形式でダウンロード (599K) -
安茂 寿夫, 和志 武三徳, 漆崎 文男, 野田 国男1968 年 88 巻 11 号 p. 1404-1411
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリー2, 2-Diphenyl-2-propargyloxyacetic acid (2-dimethylaminoethyl) ester hydrochloride (DPDM) is decomposed in aqueous solution. It was confirmed by thin-layer chromatography and gas chromatography that the decomposition of DPDM occurs as consecutive reactions. In the first step, DPDM is hydrolysed to propargyloxy-benzilic acid (BPE) and β-dimethylaminoethanol hydrochloride and next, BPE is decomposed to benzilic acid (BA) and propargyl alcohol. As BPE is extremely slightly soluble in water, BPE precipitates in aqueous solution in proportion to decomposition of DPDM. In the present investigation, the hydrolytic decomposition of DPDM and BPE was studied in order to obtain more stable aqueous preparations, and DPDM was found to be stable at pH 2.5 to 3.5. Variations in the concentration of DPDM, BPE, and BA in aqueous solution were calculated by an analog computer. Data observed in the experiment corresponded with those calculated by the computer.抄録全体を表示PDF形式でダウンロード (801K) -
松本 弘一, 永田 正典, 川平 準市, 山崎 高応1968 年 88 巻 11 号 p. 1412-1418
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリー6-Acetylquinoline (II) underwent rearrangement to 5-acetyl-6-quinolinol (III) with aluminium chloride in nitrobenzene. It was concluded that (III) had the given structure from the nuclear magnetic resonance spectral analysis of the compound (V) derived from (III) and separate synthesis of V starting with 5-amino-6-quinolinol. The compound III was condensed with some aromatic aldehydes (IX a-h) to give the corresponding chalcones (Xa-c) or the corresponding flavanones (XId-h). XIa-c were produced on heating Xa-c in 50% acetic acid.抄録全体を表示PDF形式でダウンロード (684K) -
中垣 正幸, 砂田 久一1968 年 88 巻 11 号 p. 1419-1422
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーIn a previous paper, studies on the influence of particle size distribution upon the sedimentation volume of spherical particles cohesive on contact were reported. This paper dealts with the theoretical calculations of the sedimentation volume of attractive spherical particles and the distribution of contact number. When there is an attractive force among particles, both the range of the attraction of gravity and the polydispersity are considered to give influences on the sedimentation volume, and so the examination was focussed at this point. Then the volume fraction <VF>W, when two kinds of particles are mixed, is determined from the weight average <δ/γ>W of the ratio of the larger particle attractive force to the radius, δ1/γ1 and the ratio of the smaller particle attractive force to the radius δ2/γ2, that is [numerical formula] where x2 is the ratio of smaller particle number. When the size between larger and smaller particles is different remarkably, and also the interparticle attractive force is greater, then a little increasing effect of volume fraction, surrounding the particle, is considered to be additive.抄録全体を表示PDF形式でダウンロード (524K) -
小菅 卓夫, 横田 正実, 落合 明男1968 年 88 巻 11 号 p. 1423-1427
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーThe rice bran tar has been used for a long time as a home remedy for eczema. It was clarified that a mixture of sat. fatty acids with 7-10 carbons in their structures, play important part in antifungal activity of the tar. These fatty acids would be produced from the fat in the rice bran by pyrolysis.抄録全体を表示PDF形式でダウンロード (460K) -
藤川 福二郎, 平井 邦夫, 平山 晃久, 内藤 益一, 津久間 俊次, 蒲田 迪子, 太田 令子1968 年 88 巻 11 号 p. 1428-1432
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーForty-one kinds of 1-(2-pyridyl)-3-alkyl (or aryl)-2-thiourea, 1-(4-antipyrinyl)-3-alkyl (or aryl)-2-thiourea, and 1-(2-benzothiazolyl)-3-alkyl (or aryl)-2-thiourea were systematically synthesized and their antibacterial action against human type tubercle bacilli H37Rv strain was comparatively examined using the Kirchner medium added with 10% serum or Tween-albumin medium. 1-(2-Benzothiazolyl)-3-butyl-2-thiourea, 1-(2-benzothiazolyl)-3-hexyl-2-thiourea, 1-(2-benzothiazolyl)-3-(p-ethoxyphenyl)-2-thiourea, and 1-(2-benzothiazolyl)-3-(p-tolyl)-2-thiourea showed antibacterial activity comparable to Isoxyl (1, 3-bis (p-isoamyloxyphenyl)-2-thiourea) and Thioban (4-(2-pyridyl)-4'-isobutoxythiocarbanilide) used as the control.抄録全体を表示PDF形式でダウンロード (595K) -
入谷 信彦, 滝野 吉雄, 谷沢 久之1968 年 88 巻 11 号 p. 1433-1436
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーA spectrophotometric method for the micro amount determination of 4-iodothymol (I) and thymol (II) which may co-exist as impurities in sample was studied and the following procedure was found to be very simple and give accurate results. To 5 ml of the sample solution containing about 2 mg of I or/and II in a separate funnel, 2 ml of conc. HCl, 3 ml of water and 10 ml of 10% NaCl solution are added, and the mixture is extracted 3 times with about 7 ml portions of chloroform. The chloroform extracts are combined and made up exactly to 25 ml. The absorbancies at 275.5 mμ and 281.0 mμ are measured against a chloroform blank and the amounts of I and II are calculated according to the equations (1)-(5). Interference from surface active agent could be eliminated by passing the sample solution through a column of anion exchange resin, OH form.抄録全体を表示PDF形式でダウンロード (523K) -
野口 照久, 橋本 喜信, 森 俊郎, 加納 三郎, 宮崎 幸信1968 年 88 巻 11 号 p. 1437-1449
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーOver 60 kinds of 1, 2, 4-thiadiazole derivatives were synthesized and their biological activities were examined. It was found that 3-methyl-5-(p-chlorophenylsulfonyl)-1, 2, 4-thiadiazole and 3-methyl-5-(p-tolylsulfonyl)-1, 2, 4-thiadiazole had the most powerful antimicrobial activity. Among the biological activities of these ring derivatives, the antimicrobial activity of the 5-phenylsulfonyl substituent seemed to depend on the-SO2-group and its conversion to the -NH-, -O-, or -S- type markedly reduced the effect. Introduction of a substituent in the para position of the benzenesulfonyl group had little effect on the antimicrobial activity but substitution of Cl with CH3 increased nematocidal effect while conversion to -SCN further increased this activity. In contrast, acaricidal activity was decreased in the -SO2- form and became effective in -S- form. Antifungal activity was tested by animal experiment. The compounds were effective against Trichophyton but ineffective against Candida. Toxicity and pharmacological tests revealed that these compounds had comparatively low toxicity.抄録全体を表示PDF形式でダウンロード (1128K) -
清水 岑夫, 森田 直賢1968 年 88 巻 11 号 p. 1450-1453
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーA New glycoside (A), C23H24O12·2H2O, mp 206-207° was isolated from Chrysosplenium maximowiczii FRANCE. et SAVAT. (Japanese name "Mukagonekonome"). A was assumed to be 5, 6, 4'-trihydroxy-3, 7, 3'-trimethoxyflavone-6-monoglucoside. A was named chrysosplenoside-C, and chrysosplenol-C the name was given to the aglycone.抄録全体を表示PDF形式でダウンロード (526K) -
西本 行雄, 豊島 昭二1968 年 88 巻 11 号 p. 1454-1458
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーTailing of chelating agents in thin-layer chromatography was found to be due to the different adsorptivity of the chelate compounds formed against silica gel during development. This was clarified by the analysis of distribution coefficient using oxine (8-hydroxyquinoline) and adsorption isotherm. Effective prevention of this tailing by treatment with disodium salt of EDTA was also proved by the foregoing analyses.抄録全体を表示PDF形式でダウンロード (526K) -
三浦 博史, 河野 信助1968 年 88 巻 11 号 p. 1459-1462
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーBisflavones contained in the leaves of eleven kinds (A-K) of conifer plants belonging to Taxodiaceae and Cupressaceae were studied by using countercurrent distribution method. The results obtained are shown in the Table. Chamaecyparin (V) was isolated from the natural source for the first time. Occurrence of hinokiflavone 4''', 7dimethyl ether, a new compound in the leaves of Glyptostrobus pensilis (K), was presumed.抄録全体を表示PDF形式でダウンロード (579K) -
糸川 秀治, 澤田 尚敏, 村上 孝夫1968 年 88 巻 11 号 p. 1463-1466
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーCamellia saponin was isolated from Camellia japonica L. The saponin was first hydrolyzed by alkali to give prosapogenin and was further hydrolyzed by hydrochloric acid to yield camelliagenin A, B and C. Camelliagenin A was derived from camelliagenin B by Wolff-Kishner reduction, and camelliagenin C also derived from camelliagenin B by LiAlH4 reduction. The physical and the chemical results suggested that these sapogenins belong to the pentacyclic triterpenes.抄録全体を表示PDF形式でダウンロード (512K) -
高石 清和1968 年 88 巻 11 号 p. 1467-1471
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーCoumarin (1) and coumaric acid glucoside (2) were isolated from the leaves of Prunus yedoensis MATSUM. (cherry tree). The structure of (2) was proved as o-coumaric acid β-D-glucoside which had been isolated from Melilotus altissima TEUIL. and named melilotoside by C. Charaux. Comparative determination of (1) and (2) in the leaves of cherry tree was made, and it was thereby found that red leaves in autumn contained much more o-coumaric acid glucoside than green leaves in spring, with a very small amount of coumarin in free state throughout the year. It is noteworthy that the deeper the red color of the leaves, the higher the content of o-coumaric acid glucoside. It is also interesting from biosynthetic point of view that both coumarin and anthocyan are synthesized through shikimic acid pathway. It was suggested that the leaves of cherry tree contain a fairly high amount of coumarin in the form of o-coumaric acid glucoside with a very small amount of free coumarin, although Kosuge, Brown, and Soine, have reported that o-coumaric acid glucoside in Melilotus spp. is finally converted into free coumarin.抄録全体を表示PDF形式でダウンロード (575K) -
石川 浩, 新延 信吉, 鶴藤 丞1968 年 88 巻 11 号 p. 1472-1477
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーA new method has been established by which the time course of the vascular permeability increase and leucocyte emigration in the exudative inflammation can be traced on individual animals with the aid of carboxymethyl cellulose as an inflammatory agent. This method provides useful meansto evaluate the characteristics of anti-inflammatory agents. By this method, the mode of action of steroidal and non-steroidal anti-inflammatory agents was studied and results were are as follows : 1) There is a lag phase of three hours in the leucocyte emigration. 2) Steroids strongly inhibited the emigration of leucocyte into the experimental inflammatory locus. The inhibitory effect increased gradually with lapse of time. Non-steroidal anti-inflammatory agents, like Indomethacin, and salicylic acid inhibited the leucocyte emigration at a nearly constant rate. 3) The inhibitory effect on the vascular permeability was comparatively weak with the steroidal anti-inflammatory agents except sodium betamethasone phosphate, while Phenylbutazone and Indomethacin gave a moderate suppresive effect.抄録全体を表示PDF形式でダウンロード (627K) -
佐々木 喜男, 日比野 俊彦1968 年 88 巻 11 号 p. 1478-1481
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーHofmann degradation of methylsinomenine (I) and 1-bromosinomeneine (VII) was carried out, and the structures and mechanisms in the formation of methine bases (II, III, IV, V, and VIII) have been discussed.抄録全体を表示PDF形式でダウンロード (526K) -
亀谷 哲治, 福本 圭一郎, 飯田 英夫, 菊地 豊彦1968 年 88 巻 11 号 p. 1482-1486
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーIn order to confirm the structure of natural capaurimine (I), 1, 10-dihydroxy-2, 3, 11-trimethoxy-5, 6, 13, 13a-tetrahydro-8H-dibenzo [a, g] quinolizine (IIa) was synthesized and its nuclear magnetic resonance spectrum was compared with that of capaurimine (I). The patterns of all the signals of the synthesized sample (IIa) were found to be similar to those of the natural one, but the τ values were different. Further, methylation of IIa with diazomethane afforded 1, 2, 3, 10, 11-pentamethoxy-5, 6, 13, 13a-tetrahydro-8H-dibenzo [a, g]-quinolizine, which was identical with an authentic specimen in spectral characteristics.抄録全体を表示PDF形式でダウンロード (582K) -
小菅 卓夫, 横田 正実, 澤西 啓之1968 年 88 巻 11 号 p. 1487-1488
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーExperiments were made for the development and further classification of the free-radical reactions in heterocyclic compounds. 4-Chloroquinoline 1-oxide and 4-chlorocarbostyril were obtained from the reaction of 4-nitroquinoline 1-oxide with nitrosyl chloride under ultraviolet ray irradiations. From this result, it is assumed that this reaction proceeded by a free-radical mechanism and that the 4-position in 4-nitroquinoline 1-oxide is sufficiently active to free radical reagents as well as to ionic nucleophilic reagents.抄録全体を表示PDF形式でダウンロード (322K) -
三浦 博史, 河野 信助1968 年 88 巻 11 号 p. 1489-1491
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーSequoiaflavone, C31H20O10 (V), a new bisflavone, was isolated from the leaves of Sequoia sempervirens and Cunninghamia lanceolata var. Konishii. It was also formed by partial demethylation of sciadopitysin (IV).抄録全体を表示PDF形式でダウンロード (460K) -
石川 浩, 森 陽, 鶴藤 丞1968 年 88 巻 11 号 p. 1491-1493
発行日: 1968/11/25
公開日: 2008/05/30
ジャーナル フリーThe time course study of leucocyte emigration in acute experimental inflammation using carboxymethyl cellulose pouch method was done in order to decide optimal time for assay of steroidal anti-inflammatory agents. Consequently all the assays were carried out 7.5 hours after the injection of CMC. The relative potencies between hydrocortisone acetate and other corticosteroids by this assay were shown in Table I. The order of inhibitory activity with tested steroidal anti-inflammatory agents, viz., fluocinolone acetonide>triamcinolone acetonide⪇fluoroformylone>betamethasone 17-valerate>prednisolone acetate>hydrocortisone acetate, was in agreement with data obtained in other laboratories.抄録全体を表示PDF形式でダウンロード (447K)
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