巻号一覧
88 巻, 2 号
選択された号の論文の23件中1～23を表示しています
- |<
- <
- 1
- >
- >|
-
木村 正康, 長田 永三朗1968 年 88 巻 2 号 p. 119-124
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーIn order to clarify the action of a proprietary drug "Rokusingan", its componental crude drugs (Bufonis, Bezoar, Moschus, Borneo-Camphora, Realgar, and pearl powder) were examined for mutual complex action. As a result of blood pressure measurements and analysis of central pulse wave form, the site of action of Rokusingan was assumed to be in the cardiac side, and Bufonis was proved to be the principle among the componental crude drugs responsible for this action. It was also found that Bufonis effected elevation of blood pressure after a transitory fall, and it was presumed from experiments that this fall of blood pressure was due to its stimulative action on the vagus nerve and hypertension to direct action on the myocardium and stimulation of the ganglion. While this hypertensive effect of Bufonis is not affected by each of the componental crude drugs alone, combination of Bezoar, Moschus, and Fel bovis inhibited this action by their conjugated effect. It was thereby revealed that the action of "Rokusingan"on circulation system was accompanied with a conjugated action.抄録全体を表示PDF形式でダウンロード (680K) -
木村 正康, 長田 永三朗, 脇 功巳1968 年 88 巻 2 号 p. 125-129
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーIn order to clarify the action of a proprietary drug "Rokushingan"on cardiac function, conjugation action of its componental crude drugs (Bufonis, Bezoar, Moschus, Borneo-Camphora, Realgar, and pearl powder) was examined. All these crude drugs effected contraction of the coronary vascular system, while Bufonis alone effects selective contraction of the excised heart, indicating that Bufonis is responsible for the principal action of Rokusingan. Conjugation effect of the componental crude drugs was examined with the papillary Muscles of a cat and a rabbit, and the contraction of papillary muscles by Bufonis was found to be inhibited by the combined use of Moschus, Bezoar, and Realgar. This fact suggests that the crude drugs contained in Rokusingan show the effect not appreciable by each of them alone but by their conjugation effect.抄録全体を表示PDF形式でダウンロード (687K) -
木村 正康, 脇 功巳, 池田 浩子1968 年 88 巻 2 号 p. 130-134
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーDuring the examination of the cardiac action of a Chinese crude drug, musk, it was found that musk selectively increased the effect of isoprenaline in catecholamine at a concentration of 10-4 g/ml at which musk itself has no action on the papillary muscle. This activity of musk was also proved with tracheal smooth muscle but it had no effect on the action of noradrenaline on vascular smooth muscle. The action of musk does not inhibit the tyramine action, as does cocaine, and there is no change in its action on reserpinized muscle. On the other hand, it inhibits electrical stimulation of the nerves in the hypogastric nerve-vas deferens smooth muscle system. It showed different behavior from cocaine against external noradrenaline and there was no direct effect on it. From these facts, it was assumed that the effect of musk in increasing the action of catecholamine is due to direct participation in β-adrenergic receptor.抄録全体を表示PDF形式でダウンロード (624K) -
木村 正康, 長田 永三朗, 松井 竹史, 小林 千代子1968 年 88 巻 2 号 p. 135-139
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーAnti-inflammatory action of the proprietary drug, Rokusingan (musk, bezoar, bufotalis, borneol, pearl, realgar=2 : 3 : 2 : 2 : 3 : 2), and its componental crude drugs was examined by the filter pellet method. Although the effect of Rokusingan was about 6% of that of hydrocortisone acetate in this action, the complex effect of the combined use of musk, bezoar and bufotalis in 2 : 3 : 2 ratio was found to be responsible for 50% of this action. ID50 values of each of these crude drugs were 388 mg/kg (282-523) in musk, 433 mg/kg (246-767) in bezoar, and 159 mg/kg (114-223) in bufotalis. Based on these values, additive theoretical value was calculated as 284 mg/kg. Since the complex effect of the three drugs, 69.4 mg/kg, is smaller than the theoretical value, this complex effect is considered to be due to the concerted action of these three drugs. It was revealed that the concerted effect of musk and bezoar in 2 : 3 ratio was the principle one in this complex effect. Combined effect of borneol, pearl, and realgar in 2 : 3 : 2 ratio is extremely weak and these drugs probably inhibit the anti-inflammatory action of the foregoing three crude drugs.抄録全体を表示PDF形式でダウンロード (554K) -
柴崎 利雄, 鯉淵 昌信1968 年 88 巻 2 号 p. 140-144
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーThe principle that extinction of a ferric thiocyanate complex solution is reduced with mercuric ion in 5 N sulfuric acid is successfully applicable for determination of phenylmercuric acetate in contraceptive preparations. This method is convenient since the color formation is carried out in a sulfuric acid solution and the absorbance can be measured at 460 mμ. Mercury in concentration of 2-16 ppm can be determined by this method. This method is interfered by the presence of halogen, cerium, chromium, and silver ions.抄録全体を表示PDF形式でダウンロード (553K) -
杉村 継治, 田中 善正1968 年 88 巻 2 号 p. 145-150
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーBis (carboxyphenyl) disulfide is very readily hydrolysed with aqueous alkali hydroxide at room temperature. Simultaneous oxidation and reduction take place and m-thiobenzoic acid is obtaind as the reduction product. Examination of this reaction showed that the disulfoxide, which Smiles reported as the oxidation product, did not exist, but that m-sulfinobenzoic acid was found as the oxidation product. Furthrer, hydrolysis of many aromatic disulfide was examind. The disulfides which were soluble in aqueous alkali hydroxide, except the ortho-substituted compounds, were hydrolysed in the same manner as the above compound. The mechanism of hydrolysis with alcoholic alkali hydroxide seems to be different.抄録全体を表示PDF形式でダウンロード (675K) -
中垣 正幸, 河村 成男1968 年 88 巻 2 号 p. 151-155
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーThe electrokinetic potential (ζ-potential) of sulfisoxazole, sulfadimethoxine, and N1-acetylsulfisoxazole in aqueous solutions of sodium lauryl sulfate (SLS) was measured by the streaming potential method and the influence of particle size on the electrokinetic potential of these sulfanilamides was investigated. It was thereby recognized that the value of -ζ increased with the decrease of particle size, and it reached a maximum value at the 60-100 mesh samples and again decreased with a further decrease in particle size, although the influence of particle size on the ζ-potential does not appear in the Helmholtz-Smoluchowski's equation ζ=H/P·4πηκ/D. It was found that there is a maximum point in the cruve of-ζ vs. the particle size. The value of-ζ and saturated adsorption of SLS increased in the order of N1-acetylsulfisoxazole > sulfadimethoxine > sulfisoxazole. This order was the same as the order of contact angle values, 56.4°, 50.2°, and 47.6°. It was concluded that the adsorption of SLS on sulfanilamides is ascribed to interaction between hydrophobic part of sulfanilamides and SLS molecule.抄録全体を表示PDF形式でダウンロード (590K) -
小澤 光, 原 洋一1968 年 88 巻 2 号 p. 156-162
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーPharmacological properties of 2-aminoethylisothiuronium (AET) derivatives were examined with 2-aminoethylisothiuronium bromide hydrobromide (I), 2-aminoethyl-N'-phenylisothiuronium bromide hydrobromide (II), 2-(2-aminoethylmercapto) imidazoline bromide hydrobromide (III), 2-aminoethyl-N', N"-dimethylisothiuronium bromide hydrobromide (IV), 2-aminoethyl-N', N"-diethylisothiuronium bromide hydrobromide (V), 2-(2-aminoethylmercapto) benzimidazoline bromide hydrobromide (VI), 2-aminoethyl-N'-α-naphtylisothiuronium bromide hydrobromide (VII), 2-dimethylaminoethylisothiuronium chloride hydrochloride (VIII), 2-diethylaminoethylisothiuronium chloride hydrochloride (IX), 2-diethylaminoethyl-N'-phenylisothiuronium bromide hydrobromide (X), and 2-(2-diethylaminoethylmercapto) imidazoline chloride hydrochloride (XI). Among these compounds, only X showed a hypertensive action on rat, cat, dog, and guinea pig, and caused a prolonged contraction of nictitating membrane of cat. Pressor actions of noradrenaline and tyramine were weakly inhibited by II, VI, VII, and X. Five mg/kg of IV and V depressed the nictitating membrane contractions of cat evoked by preganglionic stimulation of the sympathetic nerve, but did not depress the contractions evoked by postganglionic stimulation. I, VIII, and IX showed marked positive inotropic and chronotropic actions, but II, VI, VII, and X did negative inotropic and chronotropic actions on isolated heart of guinea pig. II, V, VII, and X possessed a marked muscle relaxing action on diaphragm of rat. Their activities were found to be almost the same as that of succinylcholine chloride or more. Local anesthetic, antispasmodic actions, and acute toxicity were also tested.抄録全体を表示PDF形式でダウンロード (795K) -
亀谷 哲治, 小笠原 国郎, 原田 悌治1968 年 88 巻 2 号 p. 163-165
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーThe by-product formed during high-pressure reduction of 3, 4-dimethoxybenzyl cyanide was examined and it was found to be a secondary amine (I) by the formation of various derivatives. This amine was utilized to prepare bis (3-hydroxy-4-methoxyphenethyl)-amine (II) and some N-phenethylisoquinoline derivatives. Pharmacological action of these compounds are being examined.抄録全体を表示PDF形式でダウンロード (487K) -
三田 周, 中島 辰己, 利岡 誠夫, 千葉 剛久1968 年 88 巻 2 号 p. 166-177
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーSH compounds (glutathione, 2-mercaptopropionylglycine, and cysteine) and insulin were administered to normal and alloxan-diabetic rabbits, and the variations in blood sugar value, and acid-soluble SH and S-S groups in the blood were examined for one week. The amount of SH and S-S groups in diabetic rabbits was lower than that in the normal rabbit. Administration of 100 mg/kg of 2-mercaptopropionylglycine to a normal rabbit resulted in 10% fall in blood sugar after 7.5 hr, with attendant increase in SH group and marked decrease in S-S group. Administration of insulin (1.0 unit per head) caused 52% fall in blood sugar after 2.5 hr, and the variations in SH and S-S groups were reverse to the changes by the administration of SH compounds. Amount of SH and S-S groups was increased by the administration of SH compounds or insulin in alloxan-diabetic rabbits. Blood sugar fell to 60-78% of the initial level 7.5 hr after the administration of SH compounds and 27-30% 5 hr after the administration of insulin. These results suggest that there is a relationship between the fall in blood sugar level and the increases in SH and S-S groups.抄録全体を表示PDF形式でダウンロード (1105K) -
高木 敬次郎, 岩沢 義郎1968 年 88 巻 2 号 p. 178-184
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーA method has been described for studies of the central effects of drugs by intraventricular injection to the unrestrained conscious mouse. The site of the chronic cannulation was 3.5 mm caudal from the inferior cerebral vein and 1 mm lateral from the sagittal suture. A stainless steel cannula (0.8 mm diameter) held in the carrier of a stereotaxic instrument was inserted vertically into the brain at a depth of 3 mm, and 0.005 to 0.01 ml of drug solution was administered through a needle which had been inserted into the cannula and connected at the opposite end to a microinjector through a flexible plastic tube. Immediately after the intraventricular injection of methamphetamine (MA), methylphenidate (MP), and caffeine sodium benzoate (C.S.B.), an increased rotation ratio and a decreased center-passing ratio were obsereved as in the case of the subcutaneous injection of MA and MP. After subcutaneous administration of C.S.B., however, the center-passing ratio increased remarkably but the rotation ratio did not increase significantly.抄録全体を表示PDF形式でダウンロード (852K) -
斎木 保久, 上野 明, 佐々木 久子, 森田 俊夫, 鈴木 雅子, 斎藤 照代, 福島 清吾1968 年 88 巻 2 号 p. 185-190
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーGas chromatographic studies on phenylpropene derivatives were carried out. As stationary phases, diethylene glycol succinate (DEGS) and SE-30 were used, and values of relative retention time of these compounds were measured. The following facts were observed with respect to their relative retention time. (1) Allyl compounds < cis-propenyl < trans-propenyl. (2) Vicinal substituted compounds to C3-chain have smaller retention time. (3) In the case of DEGS free phenol derivatives have extremely large values. (4) Correlation of substituted position to retention time is not simple. As new materials, 2, 4, 5-trimethoxy-1-allylbenzene, corresponding to the allyl compound of asarone, its two synthetic precursors, and 2, 3, 4-trimethoxy-1-allylbenzene were synthesized. It was found that, β-asarone is not an allyl compound.抄録全体を表示PDF形式でダウンロード (654K) -
Glucuronidesの生化学的研究(第2報) : p-Nitrophenyl GlucuronideのL-Ascorbic AcidあるいはHydrogenPeroxideによる解離生成物質の検討山根 靖弘, 宮崎 元一, 坂井 和男1968 年 88 巻 2 号 p. 191-195
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーThe dissociation products of p-nitrophenyl glucuronide with L-ascorbic acid and cupric ion, or with hydrogen peroxide and cupric ion were identified as p-nitrophenol, 4-nitrocatechol, glucuronic acid, and glucaric acid which is a strong inhibitor of β-glucuronidase. It was assumed that p-nitrophenyl glucuronide was hydrolyzed to p-nitrophenol and glucuronic acid. With L-ascorbic acid and cupric ion or with hydrogen peroxide and cupric ion, glucuronic acid was oxidized easily to glucaric acid, and p-nitrophenol to 4-nitrocatechol. Therefore, 4-nitrocatechol and glucaric acid might be produced respectively from p-nitrophenol and glucuronic acid, which were the primary dissociation products of the glucuronide. However, it is also possible that p-nitrophenyl glucuronide is dissociated oxidatively to 4-nitrocatechol and glucaric acid.抄録全体を表示PDF形式でダウンロード (565K) -
神 久策, 芦立 義一, 遠藤 信1968 年 88 巻 2 号 p. 196-202
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーTwelve a-hydroxyamino compounds were synthesized to examine their biological activity. Their chemical structure was determined as dl-erythro-3-alkylamino-2-hydroxybutyl benzhydryl ether from of mass spectral analysis.抄録全体を表示PDF形式でダウンロード (626K) -
岡野 定輔, 辻 和之1968 年 88 巻 2 号 p. 203-208
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーThe nature of the interaction between riboflavin and ascorbic acid, which was assumed from the brown coloration occurring upon mixing the components in high concentrations, was investigated by both spectrophotometric and solubility methods. The difference spectra of aqueous mixtures of riboflavin and ascorbic acid exhibited absorption maximum at 493 mμ (ε=2700), which was ascribed to semiquinone of riboflavin brought about by the formation of a complex of 1 : 1 molar ratio with ascorbic acid. The formation constant values at various pH's indicated the participation of non-ionized species in the complex formation. The values of ΔH and ΔS revealed that the complexation reaction was exothermic. These findings were further ascertained by examination of the solubility changes due to the complex formation. A new absorption band was observed at about 380 mμ in the spectra of non-aqueous mixtures of riboflavin and ascorbic acid, which were ascribable to π→π* electronic transition. As to the correlation of the two absorption bands, it was presumed that charge transfer (appearance of the absorption band in the vicinity of 380 mμ) which takes place in non-aqueous media proceeds to the extent of formation of semiquinone (light absorption at 493 mμ) in aqueous media.抄録全体を表示PDF形式でダウンロード (665K) -
安田 貞夫, 山中 清行, 栗原 拓史, 斎藤 徳男1968 年 88 巻 2 号 p. 209-211
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーTreatment of o-nitroaniline in ethanol with fluoroboric acid and ethyl nitrite, followed by thermal decomposition, only gave the rearrangement product, p-fluoronitrobenzene, contrary to the result of Bergmann, et al.抄録全体を表示PDF形式でダウンロード (390K) -
山崎 高応, 永田 正典, 荒木 博之, 野原 冨士夫1968 年 88 巻 2 号 p. 212-215
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリー2-Chloropyridine was converted with 3-aminopropanol into 3-(2-pyridylamino) propanol, which was treated with phosphoryl chloride to the corresponding 2H-pyrido [1, 2-a]-pyrimidine derivative (III). III was reduced over platinum oxide catalyst to the expected compound, 1, 3, 4, 6, 7, 8, 9, 9a-octahydro-2H-pyrido [1, 2-a] pyrimidine (IV), which was also prepared by the reduction of 1, 3, 4, 6, 7, 8, 9, 9a-octahydro-2H-pyrido [1, 2-a] pyrimidin-2-one with lithium aluminium hydride.抄録全体を表示PDF形式でダウンロード (480K) -
山崎 高応, 永田 正典, 菅野 紘, 井上 信1968 年 88 巻 2 号 p. 216-218
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーReaction of picolyllithium with bromoacetaldehyde acetal gave 2-pyridylpropionaldehyde acetal (I), whose reduction over platinic oxide catalyst at room temperature under a high pressure yielded β-(2-piperidyl) propionaldehyde acetal (II). The N-nitroso compound (III) derived from II was reduced to the corresponding N-amino compound (IV) with lithium aluminium hydride. An alcoholic solution of IV was heated with oxalic acid, resulting in the cyclization of (IV) to 3, 4, 5, 6, 7, 8-hexahydro-4aH-pyrido-[1, 2-b] pyridazine (V). Acetic acid solution of V absorbed one mole of hydrogen over platinic oxide catalyst to give 2, 3, 4, 4a, 5, 6, 7, 8-octahydro-1H-pyrido [1, 2-b] pyridazine (VI).抄録全体を表示PDF形式でダウンロード (421K) -
荒田 義雄, 酒井 寛吾, 浅井 武, 月岡 美代子1968 年 88 巻 2 号 p. 219-222
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーCondensations of octahydro-4-oxoquinolizidine (I) with ethyl 2-furoate and ethyl 2-thenoate afforded the respective products IIa and IIb, which were hydrolized to give enamines IVa and IVb. The reduction of IVa and IVb with sodium borohydride gave 4-substituted octahydroquinolizidines (VII) which were separated into VIIIa and Xa, and VIIIb and Xb, respectively.抄録全体を表示PDF形式でダウンロード (507K) -
須山 正, 都河 竜一郎, 奥村 信二, 金尾 清造1968 年 88 巻 2 号 p. 223-226
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーSome pelargonic acids variously substituted at 7-and 8-position with amino, ketone, and hydroxyl groups were synthesized. 7, 8-Diaminopelargonic acid was found to serve as a growth factor, its activity being almost equal to that of biotin in the fermentative production of L-glutamic acid from D-glucose. The biotin activities of pelargonic acid derivatives decrease in the order of 8 (or 7)-amino-7 (or 8)-oxopelargonic acid, 7, 8-dioxopelargonic acid, and 7-amino-8-hydroxypelargonic acid. 7-Oximino-8-oxopelargonic acid was isolated from the hydrolysate of 7, 8-dioximinopelargonic acid.抄録全体を表示PDF形式でダウンロード (522K) -
野口 照久, 橋本 喜信, 宮崎 幸信, 加治 有恒1968 年 88 巻 2 号 p. 227-234
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーRelationship between structure and antimicrobial activity of alkyl dithiocarbamates was examined. The compounds [A] of (A, R)-N-C (=S)-S-C (=Y)-X-Ar type generally possess a wide antimicrobial spectrum, and the activity is the strongest when both A and R are methyl groups. In the four combinations with X and Y as S or O, the antimicrobial activity falls in the order of SS, SO or OS, and OO (labile). As the compounds with the strongest antimicrobial activity, 2-or 4-chlorophenyl-N, N-dimethylthiocarbamoyl dithiocarbamate and 2-or 4-chlorophenyl-N, N-dimethylthiocarbamoyl dithiocarbamate were identified. In general, [A]-type compounds are labile and tend to change into [B] compounds of (A, R)-N-C (=S)-X-Ar type, losing their antimicrobial activity. However, substitution of A and Ar with aryl groups and R with methyl group suddenly give selective antimicrobial activity to such compounds.抄録全体を表示PDF形式でダウンロード (723K) -
金子 秀彦, 成戸 俊介, 池田 登1968 年 88 巻 2 号 p. 235-238
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーThe quaternary base fraction of Korean Corydalis was examined. The alkaloids isolated from this fraction by means of alumina column chromatography were berberine nitrate, berberine chloride, coptisine nitrate, and noroxyhydrastinine. On the other hand, reduction of the quaternary base fraction to tertiary bases with sodium borohydride afferded dl-canadine, dl-tetrahydrocoptisine, and dl-tetrahydrocorysamine. From this finding, the presence of corysamine in situ was suggested.抄録全体を表示PDF形式でダウンロード (513K) -
木村 雄四郎, 高橋 周七, 吉田 郁夫1968 年 88 巻 2 号 p. 239-241
発行日: 1968/02/25
公開日: 2008/05/30
ジャーナル フリーFrom the seeds of Alpinia katsumadai HAYATA, alpinetin (A) (7-hydroxy-5-methoxyflavanone) and a compound (B), whose structure has been established as 2', 4'-dihydroxy-6'-methoxychalcone by both spectroscopic methods and derivation from the known compound (A), were isolated by chromatography. The compound (B) was named cardamomin.抄録全体を表示PDF形式でダウンロード (426K)
- |<
- <
- 1
- >
- >|