Several cataractogenic compounds were studied, especially quinone compounds in detail, for their inhibitory action on active transport in rabbit lens surviving in vitro. 1, 4-Benzoquinone, 1, 2-naphthoquinone and vitamin K
3 inhibited cation transport and glycolysis in the lens, whereas coenzyme Q
7 did not. Hydroquinone and β-naphthol, the reduced form of 1, 4-benzoquinone and 1, 2-naphthoquinone, scarcely affected cation transport and glycolysis. Among the reducing substances found in the lens, ascorbic acid showed potent antagonistic action against 1, 4-benzoquinone. CySH competed with 1, 2-naphthoquinone slightly. GSH competed with 1, 2-naphthoquinone certainly and with the other quinone compounds in less degree. 2, 4-Dinitrophenol inhibited cation transport, but did not inhibit glycolysis. Alloxan had no effect on both responses.
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