巻号一覧
89 巻, 12 号
選択された号の論文の27件中1～27を表示しています
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森 昌斗, 金山 久範, 田畑 耕一, 田口 胤三1969 年 89 巻 12 号 p. 1631-1636
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーBordwell, et al.8) had reported that DL-trans-2-p-tolylthiocyclohexyl S-methyl xanthate (IX) suffered cis-elimination by the Chugaev reaction. However, the present study revealed that the analogue (Ia) carrying a methylthio group in place of the tolylthio group in IX underwent rearrangement to the corresponding dithiolcarbonate. The rearrangement of Ia was attributed to the anchimeric power of the methylthio group. A variety of 2-methylthioalkyl S-methyl xanthates and DL-trans-2-methylthiocyclohexyl N, N-dimethylthionocarbamate (Ib) were thermally treated and the results provided evidences for this rearrangement mechanism which was analogous to that proposed in the case of 2-dialkylaminoalkyl S-methyl xanthates.抄録全体を表示PDF形式でダウンロード (697K) -
加藤 鉄三, 山中 宏, 川又 淳司1969 年 89 巻 12 号 p. 1637-1640
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーAcetylation of ethyl 3-aminocrotonate (I) gives three kinds of monoacetate according to the kind of acetylation agent used. The product of mp 54° is a C-acetate (V) which is obtained in a good yield from I and ketene. The isomer (II) of mp 63° obtained by the treatment of I with acetic anhydride is an N-acetate of I, while the other isomer (III) of mp 108° obtained by the treatment of I with acetyl chloride in pyridine is also an N-acetate of I. II and III are considered to be cis-trans isomers with respect to the enamine carbon-carbon double bond. The structure of II, III, and V is not inconsistent with the result of their decomposition reaction and instrumental analyses.抄録全体を表示PDF形式でダウンロード (446K) -
高木 修造, 加多木 豊之, 竹林 圭子1969 年 89 巻 12 号 p. 1641-1645
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーIn a previous paper, 3) several alkaloids of Lycoris radiata HERB. were separated by gas chromatography using HI-EFF 8B as liquid phase, but lycorenine, one of the main bases, failed to be detected under various conditions. In this report, we give a description of conversion of lycorenine into various derivatives such as acetyl lycorenine, tetrahydrohomolycorine trimethylsilyl ether, diacetyl tetrahydrohomolycorine and deoxylycorenine ; these derivaties were chromatographed with OV-101, OV-17 and XE-60 column. An excellent separation of lycorenine was obtained by converting to tetrahydrohomolycorine TMS ether on 3% XE-60 column at 200°. We tried also to applicate this method to the extract of the alkaloids of Lycoris radiata HERB. Both lycorenine and homolycorine, in the extract, were converted to tetrahydrohomolycorine, which then was trimethylsilanized and chromatographed. The elution pattern is shown on Fig. 5. The quantitative determination of total tetrahydrohomolycorine was carried out using carbazole as internal standard. The amount of homolycorine was determined with a HI-EFF 8B column, while the approximate quantity of lycorenine was obtained by subtracting the amount of tetrahydrohomolycorine corresponding to homolycorine from the total tetrahydrohomolycorine.抄録全体を表示PDF形式でダウンロード (608K) -
杉浦 寿美, 井上 昭二, 岸 義人, 後藤 俊夫1969 年 89 巻 12 号 p. 1646-1651
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーTo confirm the sutructure of Cypridina luciferin, synthesis of 2-amino-5- (3-indolyl) -pyrazine (XXI) was carried out by condensation of 3-indolylglyoxal and α-aminoacetamidine. We confirmed that the indolyl group in XXI is substituted at 5 and not at 6 position of the pyrazine ring in comparing the nuclear magnetic resonance spectrum of XXI with that of authentic 2-amino-5-phenylpyrazine (IX) obtained by condensation of phenylglyoxal aldoxime and aminoacetonitrile followed by reduction. IX was also synthesized from phenylglyoxal and α-aminoacetamidine. Ultraviolet spectral behavior of the pyrazine (XXI) is nearly identical with that of etioluciferin obtained from natural luciferin, indicating that both XXI and etioluciferin have the same chromophore.抄録全体を表示PDF形式でダウンロード (668K) -
杉浦 寿美, 井上 昭二, 岸 義人, 後藤 俊夫1969 年 89 巻 12 号 p. 1652-1656
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリー2-Amino-5-benzamidovaleramidine dihydrobromide (X) was synthesized from 4-benzamidobutyraldehyde diethyl acetal. Using the similar procedure reported in the previous paper for the preparation of 2-amino-5- (3-indolyl) pyrazine, X and 3-indolylglyoxal were condensed to afford benzoyletioluciferamine (XII), which in turn was hydrolyzed with methanolic KOH to give etioluciferamine (I). Synthetic I was proved to be identical with I obtained from natural luciferin.抄録全体を表示PDF形式でダウンロード (619K) -
岸 義人, 杉浦 寿美, 井上 昭二, 後藤 俊夫1969 年 89 巻 12 号 p. 1657-1660
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーSynthetic Cypridina etioluciferamine (I) described in the previous paper, was transformed in a good yield to Cypridina etioluciferin (II) by condensation with S-ethylisothiourea. II was identical with the natural Cypridina etioluciferin in every respects. II was successfully converted to Cypridina luciferin (III) by using the following procedures ; the etioluciferin (II) was treated with D-2-oxo-3-methylvaleric acid (IV) in ethanol, reduced by aluminum amalgam or by catalytic hydrogenation, and finally treated with DCC in ethanol under argon at 4°. The product, Cypridina luciferin (III), was purified through an alumina column and isolated as its hydrobromide. The synthesized luciferin (III) hydrobromide was found to be identical with the natural luciferin hydrobromide in every respects (biological activity, UV spectrum, IR spectrum, mp, mixed mp, paper chromatography).抄録全体を表示PDF形式でダウンロード (555K) -
村越 勇, 高田 邦夫, 萩庭 丈寿1969 年 89 巻 12 号 p. 1661-1663
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーDry distillation of ethyl 3-oxoindolizidine-5-propionate (I) with the same amount of soda lime as reported previously affords 1, 2, 4, 4a, 5, 6, 7, 7a-octahydropyrrolo [2, 1, 5-cd] -indolizine (II) in 48% yield. In order to confirm the α, β-enamine structure of II, conc. potassium cyanide solution was added dropwise with stirring to a solution of the perchlorate (III) of II. In this case, the cyano compound (IV) was also obtained in a quantitative yield. Attempted recrystallization of the picrate of IV from hot ethanol yielded the picrate of II by elimination of hydrocyanic acid as shown in Chart 1.抄録全体を表示PDF形式でダウンロード (432K) -
相沢 義雄, 岩崎 守男1969 年 89 巻 12 号 p. 1664-1668
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーInfluence of inflammation on the phospholipid metabolism in skeletal muscle and action of anti-inflammatory drugs on that were examined. Phospholipid content in skeletal muscle increased by inflammation and reached a maxium on the sixth day of inflammation. Incorporation of orthophosphate-32P into phospholipid of skeletal muscle was also increased by inflammation and reached a maxium on the fourth day of inflammation. The increase of incorporation of orthophosphate-32P into phospholipid by inflammation was inhibited by subcutaneous injection of cortisone or prednisolone. The incorporation of orthophosphate-32P into phospholipid in inflammatory skeletal muscle was inhibited by the addition in vitro of cortisone, prednisolone, or dexamethazone but that of intact muscle was not affected.抄録全体を表示PDF形式でダウンロード (620K) -
森 五彦, 常松 範子, 志野木 正樹1969 年 89 巻 12 号 p. 1669-1672
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリー無機金属イオンの電気泳動的分離は濾紙3-7)および薄層8,9)において多数報告されているが, 著者等はすでに薄層クロマトシート電気泳動法により90Sr-90Y, 212Pb-212Bi, および15種類の陽イオンの迅速分離について報告している10,11)本報では34種の金属イオンの分離定性ならびにBa2+とLa3+, Mg2+とAl3+, Cd2+とIn3+の相互分離を検討し, さらにBa2+とLa3+の放射性同位体140Baと140Laについて分離した結果を報告する.抄録全体を表示PDF形式でダウンロード (509K) -
瀬戸 秀一, 平塚 利勝, 戸田 紘子1969 年 89 巻 12 号 p. 1673-1677
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーIt has been clarified that tropone4) (Ia) is stabilized by the resonance effect of the structure Ib, from some experimental data, for example, dipole moment, 5) electron diffraction, 6) and IR spectrum.7) In aminotropone and aminotropolone derivatives, contribution of the structure Ib should result in the decrease of basicity of the amino group. The pKa values of aminotropones and aminotropolones11-18) (III to XIII) were measured by the spectroscopic method8) in order to investigate the contribution of the structure of Ib type for stabilization of the compounds III to XIII. It was found that the basicity of aminotropones and aminotropolones (Table II) tends to rise as the distance between the amino group and the carbonyl group increases, and is comparable to those of cyanoaniline, 19) chloroaniline, 20) and bromoaniline.21) Tautomerism of asymmetric aminotropolones was also discussed. By comparison of the UV spectra of aminotropolones with those of aminotropones, it was concluded that 3-aminotropolone (XI) and 4-aminotropolone (XII) exist predominantly as the tautomeric structure of 2-aminotropone type (XIa) and 3-aminotropone type (XIIa), respectively, in water.抄録全体を表示PDF形式でダウンロード (526K) -
富田 眞雄, 澤田 徳之助, 小塚 睦夫, 竹内 允子, 赤須 通美1969 年 89 巻 12 号 p. 1678-1681
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーFrom the root tuber of Stephania cepharantha HAYATA (Japanese name "Tamasaki-tsuzurafuji") cultivated in Japan, cepharanthine (I), isotetrandrine (II), cycleanine (III), and berbamine (IV) were isolated together with a new crypto-phenolic base of bisbenzylisoquinoline type, cepharanoline (decomp. 270°, [α]35D +319° (CHCl3), C36H36O6N2). The O-methylcepharanoline (mp 103°, [α]30D +287° (CHCl3), C37H38O6N2) was identified by comparison with cepharanthine (I). The mass spectrum of cepharanoline revealed that the phenolic hydroxyl in cepharanoline is present in 4'-position. These experiments revealed that cepharanoline is represented by formula VII.抄録全体を表示PDF形式でダウンロード (583K) -
大本 太一1969 年 89 巻 12 号 p. 1682-1687
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーDistribution of triterpenoids and related compounds was examined for six species of Gramineous plants, with special reference to the chemotaxonomical point of view. The triterpenoids thus identified are shown in Table I. Arborinol methyl ether (Vd), a new triterpene methyl ether, was isolated from the culms and leaves of Imperata cylindrica BEAUV. var. koenigii, DURAND et SCHINZ and identified with the synthetic specimen.抄録全体を表示PDF形式でダウンロード (760K) -
小山 鷹二, 戸田 睦子, 廣田 喬, 橋本 満紀, 大和 正利1969 年 89 巻 12 号 p. 1688-1690
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーHeating of α-acyl-3, 4-methylenedioxyphenylacetonitriles (I) with H2NCHO and POCl3 afforded pyrimidines (II) and enamines (III), the intermediate of pyrimidines, but isoquinolines were not isolated. Thus α-formyl derivative (Ia) gave 4-amino-5- (3', 4'-methylenedioxyphenyl) pyrimidine (IIa), α-acetyl derivative (Ib) gave β-amino-α- (3, 4-methylenedioxyphenyl) crotononitrile (IIIb), but under more drastic conditions Ib or IIIb gave 4-amino-6-methyl-5- (3', 4'-methylenedioxyphenyl) pyrimidine (IIb), and α-benzoyl derivative (Ic) gave 4-amino-5- (3', 4'-methylenedioxyphenyl) -6-phenyl-pyrimidine (IIc), and β-amino-α- (3', 4'-methylenedioxyphenyl) cinnamonitrile (IIIc), but under more drastic conditions Ic or IIIc gave only IIc. 3, 4-Methylenedioxyphenylacetonitrile (IV) gave IIa and 3, 4-methylenedioxyphenylacetamide (V) under the same reaction conditions.抄録全体を表示PDF形式でダウンロード (532K) -
國友 順一, 岡本 靖子, 弓削 税子, 永井 嘉子1969 年 89 巻 12 号 p. 1691-1695
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーExaminations were made on tertiary bases contained in Formosan Stephania sasakii HAYATA, and pronuciferine (VII), roemerine (IX), nuciferine (VIII) (a non-phenolic base), and tuduranine (X) (a phenolic base) were isolated and identified besides the known cepharanthine (I), crebanine (II), phanostenine (IV), and berbamine (III). Three new bases, aknadinine, base VI, and base XIII were also isolated.抄録全体を表示PDF形式でダウンロード (642K) -
安茂 寿夫, 成富 正温, 浅野 正道, 鈴木 肇, 赤堀 暢子1969 年 89 巻 12 号 p. 1696-1699
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリー一般に錠剤強度は圧縮圧力の上昇に伴って増大すると報告3)されているが, これらの報文の実験データを詳細に検討するとある圧力以上, またはある圧力範囲で特異的に強度が劣化する場合が認められる.3,4)著者等の実験においても前報1,5)までに述べてきたように圧縮圧力の上昇に伴う錠剤強度の増大傾向は一様ではなく, ある圧力範囲で特異的に変化し, 打錠圧力の上昇に伴い錠剤強度が劣化する場合すら認められた.打錠圧力の上昇に伴う錠剤強度劣化の典型としてキヤッピング発生が知られている.打錠圧と粉体応力緩和との関連において, キヤッピング発生に関する考察をなすためにキヤッピングを起こしやすい試料として, エトキシベンズアミド(以下EBAと略す)を選び実験を行なった.EBAは解熱鎮痛剤として使用されている医薬品である.単味のEBAを高圧で打錠するとキヤッピングを起こす.本報ではEBAの粉体応力緩和速度定数と錠剤の瞬間的弾性回復率を測定しキヤッピング発生に対する考察を行なった.抄録全体を表示PDF形式でダウンロード (503K) -
新海 弘之, 田中 一郎1969 年 89 巻 12 号 p. 1700-1703
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーAccumulation of hydrocortisone [4-14C] acetate into the epidermis and its release from the corium into saline were examined by the in vitro method described previously. The skin used was epidermis separated from a full-thickness of the skin excised from human or guinea pig abdomen. The results of examination showed that the rate of release of hydrocortisone [4-14C] acetate from the liquid vehicles to the epidermis was equal to the rate of its release to the full-thickness skin, and radioactivity was not detected in the saline, as reported ealier. However, when the corium, removed of epidermis, was used, release of labeled hydrocortisone acetate from liquid paraffin into saline through the corium was remarkably increased, and the amount of labeled hydrocortisone acetate in saline increased with lapse of time. When other vehicles were used, such as propylene glycol-water (30 : 70) or HS-12-P (Iauricdiethanolamide) -water (10 : 90), the release of labeled hydrocortisone acetate into saline was not detected. Therefore, release of hydrocortisone [4-14C] acetate from liquid vehicle into saline through the corium dose not always increased with removal of the epidermis.抄録全体を表示PDF形式でダウンロード (526K) -
馬場 貞雄, 扇谷 正三郎1969 年 89 巻 12 号 p. 1704-1711
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーThe following investigations were carried out on : 1. The yield of dinitrophenyl derivatives of aliphatic amines in human urine and their extraction rate from the reaction mixture using various solvents. 2. The thin-layer chromatographic identification of aliphatic amines in urine of patients after dinitrophenylation. 3. The separatory estimation of ethanolamine, methylamine and dimethylamine in urine of patients by isolating their dinitrophenyl derivatives by ion exchange chromatography and reversed phase chromatography. 4. The gas chromatography of dinitrophenyl derivatives of aliphatic amines in human urine with SE-30 or OV-17 as liquid phase.抄録全体を表示PDF形式でダウンロード (810K) -
馬場 貞雄1969 年 89 巻 12 号 p. 1712-1714
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーThe occurrence of three new aliphatic amines in human urine was definitely proved. A satisfactory analytical procedure was established by extracting the amine distillate derived from a large quantity of urine (100-200 ml) with chloroform and by removing a great part of ammonia and methylamine. Isobutylamine and n-butylamine were identified by analyzing the extract in the amino acid analyzer. Each fraction containing isobutylamine or n-butylamine was collected, dinitrophenylated and then submitted to gas chromatography to provide further identification of isobutylamine and n-butylamine as their DNP-derivatives. Moreover, n-hexylamine was evidently identified by thin-layer and gas chromatography.抄録全体を表示PDF形式でダウンロード (447K) -
加藤 鉄三, 窪田 幸夫1969 年 89 巻 12 号 p. 1715-1718
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーReaction of diketene with urethan and acid amide was examined. Heating of urethan with excess of diketene results in the formation of N-acetoacetylurethan (III) and N-ethoxycarbonyl-2, 6-dimethyl-4-oxo-4H-pyran-3-carboxamide (IV). IV is also obtained by refluxing III and diketene in benzene, in the presence of triethylamine. Acetamide and benzamide react with diketene in acetic acid to form respectively N-acetoacetyl-acetamide (VI : R=CH3) and N-acetoacetylbenzamide (VI : R=C6H5). Under the same condition, formamide and diketene form 3-acetyl-6-methyl-2, 4-pyridinedione (V) but the corresponding products were not isolated in the reaction with other acid amides.抄録全体を表示PDF形式でダウンロード (543K) -
森坂 勝昭, 中元 安雄1969 年 89 巻 12 号 p. 1718-1723
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーIt was clarified through animal experiments with rats that absorption of salicylic acid series compounds, such as aspirin, through the digestive tract was accelerated by the presence of an additive of taurine-like or related compounds such as glycine, glycine ethyl ester, sarcosine, and l-, d-, and β-typg alanines. Distribution coefficient of aspirin and such compounds was found to remain unchanged by the presence of these additives, and it was assumed that the action of these additives was specific to the membraneous surface of the digestive tract. Such effect of the additives was also indicated in the measurement of urinary excretion of salicylic acid series compounds after their oral administration in rats, and approximate correlation between was confirmed.抄録全体を表示PDF形式でダウンロード (653K) -
村越 勇, 葉 英梅, 郷 正士, 萩庭 丈寿1969 年 89 巻 12 号 p. 1723-1725
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーIt was found that (-)-trans-4-hydroxypipecolic acid (I) is present in young leaves of acacia species in a high concentration (as shown in Table I) and that the young leaves of Acacia mollissima before flowering time are useful as a natural source of I. The structure of I was determined by chemical reactions shown in Chart I.抄録全体を表示PDF形式でダウンロード (393K) -
森 五彦, 志野木 正樹, 常松 範子1969 年 89 巻 12 号 p. 1726-1728
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリー無機陰イオンの濾紙および薄層電気泳動についてはすでにいくつか報告3-7)されているが, いずれも比較的高電圧で, 長時間を要し冷却を必要としている.著者等は既報8-10)の小型泳動装置を用い, 無機陰イオン類20種について迅速分離を行ない, 同時に支持物質による違いを検討した.抄録全体を表示PDF形式でダウンロード (418K) -
福島 清吾, 赤堀 幸男, 恒屋 知之1969 年 89 巻 12 号 p. 1729-1731
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーNumerous compounds have been identified in the essential oil of green tea but in the present series of experiments, several unknown components were isolated from the high-boiling fraction of the essential oil of green tea by the use of gas, column, and thin-layer chromatography. Two of these components were identified as dihydroactinidiolide and p-vinylphenol, obtained earlier from the Actinidia polygama and black tea. The identification was based on infrared, ultraviolet, mass, and nuclear magnetic resonance spectral data.抄録全体を表示PDF形式でダウンロード (455K) -
伊阪 博1969 年 89 巻 12 号 p. 1732-1735
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリー土壌菌によるステロイド, ニコチン, アトロピンなどの酸化分解については, 多数の報告があるが, アヘンアルカロイド類についての知見は少ない.2)ケシ栽培圃場から分離した土壌菌のうち, Cladosporium cladosporioides(Fres)de Vriesが, アヘンアルカロイドとくにモルヒネを変化せしめることを見出し, その変換の過程を追い, 分解産物としてプソイドモルヒネ(oxydimorphine), ノルモルヒネ(N-demethylmorphine)を単離同定し, 併せて分解機序について若干の考察を試みた.抄録全体を表示PDF形式でダウンロード (536K) -
安江 政一, 加藤 義成, 杉本 守, 榊原 仁作1969 年 89 巻 12 号 p. 1736-1739
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーThe benzene-soluble part of the methanol extract of the red shoots of Lyonia ovalifolia var. elliptica was treated by alumina column chromatography and following substances were isolated : Nonacosane, 2-nonacosanone, 1-tetracosanol, β-sitosterol, taraxerol, betulin 3-acetate, oleanolic acid, and ursolic acid. The crude nonacosane was examined through gas chromatography and it was found to be contaminated with a small amount of pentacosane, hexacosane, heptacosane, octacosane, triacontane, and hentriacontane. Betulin 3-acetate, mp 263°, was newly found as one of the natural products, and identified with the partially hydrolized product of betulin diacetate. The isomeric substance, betulin 28-acetate, mp 218.5°, a new compound, was synthesized by partial acetylation of betulin, which was obtained from the bark of Betula platyphylla var. japonica.抄録全体を表示PDF形式でダウンロード (558K) -
佐久間 真理, 佐藤 善重1969 年 89 巻 12 号 p. 1740-1742
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーPDF形式でダウンロード (608K) -
杉浦 衛, 加納 邦雄, 木村 一昭, 平工 誠治, 大野 博之, 寺島 宏, 柴田 邦治, 中尾 恵哉1969 年 89 巻 12 号 p. 1741-1742
発行日: 1969/12/25
公開日: 2008/05/30
ジャーナル フリーPDF形式でダウンロード (377K)
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