YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
89 巻, 6 号
選択された号の論文の25件中1~25を表示しています
  • 池本 文彦, 岩田 修造, 成田 不二生
    1969 年 89 巻 6 号 p. 745-749
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Sodium, potassium and water contents in crystalline lens have been studied during the development of naphthalene cataract in rabbit. Cataract was developed in the following manner : first stage…vacuolar formation within 24-48 hours after naphthalene administration, second stage…opacity on the surface in 3-5 days, third stage…opacity and swelling of the cortex after 2 weeks, matured stage…complete cataract after 3-4 weeks. Potassium content in the lens decreased progressively with advancing stage from the first, and it was the contrary with sodium and water contents. Decrease of glycolytic activity of the lens was found after the second stage. Changes in electrophoretic pattern of soluble proteins and increase of insoluble proteins of the lens were not distinctly detected until the third stage. Marked decrease of β-crystalline content was observed in the matured stage. These results indicate that the development of naphthalene cataract is in intimate correlation with changes of cationic contents and hydration of lens. It might be reasonably assumed that inhibition of cation transport is the first biochemical change occuring in naphthalene cataract.
  • 的場 勝英, 吉井 勝美, 山崎 高応, 佐々木 喜男
    1969 年 89 巻 6 号 p. 750-755
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    2-Methyl-3-methoxy-5-hydroxy-2-cyclopentenone (I) was reduced to 2-methyl-4-hydroxy-2-cyclopentenone (VI) and 2-methyl-2-cyclopentene-1, 4-diol (VII) with excess lithium aluminum hydride in ether followed by decomposition with ammonium chloride and water. The ratio of VI to VII was about 3 : 4. 2-Methyl-3-methoxy-4-hydroxy-2-cylopentenone (II) was reduced to 3-methyl-3-cyclopentene-1, 2-diol (X), 3-methyl-1, 2-cyclopentenediol (XI) and VII as a minor component under the same condition as the reduction of I. The ratio of X to XI seemed to vary with the conditions of addition of II to the suspension of lithium aluminum hydride.
  • 吉川 利善, 山口 圭子(旧姓増村), 浦部 勇次
    1969 年 89 巻 6 号 p. 756-758
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Reaction of 6-methyl-and 7-methyl-quinoline 1-oxides with tosyl chloride was examined and the higherto unclarified intermediate formation in this reaction mechanism was elucidated. The fact that the intermediate was converted to carbostyril (IV) via the pseudo base of III type was proved by isolation of the III type intermediate and its derivation to carbostyril by hydrolysis or low-pressure sublimation. It should be noted that the pseudo base can be isolated especially when the benzene ring in quinoline carries a methyl group. The large difference in the formation rate of the pseudo base between the 5-methyl derivative, and 6-and 7-methyl derivatives is probably due to the effect of the position of the methyl group.
  • 吉川 利善, 浦部 勇次, 清田 立夫
    1969 年 89 巻 6 号 p. 759-766
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Reaction of the alkylated derivatives of 2-chloroquinoline with 3-aminopropanol afforded 2-(3-hydroxypropylamino) quinoline derivatives. The hydroxyl group in the ω-position in the side chain was chlorinated with phosphorus pentachloride and phosphoryl chloride and the hydrochlorides (Xa-f) of 2-(3-chloropropylamino) quinoline derivatives were obtained. These hydrochlorides were neutralized with sodium hydrogencarbonate to pH 7.0-7.1 in order to obtain free 2-(3-chloropropylamino) quinoline but the precipitated crystals were not those of the anticipated free compound but was found to be 1, 2, 3, 4-tetrahydropyrimido [1, 2-a] quinolinium chloride, a compound formed by the additional cyclization into a six-membered ring between the chlorinated carbon atom and the non-conjugated electron pairs in the sp orbital of the nitrogen atom in the quinoline ring during neutralization. Treatment of this quaternary salt with alkali resulted in the bonding of OH- with the carbon at 4a position in the ring due to the E effect of positively charged ring nitrogen, and the pseudo base, i.e., methyl dreivative of 4a-hydroxy-1, 2, 3, 4-tetrahydropyrimido [1, 2-a] quinoline, was obtained. This compound was found to undergo isomerization to a lactam when heated.
  • 吉川 利善, 清田 立夫, 浦部 勇次
    1969 年 89 巻 6 号 p. 767-770
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Nucleophilic reaction of the methyl derivatives of 2-chloroquinoline with aminoethanol, ε-aminocaproic acid, and its ester was examined. ε-Aminocaproic ester was extremely difficult to react, aminoethanol reacted with better yield than 3-aminopropanol, and reaction with ε-aminocaproic acid failed to give any reaction product. The hydroxyl group in ω-position of 2-(2-hydroxyethylamino) quinoline, obtained by reaction with aminoethanol, was chlorinated to obtain the methyl derivative of 2-(2-chloroethylamino)-quinoline hydrochloride. Neutralization of this hydrochloride by addition of saturated sodium hydrogencarbonate solution to pH 7.0-7.1 afforded some crystals which were found to be not the liberated base but 2, 3-dihydro-1H-imidazo [1, 2-α] quinolinium chloride, produced by the new formation of a five-membered ring between the chlorinated carbon atom and the non-conjugated electron pairs in the sp orbital of the ring nitrogen during neutralization. This quaternary salt was heated with 10% sodium hydroxide solution and a pseudo base possessing a hydroxyl in 3a-position was obtained.
  • 池田 喜明
    1969 年 89 巻 6 号 p. 771-778
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Examinations were made on the effect of 45 kinds of piperazinoalkyltheophylline derivatives (Table I) on the coronary blood flow and peripheral (femoral vein) blood flow, using anesthetized dogs. Acute toxicity (LD50) of these pharmaceutics was examined by intravenous injection into tail vein of mice. The values obtained were calculated into potency index and toxicity index, taking the value of aminophylline, used as the control, as 1. Compounds possessing aralkyl group as the substituent in 4-position of the piperazine ring showed strong increasing action on blood flow of both circulatory systems, the degree of such action differing with the structure of the substituents. Changes in the structure of the bonding bridge between the piperazine ring and theophylline also affected the degree of activity, acylation of the β-hydroxypropylene group resulting in increased activity. Examination of the ratio of potency index on coronary blood flow to that on femoral blood flow suggested that acylation of the hydroxyl group on the bonding bridge increased the peripheral blood flow rather than coronary blood flow. Acute toxicity was generally lower in compounds having a β-hydroxypropylene group as the bonding bridge.
  • 豊島 昭二, 島田 勝年, 河部 靖, 金沢 保
    1969 年 89 巻 6 号 p. 779-782
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    5-Methylthio-2-furaldehyde (III) was obtained by the application of phosphoryl chloride and dimethylformamide to 2-methylthiofuran (II). Oxidation of III with hydrogen peroxide and acetic acid gave 5-methylsulfonyl-2-furoic acid (VIII). Compounds listed in Chart 1 were prepared from III and VIII, and antimicrobial activities of these compounds in vitro were tested (Table I).
  • 柘植 乙彦, 外間 宏三, 渡辺 晴之
    1969 年 89 巻 6 号 p. 783-788
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    2-Phenylacetylthiopheneketazine (Ia), 2-(Ib), 3-(Ic) and 4-phenacylpyridineketazine (Id) were pyrolyzed by a free radical process in order to obtain information concerning effect of heterocyclic rings on azine pyrolytic processes. The pyrolysis of Ia at 270° or 290° afforded principally ammonia, toluene, thiophenecarbonitrile and 3, 5-dithienyl-4-phenylpyrazole (III), accompanied by lesser quantities of nitrogen, diphenylethane and an unidentified compound. The compound III was proved, by the investigation of the admixed melting point and infrared spectrum, to be identical with an authentic sample prepared from the reaction of 1-phenyl-1-thenoyl-2-thienylethylene with hydrazine. On the other hand, Ib and Id decomposed at 250° to afford nitrogen, ammonia and 2, 5-diphenyl-3, 4-di (α-pyridyl)-(VIIb) or 2, 5-diphenyl-3, 4-di (γ-pyridyl) pyrrole (VIId) as main products, accompanied by 1-or 4-picoline, benzonitrile and 3, 5-diphenyl-4-(α-pyridyl) pyrazole (VIIIb) in small amounts. In the pyrolysis of Ic at the same temperature, however, 3-picoline, benzonitrile and 3, 5-diphenyl-4-(β-pyridyl) pyrazole (VIIIc) were mainly formed, but nitrogen, ammonia and the corresponding pyrrole (VIIc) were formed in low yields. The structures of VII and VIII were confirmed by spectral studies as well as elemental analyses.
  • 柘植 乙彦, 外間 宏三, 古賀 政博
    1969 年 89 巻 6 号 p. 789-795
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    The pyrolyses of acenaphthenoneketazine (I) and acenaphthenone N-benzoylhydrazone (II) were investigated in order to elucidate whether the Pilotz-Robinson reaction product (III) is formed or not. It has been found that the pyrolysis of I afforded ammonia, 2, 3-dihydro-6H-triacenaphtho [1, 2-b, -d, -f] azepine (IV), decacyclene (V) and acenaphthazine (VI) ; although a large amount of resinous material was formed, III was not obtained. On the other hand, III was not also obtained in the pyrolysis of II, but 2-phenyldiacenaphtho [1, 2-c, -e] pyridine (VIII), acenaphthopyridazine (IX), benzamide (X) and N, N'-dibenzoylhydrazine (XI) were also obtained, besides IV, V and VI. The structures of these products were confirmed by direct comparison with the samples prepared by unequivocal routes, or by ultraviolet, infrared, nuclear magnetic resonance and mass spectral studies. The processes of the products formation are also discussed.
  • 楢府 直大
    1969 年 89 巻 6 号 p. 796-803
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    In a previous work of this series, it was found that (2-bromoacyl) ureides administered orally and subcutaneously to rabbits were excreted as the corresponding debrominated metabolites in urine. The present investigation was undertaken in order to determine whether these metabolites were formed by enzymatic reaction, using various preparations of rabbit tissues. As the results, the most debromination of (2-bromoacyl) ureides was found in the anaerobic incubation with liver 9, 000×g supernatant fraction consisting of microsomes and soluble fractions. In this enzymatic reaction, microsomes and soluble fraction served as enzyme and cofactor sources, respectively. Nonenzymatic reduction of these drugs with cysteine, glutathione and ascorbic acid could not be observed.
  • 山口 良二, 町田 孝夫
    1969 年 89 巻 6 号 p. 804-808
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    A new colorimetric method for the determination of ammonia with guaiacol and sodium hypochlorite was studied and a recommended procedure was proposed. This method gave remarkably lower absorbance of blank and better reproducibility than the previously reported o-phenylphenol method. With considerations on the occurrence of side reaction and the reaction rate, suitable concentrations of hypochlorite and nitroprusside were determined. Almost all the variables influencing the color reaction were examined. Coefficient of variance at 20 μg/ml ammonium sulfate solution and apparent molar extinction coefficient (based on N atom) at 680 mμ were found to be ca. 2.3% and 1.92×104, respectively. These values indicate sufficient sensitivity for estimating the quantity of ammonia and correspond to absorbance of 1.36 per μg·N/ml of the final colored solution. The probable reasons for the better reproducibility and low blank value were also briefly discussed.
  • ヒキノ ヒロシ, 鍋谷 将, 竹本 常松
    1969 年 89 巻 6 号 p. 809-813
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Oleanolic acid has been incubated with Cunninghamella blakesleeana. Chromatography of the fermentation product has led to the isolation of six metabolites which have been found by physico-chemical studies to be II, III, IV, V, VI, and VII.
  • 大本 太一
    1969 年 89 巻 6 号 p. 814-820
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Distribution of triterpenoids and related compounds was examined for seven species of Gramineae plants with special reference to a chemotaxonomical point of view. The triterpenoids thus identified are shown in Table I. Lupeol methyl ether (VIIa), a new triterpene methyl ether, was isolated from the culms and leaves of Pasparum dilatatum POIR. and identified with the synthetic specimen. Fernenone (IIIc) and 12-ketoarundoin (IIId) have been isolated from a natural source (Zoysia matrella MERR.) for the first time. Some observation on new triterpenoids are also described.
  • 後藤 正義, 佐藤 春郎
    1969 年 89 巻 6 号 p. 821-827
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    An agar diffusion technique was applied for assaying antitumor agents by using four strains of rat ascites hepatoma (AH 7974, AH 66F, AH 13R, AH 13C) and cultured FM3A cells. The agar diffusion plate consisted of two layers ; a base layer of 1% agar medium and a seed layer containing 0.6% agar and a certain number of tumor cells. The number of cells inoculated was 2.0×106 cells in the case of rat ascites hepatoma. The paper discs were placed 3-5 hours after inoculation, and kept unremoved until observation. All of the antitumor substances tested (nitrogen mustard N-oxide, thio-TEPA, S261, Mitomycin-C, Chromomycin-A3, 6-mercaptopurine) inhibited growth of cells and produced inhibition zone of various sizes around the paper disc. The activity of 2-amino-6-mercaptopurine was different from them. Its inhibition zone was not visible, but was revealed as a blue inhibitory zone by using indicator dye of 2, 6-dichlorophenol indophenol. When a large number of cells was inoculated, the size of inhibition zone decreased. The correlation between the size of inhibition zone and the concentration of substances was linear. Comparison of the present method with some reported procedures was also discussed.
  • 内山 貞夫, 近藤 龍雄, 川城 巌
    1969 年 89 巻 6 号 p. 828-832
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    A new fluorometric determination of dulcin (4-ethoxyphenylurea) was established as follows : To 1 ml of dulcin solution in a test tube with a stopper is added 0.4 ml of 1N HCl, and the test tube is heated in a boiling water bath for 10 minutes. After cooling to room temperature, 0.5 ml of 10% NaNO2 solution is added and the solution is allowed to stand for 30 minutes at room temperature. Then, 0.5 ml of 6% NaOH solution is added and the solution is allowed to stand for 40 minutes at room temperature. Subsequently, the solution is extracted with 10 ml of CHCl3 by an automatic shaker for 5 minutes. The CHCl3 phase gives a fluorescence spectrum with an excitation maximum at 354 mμ and an emission maximum at 446 mμ. A straight line relationship between dulcin concentration and fluorescence intensity was obtained within the range of 1-8 μg/ml in CHCl3. This method was successfully applied to the determination of dulcin in some foods.
  • 馬場 茂雄, 松田 暁忠, 長瀬 雄三
    1969 年 89 巻 6 号 p. 833-836
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    l-Ephedrine (α-14C, ca. 1×106 dpm/mg) was incubated with rabbit liver preparation (supernatant fraction of 15000 g, 20 min centrifugation and NADPH2 regenerating system) for 2 hours. The metabolites were separated by paper partition and thin-layer chromatography and were determined by the reverse isotope dilution analysis. Norephedrine (33.4%), 1-phenyl-2, 2-propanediol (11.4%), 1-hydroxy-1-phenyl-2-propanone (4.2%), and benzoic acid (39.3%) were identified as the metabolites together with unchanged ephedrine (6.2%).
  • 田中 由紀子, 田中 善正
    1969 年 89 巻 6 号 p. 837-841
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Previously in this series we have discussed the characteristic bands in infrared spectra of various kinds of benzenesulfonamide, methanesulfonamide, and benzenesulfinamide derivatives. Special attention was focussed in the S-N bands which were recognized near the 900 cm-1 region and also on the corresponding band of N-deuterated compounds which was observed in a lower wave number region than those of the ordinary compounds. In the present work, the characteristic bands of benzenesulfenamide derivatives were discussed, and the S-N frequencies of these compounds and several N-deuterated compounds were examined. The S-N bands appeared between 1000 and 900 cm-1, which is comparatively higher and weaker than those of sulfon-or sulfin-amide derivatives.
  • 正山 征洋, 山口 章子, 佐藤 諦, 山内 辰郎, 西岡 五夫
    1969 年 89 巻 6 号 p. 842-845
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Smoking tests of the hashish tetrahydrocannabinol, cannabidiol and cannabigerol were carried out, and the components in the smoke condensates were examined with the acid of thin-layer and gas liquid chromatography techniques. The following results were obtained ; 1) Acid-form genuine substances were decarboxylated to give the physiologically active phenols. 2) Tetrahydrocannabinol was partly converted to cannabinol (ca. 10%), but the conversion of tetrahydrocannabinol (Δ2) to Δ3-derivative was not observed. 3) Cannabidiol and cannabigerol were smoked without remarkable change in their structures. 4) A good amount of the marihuana components in the hashish cigarette were determined in the smoke condensate. The effect of the hashish smoking, therefore, seems to be represented as the combined action of tetrahydrocannabinol and cannabinol.
  • 近藤 紀子, 庄司 順三, 南雲 昇, 小松 信彦
    1969 年 89 巻 6 号 p. 846-850
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Examinations were made on the chemical structure of chikusetsusaponin (IV), C47H74-O18·4H2O, mp>235°(decomp.), [α]19D-9.7°(pyridine), a crystalline saponin isolated from the rhizome of Panax japonicum. The structure was established as represented by formula (1) which agrees with the structure of araloside-A proposed by Kochetkov and others, but their direct comparison could not be made. In the present series of work, the compound O (10) was determined by microbial decomposition. In addition, isolation of erythrodiol 2, 3-di-O-methyl-β-D-glucopyranoside by partial decomposition of erythrodiol bioside (3) made it cleasr that L-arabinose makes an α-furanoside bonding with glucuronic acid.
  • 野呂 忠敬, 福島 清吾, 斎木 保久, 上野 明, 赤堀 幸男
    1969 年 89 巻 6 号 p. 851-856
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Structural elucidation was carried out on protofarrerol (I), a component of Leptorumohra miqueliana H. ITO (=Polystichopsis miqueliana TAGAWA) (Aspidiaceae). Examinations were made on the infrared, ultraviolet, and nuclear magnetic resonance spectra of I and its derivatives and, from the decomposition reaction of I, it was found to be 5, 7-dihydroxy-6, 8-dimethyl-2-(1'-hydroxy-4'-oxo-2'-cyclohexenyl)-4-chromanone. One of the decomposition products of I, 5, 7-dihydroxy-6, 8-dimethyl-2-(4'-oxocyclohexyl)-4-chromone (XII), was synthesized. I is the first natural flavanoid compound in which the B ring is not a benzene ring and, since I easily forms a flavanone by dehydration, it is of interest from biosynthetic viewpoint.
  • 福島 英明, 青野 俊二, 仲谷 坦
    1969 年 89 巻 6 号 p. 857-862
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Cholesterol-lowering effects of two amide derivatives of linoleic acid, N-cyclohexyl linoleamide (CHLA) and N-(α-methylbenzyl) linoleamide (MBLA), were studied in chicken and mice. (1) In normocholesteremic chickens, CHLA and MBLA showed a slight cholesterol-lowering effect at a dose of 1.0%, but they did not show any cholesterol-lowering effect in normocholesteremic mice at a dose of up to 0.2%. (2) By the addition of 0.2% of CHLA or MBLA to the cholesterol diet in chickens and in mice, the elevation of serum cholesterol levels was markedly depressed and the content of cholesterol and total lipids in the liver was also depressed. The effectiveness of CHLA and MBLA in chickens was almost the same, and was about 5-fold of that of β-sitosterol. In mice, the potency of MBLA was about twice that of CHLA, and about 10 times that of β-sitosterol. (3) CHLA and MBLA showed no marked effect on hypercholesterolemia induced by β-estradiol in chickens or by Triton WR 1339 in mice.
  • 山根 靖弘, 宮崎 元一, 坂井 和男, 安食 親孝
    1969 年 89 巻 6 号 p. 863-865
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Ultraviolet light irradiation (UV irradiation) was applied to p-nitrophenyl β-D-gluco-pyranosiduronic acid (PNG) in various systems ; (i) acetate buffer pH 4.0, (ii) acetate buffer-CuSO4, (iii) acetate buffer-FeSO4, (iv) acetate buffer-hydrogen peroxide, (v) acetate buffer-CuSO4-hydrogen peroxide, (vi) acetate buffer-FeSO4-hydrogen peroxide. In all the systems investigated, the cleavage of PNG was clearly observed, however, the ratio of this cleavage was different in each system. The cleavage was : a few per cent in i, 30 per cent in iv, 39 per cent in v, and 70 per cent in vi, respectively. From the above results it was assumed that UV irradiation might have a promoting effect on the formation of hydroxyl radical·OH, and thus the hydroxyl radical formed would have a potent influence on the cleavage of PNG.
  • 福田 英臣, 渡辺 和夫, 工藤 富貴子
    1969 年 89 巻 6 号 p. 866-868
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Experiments were made so as to examine the availability of young chicks for the assay of digitalis glycosides. Alar or jugular vein was cannulated and a volume of the test solution (Digitamin Injection, Shionogi) equivalent to 2 ml/kg was infused within a few sec. The dose was repeated at 5 min intervals until cardiac arrest was noticed. Problems of susceptibility difference depending on strain, sex, age, and feeding were examined. Influences of these factors on the susceptibility were not serious in practice. The order of susceptibility of tested animals was as follows : pigeon>chick>rat, mouse. From these results it is concluded that young chicks are available for digitalis assay if a sufficient number of animals is used.
  • 山口 秀夫, 沼田 敦, 森田 亘浩
    1969 年 89 巻 6 号 p. 869-872
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Two kinds of 4-benzylidene-tetrahydroisoquinolines (III and V) were obtained from 1-α-or 1-β-narcotinediol (Ia, Ib) and 1-β-or 1-α-hydrastinediol (IIa, IIb) by their reaction with stannous chloride-hydrochloric acid in acetic acid solution. Besides V, an optically active 1-(α-hydroxybenzyl) tetrahydroisoquinoline (VI), the configuration of which is (1R : α R), was isolated from both 1-β-hydrastinediol (IIa) (1R : α S) and 1-α-hydrastinediol (IIb) (1R : α R). The structures of the reaction products were determined and some of them were identified by comparison with authentic samples.
  • 安江 政一, 加藤 義成, 林 玉美, 榊原 仁作
    1969 年 89 巻 6 号 p. 872-876
    発行日: 1969/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    In the previous paper, it was reported that kaempferitrin, antoside, myoinositol and scyllitol were isolated from the leaves of Acanthopanax sciadophylloides and the constituents were different according to the districts where the materials came from. By further investigation, kaempferol 7-rhamnoside and quercetin 7-rhamnoside were isolated and the differences of the constituents were found to be quantitative ; in some cases, some of these compounds were detected only by paper chromatography as shown in Table I. The benzene extract of the leaves was examined by column chromatography. Hydrocarbons, dotriacontanol, 2-nonacosanone, taraxerol and a new compound, mp 184°, were isolated. The gas chromatogram of the hydrocarbons (Fig. 2) showed that the main component was nonacosane (77%) accompanied by heptacosane (1%), octacosane (4%), triacontane (8%), and hentriacontane (10%). It was concluded that hirsutrin was identical with isoquercitrin (quercetin 3-β-D-glucoside).
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