巻号一覧
90 巻, 6 号
選択された号の論文の23件中1～23を表示しています
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成実 重彦, 鈴木 幸子, 羽野 寿1970 年 90 巻 6 号 p. 651-660
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーElectroencephalographic (EEG) and behavioral effects of atropine and scopolamine were examined and also the effect of atropine and scopolamine on the convulsion induced by nikethamide, pentetrazol and acetylcholine in cats, dogs, rabbits, guinea-pigs, rats, and mice. 1) Atropine and scopolamine (0.1-10 mg/kg) caused, in all the species except guineapigs, bursts of 15-16 cps spindle waves or high-voltage slow (1-2 cps) waves in the cortical and subcortical EEG. 2) In guinea-pigs, atropine (higher than 100 mg/kg) had no effect on their EEG, but scopolamine in 1-5 mg/kg produced high-voltage slow waves. 3) Nikethamide in 80-100 mg/kg induced convulsion on behavior and spike or seizure pattern on EEG in all species except guinea-pigs. Pretreatment (10 min) of the animals with atropine antagonized the convulsion and the spike of seizure pattern induced by nikethamide, but pretreatment with scopolamine did not have such an antagonistic effect. 4) Pentetrazol in 20 mg/kg induced convulsion on behavior and spike or seizure pattern on EEG in rabbits and cats. Neither atropine nor scopolamine had no effect on the Pentetrazol convulsion. 5) Intracisternal injection of acetylcholine (1.0 μg/0.1 ml) into curarized cats produced a spike pattern on EEG. Both atropine and scoploamine antagonized this spike induced by acetylcholine. 6) Consequently, the difference between atropine and scopolamine is found only in their antagonistic effect on the convulsion induced by nikethamide.抄録全体を表示PDF形式でダウンロード (1146K) -
平田 五一1970 年 90 巻 6 号 p. 661-664
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーThree kinds of bridged gum arabic of below 27 in degree of swelling were prepared by using epichlorohydrin as the cross linked agent. Examinations were made on the effectiveness of its use as a disintegration agent for iodochlorohy droxyquinoline tablets from wetting heat and swelling of polymers in comparison with disintegration effect of Amberlite IR-120 resin (H, Na, and Mg forms), and calcium carboxymethylcellulose. The rate of swelling of a tablet was faster when a polymer of small degree of swelling was added and disintegration was accelerated. Time of disintegration extended with decrease in the void space of tablets, but this relationship was not established in tablets using Amberlite IR-120. There was no effect of wetting heat on disintegration of tablets added with any of the polymers.抄録全体を表示PDF形式でダウンロード (441K) -
小沢 樹夫, 木苗 直秀1970 年 90 巻 6 号 p. 665-669
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーN-Aryl-D-glucosylamine was cleaved autoxidatively in ethanol solution containing the same arylamine, and a pigment (1) was isolated from the reaction mixture. When p-toluidine was used, the pigment was obtained as red-brown needles. The result of analysis and the fact that 5-methylisatin was isolated from the hydrolysis of I with hydrochloric acid indicate I to be 2, 3-bis-(p-tolylimino)-5-methylisatin (Ia) or 2-(p-tolylamino)-3-(p-tolylimino)-5-methylisatin (Ib). 2, 3, 4, 6-Tetra-o-acetyl-2-oxyglucal (AOGA) and 3, 4, 6-triacetylglucal (AGA) were cleaved by ammonia, p-toluidine, and cyclohexylamine respectively. When ammonia was used, formic acid and arabonic acid were isolated. In the case of p-toluidine N-(p-tolyl)-2, 3, 4, 6-tetra-o-acetyl-D-glucosylamine (VI) was obtained accompanied with a small amount of oxalic acid, arabonic acid, and azo-p-toluene. When cyclohexylamine was used, oxalic acid and D-arabonic acid were isolated only. The yields of each decomposition products from AOGA was higher than those from AGA. Since acetylated amine was obtained, it was considered that acetyl migration by amine occured first in these reactions, followed by autoxidative decomposition.抄録全体を表示PDF形式でダウンロード (599K) -
小嶋 正治1970 年 90 巻 6 号 p. 670-674
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリー2-Amino-1, 3-propanedithiol (I) and its N-methyl (II), N, N-dimethyl (III) derivatives, and 4-dimethylamino-1, 3-dithiolane (nereistoxin) (IV) were synthesized, in relatively good yield, from dichloroacetone via the oxime or by the Leuckart method. I-HCl and II-HCl showed a considerable toxicity to mice (LD50 (i.v.) : 11.5 mg/kg and 11.8 mg/kg respectively).抄録全体を表示PDF形式でダウンロード (585K) -
佐久間 真理, 佐藤 善重1970 年 90 巻 6 号 p. 675-682
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーWhole body autoradiographic studies were made on the distribution of a radioactive local anesthetics, 3H-Quatacaine administered intrathecally. Spinal anesthesia was induced in young cats, weighing about 900 g, by injection of 2.5% solution of 3H-Quatacaine in the spinal canal at the fifth lumbar interspace. Whole body sagittal or transverse sections about 40-60 μ in thickness were prepared with a cold microtome at 5 and 20 min after the administration. It was found that 3H-Quatacaine and/or its metabolites were distributed in most of the tissues and organs soon after its administration. The highest radioactivity in vein from vena azygos to vena dorsalis demonstrated that the venous drainage might be the main route of departure of 3H-Quatacaine administered intrathecally. In the spinal canal, considerably high radioactivity was found in the dura water, the periphery of the spinal cord, and dorsal nerve root at subarachnoid space. The concentration of radioactivity was higher in the grey mater, especially at the posterior horn, than in the white mater of the cord. The ganglion cells showed higher accumulation of 3H-Quatacaine than the nerve fibers of the spinal ganglion.抄録全体を表示PDF形式でダウンロード (3252K) -
中西 豊, 貴志 昌高, 三奈木 康夫1970 年 90 巻 6 号 p. 683-692
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーFollowing previous experiment on the fate of iron-chondroitin sulfate colloid using 59Fe-labeled compound, sodium chondroitin sulfate labeled with tritium was synthesized in order to examine its fate in vivo. Using this 3H-labeled compound, tritiated iron chondroitin sulfate was synthesized, this compound was given as an intravenous injection to normal male mice, and distribution and excretion of tritium were examined. The result of this experiment was comparatively examined with the result of administration of 59Fe chondroitinsulfate. Chondroitinsulfuric acid in the parenteral solution used here was present in two kinds ; one bound with iron colloid and the other not. By assuming that the former is phagocytized in reticuloendothelial system with the iron colloid but the latter is not phagocytized much in the reticuloendothelial system, biological distribution and excretion of 59Fe and 3H were explained well. Quantitative analysis was made on a part of these results.抄録全体を表示PDF形式でダウンロード (1001K) -
野崎 正勝, 鶴見 介登, 藤村 一1970 年 90 巻 6 号 p. 693-695
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーA specific and highly sensitive method for the determination of glycyrrhetinic acid (G) by gas chromatography is described. G was extracted from a mixture of biological media and was converted to the trimethylsilyl derivative with bis (trimethylsilyl) acetamide which was estimated by using vitamin K2 as internal standard as shown in Fig.1.抄録全体を表示PDF形式でダウンロード (371K) -
亀谷 哲治, 水島 正勝1970 年 90 巻 6 号 p. 696-698
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーPhenolic oxidative coupling of 1, 2, 3, 4-tetrahydro-1-(4-hydroxy-3-methoxyphenethyl)-6-methoxy-2-methyl-5-isoquinolinol (X) with ferric chloride afforded a cyclohexadienone (Ia) in 60% yield.抄録全体を表示PDF形式でダウンロード (433K) -
中垣 正幸, 河村 成男, 寺尾 純一1970 年 90 巻 6 号 p. 699-706
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーThe dispersibility of sulfisoxazole, sulfadimethoxine, and N1-acetylsulfisoxazole in aqueous sucrose solutions (0-30%) in the presence of polyoxyethylene nonyl phenyl ether (PEN) (0.05-8.0×10-3 mole/liter) was examined on the basis of the apparent median radius (γmed) as estimated from the particle size distribution obtained by the use of sedimentation balance, as well as the sedimentation volume and the amount of PE-N adsorbed on sulfonamides. It was found that the γmed decresed markedly in a PE-N concentration range of 4-6×10-4 mole/liter, and showed a minimum at about 1×10-3 mole/liter, and that the sedimentation volume was also reduced markedly in the same conecntration range of PE-N and then levelled off. Influence of the presence of sucrose on γmed and sedimentation volume was observed only with N1-acetylsulfisoxazole, both of which increased with the sucrose concentration. From these results it was concluded that the dispersive sedimentation of sulfonamides began at the PE-N concentration of about 1×10-3 mole/liter, and the dispersibility rather decreased by the addition of sucrose. Correlation between dispersibility and amout of PE-N adsorbed on the sulfonamides was examined. It was found that the saturated amout of PE-N adsorbed on the sulfonamides was almost monolayer saturated adsorption, and the dispersive sedimentation began on the monolayer saturated adsorption.抄録全体を表示PDF形式でダウンロード (728K) -
杉浦 寿美, 井上 昭二, 後藤 俊夫1970 年 90 巻 6 号 p. 707-710
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーThe previously reported3) synthesis of Cypridina luciferin (I) by condensation of etioluciferin (II) and the α-keto acidfollowed by reduction gave the yield of only 1.3% and hence it cannot be a practical method. Heating of 2-amino-5-phenylpyrazine (III) with pyruvic acid (IV) also gave an imidazopyrazinone derivative (V) but the yield was as low as 7%. As an alternative method, previously reported condensation of aminopyrazines and glyoxals1) was applied to 2-amino-5-(3-indolyl) pyrazine (VII) and methylglyoxal (VI), and its yield was 70%. This method was therefore applied to the synthesis of I. Thus, condensation of II with dl-sec-butylglyoxal (IX) gave I (racemic) in 80% yield.抄録全体を表示PDF形式でダウンロード (465K) -
杉浦 寿美, 井上 昭二, 後藤 俊夫1970 年 90 巻 6 号 p. 711-715
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーCypridina oxyluciferin (II) is a product of Cypridina bioluminescence and its structure had been assigned as IIa. However, since the product of chemiluminescence of 3, 7-dihydro-2-methylimidazo [1, 2-a] pyrazin-3-one (III) was determined as an acylamidopyrazine, the structure of II was assumed to be acylamidopyrazine derivative (IIb). This assumption has been substantiated by comparison of ultraviolet (UV) spectra of synthetic 2-acetamido-5-(3-indolyl) pyrazine (VI), and finally by unambiguous synthesis of IIb from etioluciferamine (VIII), through tosyletioluciferin (IX) followed by acylation and detosylation.抄録全体を表示PDF形式でダウンロード (548K) -
岡野 定輔, 松本 仁, 石井 真一, 磯部 明彦1970 年 90 巻 6 号 p. 716-723
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーA study was undertaken with a view to inhibiting decomposition of medicinal compounds by the use of alteration of their electronic states, which is accompanied with charge-transfer complexation. The photodecomposition of riboflavine in aqueous solution was shown to be inhibited by the presence of pyrazolone derivatives, the effectiveness of which decreased in the following order : 4-aminoantipyrine>aminopyrine>antipyrine>4-isopropylantipyrine. The examination of the following phenomena has been carried out in ethylene dichloride : ouenching caused by the presence of pyrazolones, of fluorescence of riboflavine tetrabutyrate and new absorption bands in the difference spectra of riboflavine tetrabutyrate-pyrazolone derivative systems. It was confirmed that complexes of 1 : 1 molar ratio were formed through participation of charge transfer, and the values of apparent quenching constant and formation constant were determined. The substituent group in 4-position of the isopropyl derivative was found to hinder the interaction sterically. Comparison of the quenching effects of pyrazolones on the fluorescence of lumiflavine and 3-methyllumiflavine indicated that hydrogen bonding was also involved in the complex formation. From the correspondence of stabilities of the complexes and the inhibitory effects of the pyrazolone derivatives, it was presumed that charge transfer with pyrazolone derivatives plays an important part in inhibiting the photodecomposition of riboflavine in aqueous medium.抄録全体を表示PDF形式でダウンロード (886K) -
石井 永, 村上 泰興, 谷 昇平, 阿部 和也, 池田 仁三郎1970 年 90 巻 6 号 p. 724-729
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーTreatment of anti-ethyl phenylpyruvate 2, 5-dimethoxyphenylhydrazone (IVb) with ethanolic hydrogen chloride gave 2, 5-dimethoxy-p-phenylenediamine dihydrochloride (V) as a main product, with ethyl α-ethoxycinnamate (IX) and the expected ethyl 4, 7-dimethoxy-3-phenylindole-2-carboxylate (II). 2, 5-Dimethoxyphenylhydrazine (XVII) also afforded the same phenylenediamine (V) under the same condition.抄録全体を表示PDF形式でダウンロード (738K) -
島 和弘, 市橋 節子, 山本 隆一1970 年 90 巻 6 号 p. 730-735
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーAs a part of a program concerning complex formation among pharmaceuticals, investigation was made on the interaction between styrene-maleic anhydride copolymer (SMA) and the following 12 pharmaceutical compounds in ethylene dichloride solution, using a solubility method ; hydroxybenzoic acids (ortho, meta, and para isomers), p-aminosalicylic acid, methyl and ethyl p-hydroxybenzoates, caffeine, theobromine, theophylline, barbituric acid, barbital, and allobarbital. In the hydroxybenzoic acid series, p-hydroxybenzoic acid exhibited the greatest binding to SMA, followed by the meta and ortho isomers. p-Aminosalicylic acid was more reactive than salicylic acid because of the presence of the amino grouping. Elimination of the acidic hydrogen atom from p-hydroxybenzoic acid by esterification, as in methyl and ethyl p-hydroxybenzoates, reduced the ability of the molecule to participate in complex formation. A comparison of three barbiturates has shown that greater the aliphatic character of the disubstitution at the 5-position of barbituric acid, the less was their affinity to SMA. This may be due, in part, to a decrease in polarity of the molecule or to an increase in the steric factor of the substituent. Theophylline and theobromine were also found to bind with SMA, but no evidence of binding was detected between caffeine and SMA. The ability of complexation probably rests on the relative proton-donating properties of these xanthine derivatives. The significance of these results with respect to possible mechanisms of complex formation is discussed.抄録全体を表示PDF形式でダウンロード (690K) -
後藤 実, 今井 俊司, 村田 忠一, 野口 友昭, 藤岡 章二1970 年 90 巻 6 号 p. 736-743
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーTwo new glycosides, named eupteleoside A (I) and eupteleoside B (II), were isolated from the leaves of Euptelea polyandra SIEB. et ZUCC. (Eupteleaceae). I, C46H70O17·2H2O, was shown to be a triterpene saponin which gave upon acid hydrolysis the aglycone eupteleogenin and one mole each of L-rhamnose, L-arabinose, and D-glucose. II, C48H72O18·H2O, was correlated to I establishing that II is a monoacetate of I. I and II showed relatively intense anti-microbial activity against Saccharomyces cerevisiae and Piricularia oryzae, as well as some phytopathogenic fungi. Synergistic effect of I and II is also described.抄録全体を表示PDF形式でダウンロード (870K) -
村田 忠一, 今井 俊司, 今西 正之, 後藤 実1970 年 90 巻 6 号 p. 744-751
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーThe structure of eupteleogenin (I), C29H42O4, the new triterpene aglycone of the antimicrobial glycosides eupteleoside A and eupteleoside B, has been elucidated as formula I on the basis of chemical and spectroscopic evidence.抄録全体を表示PDF形式でダウンロード (888K) -
上田 道廣, 奥村 美喜子, 畑中 育子, 大村 正信1970 年 90 巻 6 号 p. 752-756
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーExaminations were made on the colorimetric determination of liquid and ointment for external use containing naphthiomate-T, an anti-trichophyton agent, and the following procedure was established. To a test tube graduated to 10 ml, 0.2 ml of the liquid or ca. 10 mg of the ointment accurately weighed on a microspatula (both corresponding to less than 200 μg of naphthiomate-T) is placed, 0.5 ml of propanol in which metallic sodium has been dissolved to 2% concentration is added, and the test tube is warmed on a water bath to effect solution. The test tube is attached with an air cooling tube and the heated in a boiling water bath to effect exchange decomposition to form 2-naphthol. When cooled, 0.5 ml of methanol solution containing 0.55N hydrochloric acid is added, followed by 0.7 ml of diazonium test solution (containing 0.2% of sulfanilic acid and 0.25% of sulfamic acid), and the mixture is allowed to stand for 5 minutes by which the solution colors by the formation of orange II. This mixture is diluted to 10 ml with methyl ethyl ketone containing 0.06N hydrochloric acid-formaldehyde and optical density of this solution at pH 1-2 is read at 485 mμ. The content of naphthiomate-T is calculated from the calibration curve prepared beforehand. This method enables determination of 25-200 μg/10 ml of naphthiomate-T and the time required for the whole procedure is approximately 2 hours.抄録全体を表示PDF形式でダウンロード (583K) -
ヒキノ ヒロシ, 鍋谷 将, 竹本 常松1970 年 90 巻 6 号 p. 757-761
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーErythrodiol has been incubated with Cunninghamella blakesleeana. Chromatography of the fermentation product has resulted in the isolation of four metabolites in which three has been found to be II, III, and IV. A possible structure of another product V is also discussed.抄録全体を表示PDF形式でダウンロード (599K) -
鈴木 徳治, 谷村 勇一1970 年 90 巻 6 号 p. 762-770
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーA study was made on the chemical kinetics of the hydroxyl ton catalyzed hydrolysis of distigmine bromide (1-methyl-3-hydroxypyridinium bromide-1, 6-hexamethylene-bis-N-methylcarbamate) in solution to evaluate its stability in ophthalmic solution. Mechanism of this hydrolysis was found to consist of consecutive first-order reactions by thinlayer chromatography and ion-exchange chromatography. Analog computation of ultraviolet (UV) spectral data and quantitative ion-exchange chromatography were used to determine the rate constants of the consecutive reaction. The temperature dependency of each reaction was established, and the Arrhenius parameters were determined.抄録全体を表示PDF形式でダウンロード (889K) -
亀谷 哲治, 鈴木 敏夫1970 年 90 巻 6 号 p. 771-773
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーTreatment of indole with benzoyl chloride in chloroform afforded a mixture of 2, 3-dihydro-2-(3-indolyl) indole (II) hydrochloride, 1-benzoyl-2, 3-dihydro-3-(2-indolyl)-indole (IV) and trimer (V). The compound (II) was synthesized and proposed to be 2, 3-dihydro-3-(2-indolyl) indole (I) hydrochloride by O. Schmitz -DuMont, but, afterwards, H.F. Hodson, et al. corrected the above mentioned compound (I) to be 2, 3 -dihydro-2-(3-indolyl) indole (II) hydrochloride by Hofmann degradation. We could confirm the structure proposed by Hodson by examination of nuclear magnetic resonance (NMR) spectral data of the compound (II) and ethyl 2, 3-dihydro-2-(3-indolyl) indole-1-carboxylate (III).抄録全体を表示PDF形式でダウンロード (439K) -
島 和弘, 溝尻 顕爾, 市橋 節子, 山本 隆一1970 年 90 巻 6 号 p. 774-777
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーIn the previous papers of this series, the binding tendency of styrene-maleic anhydride copolymer (SMA) with certain pharmaceuticals was discussed. In this study, data have been collected for quinine, dibucaine, sinomenine, procaine, methylephedrine, diphenhydramine and dextromethorphane. New absorption bands were observed in the visible region of the spectra for ethylene dichloride solutions of SMA containing quinine, diphenhydramine or dextromethorphane, indicating occurrence of interaction. By means of an equilibrium distribution method, it was shown that all the compounds investigated exhibited binding with SMA in the ethylene dichloride phase, and that the binding equilibria fits a Langmuir-type equation. The maximum amount (ym) of each compounds bound to SMA was found to be about 0.3 to 0.6 mmole/g. SMA at 25°. There was no significant relationship between the binding constant (K) or ym and the chemical structure of guest molecules.抄録全体を表示PDF形式でダウンロード (486K) -
森 逸男1970 年 90 巻 6 号 p. 778-781
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーExaminations were made on the determination of Sn (IV) by isoamyl alcohol extraction using 3, 4, 5, 6-tetrachloro-3', 4', 5', 6'-tetrahydroxyfluoran and 1, 3-diphenylguanidine. It was thereby found that extractive determination of Sn (IV) is possible in the range of 0-90.0 μg/10 ml of Sn (IV) by measuring the optical density of the Sn (IV) complex formed with the above two reagents, with the reagent blank as the control, at 540 mμ. Presence of Fe (III), Bi (III), Sb (III), Zr (IV), and Al (III) interferes in the extractive determination of Sn (IV) and these ions should be removed beforehand.抄録全体を表示PDF形式でダウンロード (438K) -
[記載なし]1970 年 90 巻 6 号 p. 782-783
発行日: 1970/06/25
公開日: 2008/05/30
ジャーナル フリーPDF形式でダウンロード (320K)
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