巻号一覧
92 巻, 6 号
選択された号の論文の25件中1～25を表示しています
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立松 晃, 灘井 種一, 吉住 秀夫1972 年 92 巻 6 号 p. 655-660
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリー薬物の代謝産物についての研究は古くから行なわれているが, その代謝産物の推定あるいは同定には通常繁雑な操作を必要としている.そこでわれわれは質量分析計が少量の試料で, しかもその中に多くの混合物を含んでいても, 他の測定機に比べてはるかに多くの情報を与えてくれることに着目し, 簡単な処理を行なった薬物服用尿の質量スベクトルを測定することにより短時間に多くの代謝産物を推定する方法を検討してきている.前報ではスルフォンアミド類のアセチル体について報告したが, 今回はsulfisomezoleを選びその代謝産物の検索を行なった.その結果簡単な処理をした試料尿の質量スベクトルより尿中に排泄された未変化体, アセチル体, sulfanilamide, そのアセチル体およびグルクロナイド等現在までに報告されている代謝物を容易に推定あるいは同定することができ, 同時に尿中からの代謝物の推定, 同定に質量分析計を利用する方法について考察したので報告する.抄録全体を表示PDF形式でダウンロード (640K) -
上田 武雄, 高田 純, 坂本 康夫1972 年 92 巻 6 号 p. 661-664
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーColoration of naphthylamines (NA) such as α-naphthylamine (α-NA), β-naphthylamine (β-NA), acetyl-β-naphthylamine, (A-NA) and N-methylene-β-naphthylamine (M-NA) with the Marquis reagent was examined. Among them, β-NA was found to show a specific coloration with the Marquis reagent, and this coloration was useful for the detection of β-NA in a mixture of α-NA and β-NA. By the inspection of ESR spectra of NA, signals at g=2.0020 were observed in all of the colored solution of these NAs with the Marquis reagent, and the coloration of NA with the Marquis reagent was considered to be due to the formation of free radiclas. After decomposition of the colored reaction mixture β-NA with the Marquis reagent, a polymer was obtained, which was insoluble in all organic solvents except DMSO and contained a sulfur atom. The solution of this polymer in sulfuric acid showed an ESR signal at g=2.0020 and the same absorption maximum as the mixture of β-NA and the Marquis reagent. From these results, it was assumed that this coloration is due to the free radical formed from the polymer in surfuric acid.抄録全体を表示PDF形式でダウンロード (548K) -
北辻 栄太郎, 吉井 英一, 飯田 武夫1972 年 92 巻 6 号 p. 665-669
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーThe "middle-layer base"in NTU shale oil was characterized as long-chained 2, 4, 6-trialkylpyridines (TAP). The distribution of the number of carbon atoms in the chain of TAP (bp 152-153°/0.07 Torr fraction) was examined by the Hofmann degradation. The alkyl substituents in the α-position of TAP were found to be a mixture of alkyl groups from C2 to C12, and those in the γ-position, to be a mixture of alkyl groups from C2 to C11. The alkyl group found in the largest volume was a heptyl group (16.5%) in the α-position and pentyl group (17.0%) in the γ-position. The alkyl group was a normal, unbranched chain of carbon atoms. It was found that TAP had more unsymmetric alkyl substituents than symmetric alkyl groups.抄録全体を表示PDF形式でダウンロード (622K) -
藤田 直, 安田 正秀, 北村 讓, 島村 幸子1972 年 92 巻 6 号 p. 670-676
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリービタミンE(VE)の生体における主な生化学的作用はnonspecificな脂質の抗酸化作用にあるといわれている.一方種々な動物を用いた実験でVE欠乏によって生殖機能の低下, 筋ジストロフィー, anemiaなどを生じ, これらはVE投与によって回復すると報告されている.しかし, これらの症状がVEの抗酸化作用とどのような関係があるか明らかでない.なお, coenzyme Q10(CoQ10)がVE欠乏状態に有効であるという報告もある.このCoQ10はミトコンドリア(Mit)に含まれ, しかもMitの脂質は高度の不飽和脂肪酸のfatty acyl残基によって特徴づけられていることなどから, これらのpoly-不飽和脂肪酸がVE欠乏状態でどのような変化を示すかは興味ある問題である.著者はVE欠乏ラットを用いてその各臓器Mitの脂肪酸構成の変動を対照群のそれと比較検討し, 2,3の知見を得たので報告する.抄録全体を表示PDF形式でダウンロード (654K) -
川副 裕一, 田口 胤三1972 年 92 巻 6 号 p. 677-680
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーIn connection with previous studies which reported the rearrangement of xanthates to dithiolcarbonates by thermal treatment, propyl xanthates holding two ethylthio groups at β-position were examined for the same purpose. 1, 3-Diethylthiopropyl S-methyl xanthate (8) underwent rearrangement to 2, 3-diethylthiopropyl methyl dithiolcarbonate (10) by distillation and the same product (10) was also obtained by the analogous treatment of 2, 3-diethylthiopropyl S-methyl xanthate (9) (Chart 3). This suggests that the reactions of 9 and 10 may pass through the same transition state, an ion pair, which has been well discussed previously. On the other hand, 2, 2-diethylthiopropyl S-methyl xanthate (7) gave 1, 2-diethylthiopropene (14) by thermal treatment (Chart 4). It is presumed that the product 14 resulted from a dithiolcarbonate which was intermediately formed by the rearrangement of the xanthate (7), although the dithiolcarbonate could not be isolated. For synthesis of the starting materials, thioketalization of pyruvic acid with ethanethiol was attempted in the cold yielding 2, 2-diethylthiopropionic acid (4) which underwent rearrangement to 2, 3-diethylthiopropionic acid (5) on heating. 4 was converted to 2, 2-diethylthiopropanol (1) by reduction with LiAlH4 (Chart 1).抄録全体を表示PDF形式でダウンロード (499K) -
長坂 光昭, 寺島 美佐子, 浅井 肇, 伊藤 磯雄1972 年 92 巻 6 号 p. 681-685
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリー1,1-Diphenylmethylamine誘導体の薬理作用として, 局所麻酔作用, 抗histamine作用, 交感神経遮断作用が報告されている.緒方らは構造が比較的簡単な酸素原子を含まないこの種の誘導体の局所麻酔作用と化学構造との関連性を報告している.しかし, この種の誘導体で局所麻酔剤として実用されているものはない.われわれは伊藤らによって合成された数10種の1,1-diphenylmethylamine誘導体のうちから, lidocaineより強い局所麻酔作用を示すN-alkyl-1,1-diphenylmethylamineを見いだした.そこで, この誘導体19種の局所麻酔作用と化学構造との関連性を検討し知見を得たので報告する.抄録全体を表示PDF形式でダウンロード (598K) -
別所 貞雄, 富岡 穗一, 伊藤 四郎1972 年 92 巻 6 号 p. 686-693
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリー粉粒体の圧縮に関する研究の中で最も基本的であり, 最も多く, また古くから研究されているものは, 圧縮圧力と粉粒体の見掛容積との関係, すなわち粉粒体の見掛圧縮状態方程式(圧縮実験式)に関するものであり, 代表的なものだけでも十種を越える.圧縮に伴なう粉粒体層の見掛容積の減少は圧縮圧力範囲を限定すれば通常実験的にはこれらいずれかの式に近似的には適合するのであるが, 粉粒体の内部構造の変化は被圧縮物の物性や各圧縮圧力範囲などの圧縮条件によりかなり異なるのであって, その全領域を簡単な一つの式で表現することには疑問がもたれるのは当然であり, 同一試料でも充填条件をも含んだ圧縮条件によって適用し得る圧縮実験式が異なる場合が往々にしてある.すなわちこれらの圧縮実験式は第6報で指摘したごとく対象となる被圧縮物の物性や圧縮条件内における圧縮圧力と平均見掛容積との関係, つまり見掛の圧縮状態方程式であり, 真の意味での粉粒体の圧縮状態方程式ではない.粉粒体の圧縮状態方程式に関する実験式, 理論式をもう一つの見方で分類すると圧縮過程が一つの過程から成立っていると考えるものと, 圧縮過程が無限に多くの過程が連続的に起っているが近似的には1-3項を考えれば十分とするものがあるが後者の方が合理的な考え方と考える.粉粒体の圧縮状態方程式に関する理論はここ数年間にいくつか発表されている.そしてその取扱い方は基本的には粉粒体をマクロ的に連続体とみなして全体としての特性から考察して行く立場と粉粒体をミクロ的に不連続体と考えて取扱って行く立場との二つの立場がある.しかしこれといって一般に認められるまでには到っていない.今回は前者の立場をとり前述したごとき点を考慮して理論的に考察し, 単位質量の位置エネルギーという共通の概念を導入することによって, 従来提出されているすべての圧縮実験式に対応する粉粒体の圧縮状態方程式を導き出すことができたので, その詳細を報告するとともに, 圧縮時間, 圧縮温度をも考慮して圧縮状態方程式の拡張について考察する.抄録全体を表示PDF形式でダウンロード (684K) -
大平 治, 工藤 寿美子1972 年 92 巻 6 号 p. 694-702
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーIn order to exemplify the usefulness of the cohesion parabola method, and to examine the adequacy of the slope in the flow rate equation as a measure of flow property of granules, stepwise regression analyses were carried out on the parameters in the Brown-Richard equation, using a FACOM 270-20/30 computer. [numerical formula] (n=0.4) The results showed that 82% of the variance of the slope M could be explained by the factors Dp/Dc, μi/k, and α, and that 82% of the variance of the width of empty annulus De could be explained by the factors DL/S, and Dp ; where Dp is the particle size (the arithmetic mean opening of the successive sieves), Dc is the diameter of a vertical brass tube, μi is the coefficient of interparticle friction, k is the co-ordination number calculated from the porosity by the use of Ridgway-Tarbuck equation, α is the apparent coherency, DL is the minimum orifice diameter which can possibly flow or slip on the wall, calculated on the basis of Gardner's theorem, and S is the shape factor (rugosity). Further, the following rule of thumb for prediction on the blocked aperture for noncohesive materials was proposed : "When the height of an apex of dynamic arch is higher than that of an imarginary pseudo-stable face, that is, the cohesion parabola face, the flow of granules commences and continues."抄録全体を表示PDF形式でダウンロード (1149K) -
松尾 泰介, 三木 卓一1972 年 92 巻 6 号 p. 703-707
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーPyrido [3, 4-d] pyridazine derivatives were synthesized from dimethyl 5-hydroxy-6-methylcinchomeronate (I). 8-Hydroxy-7-methylpyrido [3, 4-d] pyridazine-1, 4-(2H, 3H)-dione (II) was found to produce a strong chemiluminescence and 8-methoxy-7-methyl-1, 4-dimorpholinopyrido [3, 4-d] pyridazine (IX) had a diuretic activity. α-Styrylpyridine and benzimidazoylpyridine derivatives were also prepared. Dimethyl 5-methoxy-6-styrylcinchomeronate (XVa) and dimethyl 6-(p-chlorostyryl)-5-methoxy-cinchomeronate (XVb) showed a fluorescent whitening action.抄録全体を表示PDF形式でダウンロード (605K) -
奥村 保, 上遠野 哲郎1972 年 92 巻 6 号 p. 708-712
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーA newly precoated plate for thin-layer chromatography (TLC) was prepared from aluminum oxide-fused glass powder mixture. Because this sintered glass plate does not contain any organic binder, it is not charred under any drastic conditions, i. e. by heating the plate after spraying corrosive reagents such as sulfuric acid, chromic acid mixture, trichloroacetic acid, antimony trichloride, etc. By using this new plate, thin-layer chromatographic separation of various organic compounds such as azo dyes, cardiac glycosides, and genins, and alkaloids was studied, and it was found that this plate gave a good reproducibility of separation, as reliable as the commercial precoated plate such as Merck's product. The separation behavior of this plate was similar to that of a mixed layer of aluminum oxide and kieselguhr. This plate is mechanically stable, heat stable, and acid resistant. Moreover, it can be repeatedly used by soaking the chromatogram into a cleaning solution.抄録全体を表示PDF形式でダウンロード (589K) -
小林 五郎, 松田 芳郎, 夏木 令子, 富永 義則1972 年 92 巻 6 号 p. 713-718
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーReaction was carried out between 2, 2-bis (methylthio)-1-(1-methyl-2-methoxycarbonyl-indol-3-yl) acrylonitrile (III) and various amines, and several β-carboline derivatives (IVa, b, V) were obtained. 1, 3-Dioxo-β-carboline derivatives (IX, X) were obtained by the application of polyphosphoric acid to III. X is also obtained by the application of carbon disulfide to 1, 3-dioxo-β-carboline in the presence of sodium hydride and subsequent alkylation with dimethyl sulfate. Reaction of 3-cyanomethylindole derivatives and ketene thioacetals afforded a product (XIII) substituted with a methylthio group, accompanied with a carbazole derivative (XV) and a β-carboline derivative (XVI).抄録全体を表示PDF形式でダウンロード (638K) -
我謝 充弘, 辻 明良, 桜井 洋二郎, 来海 正輝, 遠藤 武, 佐藤 重男, 山口 一孝1972 年 92 巻 6 号 p. 719-723
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーA series of chalcones, and their α-bromo derivatives (44 compounds in all), were prepared. The in vitro antimicrobial activity of these compounds were determined and the results obtained were as follows : 1) Chalcones and their derivatives were found to be generally active against Trichophytons and the activity was increased by α-bromination. 2) Dihydroxychalcones having a hydroxy group on each benzene ring were found to be generally inactive.抄録全体を表示PDF形式でダウンロード (621K) -
桜井 信子, 井上 隆夫, 永井 正博1972 年 92 巻 6 号 p. 724-728
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーFrom the rhizoma of Cimicifuga dahurica MAXIM, β-sitosterol (I), cimigenol (II), cimigenol xyloside (III), and a new aglycone, named dahurinol (IV), C30H48O5, mp 237-237.5°, [α]27D+54.5°(CHCl3), were isolated. The structure of 16ξ1, 23ξ2-epoxy-9, 19-cyclo-9β-lanostan-3β, 24ξ3, 25-triol-15-one has been proposed for IV from chemical and physicochemical evidences.抄録全体を表示PDF形式でダウンロード (668K) -
飯島 千穗子, 林 英作1972 年 92 巻 6 号 p. 729-735
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーApplication of a ketone (III) to 2-chloroquinoxaline (I) in dehyd. benzene, in the presence of sodium amide, gives 2-quinoxalinyl ketone (IV). In the case of 2, 3-dichloroquinoxaline (II), the methyl or methine carbon adjacent to the carbonyl acts as a carbanion and 3-chloro-2-quinoxalinyl ketone (V) is produced (Table I) but, when methylene carbon acts as a carbanion, furo [2, 3-b] quinoxaline (VI) is formed (Table II). In the case of cyclopentanone, only V is produced. As an attempt for the synthesis of VI, reaction of 3, 4-dihydro-3-oxo-2-quinoxalinyl ketone (VIII) and V with phosphoryl chloride was examined.抄録全体を表示PDF形式でダウンロード (741K) -
飯島 千穗子, 林 英作1972 年 92 巻 6 号 p. 736-742
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーExaminations were made on the reaction of various ketones (II) with 2-chloroquinoxaline 4-oxide (I) in dehyd. benzene, in the presence of sodium amide. The ketones examined were acetophenone (IIa), propiophenone (IIb), butyrophenone (IIc), acetone (IId), diethyl ketone (IIe), cyclohexanone (IIf), methyl ethyl ketone (IIg), methyl propyl ketone (IIh), methyl isopropyl ketone (IIi), methyl isobutyl ketone (IIj), and pinacolone (IIk). The products obtained are listed in Table I. In the case of IIa, d, i, k, a small amount of the corresponding 2-substituted furo [2, 3-b] quinoxalines (V) were produced.抄録全体を表示PDF形式でダウンロード (751K) -
亀谷 哲治, 高野 誠一, 武田 裕光1972 年 92 巻 6 号 p. 743-746
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリー12-Ethyl-6, 7, 10, 12, 13, 13a-hexahydro-12-hydroxy-1H, 9H-furano [3, 4-g] indolo [3, 2-d] quinolizine (X), a corynantheidine-type indole base, was synthesised as a possible intermediate for the synthesis of camptothecin, as follows. The Perkin reaction of cinchomeronic anhydride with propionic anhydride in the presence of sodium propionate afforded 1-ethylidene-1, 3-dihydro-3-oxofurano [4, 5-c] pyridine (XII), which was converted to ethyl 4-propionylnicotinate (XV) by esterification. Treatment of XV with ethylene glycol in the presence of p-toluenesulfonic acid at 140°for 4 hr gave β-hydroxyethyl 4-propionyl-nicotinate ethylene ketal (XVI) which was reacted with 3-chloroacetylindole to give the corresponding quaternary pyridinium salt (XVIII). Lithium aluminum hydride reduction of XVIII, followed by acid treatment, gave the expected compound (X).抄録全体を表示PDF形式でダウンロード (520K) -
有澤 宗久, 清水 岑夫, 森田 直賢1972 年 92 巻 6 号 p. 747-749
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーTwo flavanone-glycosides (A and B) were isolated from the ears of Miscanthus sinensis ANDERSSON (Gramineae). A obtained as colorless needles, mp 224-226°; was identified as prunin (naringenin 7-monoglucoside) by direct comparison with the authentic sample, and B, colorless needles, mp 158-163°; C21H22O11·H2O, was determined as eriodictyol 7-monoglucoside, and was named miscanthoside.抄録全体を表示PDF形式でダウンロード (474K) -
原田 正敏, 山下 厚子, 油田 正樹1972 年 92 巻 6 号 p. 750-756
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリー牡丹皮についてその主成分であるペオノールと, 本成分を除いた牡丹皮エキスの末梢薬理作用を比較検討した.テスト項目は抗炎症作用, ストレス胃エロジオンと胃液分泌に対する抑制作用, 血圧呼吸, 摘出臓器, 生体位子宮におよぼす諸作用である.そしてこれらの薬理効果と牡丹皮の治療効果との関係につき若干考察した.抄録全体を表示PDF形式でダウンロード (849K) -
千葉 剛久, 利岡 誠夫1972 年 92 巻 6 号 p. 757-762
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーEffects of SH-compounds and their disulfides on rat hepatic hexokinase and glucokinase in vivo and in vitro were studied. 1) In vivo experiments : The time course of variation of enzyme activity by administration of 200 mg/kg of 2-mercaptopropionylglycine (MPG), 200 mg/kg oxidized MPG, 200 mg/kg of oxidized glutathione intraperitoneally, 3 g/kg of glucose orally, and 0.2 IU/head of insulin intramuscularly to normal and alloxan-diabetic rats was examined. From testing normal rats, glucokinase activity reached the maximum 1 hr after administration of MPG, and 3 hr after administration of glucose. For 3 hr after administration of insulin, the enzyme activity was the same as control, and then gradually increased with time. In disulfide compounds, oxidized MPG did not change the enzyme activity, but oxidized glutathione inhibited glucokinase activity by about 50% 1 hr after administration. Time courses of glucokinase after administration of effectors to alloxan-diabetic rats resembled those in normal rats. Hexokinase activity in both normal and alloxan-diabetic rats was hardly affected. 2) In vitro experiments (addition to the medium tested) : MPG, glutathione, and cysteine apparently, and oxidized MPG and cystine slightly increased both activities of hexokinase and glucokinase prepared from normal rat liver in concentrations from 1×10-3 to 1×10-7M. Oxidized glutathione strongly inhibited enzyme activities in concentrations from 1×10-3 to 1×10-5M, but activated in concentrations from 1×10-5 to 1×10-9M. Mechanisms of the action of SH compounds and their disulfides on hexokinase were discussed.抄録全体を表示PDF形式でダウンロード (756K) -
藤岡 弘, 中西 豊, 中村 清1972 年 92 巻 6 号 p. 763-767
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーニトロフラン誘導体の生体内挙動を明らかにするためには1μg以下の量を測定出来る方法が必要である.現在まで1μg以下の量を測定出来る方法は報告されておらず, ニトロフラン誘導体の定量は一般に紫外部吸収スペクトルの測定あるいはガスクロマトグラフィーによって行なわれている.著者らは, 2-(5-nitro-2-furyl)vinyl誘導体ガピリジンと水の混合溶媒中で特有の螢光を発することを見いだした.本報では代表物質として, 2-methyl-4-[2-(5-nitro-2-furyl)vinyl]-6-pyrimidinol(I)を中心に螢光強度におよぼす種々の要因を検討し, また化学構造と螢光特性の関係について検討した.さらに本螢光現象を応用してIの血漿濃度測定法を確立したのでこれらの結果を報告する.抄録全体を表示PDF形式でダウンロード (595K) -
藤川 福二郎, 平山 晃久, 中村 幸雄, 豊田 武, 鈴木 光子, 土井 美恵子, 仁木 知代1972 年 92 巻 6 号 p. 768-771
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーAntibacterial tests against Hiochi bacteria (Bacillus saprogenes) of Japanese Sake were carried out on 36 kinds of methyl to octyl esters of 3-chloro-, 3-bromo- and 3-iodo-4-hydroxybenzoic acids. It was thereby found that the antibacterial activity increased with increasing number of carbon atoms in the alkyl chain composing the ester group, and introduction of one halogen also increased the original activity. For example, the activity of butyl 3-bromo-4-hydroxybenzoate was about 4 times that of butyl 4-hydroxybenzoate and ca. 8-16 times that of salicylic acid ; activity of butyl 3-iodo-4-hydroxybenzoate was ca. 8 times that of butyl 4-hydroxybenzoate and ca. 16-32 times that of salicylic acid. Effect of halogens in increasing the antibacterial activity increased approximately in the order of iodine, bromine and chlorine. In 6 kinds of 4-alkylresorcinol series, antibacterial activity also increased with increasing number of carbons in the alkyl chain, and the activity of 4-heptylresorcinol showed ca. 60 times that of salicylic acid and ca. 30 times that of butyl 4-hydroxybenzoate. Introduction of one formyl group into 4-alkylresorcinol resulted in doubling of the antibacterial activity, 5-heptyl-2, 4-dihydroxybenzaldehyde showing about 125 times the activity of salicylic acid and about 62 times that of butyl 4-hydroxybenzoate. Introduction of one chlorine also increased the antibacterial activity per test tube. In phenylaminothioformic acid esters also, increasing size of the alkyl group in the esters resulted in increasing antibacterial activity, butyl phenylaminothioformate showing about 30 times the activity of salicylic acid and about 15 times that of butyl 4-hydroxybenzoate.抄録全体を表示PDF形式でダウンロード (548K) -
田村 恭光, 尾崎 和成, 小山 健一, 須本 国弘1972 年 92 巻 6 号 p. 772-774
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリー5-Hydroxy-1-(tert-aminoalkyl)-3, 4-dihydrocarbostyrils (Va-f) and their methyl ethers (IVa-f) were prepared for evaluation of their pharmacological activities. Alkylation of 5-methoxy-3, 4-dihydrocarbostyril (III) with the tert-aminoalkyl chlorides in refluxing xylene in the presence of sodium hydride gave 5-methoxy-1-(tert-aminoalkyl)-3, 4-dihydrocarbostyrils (IVa-f) in 52-92% yields. Demethylation of IVa-f with 48% hydrobromic acid gave Va-f in 81-88% yields. The results are summarized in a Chart and Tables.抄録全体を表示PDF形式でダウンロード (436K) -
白井 秀明, 早崎 孝則1972 年 92 巻 6 号 p. 775-777
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーColumnchromatography of 3-(β-bromopropionyl)-1, 2-dihydro-3H-pyrazino [3, 2, 1-kl]-phenoxazine (III) over alumina in benzene gave 3-acryl-1, 2-dihydro-3H-pyrazino [3, 2, 1-kl]-phenoxazine (VII). Catalytic hydrogenation of VII over Adams'catalyst afforded 3-propionyl-1, 2-dihydro-3H-pyrazino [3, 2, 1-kl] phenoxazine (VIII), which had been obtained by the reaction of 1, 2-dihydro-3H-pyrazino [3, 2, 1-kl] phenoxazine (II) and propionyl chloride.抄録全体を表示PDF形式でダウンロード (467K) -
長坂 達夫, 大木 貞雄1972 年 92 巻 6 号 p. 777-780
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーNitration of 1-acetyltryptophan (2) and N-phthaloyl-1-acetyltryptophan (3) with concentrated sulfuric acid and sodium nitrate afforded 1-acetyl-6-nitrotryptophan (5) and N-phthaloyl-1-acetyl-6-nitrotryptophan (6), respectively. When more than one equivalent mole of sodium nitrate was used in the nitration of 3, the neutral product was obtained in a good yield and its structure is discussed.抄録全体を表示PDF形式でダウンロード (564K) -
浅野 進吾, 北村 二朗, 高取 吉太郎1972 年 92 巻 6 号 p. 781-784
発行日: 1972/06/25
公開日: 2008/05/30
ジャーナル フリーDerivatives (I to XI) of 6-azauracil with a basic substituent in 5-position were synthesized. For the sake of comparison, uracil derivatives (XII to XVII) with the same substituent were prepared. These compounds were tested for antibacterial action against gram-negative organisms like Escherichia coli, Salmonella typhimurium, Shigella sonnei, Pseudomonas aeruginosa, Proteus morgani, and Klebisella spp., prophage induction from E. coli K-12 (λ), and inhibition of cell growth in Yoshida sarcoma, Ehrlich carcinoma, ascites hepatoma, and subcutaneously transplanted tumor. However, none of these compounds showed a marked activity.抄録全体を表示PDF形式でダウンロード (588K)
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