巻号一覧
93 巻, 7 号
選択された号の論文の23件中1～23を表示しています
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木嶋 敬二, 坂口 武一1973 年 93 巻 7 号 p. 831-835
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーThe mechanism of the Voges -Proskauer reaction was investigated using 1-pheny-1, 2-propanedione (I), morpholinoamidine (II) and α-naphthol in the presence of alkali (Barritt's method). From the nuclear magnetic resonance and mass spectral data, the structures of pigments obtained in the presence of α-naphthol (Barrit's method) were determined as 2-(2-morpholino-4-phenyl-1H-5-imidazolylmethylidene)-1, 2-dihydro-1-oxo-naphthalene (Pigment A') and 2-morpholino-5-phenyl-4-(2-morpholino-4-phenyl-1H-5-imidazolylmethylidene)-isoimidazole (Pigment C'). Pigment C' was also obtained in the absence of α-naphthol (O'Meara's method). By the reaction of I and II in a nitrogen gas stream, 2-morpholino-4-hydroxy-4-methyl-5-phenyl-4-isoimidazole (Compound D') was obtained. Compound D' produced Pigment A' by the reaction with α-naphthol in an aerobic alkaline solution, and in the absence of α-naphthol, Compound D' produced Pigment C'. These results indicate that the Voges-Proskauer reaction proceeds through an intermediate such as Compound D'.抄録全体を表示PDF形式でダウンロード (556K) -
小林 五郎, 松田 芳郎, 夏木 令子, 富永 義則1973 年 93 巻 7 号 p. 836-840
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリー3-Cyano-7-hydroxy-4-methylthiocoumarin (I) was synthesized by the application of methyl 1-cyano-2, 2-dimethylthioacrylate to resorcinol, in the presence of sodium hydride. I was derived to 7-hydroxycoumarin to prove its being a coumarin derivative.抄録全体を表示PDF形式でダウンロード (545K) -
大木 貞雄, 渡辺 徳弘, 内山 典子, 尾沢 永紀, 浜口 文子1973 年 93 巻 7 号 p. 841-844
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーReduction of α-methyl- (I) and α, α-dimethyl-N-benzylsuccinimide (II) with sodium borohydride in methanol gives 3-methyl- (III) and 2-methyl-4-hydroxy-N-benzylbutyramide (V) in 1.4 : 1 ratio from I and 3, 3-dimethyl-(IV) and 4, 4-dimethyl-4-hydroxy-N-benzylbutyramide (VI) in 10 : 1 ratio from II, indicating the more facile reduction of the carbonyl adjacent to the substituent in I and II. Hydrolysis of a mixture of IV and a small amount of VI afforded a mixture of β, β-dimethyl-(VIII) and α, α-dimethyl-butyrolactone (X), and VIII was derived to 1, 2, 4, 4-tetramethyl-3-diphenylmethylenepyrrolidine (XIV).抄録全体を表示PDF形式でダウンロード (529K) -
渡辺 徳弘, 浜口 文子, 大木 貞雄1973 年 93 巻 7 号 p. 845-853
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーIn continuation of the previously reported reduction of α-methyl- (Ia) and α, α-dimethyl-N-benzylsuccinimide (Ib) with sodium borohydride, similar reduction of α-ethyl-α-methyl- (Ic) and α-phenyl-N-benzylsuccinimide (Id), N-benzylsuccinimide (Ie), eis-α, α-dimethyl-N-benzylsuccinimide (XI), N-benzylglutarimide (XIII), and β-methyl-(XIV) and α-methyl-N-benzylglutarimide (XIX) was carried out with (a) 0.5 mol of sodium borohydride in isopropanol and (b) excess of sodium borohydride in isopropanol, ethanol, or methanol. Examination of the reduction products indicated that the carbonyl on the side of a substituent in succinimides was preferentially reduced and its selectivity increased in the order of isopropanol, ethanol, and methanol as the solvent, and the reverse was true in the case of glutarimides. Some discussions were made on this reduction mechanism.抄録全体を表示PDF形式でダウンロード (892K) -
山田 澄, 山添 寛, 田辺 玉枝, 加藤 日出男, 木下 泰恵, 毛利 隆明1973 年 93 巻 7 号 p. 854-860
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーThe spasmolytic action on the contraction produced by histamine, acetylcholine, or barium, duration of antihistaminic activity, and some depressive activity on central nervous system were investigated on 4-[β-(10-phenothiazinyl)-ethyl]-1, 4-diazabicyclo-[4, 4, 0]-decane (I) and its related compounds. The antihistaminic activity of I was found to be comparable to that of diphenhydramine and the duration of its action was more effective than the latter, though the antihistaminic activity of 2-chloro-I was very weak. In all cases of the tested compounds, the contraction produced by acetylcholine or barium was inhibited to a lesser degree. Both anticonvulsive action and depressive effect on spontaneous motor activity were weak and the potentiation of hypnosis was not observed. In accord with a general conclusion on phenothiazinylalkylamines, the most effective structural moiety of phenothiazinyl-diazabicyclodecanes for displaying of an antipsychotic activity was that possessing three carbon atoms between a basic diazabicyclodecane unit and a phenothiazine nucleus. When two carbon atoms were involved instead of three, effect on central nervous system was decreased and antihistaminic activity was enhanced.抄録全体を表示PDF形式でダウンロード (728K) -
高橋 三雄, 大沢 啓助, 佐藤 継雄, 上田 條二, 藤田 育志, 顔 焜〓, 李 族祺, 楊 玲玲1973 年 93 巻 7 号 p. 861-863
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーA new acetal, lageracetal, was isolated as a plant component from the leaves of Lagerstroemia speciosa (L.) PERS. On the basis of the spectroscopic data and chemical evidences, its chemical structure was established as 1, 1-dibutoxybutane. Lageracetal was identified with 1, 1-dibutoxybutane, newly synthesized from butyraldehyde and butanol, in physical and other properties.抄録全体を表示PDF形式でダウンロード (433K) -
中垣 正幸, 小林 征雄1973 年 93 巻 7 号 p. 864-874
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーDifferential equation that expresses the ionic flux inside the membrane, when the aqueous electrolyte solutions are separated by a membrane with fixed charge, was numerically solved by assuming the Donnan equilibrium as boundary condition (s). The result thereby obtained was able to explain the observed values for a few flux and membrane potential (s) reported to date. Effect of charge and mobility of the ion (s) constituting the electrolyte and charge density of the membrane on the ionic flux and membrane potential was systematically arranged and it was found that, taking a monovalent-monovalent electrolyte as an example, the electrolyte more easily passes through the membrane when the ratio of the mobility (B+) of the cation and that (B-) of the anion is larger than 1 compared to the electrolyte with B+/B- ratio smaller than 1. When the charge is negative, the reverse becomes true. Effect of the characteristics of each ion on the flux was studied when the electrolyte solution contains two kinds of electrolyte, and this result was compared with observed values of KCl -MgCl2-H2 and KHAsp-Mg(HAsp)2-H2O systems through the bovine lens capsular membrane. Some discussions were made on this result.抄録全体を表示PDF形式でダウンロード (1080K) -
築山 俊一, 高村 彰1973 年 93 巻 7 号 p. 875-880
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーThis paper deals with the effect of impeller velocity and emulsifying agent concentration on W/O-type emulsion. The apparatus consists of a cylindrical vessel (d=150mm) made of clear acrylate resin and Rushton-type impeller (d=49mm). Water and a mixture of n-C7H16 and CCl4 were used as dispersed phase and continuous phase. Span-20, Span-40, or Span-85 was emuployed as an emlsifying agent, and its concentration was 3, 1, 0.3, 0.1, or 10-2% (w/w). The mixture was agitated continuously for 60min, and the revolution number was in the range of 330 to 812rpm. The photographs of droplets were taken by a microscopic method, and the particle size distribution was calculated. The following results were obtained by this experiment. 1) Effect of emulsifying agent on W/O-type dispersion became better in the order of Span-20, Span-40, and Span-85. 2) Surface energy, Es, was in proportion to three-seconds power of agitation intensity, U, and is expressed as follows : log Es=3/2 log U+α' 3) If agitation energy is expressed by EA, energy efficiency of the dispersion η would be defined by the following equation : η=ES/EA As the mean length diameter decreases, the energy efficiency η will show a smaller value.抄録全体を表示PDF形式でダウンロード (602K) -
林 英作, 鈴木 紳一1973 年 93 巻 7 号 p. 881-886
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーThere are three possible sites in 2-quinoxalinecarbonitrile (I) which would be attacked by a nucleophilic reagent ; (1) the ring carbon in 3-position, (2) the ring carbon in 3-position and (3) the carbon in -C≡N bond. Based on this assumption, the reaction of I with carbanion as the nucleophilic reagent was carried out. The carbanion source were various ketones (II) such as acetophenone (IIa), propiophenone (IIb), cyclopentanone (IIc), cyclohexanone (IId), acetone (IIe), diethyl ketone (IIf), methyl ethyl ketone (IIg), methyl propyl ketone (IIh), and methyl isopropyl ketone (IIi), and the reaction was carried out in benzene in the presence of sodium amide. It was thereby found that the reaction of I with IIa afforded 2-(2-quinoxalinyl)acetophenone (IIIa) and 3-(2-quinoxalinyl)-3-iminopropiophenone (IVa) corresponding to the above assumptions (1) and (3), but no product correspondihg to that of (2). In the case of IIb, IIc, and IId, the products were IIIb, IIIc, and IIId corresponding to IIIa, while in the case of IIe, IIg, IIh, and IIi, only IVe, IVg, IVh, and IVi corresponding to IVa were obtained. The reaction of I and IIf afforded 1-(2-quinoxalinyl)-2-methyl-1, 3-butanedione (Vf), considered to be formed via IVf. For the structure of IVa, e, g, h, i, tautomerism between the enamino-ketone (IV') and iminoenol (IV") forms can be considered besides the iminoketone form (IV), and IV' or IV" structure seems more likely than IV. When the so-called active methylene compound (VII) was used as the carbanion source, the reaction II with phenylacetonitrile (VIId) gave α-phenyl-2-quinoxalineacetonitrile (VIII) corresponding to the assumption (1).抄録全体を表示PDF形式でダウンロード (634K) -
久保田 幸穂, 植木 寛, 庄司 省三, 重松 秀成1973 年 93 巻 7 号 p. 887-892
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーA hypoalbuminemic substance was extracted from mouse Ehrlich solid carcinoma. The tumors were homogenized with saline solution, centrifuged, and the resultant turbid supernatant (F-1) was separated. The turbidity was removed by freezing and thawing of the supernatant, and the resultant clear extract (F-2) was dialyzed against 12mM NaCl solution. The inner solution possessing hypoalbuminemic activity was freezedried. This fraction (F-3) was gel-filtered through Sephadex G-150, by using 12mM NaCl solution followed by 1M acetic acid containing 12 mM NaCl as the eluant. An active fraction (F-4-II) was gel-filtered again under the same condition. Of four peaks obtained the third was the active fraction (F-5-III). The yield in protein was 3.0% for F-1 and 0.2% for F-5-III. The decrease in serum albumin was statistically significant for F-1 and F-5-III, while the changes in serum globulins were not significant. F-5-III did not produce a significant change in total serum protein. F-5-III was not electrophoretically homogeneous, although it sedimented as a single peak in ultracentrifugal analysis. Its molecular weight was roughly estimated to be 16000 by ultracentrifugation. Amino acid content of F-5-III was 59.95%, and asparticacid, glutamic acid, and isoleucine were contained in fairly large amounts. Neither the extract prepared from musculus glutaeus maximus of a normal mouse by the same procedures nor bovine serum albumin displayed hypoalbuminemic activity.抄録全体を表示PDF形式でダウンロード (759K) -
坂本 正徳, 富松 祥郎, 百瀬 雄章, 岩田 宙造, 花岡 美代次1973 年 93 巻 7 号 p. 893-895
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーIt was revealed from our previous investigation that the product obtained from the reaction of dimethyl imidazole-4, 5-dicarboxylate (Ia) with anethole (II) is not a Diels-Alder type adduct (III), as proposed by Lora-Tamayo, et al., but probably a heterocyclic compound (VI). The structure of this product is assumed from the basis of its chemical behavior and spectral data. Similar treatment of Ia with butoxyethylene (IV) as in the case of II afforded dimethyl 1-(1-butoxyethyl)imidazole-4, 5-dicarboxylate (V). The evidence for this structure assignment is described.抄録全体を表示PDF形式でダウンロード (470K) -
福島 清吾, 赤堀 幸男, 野呂 忠敬, 斉木 保久, 上野 明, 森永 邦夫1973 年 93 巻 7 号 p. 896-898
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーThe following 2-methylchromone derivatives, 2, 5-dimethyl-8-methoxychromone (V), 2, 5-dimethyl-8-methoxychromanone (VII), and 2, 5-dimethyl-3-hydroxy-8-methoxychromone (VIII) were synthesized.抄録全体を表示PDF形式でダウンロード (432K) -
亀谷 哲治, 丹生 淳郷, 池田 茂夫, 岩城 利一郎1973 年 93 巻 7 号 p. 899-901
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリー11-Dimethylamino-(XI) and several 11-aminoprotoberberine derivatives (XIIa-d), which were expected to serve as hypotensives, were synthesized by alkylation and acylation of 11-amino-5, 6, 13, 13a-tetrahydro-2, 3, 10-trimethoxy-8H-dibenzo [α, g] quinolizine (X).抄録全体を表示PDF形式でダウンロード (438K) -
中垣 正幸, 佐野 洋1973 年 93 巻 7 号 p. 902-909
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーThe mechanism of denaturation of bovine serum albumin (BSA) in various urea solutions was studied by means of the light-scattering and viscosity methods. The measurements were made over a wide range of the urea concentration including the low concentrations of urea and the results were compared with those in the case of guanidine hydrochloride. When the urea concentration was below 5.5M, values of degree of denaturation, intrinsic viscosity, and second virial coefficient of BSA were not much different from the values of native state, but these values increased remarkably at above 5.5M. It is seen from these results that the mechanism of denaturation differs below and above 5.5 M of urea (about 0.9 in degree of denaturation). As for the molecular weight of BSA, the relation, M=(7.09+1.17C3)×104, was obtained between urea concentration C3 (mole/liter) and apparent molecular weight, M. Because these values were smaller than those in the case of guanidine HCl, it is concluded that the denaturation ability of urea was weaker than that of guanidine HCI. The major axis of the aggregated BSA as a prolate spheroid changed remarkably, but the minor axis took constant values at higher concentration of urea. It is, therefore, concluded that molecules of intramolecularly denatured BSA aggregate end-to-end to form aggregates of an elongated shape.抄録全体を表示PDF形式でダウンロード (826K) -
羽田 野昭, 羽田野 良一1973 年 93 巻 7 号 p. 910-915
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーPotential sweep method applied on 1-naphthaldehyde and 2-naphthaldehyde suggested formation of intermediate carbon radicals with elimination of hydrogen from the aldehyde bonded to the 1-position and 2-position, respectively, of the naphthalene ring. Measuemtent, however, was not feasible because of the extreme brevity of life-time of the carbon radicals formed in the course of the electrolytic oxidation but the observed carbon cation pointed to the difference existing between the Ep of 1-naphthalene and that of of 2-naphthalene. Photochemical reaction was introduced to elucidate the behavior of naphthaldehyde, and confirmation of the carbon radicals was made by electron spin resonance (ESR) spectroscopy. To further probe into the oxidation mechanism of naphthaldehyde in the photooxidation reaction, its mixture with hydrogen peroxide was exposed to ultraviolet ray, and while the ESR spectra were examination for carlbon radical behavior, the oxidation was examined with reference to their infrared spectra. The results suggested the following to be the most probable oxidation reaction mechanism for 1-naphthaldehyde and 2-naphthaldehyde.[chemical formula]抄録全体を表示PDF形式でダウンロード (591K) -
浅田 昌三1973 年 93 巻 7 号 p. 916-924
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーThe structures of eight alkaloids isolated from domestic Cephalotaxus durpacea SIEB. et ZUCC. were elucidated. Cephalotaxine is the main alkaloid of this plant, and chemical structures of desmethylcephalotaxine and its derivatives were discussed.抄録全体を表示PDF形式でダウンロード (1053K) -
気賀沢 和雄, 五十里 紀子, 大久保 一三, 飯村 秀樹, 芳賀 清次1973 年 93 巻 7 号 p. 925-927
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーA marked coloration was recognized on the surface of sugar-coated tablet of norphenylephrine (I) hydrochloride when it was stored in an oven for 24 hr at 80°. This browning also took place on heating of I hydrochloride with sugar. It was assumed that isoquinoline derivatives produced from I and decomposition products of sugar, 5-hydroxymethyl-furfural (II) and levulinic acid (V), would be detected in the reaction mixture of I and glucose. Phenolic cyclisation of an ethanolic solution of I and II or V gave isoquinoline derivative, 4, 6-dihydroxy-1-(4-hydroxymethyl-1-furanyl)-1, 2, 3, 4 -tetrahydroisoquinoline (III) or 6, 8-dihydroxy-10b-methyl-1, 2, 5, 6-tetrahydropyrrolo[2, 1-α]isoquinoline-3[2H]-one (VI). The presence of III and VI in the discolored reaction mixture of I and glucose was presumed from thin-layer chromatographic result.抄録全体を表示PDF形式でダウンロード (463K) -
喜谷 喜徳, 荒川 勝雅, 小池 久1973 年 93 巻 7 号 p. 928-931
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーMetal chelate formation of 1-phenazinemethiol with divalent transition metals, Cu, Ni, Co, Mn, Fe, and Zn was studied and the complexes of 1-phenazinemethiol with these metals were isolated easily. Metal chelate formation was identified by elemental and farinfrared spectral analyses. The binding ratios of 1-phenazinemethiol with divalent Cu, Zn, and Co, in 99.5% ethanol were determined to be 2 : 1, 1 : 1, and 2 : 1, respectively, by continuous variation method.抄録全体を表示PDF形式でダウンロード (530K) -
野村 敬一, 安立 準, 滑川 安彦, 三橋 監物1973 年 93 巻 7 号 p. 931-935
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーSynthesis of 7-azabicyclo[4.1.0]heptan-2-one derivatives.(VIII, XIV, XVI, and XVII) is described. In order to elucidate the mechanism of the reaction of α, β-unsaturated ketone with hydrazoic acid, hydrolysis of VIII bd XVII was examined.抄録全体を表示PDF形式でダウンロード (680K) -
野村 敬一, 安立 準, 滑川 安彦, 三橋 監物1973 年 93 巻 7 号 p. 935-938
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーThe reaction of enol ethers, dihydropyran (I), 1-ethoxycyclohexene (III), and 1-methoxy-1, 3-cyclohexadiene (VIII), with hydrazoic acid (HN3) was examined. It was found that the addition reaction of hydrazoic acid to these enol ethers proceeded at room temperature. In the case of VIII, 3-azido-1-methoxycyclohexene (IX) was obtained as a major product. Cyclohexane-1, 2-dione which was obtained by hydrolysis of an abnormal Schmidt reaction product of 2-cyclohexenone was detected by treatment of IX with sulfuric acid.抄録全体を表示PDF形式でダウンロード (580K) -
木本 正七郎, 藤原 靖弘, 岡本 正夫, 中村 憲一1973 年 93 巻 7 号 p. 939-941
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーtranse-Hexahydrophthalydylmethylamine (IVd), which was obtained on catalytic hydrogenation of trans-2-aminoacetylcyclohexanecarboxylic acid (I), and its cis-isomer (IVb), which was prepared by another method, were converted to the same known 4, 4a-cis-4-hydroxy-trans-3, 4, 4a, 5, 6, 7, 8, 8a-octahydro-1(2H)-isoquinolinone (IIId). Therefore, the steric configuration at C3-position of each of the lactones (IVd and IVb) was clarified to be identical.抄録全体を表示PDF形式でダウンロード (463K) -
鈴木 リイ子, 村田 正康, 亀井 克利, 百瀬 篤1973 年 93 巻 7 号 p. 942-947
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーGas chromatographic and mass spectrometric properties of 14 kinds of local anesthetics were studied in order to obtain a basic information on their detection and identification in urine. A satisfactory separation of these drugs was achieved by gas chromatography using 2% OV-17, 3% XE-60, and 0.5% Thermol-3 columns. In the mass spectra of these drugs, the molecular ion appeared as the peaks with a very low intensity except in the case of benzocaine, cocaine, and tropacocaine. Most of the intesive peaks were present in the relatively low mass region. The fragmentation processes were very simple and many characteristic fragments based on the structure of these drugs were observed.抄録全体を表示PDF形式でダウンロード (641K) -
北條 博史, 内山 充, 鈴木 茂生1973 年 93 巻 7 号 p. 947-950
発行日: 1973/07/25
公開日: 2008/05/30
ジャーナル フリーWhen mice were treated with mannan prepared from Saccharomyces cerevisiae daily for 10 days and left for 1 or 2 weeks before tumor implantation, the growth of sarcoma-180 was clearly inhibited. After successive injections of 3H-mannan for 10 days, the radio-activity was predominantly incorporated into the reticuloendothelial tissues and was maintained at a high level for at least 2 weeks after the last administration.抄録全体を表示PDF形式でダウンロード (478K)
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