巻号一覧
94 巻, 1 号
選択された号の論文の27件中1～27を表示しています
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村田 正弘, 馬場 義彦, 松尾 英一, 安田 紘, 小此木 丘, 渡辺 宏1974 年 94 巻 1 号 p. 1-5
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーAs described in the previous paper, an octapeptide fragment containing the heme moiety (CHP) and its re1ated compound, cytochrome c, showed a protective effect against the denaturation of cell and organelles due to oxygen deficiency. A new type of experimental hypoxia was employed to ascertain the activity of CHP against a local hypoxic effect in cardiac muscles. Racemic isoproterenol hydrochloride (i.p.) was given subcutaneously or intraperitoneally to male rats of the Wistar-Imamichi strain in doses of 3-20 mg/kg. A severe infarct-like necrosis was produced in the rats, especially at the left ventricle. In this experimental hypixia, the effect of CHP and its related compounds which were given intraperitonelly was examined by biochemical and histopathological methods. The decrease of enzyme levels such as GOT and GPT in cardiac tissue was less in the rats given CHP (1 mg/kg) than in those given saline as a control. Furthermore, it seems likely that the increment of GOT levels in serum at 5 hr after the i.p. administration was lower in the rats given CHP (1-10 mg/kg) and cytochrome (16 mg/kg) than in the controls. Hemin was not effective. Histopathological findings were similar to these biochemical observations. In addition to the results obtaihed in the two types of experimeta1 hypoxia such as hemic hypoxia and anoxic hypoxia, 2) the present results suggested that the physiological function of externally given cytochrome c may be attributed to the biological function of an effective intermediate of cytochrome c such as CHP.抄録全体を表示PDF形式でダウンロード (1100K) -
吉田 正紀1974 年 94 巻 1 号 p. 6-11
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーThe solubilizing action of fatty acid amides was studied by means of extended Huckel calculation, thermodynamic measurements, and nuclear magnetic resonance (NMR) spectroscopy, and the following results were obtained. 1) Molecular orbital calculation with acid amides showed that apparent formation constants of acid amide-solubilizate complexes had a linear re1ationship with atomic population of the amide-nitrogen but no re1ation to that of the amide-oxygen and with energy leve1 of the highest occupied mo1ecu1ar orbita1s (εho) of acid amides. 2) In the transfer of theophylline from aqueous solution to aqueous fatty acid amide solutions, the entropy change increasid with the concentration of acid amides and the enthalpy change was negligible, contrary to those of aromatic acid amides. 3) NMR spectra indicated that the proton signals of theophylline moved significantly downfield with the addition of fatty acid amides. These results suggest that the main effect on the solubilization is the entropy increase through break-down of an ice-berg by fatty acid amides added to aqueous solution of solubilizates.抄録全体を表示PDF形式でダウンロード (680K) -
萩庭 丈寿, 樋口 義洋1974 年 94 巻 1 号 p. 12-16
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーDehydrogenition-condensation reaction was carried out on the following compounds using palladium-carbon catalyst added with platinum (Pd/Pt-C) and pyridine 1-oxide, (II), under the same conditiohs as reported previously.1) The cmopounds examined were pyrimidine (I), 4-methylpyrimidine (VII), 4, 6-dimethylpyrimidine (X), and 6, 7-dimethoxyquinazoline (XI). Various compounds were thereby formed (Charts 1 and 2), and III, V, VI, and VIII are new compounds. I underwent selective dehydrogenation-condensation at position a to the ring nitrogen, not at 2-position between the two nitrogen atoms, while the reaction did not progress in X and XI. The dehydrogenation-condensation reaction of I using only the palladium-carbon catalyst, without pyridine 1-oxide, resulted in a poor yield, indicating that pyridine 1-oxide gives a good effect on this reaction.抄録全体を表示PDF形式でダウンロード (558K) -
深田 剛毅, 川副 裕一, 田口 胤三1974 年 94 巻 1 号 p. 17-22
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーReactivity of 4-diazo-3, 5-dimethylpyrazole (1), first synthesized by Patel, et al., 3) still remains to be clarified, and a study was made on the intramolecular cyclization reaction of 1. The reaction was found to be cata1yzed by acetic acid in a little polar or nonpolar solvent, giving 1H, 4H-3-methylpyrazo1o [4, 3-c] pyrazole (4). Analogous catalytic action of acetic anhydride. and some carboxylic acid is described and the reaction mechanism is discussed.抄録全体を表示PDF形式でダウンロード (644K) -
深田 剛毅, 川副 裕一, 田口 胤三1974 年 94 巻 1 号 p. 23-30
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーCoupling reaction of 4-diazo-3, 5-dimethylpyrazole (1) with compounds possessing active methylene or methyl group and phenolic compounds was examined. Of these, the reaction of 1 with phenol was mechanistically discussed, because it proceeded with ease to afford bis-azo compound (13) in the main, even when equimoles of the two reagents were used. It was also found that 6-(3, 5-dimethylpyrazol-4-ylazo)-1H, 4H-3-methylpyrarazolo-[4, 3-c] pyrazole (23) was formed via both intramolecular and intermolecular coupling reactions when 1 was heated in tert-butanol, contrasting with the previous finding1) that the same reaction yielded 1H, 4H-3-methy1pyrazo1o [4, 3-c] pyrazole (10) in the presence of acetic acid. Additionally, the reaction of alkyl- or aryl-magnesium halide with 1 was undertaken and its usefulness was found for the preparative of 4-arylazo-3, 5-dimethylpyrazole which has not been obtained by the coupling reactions.抄録全体を表示PDF形式でダウンロード (818K) -
深田 剛毅, 川副 裕一, 田口 胤三1974 年 94 巻 1 号 p. 31-35
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーThe use of 4-diazo-3, 5-dimethylpyrazole (1) as an alcoho1 oxidizing reagent was examined because 1 is easily reproduced3) by the action of nitrous acid on 3, 5-dimethy1pyrazole (4) which remains after the oxidation reaction has ceased. Judging from trials, 1 oxidizes alcohols into aldehydes or ketones in a fairly good yield. In these cases, it was found that addition of hydroquinone in catalytic quantity was very effective in increasing the yie1d of products and reducing the reaction time. However, when solvents were used in this oxidation reaction, yields bacame poorer than without the solvent.抄録全体を表示PDF形式でダウンロード (585K) -
深田 剛毅, 川副 裕一, 田口 胤三1974 年 94 巻 1 号 p. 36-43
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーRefluxing of 4-diazo-3, 5-dimethylpyrazole (1) in benzene for a long time afforded 1H, 4H-3-methylpyrazolo [4, 3-c] pyrazole (2), 3, 5-dimethylpyrazole (6) and biphenyl in 15, 12, and 7% yields, respectively, besides 4-phenyl-3, 5-dimethylpyrazole (3) in 36% yield. Replacement of benzene with nitrobenzene in this reaction gave o-, m-, and p- isomers of 4-nitrophenyl-3, 5-dimethylpyrazole in a ratio of 10 : 2.8 : 3.0. In these reactions, addition of hydroquinone in catalytic quantity (5% by weight of 1) was found to be very effective in increasing the field of 4-aryl-3, 5-dimethylpyramle and reduction of reaction time. It was found that the intermediate in these reactions was a diazonium salt (7) which was formed by the addition of one mole of hydroquinone to two moles of diazo compound (1). From those observations, the reaction mechanism was discussed.抄録全体を表示PDF形式でダウンロード (842K) -
小林 五郎, 松田 芳郎, 夏木 令子, 富永 義則, 間瀬田 千香暁1974 年 94 巻 1 号 p. 44-49
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーReaction of 3-cyano-2-methylthio-4-oxo-4H-pyrido [1, 2-a] pyrimidine (V) and diethyl malonate gave the corresponding substituted product (IX). Reaction of V with PPA (polyphosphoric acid) easily gave the decyanated product (XI), while reaction of V with NaBH4 gave the tetrahydro compound (XII). Reaction of 3-cyago-4-imino-2-methylthio-4H-pyrido [1, 2-a] pyrimidine (VII) and amines resulted in addition of amino to 4-position (XVIIa, b, c). Reaction of VII with conc. H2SO4 gave V, that with CH3I gave the Nmethyl compound (XX), that with NaOH the substituted product (XXI), and that with NaBH4, the tetrahydro compound (XXII).抄録全体を表示PDF形式でダウンロード (581K) -
小林 五郎, 松田 芳郎, 夏木 令子, 富永 義則, 間瀬田 千香暁, 粟屋 博義1974 年 94 巻 1 号 p. 50-54
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリー1, 3-Dicyano-4-imino-2-methylthio-4H-quino1izine (II) was synthesized from 2-pyridineacetonitrile and 2-cyano-3, 3-bis (methylthio) acry1oitrile, and the reactivity of II was examined. The reaction of II with amines resulted in the formation of products (IVa, b, c) with addition at 4-position, while the reaction with methy1 iodide and acetic anhydride gave the corresponding N-methy1 (V) and N-acetyl (VI) compounds. The reaction of II or 1, 3-dicyano-4-imino-4H-quinolizine (VIII) with dimethyl acetylenedicarboxylate afforded 1-azacycl [3.3.3] azine derivatives (VII, IX), and the reaction of VII with amines gave the corresponding substituted products (X, XI).抄録全体を表示PDF形式でダウンロード (517K) -
木本 正七郎, 岡本 正夫, 川端 哲郎, 太田 俊作1974 年 94 巻 1 号 p. 55-61
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーHeating of 2-acylamido-3-aminosocarbostyrils, having an acidic hydrogen at 2-acylamido group, in acetic acid gave the corresponding 1-H (or 3-H), 5H-s-triazolo [1, 5-b]-isoquinolin-5-one derivatives, but, in the absence of acidic hydrogen, the cyc1ization occurred in alkaline medium at a room temperature. It was also found that the thermal decomposition of 4, 5- or 2, 5-disubstituted 3-(o-carboxybenzoyl)-s-triazole derivatives to phthalic anhydride and the substituted s-triazo1e took place easily.抄録全体を表示PDF形式でダウンロード (814K) -
大和田 栄治, 高橋 克幸1974 年 94 巻 1 号 p. 62-68
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーIn order to obtain wider biophaomaceutical knowledge on drug interactions, the effect of 4-homosulfanilamide on the blood 1evels of sulfisoxazole after simultaneous administration to rabbits were investigated. After the ora1 administration of su1fisoxazo1e with equimolar 4-homosu1fanilamide, the total blood levels of sulfisoxazole equivalents rapidly increased and then fluctuated or slow1y rose for about 10 hr. These patterns differed considerably from that observed after the oral administration of sulfisoxazole alone. To understand these phenomena the effect of 4-homosulfanilamide on the dissolution, intestinal absorption, blood elimination, and renal excretion of sulfisoxazole were examined. It was assumed from these results that rapidly elevating and fluctuating blood levels of sulfisoxazole were partly due to the change of the dissolution behavior by 4-homosulfanilamide in the gastro-intestina1 tract. The inhibition of renal excretion of sulfisoxazole by p-sulfamoylbenzoic acid, which is metabolized from 4-homosulfailamide in the body, also might maintain the blood levels of sulfisoxazole.抄録全体を表示PDF形式でダウンロード (770K) -
福沢 寿, 木村 真太郎1974 年 94 巻 1 号 p. 69-74
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーInfluence of partic1e shape on cohesiveness of partic1es was studied. Experiments were made using the cylindrical particles such as vermicelli and copper wire having different diameter and length. The apparatus and procedures reported in the previous paper were used for cohesion measurement. The samples used were considered to have no diffence in their size and shape, and to have a geometrical shape, and seem to be convenient for determination of the shape factor (ψ). For simplification ; the ratio of dl to do was used as a shape factor, where dl is the diameter of the sphere inscribed with the particle and do is that of the one circumscribed with the particle. The effects of particle diameter (φ), length (l), and shape factor (ψ) on cohesive force (fe), and the apparent cohesiveness (αe) were shown experimentally. The relationship between fe and l gave almost a straight line, but fe and φ did not. This difference may be attributed to the difference in particle weight and the degree of leaning between particles which was represented as leaning efficiency (P) previously. The αe decreases with increase in particle diameter, and increases with particle length. It was found that the relation between αe and ψ can be given by αe=A lom ψ+B, where A and B are constants. This relation is recognized in the case of particles of other shape such as lactose granules with different size and shape. The inherent values of A with each sample were observed but the physical meaning of A is still obscure.抄録全体を表示PDF形式でダウンロード (599K) -
佐藤 義朗, 小川 雅清, 小島 寛之, 竹内 正孝, 白井 秀明1974 年 94 巻 1 号 p. 75-79
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーReaction of N-(2-halogenoethyl)-N-methylaniline (I) with magnesium under the Grignard condition was investigated to isolate N-methyl-N-ethylaniline (IV), 1, 4-bis-(methylphenylamino) butane (V), N-methylaniline (VI), and 1, 2-bis (methylphenylamino)-ethane (VII), which must have been formed by way of 2-(methylphenylamino) ethylmagnesium halide (II). However, the addition of propionaldehyde in this reaction gave unexpected 1, 3-dimethyl-2-ethyl-1, 2-dihydroquinoline (IX) instead of the Grignard additon product (VIII). Related reactions are also described.抄録全体を表示PDF形式でダウンロード (630K) -
浅田 昌三, 藤田 麗子, 白倉 由可利1974 年 94 巻 1 号 p. 80-87
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーFor thirty N2-substituted-N1-arylsulfonylurea derivatives (I), acid dissociation constants were determined by spectrophotomeric method, and the partition coefficients between water and carbon tetrachloride, cyclohexane, or chloroform were investigated systematically. 1. Distribution of the compounds is affected by the number of carbon atoms present and Taft's polar substituent constant of their N2-substituent. 2. In respect to the effect of the aromatic substituent for the partition coefficient, it is presumed that the substituent constant π (Eq. 2) for a particular function is almost constant. 3. The Hammett-Taft linear re1ationship (Eq.6) was found to be estab1ished for the acid dissociation of these compounds.抄録全体を表示PDF形式でダウンロード (735K) -
気賀沢 和雄, 飯村 秀樹, 渡部 一夫1974 年 94 巻 1 号 p. 88-92
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーAn examination for the accurate estimation of flow rates of various powders, which flow from the horizontal circular orifices, showed that the weight of powders (W) which flow from the horizontal circular orifice with each diameter (Do) can be estimated by the equation, W=ρB Do2.58 1/K 1/36 (g/sec), using the apparent specific gravity of powder (ρB) and the fluidity index of powder (K) obtained by the variable rotating cylinder method.抄録全体を表示PDF形式でダウンロード (492K) -
丹野 慶紀, 今井 明子, 上村 和夫1974 年 94 巻 1 号 p. 93-96
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーIn preparing suppositories by the fusion method, when the active ingredients are insoluble in bases, it is necessary to pour the mixture into a mold with stirring so as to allow the active ingredient to be homogeneously dispersed. The relation between the suppository preparation methods and distribution of the active ingredients has been little elucidated because there is a difficulty in separating and assaying the active ingredients. In the present study, such a method was examined and a suppository was prepared by labeling zinc oxide with 113mIn, a short-1ived isotope, and mixing it with cacao butter, and the distribution of zinc oxide was determined in terms of radioactivity. As a result, a method was developed which determines the distribution of zinc oxide, with 113mIn.Fe(OH)3 of the particle size of 10 to 100 nm as tracer (Chart 1). Sixty suppositories containing 10% of zinc oxide were measured by this method, and the coefficients of radioactivity variation were 3.3.% and 6.57% for the suppository poured with and without stirring, respectively.抄録全体を表示PDF形式でダウンロード (673K) -
國友 順一, 十一 元晴, 吉川 陽子, 近松 啓明1974 年 94 巻 1 号 p. 97-100
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーAmong the bases known to be present in the tree bark of Nandina domestaca THUNB., structure of nandazurine3-5) and a tertiary phenolic base5) is still unknown. This was examined in the present work and nandazurine was c1arified as an oxoaporphine-type base having a zwitterion structure (I), from its chemical reactions and spectral data. This base is also obtained by the oxidation of O-methyldomesticine (IV) or domesticine (III), which are the main bases of this plant. The phenolic base melting at above 200° was proved to be sinoacutina (VII) belonging to the morphinandienone-type base.抄録全体を表示PDF形式でダウンロード (600K) -
中垣 正幸, 中村 康彦1974 年 94 巻 1 号 p. 101-109
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーThe adsorption of ions from NaCl, dodecylamine-HCI (DAHCl) or dodecyl-NaSO4 (SDS) solution on the glass particles, whose surface have been treated, was studied by streaming potential method. These surface treatments were done either by coating with dodecylamine, cholesterol, lauric acid, or dodecano1 to form a layer of about 0.2 μ in thickness, according to the fusion-diffusion-cooling method, or by treating with trimethylchlorosilane (TMCS) in benzene solution. According to the results of these experiments, the adsorbed amount of ions in DAHCl solution was the most in the case of g1ass particles treated with TMCS and, in SDS solution, glass particles coated with dodecylamine. The adsorbed amount was the least in the case of untreated glass particles in SDS solution. These results were explained by competitive influence of electrostatic interaction and hydirophobic interaction.抄録全体を表示PDF形式でダウンロード (908K) -
梅本 光一郎1974 年 94 巻 1 号 p. 110-115
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーIn continuation of previous reports that the pattern analysis of the low-temperature ashed image of crystalline inorganic components present in the plants would be useful in elucidating a kinship among plants, the morphological pattern of calcium oxalate crystals was examined in the leaves of hydrangea genus of Saxifragaceae family ; Hydrangea paniculata SIEB.H. macrophylla (THUNB.) SER. var. acuminata (SIEB.et ZUCC.) MAKINO, H. macrophylla (THUNB.) SER.var. thunbergii (SIEB.) MAKINO, and H. hirta (THUNB.) SIEB. Mode of this pattern according to the district where the plant was collected, and characteristics of the pattern of calcium oxalate crystals in the leaves of Japanese hydrangea genus were also exmined The following points were thereby revealed : 1) Difference of locality hardly affected the characteristic pattern of crystals in the samples. It might be said that the characteristic pattern of crystals in the sample remains unchanged as long as the sample plants are able to grow in natural environment, and this fact seems to the applicable to all the plants with a high probability. 2) Japanese hydrangea genus plants of the Saxifragaceae family possess a crystal pattern with at least one characteristic of a "distribution of bundle of raphides of calcium oxalate." Although the shape of bundle of raphides is varied, there seems to be some limit in this variation, and interpretation of the pattern taking that into consideration would be useful for pattern analysis. This fact suggests that pattern analysis with considerations on the variety of shapes of various crystalline inorganic components and the extent of this variation would offer many useful informations.抄録全体を表示PDF形式でダウンロード (1012K) -
石黒 伊三雄, 池野 武行, 松原 弘1974 年 94 巻 1 号 p. 116-123
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーThe fluoreicent substances in the body of four kinds of bees were examined at the three stages of larva, pupa, and imago by paper chromatography. It was confirmed clearly on chromatograms that fluorescent substances of Apis melliferea L. and other species were four and five, respectively, excluding riboflavin. Three of these fluorescent substances, BV-substance of Rf 0.05, V-substance of Rf0.18, and B-substance of Rf0.45 on the paper, were recognized as major components at three stages of bees, and other substances were negligible on the paper. These three substances were isolated in a crystalline form from defatted powder of the larva of Vespa lewisi C. by gel filtration over Sephada G-10 and absorption chromatography on a1umina. These three substances were identified with L-kynurenine, isoxanthopterin, and xanthurate 4, 8-diglucoside from chemical and physical properties. The occurrence of xanthurate 4, 8-diglucoside as a tryptophan metabolite has been demonstrated for the first time in bees.抄録全体を表示PDF形式でダウンロード (838K) -
富沢 宏, 王 昭雄, 加藤 秀樹1974 年 94 巻 1 号 p. 124-126
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーThe Mannich reaction of 2-methyl-1(2H)-thioisoquino1one (II) was carried out. The products obtained were 4, 4'-methylene-bis[2-methyl-1(2H)-thioisoquinolone] (III), 4-dimethylaminomethyl-2-methyl-1(2H)-thioisoquinolone (IV), 4-diethylaminomethyl-2-methyl-1(2H)-thioisoquinolone (VI), and 4-piperidinomethyl-2-methyl-1(2H)-thioisoquinolone (VII), and these structures were confirmed by nuclear magnetic resonance spectral comparison.抄録全体を表示PDF形式でダウンロード (460K) -
五十嵐 治義1974 年 94 巻 1 号 p. 126-137
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーIn order to investigate the relation between clemical structure and pharmacological activities, 1-dialkylamino-2-propanol derivatives and their related compounds were synthesized. These compounds were examined in rabbit and mouse for local anesthetic activity, anti-spasmodic activity, ana1gesic activity on pain produced by a hot plate and inhibitory action on writhing syndrome produced by acetic acid. Several substances had stronger analgesic action that pyrabita1 and almost all the compounds were proved to have antispasmodic aitivity at the concentration from 10-5 to 10-6 g/ml. 1-Diisobutylamino-3-piperidino-2-propanol dihydrochloride (IIIf), 1-dibutylamino-3-butoxy-2-propapol hydrochloride (IVf), 1-dibutyl-amino-3-hexylthio-2-propanol hydrochloride (Vk), and 1-dibutylamino-2-(β-cyanoethoxy)-3-diethylaminopropane dihydrochloride (VIIId) showed a stronger local anesthetic activity than cocaine or lidocaine.抄録全体を表示PDF形式でダウンロード (1082K) -
岩崎 正武, 太田 睦子, 大谷 嘉孝1974 年 94 巻 1 号 p. 138-143
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーA new saccharogenic method is presented for the micro-determination of serum amylase activity, which uses only 5 μl of a sample. This is based on the determination of reducing sugar mixture produced in the enzyme reaction with insoluble starch substrate under conditions similar to that of the Somogyi method by means of micro-colorimetric technique for the determination of blood sugar with 3, 6-dinitrophthalic acid. The measured enzyme activity in this method can be converted into Somogyi units, by dividing it by 3, 66, which is commonly adopted in the saccharognic methods. The method gives reliable results, does not requure a standardized starch, and may be suitable for the micro-assay of enzyme in practical use.抄録全体を表示PDF形式でダウンロード (686K) -
植木 寛, 恒見 忍, 田中 正比古, 山下 節男, 久保田 幸穂1974 年 94 巻 1 号 p. 143-146
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーHypoalbuminemic substances were partially purified from Ehrlich ascites carcinoma cells and from tissues of normal and tumor-bearing mice. The homogenate of tumor cells was extracted with saline, and the extract (F-1) obtained was fractionated by the addition of the same volume of a saturated solution of ammonium sulfate. After removal of the precipitate, the supernatant (F-2) was adjusted to pH 4.7 and fractionated again at 0.66 saturation of ammonium saulfate. The supernatant (F-3) thereby obtained showed a hypoalbuminemic activity. The decreases in total protein and albumin in the blood of mice, elicited by the intraperitoneal injection of 25-75 mg/kg of F-3, were statistica11y significant. The most pronounced decrease in total protein and albumin was produced 3 and 24 hr, respectively, after the injection of F-3. Qualitative ana1yses revealed the presence of protein, carbohydrate, lipid, and nuc1eic acid in F-3. The corresponding fractions obtained from liver and kidney of normal and tumor-bearing mice also showed hypoalbuminemic activity.抄録全体を表示PDF形式でダウンロード (563K) -
藤田 直, 松本 研一1974 年 94 巻 1 号 p. 147-149
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリー1) An in vivo study was made to obtain quantitative data on the fatty acid composition of mitochondria, microsomes, and supernatant fraction (105000×g) of livers from rats fed a diet deficient in vitamin E. 2) Difference in the fatty acid composition was observed in subcellu1ar fraction of liver from control and vitamin E-deficient rats. 3) In the fractions of liver from vitamin E-deficient rats, palmitooleic acid and oleic acid increased, but linoleic acid, arachidonic acid, and docosahexaenoic acid decreased. 4) Fatty acid composition of mitochondria and microsomes of liver from vitamin E-deficient rats were recovered by treatment with α-tocopherol (100 mg/kg/day, for five days). 5) Tinoridine has the same effect as α-tocopherol on the fatty acid composition in the microsomes and supernatant fraction of liver from vitamin E-deficient animals.抄録全体を表示PDF形式でダウンロード (441K) -
松浦 信, 李 連滋1974 年 94 巻 1 号 p. 150-152
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリーBehenic acid, palmitic acid, stearic acid, ursolic acid, 19α-hydroxyursolic acid, β-sitosterol, β-sitosteryl-β-D-glucoside, a hydroxya1iphatic acid ester, and two unsaturated aliphatic alcohols were isolated from the roots of Bochmeria frutescens THUNB. var. frutescens. The methanol extracts of the roots of B. tricuspis, B. siebordiana, B. longispica, and B. nivea were also investigated by comparison with those of B. frutescens var. frutescens and B. platanifolia by thin-layer chromatography. It is apparent that all Boehmeria species have almost the same components.抄録全体を表示PDF形式でダウンロード (453K) -
安田 正秀, 藤田 直, 森本 史郎1974 年 94 巻 1 号 p. 153-156
発行日: 1974/01/25
公開日: 2008/05/30
ジャーナル フリー1) Effect of glutathione, cysteine, and thiamine on the accumulation of cadmium in the liver and kidney of rats was investigated. 2) Growth of rats was inhibited by daily intraperitonea1 administration of cadmium chloride (1 mg/kg/day as Cd) for 14 days. In combined application of glutathione, cysteine or thiamine with cadmium chloride, no apparent difference in growth curves were observed as compared to that of control animals. 3) The amount of cadmium in the kidney increased more by simultaneous administration of glutathione or cysteine with cadmium than by application of cadmium alone. By application of thiamine with cadmium, however, cadmium content in the kidney decreased marked1y. On the other hand, there was no significant difference in the amount of cadmium in the liver between cadmium administered alone and animals given glutathione, cysteine, or thiamine with cadmium. 4) Calcium content in the liver and kidney increased significantly by the administration of cacmium, as compared with the control groups, and the combined application of glutathione, cysteine, or thiamine with cadmium had little effect on the accumulation of calcium. 5) Protein-bound sulfhydryl content in the liver increased markedly by the administration of cadmium but no effect was observed in the kidney. Protein-bound su1fhydryl content in the liver decreased by the simultaneous administration of glutathione, cysteine, or thiamine with cadmium, as compared with the animals given cadmium alone.抄録全体を表示PDF形式でダウンロード (551K)
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