YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
95 巻 , 6 号
選択された号の論文の24件中1~24を表示しています
  • 畠田 孝幸, 曽根 正勝, 富永 義則, 夏木 令子, 松田 芳郎, 小林 五郎
    1975 年 95 巻 6 号 p. 623-628
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    By the reaction of dimedone and ketene thioacetals, corresponding substitution products (I, II, III], coumarin derivatives (VIII, X), and quinolone derivative (IX) were synthesized. Treatment of II with conc. hydrochloric acid gave the quinolone derivative (IX). Reaction of acetylacetone and ketene thioacetals also gave the corresponding substitution products (IV, V, VI, XII) and a pyridone derivative (XIII). Reaction of I and amines gave corresponding substitution prducts (XIV, XV, XVI, XVII, XVIII) in a good yield. Reaction of II with conc. ammonia in a sealed tube at 180° afforded the substitution product (XIX), while the reaction of II with methylamine under the same condition gave a quinolone derivative (XXI).
  • 宮崎 正三, 堀 了平, 有田 隆一
    1975 年 95 巻 6 号 p. 629-633
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Four different solid phases of tetracycline (trihydrate, anhydrate, dehydrate, and amorphous) were isolated. These phases were characterized by using IR spectroscopy, X-ray powder diffraction, and thermogravimetric and differential thermal analyses. Dissolution behavior of these phases in distilled water was investigated and an appreciable difference in the dissolution behavior was detected between the amorphous and the other solid phases. The effect of the solid phases on bioavailability of tetracycline was also studied. Blood plasma levels obtained in rabbits and blood levels in rats after intraduodenal administration of the trihydrate and amorphous were compared, and its results indicated that the solubility difference between the two phases has an effect on the bioavailability of tetracycline. The cumulative excretion of tetracyc1ine in urine after oral administration of the two phases to human subjects was also examined and its results indicated that the cumulative amount after administration of the amorphous was slightly higher than that of the trihydrate.
  • 堀 幹夫, 片岡 貞, 清水 洋, 今井 豊, 藤村 一
    1975 年 95 巻 6 号 p. 634-640
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Reaction of 3-methyl-2-phenylbenzothiazolium iodide (I) and metal hydride (LiAlH4 and NaBH4), when carried out in air, gave o-(N-benzoyl-N-methylamino)phenyl disulfide (III) as the main product but, when the reaction was carried out in a nitrogen stream, 3-methyl-2-phenylbenzothiazoline (II) was obtained as the main product. Reaction of I and phenylmagnesium bromide gave 3-methyl-2, 2-diphenylbenzothiazoline (VII) alone, either in air or in a nitrogen stream. Reaction of 3-methylbenzothiazolium iodide (VI) and phenylmagnesium bromide in air gave III as the main product, while II was the main product when the reaction was carried out in a nitrogen stream. From the stability of benzothiazolines in air, from the reaction of II with lithium aluminum hydride, phenylmagnesium bromide, and potassium hydroxide, and from the fact that the oxidative ring cleavage reaction of 5-chloro-3-methyl-2-phenylbenzothiazoline (XI) is accelerated by the addition of a radical reaction promotor, a radical mechanism in which benzothiazolines formed during the synthetic process undergo auto-oxidation by oxygen was proposed as the mechanism for the formation of an oxidative ring cleavage product.
  • 米勢 政勝, 中垣 正幸
    1975 年 95 巻 6 号 p. 641-647
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Mixed membranes composed of various fractions of gelatin and chondroitinsulfate C (chs) were made insoluble by formaldehyde. The swelling of these in aqueous media were experimented in the range of pH 2.9-7.0. The rate constant (k) of swelling (obtained from the equation of the first-order reaction), the rate of increase in membrane thickness (αL) and that in membrane radius (αr) in the initial step of swelling were obtained. With increasing weight fractions of chs (Xchs), k increased in the case of pH 5.6 and 4.2, but decreased when pH was 2.9. It was estimated from the analysis of these results that the insoluble complex formation between gelatin and chs occurs and depresses the swelling rate. The swelling of these membranes were anisotropic, and the values of αL and αr depended on Xchs as well as on pH in a similar behavior as that of k.
  • 瀬山 義幸, 山下 三郎, 石川 信雄
    1975 年 95 巻 6 号 p. 648-654
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Behavior of deiodination of diiodohistidine (DIH) in the presence of liver and kidney homogenates of the rat was studied qualitatively in terms of time course on thin layer chromatography and paper chromatography comparing with the known course of metabolism of diiodotyrosine (DIT) . Differing from DIT, iodine was split from DIH depending neither on the amount of homogenate or time course. In order to examine the mode of deiodination from DIH and monoiodohistidine (MIH) more precisely, they were labeled with 131I, and the metabolism of DIH and MIH was found to be considerably different : 1) Deiodination of DIH occurred partly non-enzymically, and proceeded only by incubation of the aqueous solution at 37°, and the rate of deiodination increased to some extent by the addition of the thyroid gland, liver, or kidney homogenate to the solution. 2) On the other hand, MIH was not deiodinated by a short-time incubation (up to 2 hr) of the aqueous solution with the thyroid gland, liver, or kidney homogenate. MIH was then administered to intact rats to detect any metabolites. Radioactive iodide began to appear in the urine 24 hr after the subcutaneous administration of MIH. It may be concluded from the present study that DIH is deiodinated enzymically and non-enzymically, but MIT resists rapid metabolism, and it is deiodinated slowly in the body.
  • 小川 宗治, 荻原 幸夫
    1975 年 95 巻 6 号 p. 655-658
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    A new natural flavone glucoside, eudiposide, was isolated from the stems of Enkianthus nudipes (HONDA) OHWI and found to be quercetin-7-β-D-glucoside-6'-tiglate.
  • 村田 正弘, 安田 紘, 馬場 義彦
    1975 年 95 巻 6 号 p. 659-664
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    An octapeptide fragment containing the heme moiety (CHP), which was prepared from Candida krusei cytochrome c, showed a protective effect against the denaturation of cells and organelles due to oxygen deficiency in various types of experimental hypoxia. In vivo and in vitro experiments were carried out to investigate the effect of CHP on the lipid peroxide as a result of the oxidation of unsaturated fatty acids. Lipoxidase-catalyzed oxidation was more effectively blocked by the addition of CHP solution (2×10-6M) than of other antioxidants such as vitamin E and α-naphthol (1.7×10-5M). Linolenic acid peroxide was decomposed in the presence of CHP, as well as other heme containing molecules, although vitamin E and α-naphthol were not effective. The increase of lipid peroxide formation in liver tissues in rabbits fed on a vitamin Edeficient diet was proved by the colorimetric thiobarbituric acid method (TBA). The TBA values of CHP-treated group (0.5 mg/kg/day, 4 weeks) were significantly lower than that of saline control (p<0.05). Liver homogenates of rats in hemic hypoxia also formed much lipid peroxide as measured by the TBA method, and the degree of increase in CHP-treated group (1 mg/kg) was somewhat lower. These results suggested that CHP may serve as a protective agent against cellular damage in hypoxia, when its native cytochrome c or itself is properly administered.
  • 米勢 政勝, 中垣 正幸
    1975 年 95 巻 6 号 p. 665-671
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    The mixed membranes were prepared from gelatin and chondroitinsulfate (chs), whose fractions (Xchs) were 0.0, 0.108, 0.226, and 0.317. They were cross-linked by formaldehyde. The permeability of electrolytes (KCI and CaCl2) through the membranes and their pH dependence were investigated in order to elucidate the effects of Xchs and the formation of complex between gelatin and chs on the permeability. The permeability (P*) of KCl and CaCl2 decreased with the content of the membrane constituent (WM). The effect of Xchs on P* depended on the kind of electrolytes ; permeability of KCl decreasded with increasing, Xchs but that of CaCl2 was independent of it. In a strongly acidic region, effect of the concentration of hydrogen ion on P* (KCl as solute) varied with the fraction of chs (Xchs) ; permeability through the membranes with Xchs=0.0 and 0.108 increased as pH of the bulk solution departed from the isoionic point of gelatin (pH 4.9), but that through the membrane of Xchs=0.226 decreased apparently at pH 2.2. For these systems, the relations between WM and pH, and between P* and WM were investigated at various pH. From these results, it was found that the formation of the insoluble complex repressed the swelling of the membrane and decreased P*.
  • 中西 美智夫, 後藤 一洋
    1975 年 95 巻 6 号 p. 672-679
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Endotoxin was injected intradermally to rabbits. Within 12 hr after this treatment, administration of 2-(5H-[1]benzopyrano[2, 3-b]pyridin-7-yl)propionic acid (Y-8004) was started. Y-8004 as well as indomethacin was found to inhibit the local Shwartzman reaction. Within 23 hr after the injection of endotoxin, administration of steroidal antiinflammatory drugs such as prednisolone were started and its results were similar to that of Y-8004, although the cell infiltration at the injection site of endotoxin was markedly observed at 23 hr after the injection of endotoxin. In addition, the leucocyte and lysosome suspension were prepared from the emigrated polymorphonuclear leucocytes of rabbits. Y-8004 and nonsteroidal acidic anti-inflammatory drugs inhibited the release of lysosomal enzymes both from the leucocytes by phagocytosis and from the lysosomes by incubation in vitro. However, steroidal antiinflammatory drugs did inhibit not only the above release reaction, but also the release of enzymes from the preincubated lysosomes. Based on these evidences, discussion was extended on the possible mechanisms of the inhibitory action of Y-8004 and anti-inflammatory drugs against the local Shwartzman reaction.
  • 本間 誠次郎, 神戸 川明
    1975 年 95 巻 6 号 p. 680-689
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    The distribution, blood level, and biliary metabolites of D-32, a new adrenergic β-blocking agent, were investigated in rats, rabbits, and dogs using 3H-labeled D-32. When D-32-3H was administered intravenously to the rat, radioactivity was taken up by the lung in higher concentration than by other organs and then decreased gradually with time. In the lung and brain, the main radioactivity accumulated was due to D-32, whereas most part of it was present as metabolites in the liver and kidneys. After both intravenous and oral administration, the half-life in plasma was approximately 45 min in rats, but was of the order of 110-160 min in dogs and rabbits. After oral administration there was virtually a complete absorption and peak blood levels of D-32 and active metabolites, 4'-hydroxy-D-32 and 3'-hydroxymethyl-D-32, were seen at about 1.5 hr after the administration. Further these metabolites appeared in the blood in amounts equal to D-32. On the other hand, after intravenous administration, total amount of active metabolites was only 1-10% of D-32 in the blood. These findings demonstrate that D-32 is absorbed easily from the gastrointestinal tract and is rapidly metabolized in the liver. The rat excreted approximately 40% of the dose in the bile during 24 hr. The major metabolites obtained from the bile were identified as 4'-hydroxy-D-32 4-O-glucuronide and 3'-hydroxymethyl-D-32 3-O-glucuronide by chemical degradation, nuclear magnetic resonance and mass spectra. D-32 undergoes metabolism in the rabbit liver involving NIH shift migration of the deuterium on metabolic 4'-hydroxylation of 4-deuterated D-32.
  • 辰巳 淳, 中野 正行, 北村 繁幸, 吉村 英敏
    1975 年 95 巻 6 号 p. 690-697
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    The metabolic fate of 1-p-chlorophenyl-2, 3-dimethyl-4-dimethylaminobutan-2-ol hydrochloride (CDDA·HCl) in rabbits, rats, and human was studied. 1) In rabbits and rats receiving 3H-CDDA·HCl orally, the radioactivity was mainly recovered in 24 hr urine. The summation of radioactivity excreted in urine and feces during 96 hr was about 89% and 80% in rabbits and rats, respectively. 2) In rabbits, the urinary metabolites detected were 1-p-chlorophenyl-2, 3-dimethyl-4-monomethylaminobutan-2-ol (CDMA), 1-p-chlorophenyl-2, 3-dimethyl-4-aminobutan-2-ol (CDA), p-chlorobenzoic acid, benzoic acid, and hippuric acid. 3) In rats, similar result was obtained, except the excretion of p-chlorobenzoic acid found in rabbits. In humans orally receiving non-radioactive CDDA·HCl, the urinary excretion of CDMA and CDA was also suggested.
  • 徳岡 康雄, 醍醐 晧二, 竹本 常松
    1975 年 95 巻 6 号 p. 698-705
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Two new flavonoids have been isolated from the root of Epimedium grandiflorum MORR.(Berberidaceae) and named epimedoside D, C37H46O19·H2O, mp 234.5 -235.5°, and epimedoside E, C37H46O19·4H2O, mp 248-250°. Their structures were established respectively as XV and I from chemical and spectroscopic evidences.
  • 篠田 雅人, 太田 節子, 早瀬 幸俊
    1975 年 95 巻 6 号 p. 706-709
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Radiosensitivity of survival and body weight change was measured by soft X-ray irradiation of mice under various conditions, and the result was compared with that from irradiation with 200 kVp X-ray. 1) Neither the survival nor body weight was markedly affected by soft X-ray irradiation with 30 kVp. 2) At 70 kVp, survival rate and body weight change rate varied with increasing dose. When acrylate filter of 10 mm was used, significant correlation was found in the survival rate in the range of 500-2000 R and in the body weight change rate in the range of 250-2000 R. In this case relative biological efficiency was ca. 0.5. 3) Depilation of mice produced by soft X-ray irradiation can be prevented by the use of an acrylate filter.
  • 野副 利一, 柴沼 由久
    1975 年 95 巻 6 号 p. 710-714
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Attempted synthesis of 2, 3-dihydrofuro[2, 3-b]indole from α-(o-nitrophenyl)-γ-butyrolactone was found to give 2-hydroxytryptophol in stead of the objective compound. 2-Hydroxytryptophol is a novel compound and several of its derivatives were synthesized ; 3-(1-ethyl-2-hydroxyethyl)oxindole (XV), 3-(2-ethyl-2-hydroxyethyl)oxindole (XVI), and 3-(2, 2-dimethyl-2-hydroxyethyl)oxindole (XVII). Several novel α-phenyl-α-butyrolactone derivatives and their novel α-nitro- and aminophenyl derivatives were also synthesized ; α-(o-and p-nitrophenyl)-γ-butyrolactone (VI), α-(o-and p-nitrophenyl)-γ-ethyl-γ-butyrolactone (VIII), α-(p-aminophenyl)-α-ethyl-γ-butyrolactone (XI), α-(p-aminophenyl)-γ-ethyl-γ-butyrolactone (XII), and α-(p-aminophenyl)-γ, γ-dimethyl-γ-butyrolactone (XIII).
  • 磯野 博, 立浪 節子, 黒野 吾市
    1975 年 95 巻 6 号 p. 715-719
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Wax esters, wax acids (as methyl esters), and wax alcohols were analyzed qualitatively and quantitatively by gas chromatography and mass spectrometry. Gas chromatographic analysis of wax esters was made by using TCD on 5% OV-17 column at 340°. The component acid methyl ester and alcohol produced by microinteresterification of wax ester were determined simultaneously on 1.5% OV-1 column and 1.5% OV-17 column at 200-300°, at the rate of 4°/min. Analysis of wax ester by gas chromatography generally confirmed the data obtained from mass spectrometry. Bulbs of Tulipa gesneriana L. and Scilla japonica B.contained odd-numbered carbons in their wax esters, wax acid, and wax alcohol.
  • 小林 正義, 森本 武男, 山元 正昭
    1975 年 95 巻 6 号 p. 720-727
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Effect of nucleic acid-related substances, amino acids, saccharides, protein-denaturing or -precipitating agents, SH reagents, reducing agents, biological products, urine, and saliva, on the gelation reaction of limulus lysate was examined. Most of them have no effect on the gelation reaction, but some inhibition was observed in benzyl alcohol, ATP of nucleic acid-related substances, cysteine, and mercaptoethanol among SH reagents. Protein-denaturing agents inhibited the gelation reaction at the concentration higher than a certain level. Saliva, urine, and biologicd products showed no inhibition of the gelation reaction. It was also found that the limulus test was applicable to the detection of endotoxin in products at various stages of manufacturing process.
  • 鮫島 政義, 吉田 正紀, 平川 善行
    1975 年 95 巻 6 号 p. 728-731
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    The calorimetric procedure was attempted to study the solubilizing action of acid amides in aqueous solution. The interaction of nicotinamide and xanthine derivatives (caffeine, oxyethophylline, and theophylline) was studied by using the twin-type microcalorimeter. The positive heats of reaction were obtained between nicotinamide and xanthine derivatives. By using these values, the heat of complex formation (ΔHf) and complex formation constant (K) between them were calculated by the method described by Lamberts. These values obtained by the calorimetric procedure agreed with corresponding values by the solubility method. This procedure was very easy for obtaining ΔHf and K, and therefore it was considered to be one of the useful methods for studying the interaction between a solubilizing agent and a solubilizate.
  • 藤井 節郎, 奥田 拓道, 赤沢 明, 安田 行寛, 川口 安郎, 福永 育史, 西川 栄郎
    1975 年 95 巻 6 号 p. 732-740
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    In order to investigate the fate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) in comparison with that of 5-fluorouracil tritiated FT-207 (3H-FT-207) and 5-fluovouracil (3H-5-fluorouracil)were administered from the rectum in normal and AH-130 tumor-bearing rats, and rapid absorption of 3H-FT-207 or 3H-5-fluorouracil, was observed. Blood level of radioactivity after rectal administration of 3H-FT-207 was higher and more continuous than that of 3H-5-fluorouracil. Although the radioactivity after rectal administration of 3H-FT-207 and 3H-5-fluovouracil was widely distributed in the various tissues of the animal with or without tumor, the highest concentration of the radioactivity was observed in the kidneys, and higher in tumor. The radioactivity in lymphatic gland reached a maximum level within 2-4 hr after the rectal administration of 3H-FT-207 and declined very slowly. The urinary excretion of radioactivity within 24 hr was about 30% of the administered dose of 3H-FT-207. More than 85% of the excreted radioactivity accounted for FT-207 and its metabolite, α-fluoro-β-alanine. Other metabolites such as 5-fluorouracil, α-fluoro-β-ureidopropionic acid and tritiated water were detected in small amounts in rat urine. The radioactivity in blood and tumor, 4 hr after rectal administration of 3H-FT-207, was found to represent FT-207. However, the radioactivity in liver was due to the presence of α-fluoro-β-alanine. About 90% radioactivity in lymphatic gland within 2-6 hr after rectal administration of 3H-FT-207 was detected as FT-207.
  • 吉名 重多賀, 山本 勝美
    1975 年 95 巻 6 号 p. 741-748
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    The Claisen condensation of 3, 4-diphenyl-2-furaldehyde (I) and acetone gives two kinds of reaction product ; 3, 4-diphenylfurfurylideneacetone (II) and bis(3, 4-diphenylfurfurylidene)acetone (III). The same reaction of I and CH3COR ([chemical formula]) gave 4 kinds of novel 3, 4-diphenylfurfurylidene-acetones (V, VI, VII, IV). The same reaction of II and aromatic aldehydes gave 7 kinds of 5-substituted 1-(3, 4-diphenyl-2-furyl)-1, 4-pentadien-3-ones, while aldol intermediates (XV and XVI) were obtained in that of II with 4-nitrobenzaldehyde and 4-cyanobenzaldehyde. Reaction of α, β-unsaturated ketones and aminoguanidine gave 7 kinds of novel amidinohydrazone hydrochlorides. Cyclization reaction of ethyl 3, 4-diphenylfurfurylidenepyruvate amidinohydrazone hydrochloride (XXII) and 1-(3, 4-diphenyl-2-furyl)-5-(4-nitrophenyl)-1, 4-pentadien-3-one amidinohydrazone hydrochloride (XXV) with alkali in dimethylformamide gave the corresponding cyclized products ; 3-amino-6-[2-(3, 4-diphenyl-2-furyl)vinyl]-1, 2, 4-triazine-5-(4H)one (XXVII) and 3-amino-6-[2-(3, 4-diphenyl-2-furyl)vinyl]-1, 2, 4-triazine (XXVIII). Antibacterial activity of unsaturated ketones was almost ineffective but, among amidinohydrazones, XX and XXIV showed an interesting antibacterial activity.
  • 中島 徳保, 岩尾 豊, 九岡 辰男, 鈴木 周一, 相沢 益男
    1975 年 95 巻 6 号 p. 749-752
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    The properties of insoluble particles which are formed on the storage of 10% Dextran in vials containing injectable solution were investigated. No evident difference between the insoluble particles and Dextran 40 was detected in the physico-chemical properties such as mp, specific rotation, intrinsic viscosity, and sedimentation constant. Furthermore, the insoluble particles were found to consist mainly of α-1, 6-glucan by measurement of nuclear magnetic resonance and infrared of the substance and after acid hydrolysis. The insoluble particles were found to be soluble in water at 90° and in solutions of 8M urea, 3M guanidine hydrochloride, 2.5M NaOH, and dimethyl sulfoxide. The solution of Dextran 40 of more than 30% in concentration tended to become turbid on standing, followed by gelation. From these facts it was speculated that the formation of particles in the vial might be that Dextran 40 adhered was concentrated on the surface of a rubber stopper and formed an intermolecular hydrogen bonding with one another.
  • 工藤 忠宏, 野瀬 敦子
    1975 年 95 巻 6 号 p. 753-757
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Reaction of trialkylborane with nitrobenzene derivatives was examined. Reaction of nitrobenzene (I) and tricyclohexylborane (II) was found to proceed in ethanol or without a solvent and gave N-cyclohexylaniline (IIIa) and nitrosobenzene (IV), respectively reaction of II with IV yielded IIIa. Generally N-alkylaniline derivatives were obtained in analogous reaction. 4-Chloronitrobenzene (IX) gave azo or azoxy compound with N-alkyl-4-chloroaniline, and m-dinitrobenzene (XIV) gave m-dinitrobenzene (XV).
  • 野副 利一, 柴沼 由久, 重久 晃
    1975 年 95 巻 6 号 p. 758-759
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    Corynoxeine, which is contained in crude rhynchophylline obtained from Uncaria rhynchophylla MIQ., was isolated by using an ion-exchange resin and identified.
  • 石黒 敏弘, 近藤 嘉和, 竹本 常松
    1975 年 95 巻 6 号 p. 760-763
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    An 11-membered ring diterpenoid, ester L3 (I), was isolated from the seed oil of Euphorbia lathyris and its structure was determined as Ia or Ib, from the conversion of I to the triol compound (III) which was found to be related to epoxylathyrol. The fact was also confirmed from the partial deacylation product of I, and from the spectrometric data of it.
  • 石黒 敏弘, 近藤 嘉和, 竹本 常松
    1975 年 95 巻 6 号 p. 764-766
    発行日: 1975/06/25
    公開日: 2008/05/30
    ジャーナル フリー
    The seed oil Euphorbia lathyris (coper-spurge seed) mainly consists of free fatty acids. Gas chromatographic analysis of the fatty acids after methylation indicated the presence of palmitic (5.5%), oleic (89.2%), linoleic (0.4%), and linolenic (0.3%) acids, with 0.3% of unidentified acid (s). Column chromatographic separation of this seed oil yielded a hydrocarbon, glyceride, epoxylathyrol, ester L3, and ester L2.
feedback
Top