巻号一覧
96 巻, 4 号
選択された号の論文の23件中1～23を表示しています
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東野 武郎, 五井 正美, 林 英作1976 年 96 巻 4 号 p. 397-400
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーReaction of quinazoline and aromatic aldehydes in dimethyl sulfoxide, in the presence of a cyanide ion, results in the formation of 4, 4'-biquinazoline (III), aryl 4-quinazolinyl ketone (IV), and α-aryl-4-quinazolinemethanol (V), though the yield is low at times. Formation route of IV was examined, based on various observations made in the present and previous experiments.抄録全体を表示PDF形式でダウンロード (466K) -
澤 陽一, 増田 亨, 堀 幹夫, 藤村 一1976 年 96 巻 4 号 p. 401-406
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーIn order to examine their pharmacological activity, 1, 2, 3, 4-tetrahydro-4, 4-dimethyl-isoquinoline derivatives were synthesized through three routes. First, these compounds were synthesized via the Bischler-Napieralski reaction of N-formyl-2-(3-methoxyphenyl)-2-methylpropylamine (IV) ; second, via the cyclization of 2-(2-chloromethyl-5-methoxy-phenyl)-2-methylpropyl chloride (XVII), and third, via the Beckmann rearrangement reaction of 5-methoxy-3, 3-dimethyl-1-indanone oxime (XVIII). Some of the compounds were found to have an analgesic activity.抄録全体を表示PDF形式でダウンロード (744K) -
篠田 雅人, 鴨川 旭, 市川 雍子, 中陳 静男, 清水 素行1976 年 96 巻 4 号 p. 407-412
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーLeukocytosis-promoting response in rabbits was examined after intravenous injection of parotin, saliva parotin A, adrenocorticotropin (ACTH), or bacterial lipopolysaccharide (LPS-K3). 1) Potency of the agents used was in approximate ratio of 1 : 100 : 1 : 2000 for parotin, saliva parotin A, ACTH, and LPS-K3. 2) Continuous daily injection for 4 weeks resulted in the loss of reactivity except in the case of parotin. 3) When the rabbits with loss of reactivity to leukocytes by the continuous injection of saliva parotin A, ACTH, or LPS-K3 for 3-4 weeks were injected with a different agent, similarity of the action was observed only in the combination of ACTH and LPS-K3. In other combinations, leukocytosis-promoting response appeared, indicating that there is a difference in the action mechanism of these agents.抄録全体を表示PDF形式でダウンロード (606K) -
平瀬 進, 中井 幸子, 赤津 常夫, 小林 朋, 大原 稔, 松永 謙一, 藤井 雅彦, 小平 哲, 藤井 孝美, 古荘 孝雄, 大村 嘉 ...1976 年 96 巻 4 号 p. 413-418
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーA polysaccharide mixture was extracted from the mycelium of Coriolus versicolor with hot water and precipitated with ethanol. Fractionation with increasing concentrations of barium hydroxide solution and then with a cetyltrimethylammonium hydroxide solution afforded five fractions, among which a fraction precipitating with 0.3N barium hydroxide solution was found to have a marked antitumor activity against sarcoma-180 implanted in mice. This fraction was found to be composed of β-D-glucan and a smaller amount of protein, which could not be separated from the glucan moiety by any of the Sevag method, precipitation with trifluorotrichloroethane, digestion with pronase, or chromatography on a column packed with molecular sieves. On hydrolysis, this fraction gave D-glucose as the only carbohydrate component together with common amino acids. A β-glycosidic linkage was suggested from a low value of its specific optical rotation.抄録全体を表示PDF形式でダウンロード (698K) -
平瀬 進, 中井 幸子, 赤津 常夫, 小林 明, 大原 稔, 松永 謙一, 藤井 雅彦, 小平 哲, 藤井 孝美, 古荘 孝雄, 大村 嘉 ...1976 年 96 巻 4 号 p. 419-424
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーStructural examination was made on the glucan moiety of the three fractions composed of β-D-glucan and 12-14% protein, among the five fractions of the water-soluble polysaccharide mixture obtained from the mycelium of Coriolus versicolor. On periodate oxidation, each fraction consumed about 1.5mol of the oxidant with formation of about 0.5mol of formic acid. Periodate oxidation followed by reduction with potassium borohydride and subsequent hydrolysis of each fraction gave glycerol, erythritol, and glucose. Complete methylation and hydrolysis afforded 2, 3, 4, 6-tetra-, 2, 3, 6-tri-, 2, 4, 6-tri-, 2, 3-di-, 2, 4-di-, and 2, 6-di-O-methyl-D-glucoses in the proportion different for each fraction. Identification of these hydrolysis products was carried out on the crystalline basis as well as by gas-liquid chromatography. These results suggested that the glucan moiety of the fraction with highest antitumor activity is composed of 1→4 linked β-D-glucose residues, which are occasionally branched at 3- and 6-positions, and that two other fractions with lower antitumor activity have a more complicated ramified glucans with increasing proportions of 1-3 and 1-6 linkages.抄録全体を表示PDF形式でダウンロード (750K) -
松田 芳久, 南田 祐子1976 年 96 巻 4 号 p. 425-433
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーColor fading of tablets colored with Eosin, Light Green SF, or Tartrazine was examined by the irradiation of high-pressure mercury vapor lamp in the fade tester. A series of sharp-cut glass color filters were used to examine the effect of intensity of light. Changes in surface color were traced by a colorimetric method using the integrating sphere-type color difference meter. The chromaticity coordinates, a, and b, and lightness, L, in the Lab system changed exponentially with increasing exposure time. However, no functional relationship was obtained between these values and illumination, or radiation energy of the lamp. Stability to fading was evaluated using Hunter's color difference formula, and compared by the acceptable color difference. Eosin and Light Green SF had poor stability, while Tartrazine was very stable. It was confirmed that the intensity of ultraviolet rays mainly contributed to the fading, but that the visible light with longer wavelength was also responsible.抄録全体を表示PDF形式でダウンロード (971K) -
緒方 宏泰, 斎藤 恵美子, 村田 久子, 柴崎 利雄, 井上 哲男1976 年 96 巻 4 号 p. 434-439
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーStability of 0, 0-dimethyl 2, 2-dichlorovinyl phosphate (DDVP) in oil preparations was examined at 70°, 110°, 130°, and 150°. At these temperatures, DDVP was degradated to the aldehyde compound, the reaction following a sigmoid curve against standing time. From Arrhenius plots, induction time for DDVP degradation at 20°was presumed to be about 17 years. Fenitrothion, Baytex, Pynamin, and Piperonylbutoxide did not affect the stability of DDVP significantly. Kerosines with impurities and emulsifiers, especially anionic emulsifiers, increased the degradation rate of DDVP in oil preparations, while cresol inhibited the degradation of DDVP.抄録全体を表示PDF形式でダウンロード (693K) -
南川 伝憲, 松村 阜子1976 年 96 巻 4 号 p. 440-446
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーNoscapine formed a complex with Reinecke salt in the presence of tartaric acid (pH 1.7) and was extracted with chloroform. The amount of noseapine was determined indirectly by measuring chromium in the organic solvent solution by atomic absorption spectroscopy. This method was applied to the analysis of preparations and good results were obtained without any interference of various pharmaceuticals.抄録全体を表示PDF形式でダウンロード (655K) -
濱田 喜樹, 松岡 英子1976 年 96 巻 4 号 p. 447-455
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリー1) Sodium 2-chloro-5-nitrobenzenesulfonate was reacted with the corresponding anilines in water, sealed in a tube, and 4-substituted 4-nitrodiphenylamine sulfonates (I-VI) were obtained. These salts were hydrolyzed with hydrochloric acid to the corresponding 4'-substituted 4-nitrodiphenylamines (VII-XI), and they were reduced with stannous chloride and hydrochloric acid to the 4'-substituted 4-aminodiphenylamines (XII-XVI). 2) Sodium alkoxides of 4-hydroxy-4-nitrodiphenylamine were reacted with the corresponding alkyl halogenides in ethanol and the 4'-alkoxy-4-nitrodiphenylamines (XVII and XVIII) so formed were reduced with zinc and ammonium chloride to the 4'-alkoxy-4-aminodiphenylamines (XIX and XX). The N-ethl-4-methyl-4'-amino-diphenylamine (XXII) was obtained by the reduction of N-ethyl-4-methyl-4'-nitro-diphenylamine (XXI) with zinc and ammonium chloride. 3) The compounds XXIII to LII were obtained by the reaction of haloacetyl chloride with the corresponding amino compounds in acetic acid. The iodo compounds (LIII to LXII) were obtained by the reaction of the corresponding chloroacetylamino compounds with potassium iodide in acetone. 4) Antibacterial activity of these compounds were examined and XXXVI, XXXVII, XLII, XLVI, and LX showed a strong antibacterial activity.抄録全体を表示PDF形式でダウンロード (822K) -
佐伯 清太郎, 山下 絢子, 盛中 泰洋, 浜名 政和1976 年 96 巻 4 号 p. 456-464
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーTreatment of dehydro-1-methylquinolizidines (IVa and IVb) with the benzoyl chloride-adduct of pyridine N-oxide in dichloromethane followed by reduction of the reactants with sodium borohydride afforded 1-methyl-9-(2-pyridyl) quinolizidine (VI) and 1-methyl-1-(2-pyridy) quinolizidine (VII) in 4.1 and 8.3% yields, respectively. A similar treatment of IV with 4-chloropyridine 1-oxide and subsequent catalytic dechlorination of the products also gave VI and VII in 12.3 and 21.5%, respectively. From the reaction of IV with 2-chloropyridine N-oxide, 1-methyl-1-(4-pyridyl) quinolizidine (IX) was obtained as a sole product. The reaction of 9(10)-dehydro-1-hydroxy-1-methylquinolizidine (V) with pyridine N-oxide was carried out and two stereoisomers (XIa and XIb) of 1-hydroxy-1-methyl-9-(2-pyridyl) quinolizidine were isolated in respective yields of 5.9 and 4.3%. The configuration of these products and related compounds was deduced from infrared and nuclear magnetic resonance spectral examinations.抄録全体を表示PDF形式でダウンロード (971K) -
坂本 みずほ, 斉須 久美代, 高村 喜代子1976 年 96 巻 4 号 p. 465-470
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーPolarographic behaviour of benzotriazol (I) in aqueous solution and its application to the determination of I were examined. I gives a cathodic wave on direct current (DC) polarogram in only strongly acidic solution. An increase in pH of the solution results in a marked decrease of the limiting current. The half-wave potentials are correlated with pH by a straight line with a slope (ΔE/ΔpH) of ca. -0.08. These findings support the electrode reaction mechanism including the four-electron reduction of the protonated species of I reported by Lund. In the positive potential region, I shows four anodic waves due to the complex formation between mercury and I. The pH dependence of these waves has been explained in relation to the acid-base equilibria of I. The limiting current of the cathodic wave obtained in 0.2M HCl solution increases linearly with the increasing concentration of I ranging from 5.0×10-6 to 5.0×10-8M. This result is directly applicable to the simple determination of I. In a relatively higher pH region, I reacts with Cu2+ to produce a blue-green precipitate corresponding to the 1 : 2 complex of Cu2+ and I. The amperometric titration of I was examined using Cu2+ as a precipitant in acetate buffer solution (pH 5.6). This method can be used to determine the concentrations of I up to 5×10-4M, with a relative error within ±3.0%.抄録全体を表示PDF形式でダウンロード (695K) -
高取 吉太郎, 今井 一夫, 中埜 末春, 長谷川 高明, 浅野 進吾1976 年 96 巻 4 号 p. 471-474
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーBy the fusion method, 16 kinds of amide-type compounds were synthesized from the phenyl esters of heterocyclic acids and heterocyclic amines, and their antitumor activities were examined with Ehrlich ascites carcinoma and Crocker sarcoma-180 in mice. None of them had a strong antitumor activity, but 7 of the test compounds, 2-isonicotinoylamino-1, 3, 4-thiadiazole (VIII), 2-nicotinoylamino-5-isopropyl-1, 3, 4-thiadiazole (IX), 2-isonico-tinoylamino-5-isopropyl-1, 3, 4-thiadiazole (X), 2-(α-thenoylamino)-5-isopropyl-1, 3, 4-thiadiazole (XI), 2-(α-furoylamino)-5-isopropyl-1, 3, 4-thiadiazole (XII), 2-isonicotinoylamino-5-isobutyl-1, 3, 4-thiadiazole (XIV), and 2-(α-furoylamino)-5-isobutyl-1, 3, 4-thiadiazole (XVI), had a moderate to slight antitumor activity against these solid tumors. It was noteworthey that all these effective compounds were the derivatives of 2-amino-1, 3, 4-thiadiazole.抄録全体を表示PDF形式でダウンロード (469K) -
辻 邦郎1976 年 96 巻 4 号 p. 475-478
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーAs one of studies on active principles of tar, antifungal constituents in egg tar were examined. An active principle (VI) was isolated by a suitable combination of counter-current distribution and column chromatography. The oily VI (picrate, mp 109°) was found to be identical with a mixture of 2-butyl- and 2-isopentyl-benzimidazoles from physicochemical data of VI and comparison with retention time of authentic sample in gas-liquid chromatography.抄録全体を表示PDF形式でダウンロード (491K) -
辻 邦郎1976 年 96 巻 4 号 p. 479-483
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーIn connection with studies on active principles of tar antifungal constituents in egg tar were examined. 3-Dodecyl, 3-tridecyl-, and 3-tetradecyl-pyridines (I), 2-isopropyl- and 2-isobutyl-7-azaindoles (II), and 2-nonyl-5, 6, 7, 8-tetrahydroquinoline (III) were isolated as active constituents by the procedure similar to that used previously.抄録全体を表示PDF形式でダウンロード (595K) -
近 由喜子, 土橋 やよい, 桂 博二1976 年 96 巻 4 号 p. 484-489
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーExaminations were made on the microbiological properties of Strain F1, a Hyphomycetes found in excrements of Cettia diphone cantans and showed some specific properties on the uricase formation. Colonies on the Czapek agar spread rather broadly, and were pale yellowish brown to avellaneous. Conidiophores were short, 10-20 μm, mostly arising from aerial hyphae. Annellophores were in a group of 3 to 4, or singly. Conidia were lemon-shaped or globose with flattened truncate base, verrucose-walled, measuring 7-9×5-7 μm. Details of conidia and other structures were observed under an electron microscope ; annellation on anellophore necks, marginal frill at the conidial base, etc. Physiologically, the strain decomposes arsenic compounds to release arsenic gas characterized by its garlic odor. From the examination of the morphological and physiological characteristics, together with various descriptions of the genus by several microbiologists, strain F1 is identified as Scopulariopsis brevicaulis (SACC.) BAINIER.抄録全体を表示PDF形式でダウンロード (1196K) -
土谷 義己, 森 昌斗, 田口 胤三1976 年 96 巻 4 号 p. 490-497
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーTo examine the effect of neighboring group on thermal treatment of O-alkyl S-methyl dithiocarbonates, syntheses of O-ethyl S-methyl dithiocarbonates holding alkyl (or aryl)-sulfinyl group were tried by the reaction of 2-alkyl (or aryl) sulfinylethanol and carbon disulfide in an aqueous sodium hydroxide followed by methylation with methyl iodide. However, the reaction did not progress as expected and gave 2-alkyl (or aryl) sulfinylethyl methyl trithiocarbonates (Va, -d) as main products. Nuclear magnetic resonance spectral data of these products suggested the formation of trithiocarbonate to occur via elimination and addition. It was thereby clarified that the alkyl (or aryl) sulfinyl as the neighboring group worked as an electron-attracting group to favor elimination.抄録全体を表示PDF形式でダウンロード (799K) -
林 輝明, 辻 仁孝, 松田 太郎1976 年 96 巻 4 号 p. 498-502
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーTwo new methods were developed for the determination of swertiamarin, the main bitter principle of the herb of Swertia japonica and of Swertia pseudochinensis. In the preparative thin-layer chromatography-ultraviolet (TLC-UV) method, swertiamarin in the methanol extractive of Swertia herb is separated by preparative TLC developing with AcOEt·n-PrOH·H2O (6 : 1 : 3) (detected as a pink spot by a PAN-UV Lamp) and is determined by the ultraviolet absorbance at 238nm. In the TLC-densitometer (DM) method, the MeOH extractive containing swertiamarin is developed on a TLC plate (Kieselgel 60F254) using the same solvent system, and the amount of swertiamarin (Rf ca. 0.3) is determined by TLC densitometry, using a dual-wavelength TLC scanner. By these methods, the contents of swertiamarin were found to be 1-2.5% in Swertia Herba and 0.9-1.5% in Swertia Pseudochinensis Herba (both Osaka market products). It has also been found that the content of swertiamarin in Swertiae Herba varie depending on the parts of the original plant and decreases in the order of flowers, leaves, stems and roots.抄録全体を表示PDF形式でダウンロード (569K) -
Triazine系化合物の薬理学的研究(第3報)2-(Benzylidenehydrazino)-4-tert-butyl-6-piperazino-8-triazine(TR-35)の鎮痛抗炎症作用戸部 昭広, 梅津 浩平1976 年 96 巻 4 号 p. 503-510
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーAnalgesic and anti-inflammatory actions of TR-35 (2-(benzylidenehydrazino)-4-tert-butyl-6-piperazino-s-triazine) were examined and the results are briefly summarized as follows. Analgesic activity of TR-35 was on the whole more potent than that of aminopyrine and comparable to that of mepyrizole in various methods of pain responses such as pressure pain on the mouse tail, electrical stimulation method in mice, and Randall-Selitto's method in rats. TR-35 expressed significant inhibitory effect in the acute edema tests in the rat hind paw. Depressant activity of carrageenin-induced edema was in the descending order of indomethacin, TR-35, mepyrizole, and aminopyrine. TR-35 also showed more potent inhibitory action than indomethacin in serotonin, dextran, and yeast edema tests. On the other hand, inhibitory action of TR-35 on the cotton-pellet granuloma was very weak compared with that of cortisone. Concering the other pharmacological properties, TR-35 exhibited a moderate muscle relaxant action and significantly potentiated the pentobarbital-induced sleeping time in mice. TR-35 was practically devoid of gastroulcerogenic activities in rats. It may be concluded from these results that pharmacological properties of TR-35 are similar to those of basic anti-inflammatory agents.抄録全体を表示PDF形式でダウンロード (821K) -
劉 勝彦, 高井 誠, 荻原 幸夫1976 年 96 巻 4 号 p. 511-518
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーThe mass spectra of the flavonoids and their derivatives, isolated from the fruits of Lindera erythrocarpa MAKINO were examined to elucidate their fragmentation pattern. Electron impact reaction easily converted quinochalcones, the precursor of cyclopentenedione derivatives (A-norchalcone), to cyclopentenedione derivatives by decarbonylation.抄録全体を表示PDF形式でダウンロード (683K) -
小澤 光, 弘中 豊1976 年 96 巻 4 号 p. 519-526
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーHypotensive effect of dl-2-(3, 4-methylenedioxyphenyl)-2-hydroxyacetamidine hydrochloride (dl-mandelamidine) and its optical isomers (l-mandelamidine, d-mandelamidine) was examined. All the compounds used in the present experiment caused long-lasting hypotensive effect on the systolic blood pressure in both unanesthetized spontaneously hypertensive rats and unanesthetized normotensive Wistar rats). Moreover, these three compounds produced a temporary hypotensive effect followed by long lasting ones on the carotid blood pressure in normotensive Wistar rats anesthetized with urethane. In spontaneously hypertensive rats, the long-lasting hypotensive effect of l-mandelamidine) (50-100mg/kg, oral) was rather potent than those of d- and dl-mandelamidine (50-100mg/kg, oral). On the other hand, the hypotensive effect of l-mandelamidine (100-200mg/kg, oral or 10-30mg/kg, intravenous) was the same degree as those of d-and dl-mandelamidine (100-200mg/kg, oral or 10-30mg/kg, intravenous) in unanesthetized or anesthetized normotensive Wistar rats. The sympathetic nerve-blocking action of three compounds were studied by the inhibitory responses of isolated rabbit jejunum to the mesenteric perivascu1ar nerve stimulation and the contraction of the anesthetized cat nictitating membrane to the preganglionic stimulation of cervical sympathetic nerve. d-Mandelamidine (1×10-4g/ml or 5 mg/kg, intravenous) showed the most potent blocking action of both responses. The contractions of the anesthetized cat nictitating membrane to norepinephrine and epinephrine was potentiated by d-and dl-mandelamidine (5mg/kg, intravenous), but inhibited by l-mandelamidine (5mg/kg, intravenous). In the guinea-pig atria, the compounds (10-7-10-3g/ml) used herein showed negative inotropic and chronotropic actions, and these actions of l-mandelamidine were the most potent. Thus, it is likely that pharmacological action of the optical isomers of dl-mandelamidine is different from that of dl-mandelamidine.抄録全体を表示PDF形式でダウンロード (938K) -
谷 千秋, 田ケ原 清, 荒谷 せつ子1976 年 96 巻 4 号 p. 527-532
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーA new alkaloid, named nokoensine, was isolated from Corydalis nokoensis HAYATA from Taiwan, together with protopine, dl-tetrahydropalmatine, dihydrosanguinarine, capaurine, corybulbine, sanguinarine, palmatine, captisine, and dehydrocorybulbine. The structure of nokoensine was determined as capaurine N-oxide from various spectral data and by the synthesis.抄録全体を表示PDF形式でダウンロード (704K) -
八代 有, 白井 秀明1976 年 96 巻 4 号 p. 532-535
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーFor the purpose of testing their biological activity, 4-dialkylaminomethyl-4-(m-methoxyphenyl)cyclohexanol derivatives (XII, XIII, XIV) were synthesized. 4-Dimethyl-aminomethyl-4-(m-methoxyphenyl)cyclohexanone (XII) was synthesized from 4-dimethyl-aminomethyl-4-(m-methoxyphenyl)cyclohexanone ethylene acetal (XVIII), which was obtained from 1-(m-methoxyphenyl)-4-oxocyclohexanecarboxylic acid ethylene acetal (XV). 4-Dimethylaminomethyl-4-(m-hydroxyphenyl) cyclohexanol (XIII) was prepared by demethylation of 4-dimethylaminomethyl-4-(m-methoxyphenyl) cyclohexanol (VIII) with boron tribromide in dry dichloromethane. 4-Diethylaminomethyl-4-(m-methoxy-phenyl) cyclohexanol (XIV) was synthesized by the reduction of N, N-diethyl-1-(m-methoxy-phenyl)-4-acetoxycyclohexanecarboxamide (XXII) in tetrahydrofuran with lithium aluminum hydride. These compounds, XII, XIII, and XIV, did not show any significant analgesic activity.抄録全体を表示PDF形式でダウンロード (506K) -
由岐 英剛, 辻本 利雄, 沢田 照夫, 瀧浦 潔, 山口 達明1976 年 96 巻 4 号 p. 536-543
発行日: 1976/04/25
公開日: 2008/05/30
ジャーナル フリーThe ring structure of tenuazonic acid, which is an antitumor antibiotic, was modified to oxazolidine, thiazolidine, and pyrazo1idine ring, in addition to indan-dione derivatives. Their acetyl groups were condensed with a variety of aniline derivatives. The antitumor activity of these modified compounds was examined against Ehrlich solid tumor. None of the compounds tested has shown better effect than Mitomycin-C.抄録全体を表示PDF形式でダウンロード (656K)
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