Anti-inflammatory effect of C
10-C
20 saturated fatty acids was examined by using heat-induced hemolysis, hypotonic hemolysis, heat-induced denaturation of bovine serum albumin (BSA), and carrageenin-induced paw edema as the experimental systems. 1) Several fatty acids, including C
13 : 0 to C
17 : 0, were found to protect erythrocytes from heat-induced hemolysis, and C
12 : 0 to C
16 : 0 significantly inhibited hypotonic hemolysis in vitro. 2) All fatty acids tested showed a significant effect on heat-induced denaturation of BSA at a concentration of 5.0 μg/ml in vitro, but C
16 : 0 methyl ester did not show any inhibitory effect at the same concentration. 3) Palmitic acid, its methyl ester, and oleic acid suppressed carrageenin-induced paw edema in rats by oral administration at the dosage of 200 mg/kg, but C
16 : 0 methyl ester did not suppress it by intraperitoneal injection. 4) In adrenalectomized rats, palmitic acid also suppressed carrageenin-induced paw edema. 5) Palmitic acid inhibited the granuloma formation caused by felt-pellet at the dose of 100 mg/kg/day (oral) for 5 days, but did not show a significant effect on either exudation into the granuloma pouch or on formation of pouch wall.
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